CN100502925C - Antihyperglycemic hepatoprotective agent and its preparation method - Google Patents
Antihyperglycemic hepatoprotective agent and its preparation method Download PDFInfo
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- CN100502925C CN100502925C CNB2007100656504A CN200710065650A CN100502925C CN 100502925 C CN100502925 C CN 100502925C CN B2007100656504 A CNB2007100656504 A CN B2007100656504A CN 200710065650 A CN200710065650 A CN 200710065650A CN 100502925 C CN100502925 C CN 100502925C
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Abstract
The invention discloses a antihyperglycemic and hepatoprotective medicinal capsule for treating fatty liver and hyperlipemia, which comprises notoginseng, root of red rooted saliva, haw, fleece-flower root, bitter orange, white atractylodes rhizome, astragalus root, oriental water plantain rhizome, Bupleurum root and thunberg fritillary bulb.
Description
Technical field
The present invention relates to a kind of antihyperglycemic hepatoprotective agent and processing method thereof, belong to Chinese herbal medicine, especially treat the medicine and the processing method thereof of fatty liver, hyperlipemia.
Background technology
Though at present the medicine kind of treatment fatty liver, hyperlipemia is more, mostly add the Chinese herbal medicine that has the composition of suffering from diarrhoea (as Radix Et Rhizoma Rhei etc.), and complex manufacturing, cost is higher, and side effect is big, and curative effect is also not ideal, often has a rebound after the drug withdrawal.CN1586574A discloses " a kind of medicine of blood fat reducing ", and it is the medicament of being made by the following weight proportion raw material: Radix Notoginseng 5-20 gram, Fructus Crataegi 10-60 gram, Rhizoma Alismatis 10-80 gram, Semen Cassiae 5-30 gram, Rhizoma Polygoni Cuspidati 10-50 gram, Radix Polygoni Multiflori 10-40 gram, Radix Salviae Miltiorrhizae 10-40 gram, Radix Paeoniae Rubra 5-20 gram, Rhizoma Polygonati 10-40 gram, Radix Scrophulariae 10-30 gram, Fructus Lycii 10-40 gram, Rhizoma Drynariae 10-40 gram.Above raw material is cleaned the back levigation, and the reuse hydromel is modulated into pill and gets final product.The present invention all select for use to human body nontoxic, harmless, without any side effects among medical herbs be raw material, need not decoct directly and take, can absorb effective blood fat reducing composition in the Chinese herbal medicine preferably, direct drug injection is in cardiovascular, and the treatment good effect can be improved high blood coagulation state, the mediation microcirculation, strengthen the human body immunocompetence, alleviate the generation of hyperlipidemia complication, it is all very convenient to take and carry.But it is bigger that the problem of this medicine maximum is a dose, and the dose of general close ball is all more than 10 grams; Technology falls behind.As close ball, now belong to superseded dosage form; As close ball, place certain hour after, easily absorb moisture content and mildew rottenly, be difficult for preserving; Because will catching in its mouth, takes after broken this medicine, therefore very inconvenient.
Summary of the invention
The objective of the invention is to overcome the deficiency of other medicines treatment fatty liver, hyperlipemia, a kind of new drug and processing method thereof of utilizing national folk Chinese herbal treatment fatty liver, hyperlipemia is provided.This medicine benefiting QI for activating blood circulation, the kidney invigorating is soothing the liver, is used for because of diseases such as the giddy due to the disorder of QI and blood, dizzy, uncomfortable in chest, side of body rib discomforts.
Above-mentioned purpose is achieved in that antihyperglycemic hepatoprotective agent and processing method thereof, is radix with the weight portion of Rhizoma Alismatis, is made up of following medicaments in part by weight
0.5～4 part of 0.5～2 portion of Fructus Crataegi of 0.5～2 part of Radix Salviae Miltiorrhizae of Radix Notoginseng
0.4～1.5 part of 0.4～1.5 part of Rhizoma Atractylodis Macrocephalae of 0.5～2 part of Fructus Aurantii of Radix Polygoni Multiflori
0.4～1.5 part of 1 part of Radix Bupleuri of 0.4～2 portion of Rhizoma Alismatis of the Radix Astragali
0.4～1.5 part of Bulbus Fritillariae Thunbergii
This medicine processing method is as follows:
1, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Rhizoma Alismatis, Radix Bupleuri four Chinese medicine water decoct three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, and filtrate is concentrated into the thick paste of relative density 1.3～1.35 (90 ℃ of heat are surveyed);
2, Radix Notoginseng, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Bulbus Fritillariae Thunbergii were ground into the fine powder of 100 mesh sieves, mixing by weight;
3, Fructus Crataegi, Fructus Aurantii are with 70% ethanol percolate extraction, and percolate reclaims ethanol, is concentrated into the thick paste of relative density 1.3～1.35 (90 ℃ of heat are surveyed);
4, will concentrate thick paste and add in the above-mentioned fine powder, mixing with 45～55 ℃ temperature drying, was ground into the fine powder of 100 mesh sieves, granulated, sterilizes, is distributed into capsule or tablet forming.
Hyperlipemia is that to increase with blood plasma lipide concentration be the disease of main clinical manifestation, the turbid category that waits of the expectorant that belongs to Chinese medicine.Disease is seen: giddy, headache, dizzy, uncomfortable in chest, tinnitus etc.This disease Chinese medicine is divided into the turbid retardance of expectorant, deficiency of spleen-YANG and kidneyYANG, the hepatic and renal YIN deficiency, hyperactivity of YANG due to deficiency of YIN, qi depression to blood stasis more, the stagnation of liver-QI person that suffers from a deficiency of the kidney also more sees that control suitable benefiting QI for activating blood circulation, the kidney invigorating is soothing the liver.
Fatty liver how because of dysfunction of the spleen in transportation, is given birth in expectorant is turbid, and stagnation of QI due to depression of the liver is due to the blood stasis stagnation is waited until.Also suitable benefiting QI for activating blood circulation, the kidney invigorating is soothing the liver for controlling.
Antihyperglycemic hepatoprotective agent and processing method thereof, prescription is made up of ten herbal medicines such as the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Notoginseng.Wherein Radix Astragali nature and flavor are sweet, tepor.Return the spleen lung meridian.Has tonifying Qi and lifting yang, benefiting QI for strengthening the superficies, inducing diuresis to remove edema, the merit of promoting pus discharge and tissue regeneration strengthening." book on Chinese herbal medicine is looked for the truth " said: the Radix Astragali " go into the lung QI invigorating, as show real defending, for all medicines of QI invigorating, be so that the title of over sixty years of age to be arranged "." pearl sac " then said: " the sweet Wen Chunyang of the Radix Astragali ", energy " beneficial vigour ", " hemopoietic of invigorating blood circulation ".Radix Salviae Miltiorrhizae nature and flavor hardship is slightly cold, GUIXIN, Liver Channel.Has promoting blood flow to regulate menstruation, removing heat from blood eliminating carbuncle, the merit of calming the nerves." book on Chinese herbal medicine justice " said: Radix Salviae Miltiorrhizae " specially go into blood system, its merit is the promoting the circulation of blood of invigorating blood circulation, in reach internal organs and change stasis "." the southern regions of the Yunnan Province book on Chinese herbal medicine " then said: Radix Salviae Miltiorrhizae energy " QI invigorating sedate, calming heart and tranquilizing mind are controlled forgetful palpitation with a distress feeling, and palpitation with fear is insomnia ".The Radix Astragali, Radix Salviae Miltiorrhizae two medicines share, the function benefiting QI for activating blood circulation, and mind tranquilizing and the heart calming is monarch drug altogether.The Radix Notoginseng nature and flavor are sweet, little hardship, temperature.Return liver, stomach warp.Has removing stasis to stop bleeding, the merit of the analgesic therapy of invigorating blood circulation.Fructus Crataegi nature and flavor acid, sweet, tepor is returned spleen, stomach, Liver Channel, has promoting digestion and removing stagnation, the merit of circulation of qi promoting dissipating blood stasis.Radix Bupleuri nature and flavor hardship, suffering are slightly cold, and return liver, gallbladder meridian.Has dispersing the stagnated live-QI to relieve the stagnation of QI, the merit of ascending up spleen-Qi and Yang.Radix Notoginseng, Fructus Crataegi, Radix Bupleuri three medicines share, the function promoting blood circulation to remove blood stasis, and depressed liver-energy dispersing and QI regulating with the merit of the principal drug assistance Radix Astragali, Radix Salviae Miltiorrhizae inrigorating qi and promoting blood circulation, is a ministerial drug altogether.Bulbus Fritillariae Thunbergii nature and flavor hardship, cold is returned lung, heart channel, has the merit of removing heat-phlegm, dissipating depression of QI eliminating stagnation.The Radix Polygoni Multiflori nature and flavor are sweet, puckery, and tepor is returned liver, kidney channel, has tonification and purifies the blood, the merit of the crow palpus that reinforces the kidney.The Rhizoma Alismatis nature and flavor are sweet, light, and are cold, return kidney, urinary bladder channel.Has promoting diuresis to eliminate damp pathogen, the merit that expels the heat-evil.Rhizoma Atractylodis Macrocephalae nature and flavor hardship, sweet, temperature is returned spleen, stomach warp.Has air making-up and spleen enlivening, the merit of dampness diuretic.Fructus Aurantii nature and flavor hardship, suffering are slightly cold, and return spleen, stomach, large intestine channel.Has promoting the circulation of QI to alleviate the stagnation in middle-JIAO except that expanding the merit of reducing phlegm.Bulbus Fritillariae Thunbergii, Radix Polygoni Multiflori, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae four medicines share, and the function the kidney invigorating is soothing the liver, the diuretic that makes eye bright, and transforming phlegm and dispersing accumulations, promoting the circulation of QI to alleviate the stagnation in middle-JIAO are adjuvant altogether.More than all medicines in full side share, play benefiting QI for activating blood circulation altogether, the merit that the kidney invigorating is soothing the liver.So can be used for the giddy due to the disorder of QI and blood, dizzy, uncomfortable in chest, side of body rib discomfort etc., show as above-mentioned disease person as fatty liver, hyperlipemia.
We's advantage is: take into full account when solving blood fat reducing and protect the liver, solve many lipid lowerers and take back diarrhoea, problems such as liver injury.Chinese medicine is thought: cause hyperlipemia, and the reason of fatty liver, one is expectorant, the turbid retardance of expectorant; Another is that the capable then blood of qi depression to blood stasis, gas is capable.Therefore, we fully take into account these problems when prescription, so add the Bulbus Fritillariae Thunbergii of the merit with removing heat-phlegm effect, dissipating depression of QI eliminating stagnation and the Rhizoma Atractylodis Macrocephalae with merit of air making-up and spleen enlivening, dampness diuretic; Add have dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to alleviate the stagnation in middle-JIAO remove to expand the Radix Bupleuri of resolve phlegm effect, Fructus Aurantii; Have the lipid metabolism of influence, decompose and reduce the raw material of TC, reduce the Rhizoma Alismatis of serum TC and TG and rising HDL effect; Add have blood circulation promoting and blood stasis dispelling, the Radix Notoginseng of effect for reducing fat, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori and have Radix Astragali of QI invigorating effect etc.Radix Notoginseng is the special product of Yunnan mountain of papers, and contained Radix Notoginseng total arasaponins (PNS) can significantly suppress experimental AS (atherosclerosis) rabbit aorta inner membrance and form, and list is treated HLP with Radix Notoginseng powder, takes medicine and can significantly reduce serum TC, TG, ρ-LP after two months; The Radix Astragali has the function of heart tonifying, blood pressure lowering, blood vessel dilating, diuresis, enhancing human body immunity, promotion organism metabolism.Normal and lipid lowerers is share blood fat reducing, take astragalus membranaceus powder after, can make that protein content significantly reduces in the urine, the kidney pathological change alleviates, and the effect that delays to take place urine protein and hypercholesterolemia is arranged, but contained organic acid and lipase facilitating digestion and steatolysis; Fructus Crataegi all has significant reduction effect to TC and TG, and is better to the TG effect especially; Above multi-flavor share, and is used for the treatment of diseases such as giddy due to fatty liver, the hyperlipemia, dizzy, uncomfortable in chest, side of body rib discomfort, and through the clinical verification of people more than 4000, curative effect is better, does not find any toxic and side effects.
The advantage of production technology is: the characteristic that takes into full account each herbal medicine: Radix Notoginseng gives birth to usefulness, is mainly used in blood circulation promoting and blood stasis dispelling, blood fat reducing; TANSHINONES is promptly decomposed when temperature is more than 55 ℃ in the Radix Salviae Miltiorrhizae; Radix Polygoni Multiflori is given birth to effect for reducing fat is just arranged, and therefore in production technology, three flavor medicines are all considered temperature problem, so three flavor medicines are all pulverized adding, all temperature are controlled in whole process of production below 55 ℃, to prevent ingredient generation degeneration simultaneously.Effective ingredient ursolic acid in the Fructus Crataegi is slightly soluble in water, can be dissolved in ethanol; Main component limonene in the Fructus Aurantii, hesperidin etc. are slightly soluble in water, can be dissolved in ethanol, when extracting, fully take into account the liposoluble constituent of two flavor medicines, so the two fully extracts liposoluble constituent and water soluble ingredient in the two flavor medicines with 70% ethanol extraction.
Antihyperglycemic hepatoprotective agent and processing method thereof, because adopting the national folk Chinese herbal medicine makes, raw material sources are wide, cost is low, carried out people's clinical experiment more than 4000 through units such as out-patient department of Kunming Compulsory Detoxification Institute, Chinese drug dependence institute clinical research base, drug dependence rehabilitation research centers, Kunming, after taking this medicine, can significantly alleviate symptoms such as giddy that fatty liver, hyperlipemia show, dizzy, uncomfortable in chest, side of body rib discomfort, rehabilitation rapidly and special effect.
Description of drawings
Fig. 1 is the process chart of antihyperglycemic hepatoprotective agent and processing method thereof
The specific embodiment
Embodiment one
Antihyperglycemic hepatoprotective agent is formed (weight portion with Rhizoma Alismatis is a radix) by following medicaments in part by weight
3 parts of 1.5 portions of Fructus Crataegis of 1.5 parts of Radix Salviae Miltiorrhizaes of Radix Notoginseng
1.3 parts of 1.3 parts of Rhizoma Atractylodis Macrocephalaes of 1.5 parts of Fructus Aurantiis of Radix Polygoni Multiflori
1.3 parts of 1 part of Radix Bupleuri of 1.3 portions of Rhizoma Alismatis of the Radix Astragali
1.3 parts of Bulbus Fritillariae Thunbergiis
This medicine processing method is as follows:
1, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Rhizoma Alismatis, Radix Bupleuri four Chinese medicine water decoct three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, and filtrate is concentrated into the thick paste of relative density 1.3～1.35 (90 ℃ of heat are surveyed);
2, Radix Notoginseng, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Bulbus Fritillariae Thunbergii were ground into the fine powder of 100 mesh sieves, mixing by weight;
3, Fructus Crataegi, Fructus Aurantii are with 70% ethanol percolate extraction, and percolate reclaims ethanol, is concentrated into the thick paste of relative density 1.3～1.35 (90 ℃ of heat are surveyed);
4, will concentrate thick paste and add in the above-mentioned fine powder, mixing with 45～55 ℃ temperature drying, was ground into the fine powder of 100 mesh sieves, granulated, sterilizes, is distributed into capsule or tablet forming.
The king * *, the man, 40 years old, married, graduate from university, people from Kunming, the civil servant, vexed the expanding of dizzy, dizzy, the right side of body rib of sense during the patient, spirit is not good enough, drowsiness, random thoughts are uncomfortable in chest, and it is not smooth to defecate.Ultrasound diagnosis suggest severe fatty liver, liver function and blood fat chemical examination prompting GPT:92.6U/L (normal value 8～40) during in February, 2005 unit health check-up; TG:4.96mmol/L (normal value 0.56～1.69); CH:9.9mmol/L (normal value 3.9～6.5).Take fat reducing liver protecting capsule: every day three times, each 5, a course of treatment, ultrasound diagnosis prompting fatty liver disappears, liver function and blood fat chemical examination prompting: GPT:29.6U/L; TG:1.42mmol/L; CH:4.79mmol/L, the patient is conscious energetic, does not have dizzy, dizzy sense, and side of body rib is vexed to expand, transference cure, the free movement of the bowels of waiting uncomfortable in chest.
Embodiment two
Antihyperglycemic hepatoprotective agent is formed (weight portion with Rhizoma Alismatis is a radix) by following medicaments in part by weight
1 part of 0.5 portion of Fructus Crataegi of 0.5 part of Radix Salviae Miltiorrhizae of Radix Notoginseng
0.4 part of 0.4 part of Rhizoma Atractylodis Macrocephalae of 0.5 part of Fructus Aurantii of Radix Polygoni Multiflori
0.4 part of 1 part of Radix Bupleuri of 0.4 portion of Rhizoma Alismatis of the Radix Astragali
0.4 part of Bulbus Fritillariae Thunbergii
The processing method of this capsule or sheet is with embodiment 1, Therefore, omited
Lee * *, the woman, 48 years old, married, be engaged in financial transaction, normal sense in nearly 3 years is dizzy, weak, spirit is not good enough, drowsiness, forgetful, because job specification does not allow her to make mistakes, has brought very big pressure mentally.She adhered to taking fat reducing liver protecting capsule after 3 months, and it is clear-headed that conscious brains becomes, and work did not resemble originally yet and always makes mistakes, and checked to hospital, and original fatty liver has disappeared unexpectedly, and it is normal that blood fat also recovers.
Embodiment three
Antihyperglycemic hepatoprotective agent is formed (weight portion with Rhizoma Alismatis is a radix) by following medicaments in part by weight
4 parts of 2 portions of Fructus Crataegis of 2 parts of Radix Salviae Miltiorrhizaes of Radix Notoginseng
1.5 parts of 1.5 parts of Rhizoma Atractylodis Macrocephalaes of 2 parts of Fructus Aurantiis of Radix Polygoni Multiflori
1.5 parts of 1 part of Radix Bupleuri of 1.5 portions of Rhizoma Alismatis of the Radix Astragali
1.5 parts of Bulbus Fritillariae Thunbergiis
The processing method of fat-reducing liver-protecting sheet is with embodiment one, Therefore, omited
Liu * *, the man, 50 years old, married, special secondary school graduation, people from Kunming, the civil servant, the normal sense of patient is had a dizzy spell, and is drowsiness, right side of body rib vexed bloated, uncomfortable in chest, defecate not smooth.B ultrasonic suggest severe fatty liver when arrive examination in hospital in February, 2003, liver function and blood fat chemical examination prompting GPT:71.3U/L; TG:4.12mmol/L; CH:8.2mmol/L.Back by the agency of is taken the fat-reducing liver-protecting sheet, and every day three times, each 5, after the course of treatment more than one (8 bottles), ultrasound diagnosis prompting fatty liver disappears, liver function and blood fat chemical examination prompting GPT:26.6U/L; TG:1.33mmol/L; CH:4.57mmol/L, the patient is conscious energetic, does not have dizzy dizzy sense, vexed bloated, the transference cure uncomfortable in chest of right side of body rib, free movement of the bowels.
Claims (1)
1. antihyperglycemic hepatoprotective agent and processing method thereof are radix with the weight portion of Rhizoma Alismatis, are made up of following weight portion medicine
0.5～4 part of 0.5～2 portion of Fructus Crataegi of 0.5～2 part of Radix Salviae Miltiorrhizae of Radix Notoginseng
0.4～1.5 part of 0.4～1.5 part of Rhizoma Atractylodis Macrocephalae of 0.5～2 part of Fructus Aurantii of Radix Polygoni Multiflori
0.4～1.5 part of 1 part of Radix Bupleuri of 0.4～2 portion of Rhizoma Alismatis of the Radix Astragali
0.4～1.5 part of Bulbus Fritillariae Thunbergii
The processing method of antihyperglycemic hepatoprotective agent is as follows:
A, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Rhizoma Alismatis, Radix Bupleuri four Chinese medicine water decoct three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, and filtrate is concentrated into the thick paste of relative density 1.3～1.35 when 90C is warm to be surveyed;
B, Radix Notoginseng, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Bulbus Fritillariae Thunbergii were ground into the fine powder of 100 mesh sieves, mixing by weight;
C, Fructus Crataegi, Fructus Aurantii are with 70% ethanol percolate extraction, and percolate reclaims ethanol, the thick paste of relative density 1.3～1.35 when being concentrated into 90 ℃ of heat and surveying;
D, will concentrate thick paste and add in the above-mentioned fine powder, mixing with 45～55 ℃ temperature drying, was ground into the fine powder of 100 mesh sieves, granulated, sterilizes, is distributed into capsule or tablet forming.
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| CN101897746B (en) * | 2009-05-31 | 2012-11-07 | 中国科学院上海生命科学研究院 | Composite used for relieving alcoholic intoxication and protecting liver and preparation method and application thereof |
| CN104288267A (en) * | 2013-07-16 | 2015-01-21 | 谷思瑞 | Traditional Chinese medicine tea having functions of lowering lipids and decreasing blood pressure |
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