CN1899546A - Medicinal composition for treating hepatitis B - Google Patents

Abstract

The medicinal composition for treating hepatitis B is prepared with ten kinds of Chinese medicinal materials, including yangtao actinidia root, serrate rabdosia herb, astragalus root, wild black ant, Chinese mahonia, etc, and through pre-treating materials, water extraction, extracting volatile oil, filtering, alcohol extraction, spray drying, adding fine silica gel powder, dextrin and aspartame, spraying volatile oil, sieving, packing and other steps. The medicinal composition has the functions of clearing away heat and toxic material, dispelling damp, benefiting gallbladder, nourishing liver, promoting blood circulation to disperse blood clots, etc. and possesses high curative effect on hepatitis B, no toxic side effect and other features.

Description

A kind of pharmaceutical composition that is used for the treatment of hepatitis B

Technical field

The present invention is a kind of pharmaceutical composition that is used for the treatment of hepatitis B.

Background

Hepatitis B, particularly chronic hepatitis B have become global public health problem, the chronic carrier of the whole world about 3.5 hundreds of millions hepatitis type B viruses (HBV), mostly be greatly the Asian, about 1.2-1.3 hundred million people of China, wherein 20%-50% causes cirrhosis or liver cancer the most at last. HBV infects and causes the quite high incidence of disease and case fatality rate. The whole world has the people more than 1,000,000 to die from HBV infection and relevant disease thereof every year at present according to statistics. The annual direct economic loss that causes because of hepatitis B of China reaches 50,000,000,000 yuan, but so far chronic hepatitis B is still lacked desirable methods for the treatment of and medicine. Therefore how effectively to prevent and treat hepatitis B and be still the key subjects that 21 century will face and need solution.

Because a kind of research and development of new chemicals, clinical testing take more than 10 years consuming time to the listing that finally formally gets the Green Light, hundred million dollars of expensive 1-2 add the toxic and side effect of chemicals and more and more are familiar with by people, make its development prospect face great difficulty. Such as interferon, it has antiviral activity (it is to the certain inhibitory action of having copied of hepatitis B virus DNA and HCVRNA), antitumor activity and the immunoregulation effect of wide spectrum. Therefore, the prolonged application interferon not only can suppress virus replication, reduces infectiousness, can also alleviate the inflammatory reaction of liver, alleviate pathological lesion, can prevent that chronic viral hepatitis is to the development of cirrhosis simultaneously, reduce the generation of liver cancer, become the first-line drug for the treatment of hepatitis. But interferon antivirally also have simultaneously fever, chilly, bodily pain, headache, perspiration, feel sick, the side effect of vomiting etc. " influenza-like symptom ", also may cause white blood cell and hematoblastic temporary transient minimizing. The patient's medication that has alimentary canal can occur after 1 month, the symptom of the aspect such as allergic, spiritual, thereby in the use of interferon, should note monitoring blood picture (leucocyte, blood platelet), routine urinalysis, liver function, the toxic and side effect severe patient interferon of need stopping using, and its expensive also be a large shortcoming. And the used raw material of Chinese medicine preparation is autonomic drug mostly, also has animal, the natural drugs such as mineral, in addition various places " herbal medicine " of including, " ethnic drug " etc. is more than the kind, the richness of resource and use long, for exploitation, research, the production of hepatitis Chinese medicine preparation provides wide material base. The yiganning granules of including such as NF is comprised of the Radix Astragali, Radix Codonopsis, the red sage root, the tuber of multiflower knotweed, the root of herbaceous peony, Poria cocos, oriental wormwood etc., has the adjusting invigorating the spleen, and nourishing the kidney and the liver is promoting blood circulation and removing blood stasis, the effect of cholagogic heat-clearing. And chronic hepatitis shows as the spleen kidney deficiency more, and liver depression stasis, and the wet sign such as do not disappear of phlegm are treated just to its card, so the promising result of obtaining with this medicine. Data shows, yiganning granules treatment chronic hepatitis truly has good therapeutic effect, particularly eliminating and to improve aspect the symptom effect remarkable, various symptoms, total disappearance rate is 87.5%, and total effective rate is 98.2%, also has the ratio effect of falling enzyme, removing jaundice and improving hyperglobulinemia. Clinical trial results suggest yiganning granules can improve body's immunity, has certain inhibition HBV effect, and toxic effects is easy to use in addition, and is safe and effective, and price is lower, deeply is subjected to patient's favorable comment. Long-term clinical practice and modern pharmacological research proof Chinese herbal medicine have one's own knack in the control hepatitis, and Western medicine can't substitute. The westerner who has too much of chemicals thirsts for going back to nature, and believes the curative effect of Chinese medicine. In recent years, domestic medical worker makes great efforts to excavate motherland's medicine treasure-house, in succession developed such as YIGANNING CHONGJI, hepatitis B strengthening capsule, polyporus polysaccharide injection, FUGANNING PIAN, lentinan film, the Guan Shi liver protects external application bag, medicine powder for hepatitis B, tonic infusion of versicolor for liver, the Chinese patent drugs such as FUGANKANG agent, through clinical practice, though the treatment hepatitis B medicine shows certain curative effect aspect a lot, make the treatment of hepatitis and prevention that new development arranged, but effect is not remarkable, total effective rate is no more than 40%, and the hepatitis B medicine repeat usage is low, and the preparation formulation kind is few, and mostly be low-level repetition, i.e. so-called " new drug is not new, and the life-span is long " mostly is the manufactured goods of raw material crude extract. Because herbal species is many, classical prescription, proved recipe is many, must screen by the medicine of a large amount of work to the treatment hepatitis B, therefrom finds hepatitis B real effectively medicine and active component are lacked medicine and the contradiction of selecting medicine to alleviate prophylactic treatment. Given this, exploitation is efficient, and quick-acting, " a kind of pharmaceutical composition that is used for the treatment of hepatitis B " this new drug for the treatment of both principal and secondary aspect of disease has very wide application prospect.

Purpose

For satisfying clinical needs, what we developed is a kind of having no side effect, and good effect is rapid-action, treats both principal and secondary aspect of disease, efficiently new drug---a kind of pharmaceutical composition that is used for the treatment of hepatitis B. We are the improvement sides on secret prescription handed down in the family from generation to generation " hepatitis B decoction " basis, Tang Yijia and Li Fangqun doctor's for many years clinical practice and Chen Yuxiang professor and Liu Ting doctor's the side of tearing open and the research of formulation of Central South University at the characteristic medical treatment training of supporting the army through Shaoyang, Hunan, improve in conjunction with at all times medical science and modern pharmacology achievement in research, we cure mainly hepatitis B.

Content

Jaundice have yin, yang minute, the yang jaundice duty in damp and hot, the yin jaundice duty in cold-dampness. We consolidate eliminating evil effect for controlling the side of jaundice with damp-heat pathogen, having. The cause of disease is all steamed because of damp and hot friendship, and heat must not be got over outward, and wet must not and lead off, damp evil and hot and suffocating the steaming in skin, asthenia of liver and spleen again, the heat stagnation blood stasis, The liver and the kidney have a common source, just unsaturated vapor is being through disease all the time. With eliminating evil and righting two method compound uses, on the one hand heat-clearing, dampness removing, cool blood, detoxifcation, eliminating evil with righting, on the other hand with invigorating the spleen, nourishing the liver, kidney-nourishing, rectify with eliminating evil so our regulating the qi flowing in the channels invigorating the spleen nourishing the kidney and the liver, the cholagogic heat-clearing, promoting blood circulation and removing blood stasis with eliminating evil and righting. This prescription is totally 10 flavor medicines. Formed by Chinese actinidia root 800-1120g, rabdosia lophanthide 240-320g, Radix Astragali 240-320g, wild silky ant 400-560g, Chinese mahonia 160-224g, hispid fig root 400-560g, lepidogrammitis drymoglossoides Ching 240-320g, coix seed 240-320g, living hawthorn 240-320g, date 400-560g. Wherein the Radix Astragali, coix seed, hawthorn, date, Chinese mahonia 5 flavor medicines are that NF is included, wild silky ant is stated from " Guangxi province Chinese medicine standard ", Chinese actinidia root, lepidogrammitis drymoglossoides Ching, rabdosia lophanthide 3 flavor medicines are included in " national Chinese herbal medicine compilation ", and hispid fig root is medication among the people.

Chinese actinidia root among the we, sweet acid and trembling with fear lightly seasonedly is with puckeryly, and property is flat. Mainly contain cupreol, ursolic acid, daucosterol, 2a, 3a, 24-three-hydroxyl-12-alkene-28-malol (AE5) and a new triterpenic acid: Eriantic acid A and three kinds of volatile oil. Pharmacological research shows that it has good anticancer effectiveness. Have analgesic, quench the thirst, the effect of activating blood circulation and reducing swelling, treating stranguria, stomach invigorating, can treat dysphoria with smothery sensation, quench one's thirst, under the oedema, icterohepatitis, vomiting, diarrhoea, urolithiasis, rheumatic arthritis, hypogalactia, gonorrhoea, band, the disease such as sore furuncle, scrofula, and also have antidotal acting as to cure mainly medicine.

Rabdosia lophanthide, bitter but sweet flavor is little puckery, and property is flat, and is nontoxic, enters the liver lung channel. It contains the material complexity, and how composition mainly is Diterpenes and flavonoids. Pharmacological research shows that it has antibiotic, anti-inflammatory, antiviral, antitumor, liver protection effect, to smooth muscle and Cardiovascular etc. Rabdosia lophanthide extractive shows that to the experimental study of AIDS virus 1 type (HIV-1) it has certain inhibitory action to HIV-1. Reducing fever and causing diuresis removing jaundice for oral administration goes long-pending pain relieving; Externally used detumescence. Curing mainly heatstroke stomachache, weak after being ill, hepatitis, jaundice, edema caused by wind-dampness, the long-pending pain of the traumatic injury chest side of body, the pectoralgia spitting of blood is controlled married woman's breast pain outward, with upper be monarch drug in a prescription altogether.

The Radix Astragali, it is sweet warm in nature to distinguish the flavor of, and enters spleen, lung channel. Mainly contain astragalin, pharmacological research shows that it is improved immunity, experimental hepatosis has the effects such as defencive function. Have tonifying Qi and lifting yang, benefit is defended solid table, inducing diuresis for removing edema, strengthening exterior and reducing sweat, pus draining and toxin expelling, holder sore myogenic. Be used for deficiency of vital energy lassitude hypodynamia, spleen-lung Qi deficiency, anorexia and loose stool, the sinking of qi of middle-jiao, splanchnoptosia is rushed down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, ulcer is difficult bursts, and bursts for a long time and does not hold back, and the deficiency of blood is sallow, oedema, beriberi, interior heat is quenched one's thirst.

Wild silky ant, the flavor saline taste is hot, enter liver kidney two warps, contain protein more than 42%, contain 28 seed amino acids, wherein necessary 18 seed amino acids of human body are complete, and contain the necessary trace element of the human bodies such as vitamin B1, B2, B12, E, D and high energy phosphide such as zinc, the abundantest and macroelement of Se content. Ant is a kind of tonic of gentleness, have strengthen the body resistance to consolidate the constitution, the effect of tonifying kidney and strengthening yang, nourish blood flourish muscle, eliminating blood stasis and smoothing collaterals. Improving immunologic function, the treatment rheumatoid arthritis; Regulate gonadal Function, there is significant curative effect the aspects such as treatment impotence, premature ejaculation and antifatigue, anti-anoxic. Also there are some researches prove the drug effects such as ant also has calmness, calms the nerves, anti-inflammatory. The modern medicine clinical trial certificate, the pharmacological actions such as ant has anti-inflammatory, analgesia, calmness, spasmolysis, protects liver, relievings asthma, anticonvulsion, anti-epileptic, enhancing RCD, gastric acid secretion inhibiting and prevention acute ulcer also have two-way immunological regulation and the function such as anti-ageing, anticancer.

Chinese mahonia, anticancer, the anti-inflammatory detumescence of relieving internal heat, heat-clearing and damp-drying drug, the effect of purging intense heat and detonicating. Cure mainly damp-heat dysentery, jaundice, red eye, swell pain, gastropyretic toothache, the sore furuncle, carbuncle is swollen, dysentery, icteric hepatitis. More than three medicines can assist main ingredient to strengthen result for the treatment of, also can rise about treatment for double disease and double disease, playing altogether the invigorating the spleen liver-nourishing kidney-boosting is minister.

Hispid fig root: acrid-sweet flavor, flat, the tepor of property, gas fragrance is returned lung, spleen, stomach, large intestine and Liver Channel. Its complicated component contains the trace element-selenium of needed by human especially. Pharmacological evaluation proves, hispid fig root have cough-relieving, antitumor, antiviral, affect the effects such as drug metabolism. Have that beneficial gas qi-restoratives, promoting qi circulation and removing obstruction in the collateral, strong muscle are active, invigorating the spleen for eliminating dampness, the effect such as relieving cough and reducing sputum. Be used for controlling pulmonary tuberculosis cough, the night sweat spontaneous perspiration, limb is tired unable, deficiency of spleen-QI and stomach-QI, insufficiency of the spleen edema, the few abdominal distension of food, oedema, arthralgia due to wind-dampness, hepatitis, leukorrhea, postpartum the card such as agalasisa, pain in waist and lower extremities. Also be used for chronic hepatitis, cirrhotic ascites auxiliary curing.

Lepidogrammitis drymoglossoides Ching: property is flat, sweet, light, cool, the little hardship of distinguishing the flavor of. The lepidogrammitis drymoglossoides Ching water extract has antiinflammatory action, have clearing heat and detoxicating, blood circulation promoting and dispersing pathogen accumulation, the dampness removing effects such as the stasis of blood, desinsection that disappear, cure mainly: jaundice, rheumatic arthritis, mumps, scrofula, traumatic injury, breast cancer, constipation, high hot cramp, acute gastroenteritis, tonsillitis, scrofula, pain in the back, furunculosis furuncle etc.

Coix seed, living hawthorn, the date invigorating the spleen protects the liver and the property of medicine, antidote poison. All medicines are collaborative, the effect of yielding result altogether, clinical prevention and treatment for acute and chronic hepatitis, cirrhosis, liver cancer.

Herbal medicine (such as Chinese actinidia root, rabdosia lophanthide, lepidogrammitis drymoglossoides Ching) with Chinese medicine and less use is prepared into the Chinese patent drug for the treatment of hepatitis in conjunction with prescription, and its bibliographical information is we's a large characteristic seldom.

(1) Chinese actinidia root. Pharmacological research shows: 1. this product has good anticancer effectiveness, and its decoction or water soluble ingredient, ethanol extract all have obvious inhibitory action to tumor in digestive tract and cervical carcinoma etc. The Radix Actinidiae Chinensis extract anthraquinone analog compound has obvious lethal effect to tumour cell. (Zou friend and mentor etc. The experimental study of Chinese actinidia root inhibition tumor cell [J]. Traditional Chinese medicine Leader, Hunan, 1999,5 (4): 37-38) 2. Chinese actinidia root liquid main component is Kiwi berry polysaccharide (ACPS-R)) children's's immune system is had regulating action. Bibliographical information Chinese gooseberry root injection for treating infantile respiratory tract infection repeatedly is arranged. (Huang Yan etc. The research of Chinese gooseberry root injection for treating infantile respiratory tract infection repeatedly. [J] Chinese experimental clinical immunology magazine, 1993,5 (2): 42)

(2) rabdosia lophanthide. Pharmacological research shows that it has antibiotic, anti-inflammatory, antiviral, antitumor, liver protection effect, to smooth muscle and Cardiovascular etc. (Xiao Shuxiong. Rabdosia lophanthide recent research brief account situation. [J] Shantou science and technology, 2000,1:62-63)

(3) lepidogrammitis drymoglossoides Ching. Water extract has antiinflammatory action, has clearing heat and detoxicating, blood circulation promoting and dispersing pathogen accumulation, the dampness removing effects such as the stasis of blood that disappear. (Chen Zusheng etc. The antiinflammatory action of lepidogrammitis drymoglossoides Ching water extract. [J] Strait Pharmaceutical Journal, 2000,12 (3): 37-38)

Effect

Clinical onset of action is very fast, and drug effect is high and lasting, and is effective equally to the patient of liver function damage and cirrhosis, and the effect that suppresses virus replication is remarkable. Through the clinical observations (control group 30 examples) of more than 60 examples, great three positive patient 25 examples wherein, large two positive 1 examples, "small three positive" 4 examples, great three positive turns "small three positive" 5 examples, great three positive 1 example of turning out cloudy, and great three positive turns young waiter in a wineshop or an inn's sun 3 examples, large two sun 1 example of turning out cloudy, turn out cloudy 2 examples and produce surface antibody 1 examples of "small three positive", "small three positive" transfers surface antigen 1 example to, and wherein three examples are invalid, total effective rate reaches 90%, and efficient to the case that transaminase rising and virus replication are arranged is more than 90%.

	Prescription	Function cures mainly	Usage and dosage	Toxic and side effect and attention	Clinical observation	The source
							A kind of pharmaceutical composition that is used for the treatment of hepatitis B	Chinese actinidia root 800-1120g, rabdosia lophanthide 240-320g, Radix Astragali 240-320g, wild silky ant 400-560g, Chinese mahonia 160-224g, hispid fig root 400-560g, lepidogrammitis drymoglossoides Ching 240-320g, coix seed 240-320g,	Clearing heat and detoxicating, the clearing damp cholagogic, the regulating the qi flowing in the channels invigorating the spleen, nourishing the kidney and the liver, promoting blood circulation and removing blood stasis. Cure mainly virus hepatitis, cirrhosis, liver cancer	Oral 15g/ time, 2 times/days, less than cutting down according to the circumstance of mature age or body weight, the March/course for the treatment of	Without obvious toxic-side effects	Total effective rate reaches 90%, and efficient to the case that transaminase rising and virus replication are arranged is more than 90%	Secret prescription handed down in the family from generation to generation

	Living hawthorn 240-320g, date 400-560g.
							A kind of Chinese patent drug A that treats hepatitis B	Radix notoginseng 8-25 (weight) %, pig gall bladder 3-18 (weight) %, black ant 8-22 (weight) %, fruit of Chinese magnoliavine 3-18 (weight) %, ageratum 8-26 (weight) %, Radix Angelicae Sinensis 3-18 (weight) %	Patient to liver diseases such as hepatitis B, big and small three Yang, liver function is undesired, liver is congested, liver silght enlargements is evident in efficacy				Patent drug application (patent) number CN9811158 5.3 publication numbers: CN1228318
A kind of Chinese patent drug B that treats hepatitis B	Rhizoma atractylodis 12-24 processed divides, pangolin 10-20 part, capsule of weeping forsythia 2-5 part, bulb of fritillary 2-5 part, root tuber of aromatic turmeric 2-5 part, soapmaking alum 2-6 part	Build up health, improve disease-resistant (immunity) function, clearing heat and detoxicating, invigorating the spleen green blood, promoting blood circulation and removing blood stasis, soothing liver-qi stagnation, harmonizing the functional activities of vital QI	Morning every day, evening respectively take once with boiling water, and the adult is each serving 2-3g, less than cutting down according to the circumstance of mature age or body weight	Have no side effect	Produce effects is fast, cure rate is high, substantially do not recur after more	Patent drug application (patent) number: CN991 20036.5 publication numbers: CN1253823
							The Chinese patent drug for the treatment of hepatitis B	Loach powder 30-60 part, Radix Isatidis 10-30 part, Hedyotidis Diffusae 15-50 part, Radix Astragali 15-30 part, date 5-30 part, root tuber of aromatic turmeric 6-15 part, red sage root 4-20 part, Radix Glycyrrhizae 4-8 part	Hepatitis B		Have no side effect		Patent drug application (patent) number: CN011 14947.7 publication numbers: CN1322561
Hepatitis B is good for sheet	Flower anchor grass, the Radix Astragali, Radix Glycyrrhizae	Normalizing gallbladder to cure jaundice improves liver function, regulates immunity function. Be used for acute or chronic hepatitis B and other hepatitis	Oral, A, B sheet share, each 0.5-0.75g once, 3 times on the one	Accidental slight upset,gastro-intestinal, one after each meal can alleviate. Contraindication in pregnancy		The accurate word Z63020125 of national essential drugs traditional Chinese medicines
							Hepatitis B detoxifying capsule	50 parts of rhizome of cyrtomium, 10 parts in careless river car, 10 parts of golden cypresses, 10 parts of rheum officinales, 10 parts of the roots of large-flowered skullcap, 10 parts of Radix picrorrhizae, 15 parts of smilaxs, 10 parts of black alums	Clearing heat and detoxicating, the clearing liver cholagogic. Be used for hepatitis B, dialectically belong to the person of accumulateing in the liver and gallbladder damp-heat	Oral, 0.25g/grain, 4 tablets/times, 3 times/days. 6～10 years old children are each serving 2, and children below 6 years old are each serving 1.	The dialectical genus asthenia cold syndrome of hepatitis B person avoids clothes		The accurate word Z22021185 of national essential drugs traditional Chinese medicines
Yigan Qingre Jiedu Capsules	Giant knotweed, oriental wormwood, rhizoma menispermi, oldenlandia diffusa, adder-wort, Radix Glycyrrhizae madder, longspur epimedium, smilax, silkworm excrement, mother chrysanthemum, dried tangerine peel.	Protect the liver, suppress hepatitis B and immunological regulation. Be used for acute and chronic Type B viral hepatitis initial stage of liver gallbladder damp-heat type or active stage; Hepatitis b virus carrier.	Every 0.4g. Oral, one time 6,3 times on the one.	Insufficiency of the spleenly just do not let out the careful usefulness of person or decrement is taken. Quit smoking, wine, greasy	HBsAg negative conversion rate 8.99%, HBeAg negative conversion rate 42.6%, anti--HBc conversion ratio 17.13%.	The accurate word Z10980071 of national essential drugs traditional Chinese medicines
							Giant knotweed containing capsule for treating hepatitis B	Tiger account, ant, radix bupleuri, oriental wormwood etc.	Soothing liver and strengthening spleen, clearing heat and promoting diuresis, promoting blood circulation and removing blood stasis, be used for second	Every 0.2g. Oral, 5 tablets/times, 3 times/days, March/		Suppress hepatitis B virus duplication, effectively reduce ALT,	The accurate word of national essential drugs traditional Chinese medicines

		The stagnation of liver-QI with deficiency of the spleen damp and hot stasis disease of holding concurrently, acute and chronic second, hepatitis C, early-phase hepatocirrhosis	The course for the treatment of.		AST。	(1998)Z-183
							The strongly fragrant particle of hepatitis B benefit gas solution	Radix bupleuri (vinegar is processed), Fructus Aurantii, the root of herbaceous peony, the red sage root, the Radix Astragali, Radix Codonopsis, the coptis, tangerine leaf, rhizoma pinellinae praeparata, trichosanthes fruit, wilsonii, Poria cocos, cassia twig.	Wet, the soothing liver-qi stagnation of benefit gasification. Rear patient, the hepatitis b virus carrier of the deficiency of vital energy relatively are used for disappearing chronic hepatitis stationary phase, cirrhotic ascites.	Boiling water is taken after mixing it with water, one time 20 gram, 3 times on the one	Quit smoking, wine, greasy. Liver and gallbladder damp-heat, domination of pathogen card person avoids usefulness.		The accurate word Z10910045 of national essential drugs traditional Chinese medicines
Hepatitis B nourishing yin and activating blood electuary	The ten Six-element medicines such as glutinous rehmannia, radix glehniae, the tuber of dwarf lilyturf, the fruit of glossy privet, fructus schisandrae, the root of herbaceous peony, the fleece-flower root, Radix Angelicae Sinensis.	Nourishing liver and kidney promoting blood circulation and removing blood stasis. The hepatitis b virus carrier that is used for chronic hepatitis later stage, cirrhosis, the inclined to one side deficiency of Yin	Boiling water is taken after mixing it with water, one time 20 gram, three times on the one		Liver and gallbladder damp-heat, insufficiency of the spleen stagnation of the circulation of vital energy person avoids usefulness	(91) defend the accurate word Z-60 of medicine number
							Yiganning granules	408 parts of oldenlandia diffusas, 606 parts of the Radixs Astragali, 490 parts of Radix Codonopsis, 408 parts in Poria cocos, 408 parts of the root of herbaceous peonys, 606 parts of oriental wormwoods, 490 parts of the reds sage root, 490 parts of the tubers of multiflower knotweed, 408 parts of desmodiums, 408 parts of dandelions, 408 parts of moutan barks, 408 parts of the bighead atractylodes rhizomes, 408 parts of fructus toosendans	Be used for air making-up and spleen enlivening, promoting blood circulation and removing blood stasis, clearing heat and detoxicating. Be used for chronic hepatitis and belong to deficiency-weakness of spleen-QI, blood stasis resistance network, damp and hot poison accumulates card, and disease is seen hypochondriac pain, abdominal distension, weak, urine is yellow, and oxyhepatitis is belonged to above-mentioned sign also certain curative effect.	The 17g/ bag. Oral, 1 bag/time, 3 times/days, children are cut down according to the circumstance. March/the course for the treatment of		Can stop hepatitis B virus duplication, the moon of hepatitis B immune sign is turned or sun to turn the aspect all more obvious, can impel liver cell to recover and regeneration, regulate the patient immune function, interferon generates in the inductor, but copies without positive effect suppressing hepatitis viruse.	The accurate word Z43020033 of NF medicine traditional Chinese medicines
Hepatitis B strengthening capsule	The fleece-flower root, Radix Angelicae Sinensis, Chinese cassia tree, ginseng, giant knotweed, rhizome of cyrtomium, alum, semen astragali complanati, granatum, Chinese ephedra etc.	Have filling liver kidney, the effect of qi and activate blood circulation is used for that hepatitis B is dialectical to belong to liver kidney two empty sign persons	Every heavy 0.2 5g. Be grown up and whenever take 4,3 times on the one; 6～1 0 years old every takes 2, whenever below 6 years old takes 1 or cut down according to the circumstance	Hepatitis B belongs to the asthenia cold syndrome, and the person avoids clothes	The adjusting function of exempting from service	The accurate word Z42020644 of the accurate font size new drug traditional Chinese medicines of country
							I n Compound Capsules of Ursine	Bear gall powder, rough gentian, the red sage root, radix bupleuri, giant knotweed, Radix Isatidis etc.	Clearing heat and promoting diuresis, soothing liver-gallbladder is applicable to treatment and the hepatitis b virus carrier of chronic hepatitis B (chronic ductility hepatitis B, chronic active hepatitis B).	Every dress 0.45g oral meal. One time 6,3 times on the one. 3 months is a course for the treatment of, or abides by medicine and advise.	Without obvious toxic-side effects. Accidental stomach discomfort. Gestation and nursing women's forbidding. Asthenia cold syndrome is avoided usefulness, the diet life,	Have anti-hepatitis virus, repair hepatic injury, softening liver fiber, stop cirrhosis, normalizing gallbladder to cure jaundice, reduction transaminase, adjusting and enhancing body	The accurate word Z19991059 of the accurate font size new drug traditional Chinese medicines of country

				Cold, wine, garlic, oil.	The function of immunity. Clinical trial shows that this product reaches 91.3% to the total effective rate of hepatitis B, and basic cure rate is 44.0%.
							Cao Xian Yi Gan capsules	20 a herbs such as giant knotweed, Fructus meliae toosendan, umbellate pore furgus, Radix Angelicae Sinensis	Clearing heat and detoxicating, invigorating spleen to remove dampness. Be used for heavy lazy moving, the hypochondriac pain of body that damp pathogen obstruction the spleen causes, the vexed abdominal distension of gastral cavity, loose stool; Chronic hepatitis B is seen above-mentioned patient	Every dress 0.4g. Aftermeals, one time 6,3 times on the one. Be a course for the treatment of or follow the doctor's advice in 3 months	Be not taken by pregnant women		The accurate word Z10970099 of the accurate font size new drug traditional Chinese medicines of country
Alpha interferon	Common Leafflower Herb, oldenlandia diffusa, giant knotweed, the red sage root, the Radix Astragali, the fleece-flower root	Clearing heat and detoxicating, promoting blood circulation and removing blood stasis. Be used for the acute and chronic hepatitis B due to the dampness and heat stasis, seeing has weak, hepatodynia, receives poor, the disease such as gastral cavity expands	Every the dress 0.4g oral, one time 4,3 times on the one.	Be not taken by pregnant women.	The moon of hepatitis B immune sign is turned obviously, the function that reduces transaminase is arranged.	The accurate word Z20025802 of the accurate font size new drug traditional Chinese medicines of country
							The Yiganling ball	Rheum officinale, the root of herbaceous peony, oriental wormwood, radix bupleuri, rhizome of cyrtomium, Radix Glycyrrhizae, ginseng, the Radix Astragali	The hepatitis of the type such as hepatitis B, metastatic hepatitis	Every 0.1g. Oral, a 2g, 3 times on the one; Children's is cut down according to the circumstance. 20～50 days each courses for the treatment of.	Without obvious adverse reaction. Be not taken by pregnant women.		Authentication code: ZZ-549 2-Ji is defended the accurate word (1998) of medicine No. 4139
Medicine powder for hepatitis B	20 parts on king's leaf, 15 parts of solanum lyratums, 12 parts of ginsengs, 12 parts of Kiwi berrys, 9 parts of radix bupleuri, 9 parts of reticulate millettias, 12 parts of Caulis Sargentodoxaes, 6 parts of hypericum japonicums etc.	Clearing heat and detoxicating, invigorating the spleen for eliminating dampness activates blood circulation and disperses blood clots, and soothing liver-gallbladder is regulated the effect of immunity, thereby reached the positive purpose of eliminating evil peace	Every bag 9g. Oral 1 bag/time, 3 times/days, the April/course for the treatment of.	Without obvious adverse reaction	The clinical multi-joint interferon that share to be improving curative effect, bibliographical information its efficient be 69.2%-100%. Strengthen the phagocytic function of body immunity and macrophage, suppress virus replication	Through proved recipe
							FUGANKANG agent	Radix bupleuri, the red sage root, the Radix Astragali, Radix Angelicae Sinensis, rhizoma cyperi, the Chinese medicines such as the radix paeoniae rubrathe	Dispersing stagnated hepatoqi promotes liver cell regeneration, suppresses necrosis of liver cells, improves Microcirculation of Liver, falls enzyme, improves the multiple effects such as body's immunity, is conducive to liver function recovery	Every bag 10g, oral, 1 bag/time, 3 times/days, the March/course for the treatment of	Bibliographical information causes drug rash 1 example, illustrates that this medicine may contain foreign protei, needs vigilant allergic reaction in the use.	Certain inhibition HBV effect is arranged, and it is better that HBV immunological marker thing the moon turns the aspect short term effect, and late result still needs further research	Lot number (90) is defended the medicine word Z-27-2 number

Model case:

Example 1: He Yaoping, the man, 16 years old, the student, this patient suffered from the hepatitis B great three positive in 96 years, took a turn for the better through many places treatments, and card meeting look sallow is, weak, apocleisis, detest oil, takes we's February, and check is found all to turn out cloudy, and symptom, body card disappear, and reaches healing.

Example 2: Zhu sea, man, 18, student, suffer from the hepatitis B great three positive for many years, treatment still is great three positive through many places, yellow, weak, the apocleisis of face when medical, abdominal distension diarrhoea (3-4 times/day), take we's February, check discovery core antibody is turned out cloudy, and other Signs all take a turn for the better to some extent.

Example 3: Gao Lan, the woman, 19, the workman suffered from hepatitis B 2 years, weak, urine Huang, take medicine front detection HBsAg, HBeAg are positive, take we's February, and check finds that HBsAg, HBeAg turn out cloudy, and other Signs all have disappearance.

Fang Congfa goes out, and method is vertical with card, the side namely is method, and we mainly are for hepatopathy, so on prescription, mainly be the method for reconciliation, heat-clearing, detoxifcation, help, by dialectical, determine therapy, use modern crafts to prepare this pure Chinese medicinal preparation, prevention and the treatment of hepatitis B had significant curative effect.

Claims (5)

1, a kind of pharmaceutical composition that is used for the treatment of hepatitis B is characterized in that containing Chinese actinidia root 800-1120g, rabdosia lophanthide 240-320g, Radix Astragali 240-320g, wild silky ant 400-560g, Chinese mahonia 160-224g, hispid fig root 400-560g, lepidogrammitis drymoglossoides Ching 240-320g, coix seed 240-320g, living hawthorn 240-320g, date 400-560g. The above-mentioned medicine of respectively distinguishing the flavor of is followed an example to do, extract again, purifying, spray-drying, granulation.

2, a kind of pharmaceutical composition that is used for the treatment of hepatitis B as claimed in claim 1, it is characterized in that herbal medicine (such as Chinese actinidia root, rabdosia lophanthide, the lepidogrammitis drymoglossoides Ching) combination with Chinese medicine and less use, be prepared into the Chinese patent drug for the treatment of hepatitis B, bibliographical information seldom, we's a large characteristic, without the drug resistance of traditional Chinese patent drug.

3, a kind of pharmaceutical composition that is used for the treatment of hepatitis B as claimed in claim 1 is characterized in that Chinese actinidia root in the prescription, rabdosia lophanthide are 20%-28%, the 6%-8% that monarch drug in a prescription accounts for respectively total amount.

4, a kind of pharmaceutical composition that is used for the treatment of hepatitis B as claimed in claim 1 is characterized in that first Chinese actinidia root, the hispid fig root of recipe quantity being pulverized, and adds 5-7 times of water, adds hot reflux 4-6 hour, and it is for subsequent use to obtain volatile oil. The dregs of a decoction and liquid coarse filtration, the filtrate centrifugation, supernatant and the dregs of a decoction save backup respectively. Again with recipe quantity rabdosia lophanthide, the Radix Astragali, Chinese mahonia, give birth to hawthorn powder and be broken into coarse granule and merge with the dregs of a decoction that Chinese actinidia root, hispid fig root extract behind the volatile oil, add 70%-80% alcohol extract twice, extracted 1.5 hours 1 hour second time for the first time. Filter, merging filtrate, Recycled ethanol, concentrated, get this concentrate and make medicinal extract, for subsequent use. Again the dregs of a decoction after wild silky ant, lepidogrammitis drymoglossoides Ching, date, coix seed and the Radix Astragali alcohol extracting are merged, add poach and extract twice, add 10-12 times of water gaging for the first time, extracted 2 hours, add 8-10 times of water gaging for the second time, extracted 1 hour. Coarse filtration, the filtrate centrifugation, the gained supernatant merges behind the supernatant of extracted twice and the extraction volatile oil, and it is for subsequent use that reduced pressure concentration gets thick paste. Alcohol extracting, water extraction thick paste are merged, stir spray-drying.

5, a kind of pharmaceutical composition that is used for the treatment of hepatitis B as claimed in claim 1, it is characterized in that the above-mentioned medicine of respectively distinguishing the flavor of is followed an example to do, extract purifying, after the spray-drying, adding 80-120g superfine silica gel powder, 80-120g dextrin and an amount of Aspartame to total amount is 1000g, sprays into volatile oil, sieves, packing, and get final product.