CN104258305A - Traditional Chinese medicine preparation for treating chronic liver and gall diseases - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating chronic liver and gall diseases. The traditional Chinese medicine preparation is prepared from the following raw materials by weight: 30-50 g of radix bupleuri, 20-30 g of safflower, 10-20 g of artemisia anomala, 10-20 g of spina gleditsiae, 10-20 g of tribulus terrestris, 10-20 g of charred fructus crataegi, massa fermentata, malt and semen arecae, 10-20 g of semen raphani, 10-20 g of aloes, 10-20 g of stir-baked carapax triongcis with sand, 8-15 parts of endothelium corneum gigeriae galli, 8-12 g of radix curcumae, 8-12 g of radix achyranthis bidentatae, 8-12 g of astragalus membranaceus, 8-12 g of polygonum cuspidatum, 8-12 g of pseudo-ginseng powder and 8-12 g of codonopsis pilosula. The traditional Chinese medicine preparation is prepared by finely mixing the raw materials, has the effects of clearing heat and toxic materials, soothing the liver, benefiting the spleen, activating blood to remove stasis, cooling blood and resolving dharma, also has the effects of soothing the liver, benefiting the gallbladder and regulating internal organs, vital energy and yin, can treat various liver and gall diseases, has a remarkable treatment effect, and is worthy of popularization and application.

Description

A kind of Chinese medicine preparation for the treatment of Chronic Liver gallbladder disease

Technical field

The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation can treating Chronic Liver gallbladder disease.

Background technology

Liver-gallbladder disease is a kind of commonly encountered diseases, difficult disease, frequently-occurring disease, mainly comprises large and small three sun, hepatic ascites, hepatomegaly, liver cirrhosis and the disease such as gallbladder, calculus of bile duct, and according to statistics, the whole nation is annual because the number of hepatopathy death is up to about 300,000.And this disease changes into chronic and delay difficult more person is also numerous, as treated not in time, the health condition of patient will be had a strong impact on.

Although the medicine for the treatment of Chronic Liver gallbladder disease is a lot of at present, but mostly there is the shortcomings such as treatment is single, curative effect is not obvious, easy recurrence, cannot accomplish from conditioning human body internal organs, improve the aspects such as body immune system and give essence treatment, do not reach the object of thoroughly curing.Simultaneously some drugs treatment time longer, easily recur, sometimes also can cause canceration until dead.

Summary of the invention

Instant invention overcomes the technical deficiency existed in treatment Chronic Liver gallbladder disease at present, provide a kind of determined curative effect, have no side effect, cure rate and the Chinese medicine preparation not easily recurred.

The technical solution adopted in the present invention is: a kind of Chinese medicine preparation for the treatment of Chronic Liver gallbladder disease, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:

Radix Bupleuri 30-50 gram, Flos Carthami 20-30 gram, Herba Artemisiae Anomalae 10-20 gram, Spina Gleditsiae 10-20 gram, Fructus Atriplicis Sibiricae 10-20 gram, burnt four celestial 10-20 grams, Semen Raphani 10-20 gram, Aloe 10-20 gram, Carapax Trionycis (processed) 10-20 gram, Endothelium Corneum Gigeriae Galli 8-15 gram, RADIX CURCUMAE 8-12 gram, Radix Achyranthis Bidentatae 8-12 gram, Radix Astragali 8-12 gram, Rhizoma Polygoni Cuspidati 8-12 gram, Radix Notoginseng powder 8-12 gram, Radix Codonopsis 8-12 gram.

As this kind of prioritization scheme:

Described Chinese medicine preparation is made up of the raw material of following weight portion:

Radix Bupleuri 30 grams, Flos Carthami 20 grams, Herba Artemisiae Anomalae 10 grams, Spina Gleditsiae 10 grams, Fructus Atriplicis Sibiricae 10 grams, burnt four celestial beings 10 grams, Semen Raphani 10 grams, Aloe 10 grams, Carapax Trionycis (processed) 10 grams, Endothelium Corneum Gigeriae Galli 8 grams, RADIX CURCUMAE 8 grams, Radix Achyranthis Bidentatae 8 grams, the Radix Astragali 8 grams, Rhizoma Polygoni Cuspidati 8 grams, Radix Notoginseng powder 8 grams, Radix Codonopsis 8 grams.

As this kind of prioritization scheme:

Described Chinese medicine preparation is made up of the raw material of following weight portion:

Radix Bupleuri 35 grams, Flos Carthami 25 grams, Herba Artemisiae Anomalae 15 grams, Spina Gleditsiae 15 grams, Fructus Atriplicis Sibiricae 15 grams, burnt four celestial beings 15 grams, Semen Raphani 15 grams, Aloe 15 grams, Carapax Trionycis (processed) 15 grams, Endothelium Corneum Gigeriae Galli 12 grams, RADIX CURCUMAE 10 grams, Radix Achyranthis Bidentatae 10 grams, the Radix Astragali 10 grams, Rhizoma Polygoni Cuspidati 10 grams, Radix Notoginseng powder 10 grams, Radix Codonopsis 10 grams.

As this kind of prioritization scheme:

Described Chinese medicine preparation is made up of the raw material of following weight portion:

Radix Bupleuri 50 grams, Flos Carthami 30 grams, Herba Artemisiae Anomalae 20 grams, Spina Gleditsiae 20 grams, Fructus Atriplicis Sibiricae 20 grams, burnt four celestial beings 20 grams, Semen Raphani 20 grams, Aloe 20 grams, Carapax Trionycis (processed) 20 grams, Endothelium Corneum Gigeriae Galli 15 grams, RADIX CURCUMAE 12 grams, Radix Achyranthis Bidentatae 12 grams, the Radix Astragali 12 grams, Rhizoma Polygoni Cuspidati 12 grams, Radix Notoginseng powder 12 grams, Radix Codonopsis 12 grams.

The instructions of taking of medicine of the present invention is: after being mixed by the Chinese herb of above-mentioned weight proportion, traditionally the method for fried Chinese medicine gets its medicine juice, every day 1 dose, decocting 2 times, altogether extracting juice 500ml, and point morning and evening 2 decoction being taken hot ten days are a course for the treatment of.

The raw material Chinese medicine of above-mentioned Chinese medicine preparation:

Radix Bupleuri, bitter in the mouth, pungent, cold nature; GUIXIN, liver, gallbladder, tri-jiao channel.There is evacuation bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, effect of elevate a turnable ladder yang-energy.

Flos Carthami, acrid in the mouth, warm in nature; GUIXIN, Liver Channel.There is promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain.

Herba Artemisiae Anomalae, acrid in the mouth, hardship, property is put down; Return lung, spleen channel.There is clearing away summer-heat and eliminating dampness, blood circulation promoting competent silt, effect of inducing menstruation to relieve menalgia.

Spina Gleditsiae, acrid in the mouth, warm in nature; Return liver, stomach warp.There is detumescence and apocenosis, search effect that wind is drawn out pus by applying a plaster to the affected part.

Fructus Atriplicis Sibiricae, bitter in the mouth, pungent, property is put down; Return Liver Channel.There is dispersing the stagnated live-QI to relieve the stagnation of QI, circulation of qi promoting removing blood stasis, effect of dispelling pathogenic wind for improving eyesight.

Jiao Sixian, Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Semen Arecae Prepareta is generically and collectively referred to as burnt four celestial beings.Its primary efficacy is: strengthening the spleen and stomach, aid digestion.

Semen Raphani, acrid in the mouth, sweet, property is put down; Return spleen, stomach, lung meridian.There is the de-swelling that helps digestion, effect of lowering the adverse-rising QI to resolve phlegm.

Aloe, bitter in the mouth, cold in nature; Return liver, stomach, large intestine channel.There is purging liver-heat, effect of relieving constipation by purgation.

Carapax Trionycis (processed), salty in the mouth, cold nature; Return liver, kidney channel.There is nourishing YIN and clearing away heat, suppressing hyper-yang to eliminate wind, effect of hard masses softening and resolving.

Endothelium Corneum Gigeriae Galli, sweet in the mouth, property is put down; Return spleen, stomach, small intestinal, urinary bladder channel.Have invigorating the stomach and promoting digestion, controlling nocturnal emission with astringent drugs stops effect of something lost.

RADIX CURCUMAE, acrid in the mouth, hardship, cold in nature; Return liver, gallbladder, heart channel.Have promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, effect of promoting the function of the gallbladder to alleviate jaundice.

Radix Achyranthis Bidentatae, bitter in the mouth, acid, property is put down; Return liver, kidney channel.Dredge profit descending, can complementary energy let out.There is blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, conducting blood to flow downwards, effect of inducing diuresis for treating stranguria syndrome.

The Radix Astragali, sweet in the mouth, slightly warm in nature; Return spleen, lung meridian.There is benefiting QI for strengthening the superficies, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration strengthening, effect of inducing diuresis to remove edema.

Rhizoma Polygoni Cuspidati, bitter in the mouth, cold in nature; Return liver, gallbladder, lung meridian.There is promoting blood circulation and stopping pain, heat-clearing and toxic substances removing, effect of preventing phlegm from forming and stopping coughing.

Radix Notoginseng powder, sweet in the mouth, micro-hardship, temperature; GUIXIN, liver, spleen channel.There is removing stasis to stop bleeding, effect of reducing swelling and alleviating pain.

Radix Codonopsis, sweet in the mouth, property is put down; Return spleen, lung meridian.There is invigorating the spleen and replenishing QI, effect nourished blood of promoting the production of body fluid.

The traditional Chinese medical science is thought, liver-gallbladder disease mostly be damp and hot poison and in invade, liver and gall incoordination between the spleen and stomach, qi depression to blood stasis, yang blood and qi lose, and Chronic Liver gallbladder disease forms damp and hot, the stagnation of QI, blood stasis, expectorant knot just on the basis that positive exogenous pathogen is violated, negative and positive are empty, QI and blood is lost etc. has influence on the functions such as liver and gall taste kidney.

In Chinese medicine preparation of the present invention, Radix Bupleuri, Fructus Atriplicis Sibiricae, Aloe can dispersing the stagnated live-QI to relieve the stagnation of QI, heat-clearing and toxic substances removing; Flos Carthami, Herba Artemisiae Anomalae, Spina Gleditsiae can promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain; Jiao Sixian, Semen Raphani, Endothelium Corneum Gigeriae Galli can invigorating the stomach and promoting digestion, lowering the adverse-rising QI to resolve phlegm; Carapax Trionycis (processed), Radix Achyranthis Bidentatae, Radix Codonopsis can soothing livers and strengthening spleens, tonifying Qi and lifting yang, inducing diuresis to remove edema; RADIX CURCUMAE, Rhizoma Polygoni Cuspidati, Radix Notoginseng powder can cooling blood for hemostasis, reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling.We's compatibility is superior, and melting down thermal detoxification, soothing liver and strengthening spleen, blood circulation promoting and blood stasis dispelling, all methods of removing heat from blood solution are a stove, take depressed liver-energy dispersing and function of gallbladder promoting as important department, and people having the same aspiration and interest internal organs, take into account gas the moon, treat in the equal energy of various liver-gallbladder disease, evident in efficacy, are worthy of promotion and application.

For investigating clinical efficacy and the safety of medicine of the present invention further, we have selected 60 routine Chronic Liver gallbladder disease patients and have carried out clinical experiment.Wherein man 44 example, female 16 example; Age of onset in 40-75 year, average 56.58 years old.Wherein acute icterohepatitis 12 example, chronic hepatitis B 9 example, cirrhotic ascites 11 example, fatty liver 20 example, cholelithiasis cholecystitis 8 is routine.All cases all has indigestion and loss of appetite, gastral cavity painful abdominal mass abdominal distention.Thick fur is greasy.Wherein red tongue, yellow and greasy fur person 43 example, nausea and vomiting person 36 example, hypochondriac pain person 38 example, hypochondriac pain is to shoulder back radiation person 15 example.All patients are divided into treatment group and matched group at random, often organize 30 examples.

Therapeutic Method:

Treatment group is taken Chinese medicine preparation of the present invention and is treated, and after stating the Chinese herb mixing of weight proportion, traditionally the method for fried Chinese medicine gets its medicine juice, every day 1 dose, decocting 2 times, altogether extracting juice 500ml, and point morning and evening 2 decoction being taken hot ten days are a course for the treatment of.Treat and judge curative effect after one month.

Efficacy assessment standard:

Cure: clinical symptoms and sign disappear, B ultrasonic or liver function test, gallbladder examination recover normal;

Effective: clinical symptoms and sign disappear more than 70%, B ultrasonic or liver function test, gallbladder examination recover more than 70%;

Effective: clinical symptoms and sign disappearance 30%-70%, B ultrasonic or liver function test, gallbladder examination recover 30%-70%;

Invalid: clinical symptoms and sign are all without improvement or worsen, and B ultrasonic or liver function test, gallbladder examination recover less than 30%.

Therapeutic outcome:

1. clinical efficacy result of determination:

After treatment, cure 29 examples in 60 routine patients, effective 14 examples, effective 11 examples, invalid 6 examples, total effective rate 90.0%, detailed results is in table 1.

Table 1: clinical efficacy result table after treatment

Number of cases	Recovery from illness	Effective	Effectively	Invalid	Total effective rate (%)
						60	29(48.3)	14(23.3)	11(18.3)	6(10.0)	90.0

2. point disease clinical efficacy result:

For acute icterohepatitis in patient, chronic hepatitis B, cirrhotic ascites, fatty liver, cholelithiasis the symptoms such as cholecystitis carry out efficacy determination, acute icterohepatitis and cholelithiasis the effective percentage of cholecystitis is 100.0%, fatty liver effective percentage is 90.9%, chronic hepatitis B effective percentage is 88.9%, and cirrhotic ascites effective percentage is 80.0%.Detailed results is in table 2.

Table 2: point disease clinical efficacy result table

3. the untoward reaction of medicine

Before and after all patient medication, blood, routine urinalysis, renal function and electrocardiogram have no significant change, and also do not find other obvious adverse reaction in therapeutic process.

Result shows, Chinese medicine preparation of the present invention to acute icterohepatitis, chronic hepatitis B, cirrhotic ascites, fatty liver, cholelithiasis the various Chronic Liver gallbladder disease such as cholecystitis all has good efficacy, and has no side effect, and cure rate is higher, there is good clinical value, be worthy to be popularized.

Detailed description of the invention

Embodiment 1: a kind of Chinese medicine preparation for the treatment of Chronic Liver gallbladder disease, chooses Radix Bupleuri 30 grams, Flos Carthami 20 grams, Herba Artemisiae Anomalae 10 grams, Spina Gleditsiae 10 grams, Fructus Atriplicis Sibiricae 10 grams, burnt four celestial beings 10 grams, Semen Raphani 10 grams, Aloe 10 grams, Carapax Trionycis (processed) 10 grams, Endothelium Corneum Gigeriae Galli 8 grams, RADIX CURCUMAE 8 grams, Radix Achyranthis Bidentatae 8 grams, the Radix Astragali 8 grams, Rhizoma Polygoni Cuspidati 8 grams, Radix Notoginseng powder 8 grams, Radix Codonopsis 8 grams.

Embodiment 2: a kind of Chinese medicine preparation for the treatment of Chronic Liver gallbladder disease, chooses Radix Bupleuri 35 grams, Flos Carthami 25 grams, Herba Artemisiae Anomalae 15 grams, Spina Gleditsiae 15 grams, Fructus Atriplicis Sibiricae 15 grams, burnt four celestial beings 15 grams, Semen Raphani 15 grams, Aloe 15 grams, Carapax Trionycis (processed) 15 grams, Endothelium Corneum Gigeriae Galli 12 grams, RADIX CURCUMAE 10 grams, Radix Achyranthis Bidentatae 10 grams, the Radix Astragali 10 grams, Rhizoma Polygoni Cuspidati 10 grams, Radix Notoginseng powder 10 grams, Radix Codonopsis 10 grams.

Embodiment 3: a kind of Chinese medicine preparation for the treatment of Chronic Liver gallbladder disease, chooses Radix Bupleuri 50 grams, Flos Carthami 30 grams, Herba Artemisiae Anomalae 20 grams, Spina Gleditsiae 20 grams, Fructus Atriplicis Sibiricae 20 grams, burnt four celestial beings 20 grams, Semen Raphani 20 grams, Aloe 20 grams, Carapax Trionycis (processed) 20 grams, Endothelium Corneum Gigeriae Galli 15 grams, RADIX CURCUMAE 12 grams, Radix Achyranthis Bidentatae 12 grams, the Radix Astragali 12 grams, Rhizoma Polygoni Cuspidati 12 grams, Radix Notoginseng powder 12 grams, Radix Codonopsis 12 grams.

Below by concrete case, Chinese medicine preparation curative effect of the present invention is verified further:

Case 1

Summer, female, 56 years old.Patient's private prosecution finds 1,3,5 positives in Hepatitis B virus, hepatitis B great three positive in March, 2010.Feel unable, easily tired, yellow urine etc., have been to many hospitalizes, and took multiple medicine clothes, but effect is bad, poor appetite appears in patient, weak, yellowish urine, uneasy sleeping at night, red tongue, the signs such as white and thin fur is greasy, thready and rolling pulse.Start upon somebody's introduction to take the transference cures such as Chinese medicine preparation of the present invention carries out trial treatment, and after 1 course for the treatment of, patient's readme sign is obviously improved, and weak, sleep is poor; Hold on after taking 1 course for the treatment of, hospital's check liver function recovery is normal, and albumin, globulin ratio 4.62/3.02, HBsAs the moon turn, and transference cure, patient fully recovers.Follow up a case by regular visits to 1 year without recurrence.

Case 2

Lee, female, 45 years old.Occurred feeling sick without obvious inducement before patient's readme half a year, detest greasy, indigestion and loss of appetite, xerostomia is bitter, weak, yellowish urine as symptoms such as tea, cause appearance to be turned to be yellow, health slightly feels Pruritus, the miserable discomfort of eyes.Examination in hospital icteric index 60 unit, bilirubin >4 milligram %, glutamate pyruvate transaminase 440 only position, Archon protein ratio 3.97/4.2S, cholesterol 216.1mg%, HBsAg 1:16.Be diagnosed as acute jaundice hepatitis B.Adopt antiviral treatment three months, curative effect is very not remarkable, develops into chronic viral hepatitis B gradually, upon somebody's introduction, determine the treatment of trial edition invention Chinese medicine preparation, after 2 courses for the treatment of, patient's readme sign is obviously improved, check icteric index 4 unit of hospital, bilirubin 0.4 milligram of %, glutamate pyruvate transaminase test recovers normal, albumin, globulin ratio 4.7 3.17, HBsAs cloudyly to turn.Continual cure is after one month, and liver function is normal, and HBsAg is negative, Archon protein ratio 4.62 3.02, patient fully recovers.Recurrence of following up a case by regular visits to that so far there are no.

Case 3

Field, man, 55 years old.Without obvious inducement burst Nausea and vomiting before patient half a year, often there are abdominal distention, upper abdomen or right epigastric discomfort, heartburn, belch, return a series of dyspeptic symptoms such as acid, in local hospital diagnosis and treatment, be diagnosed as chronic cholecystitis, doctor gives and opens multiple oral drug therapy, poor effect.Introduce through friend, take Chinese medicine preparation of the present invention and treat, after taking medicine 20 days, patient's symptom is clearly better, and physical examination gallbladder area is without tenderness, and ultrasound diagnosis prompting gallbladder wall polishes, and after continuing to take one month, symptom disappears completely, Rehabilitation.Recurrence of following up a case by regular visits to that so far there are no.

Claims (4)

1. treat a Chinese medicine preparation for Chronic Liver gallbladder disease, it is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:

Radix Bupleuri 30-50 gram, Flos Carthami 20-30 gram, Herba Artemisiae Anomalae 10-20 gram, Spina Gleditsiae 10-20 gram, Fructus Atriplicis Sibiricae 10-20 gram, burnt four celestial 10-20 grams, Semen Raphani 10-20 gram, Aloe 10-20 gram, Carapax Trionycis (processed) 10-20 gram, Endothelium Corneum Gigeriae Galli 8-15 gram, RADIX CURCUMAE 8-12 gram, Radix Achyranthis Bidentatae 8-12 gram, Radix Astragali 8-12 gram, Rhizoma Polygoni Cuspidati 8-12 gram, Radix Notoginseng powder 8-12 gram, Radix Codonopsis 8-12 gram.

2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:

Radix Bupleuri 30 grams, Flos Carthami 20 grams, Herba Artemisiae Anomalae 10 grams, Spina Gleditsiae 10 grams, Fructus Atriplicis Sibiricae 10 grams, burnt four celestial beings 10 grams, Semen Raphani 10 grams, Aloe 10 grams, Carapax Trionycis (processed) 10 grams, Endothelium Corneum Gigeriae Galli 8 grams, RADIX CURCUMAE 8 grams, Radix Achyranthis Bidentatae 8 grams, the Radix Astragali 8 grams, Rhizoma Polygoni Cuspidati 8 grams, Radix Notoginseng powder 8 grams, Radix Codonopsis 8 grams.

3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:

Radix Bupleuri 35 grams, Flos Carthami 25 grams, Herba Artemisiae Anomalae 15 grams, Spina Gleditsiae 15 grams, Fructus Atriplicis Sibiricae 15 grams, burnt four celestial beings 15 grams, Semen Raphani 15 grams, Aloe 15 grams, Carapax Trionycis (processed) 15 grams, Endothelium Corneum Gigeriae Galli 12 grams, RADIX CURCUMAE 10 grams, Radix Achyranthis Bidentatae 10 grams, the Radix Astragali 10 grams, Rhizoma Polygoni Cuspidati 10 grams, Radix Notoginseng powder 10 grams, Radix Codonopsis 10 grams.

4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:

Radix Bupleuri 50 grams, Flos Carthami 30 grams, Herba Artemisiae Anomalae 20 grams, Spina Gleditsiae 20 grams, Fructus Atriplicis Sibiricae 20 grams, burnt four celestial beings 20 grams, Semen Raphani 20 grams, Aloe 20 grams, Carapax Trionycis (processed) 20 grams, Endothelium Corneum Gigeriae Galli 15 grams, RADIX CURCUMAE 12 grams, Radix Achyranthis Bidentatae 12 grams, the Radix Astragali 12 grams, Rhizoma Polygoni Cuspidati 12 grams, Radix Notoginseng powder 12 grams, Radix Codonopsis 12 grams.