CN108057077A - Treat Chinese medicine composition of diabete peripheral herve pathology and preparation method thereof - Google Patents

Treat Chinese medicine composition of diabete peripheral herve pathology and preparation method thereof Download PDF

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CN108057077A
CN108057077A CN201810135737.2A CN201810135737A CN108057077A CN 108057077 A CN108057077 A CN 108057077A CN 201810135737 A CN201810135737 A CN 201810135737A CN 108057077 A CN108057077 A CN 108057077A
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parts
radix
medicine composition
chinese medicine
diabete peripheral
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马飞
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The present invention relates to Chinese medicine composition for treating diabete peripheral herve pathology and its preparation method and application, the Chinese medicine composition includes the following raw material：Radix Astragali, Radix Angelicae Sinensis, corydalis tuber, Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, safflower, bush, Caulis Spatholobi, caulis lonicerae, Fructus Liquidambaris, radix cyathulae, the radix paeoniae rubrathe, lopseed and Chinese mugwort carbon.The Chinese medicine composition for being used to treat diabete peripheral herve pathology of the present invention, Radix Notoginseng, Radix Astragali in formula etc. are respectively provided with the effect of certain blood pressure lowering, it acts synergistically with other drugs, with expansion blood vessel, improve microcirculation, inhibit platelet aggregation, improve blood viscosity, so as to improve motorial conduction of velocity.With supplementing qi and nourishing yin, it is promoting blood circulation and removing obstruction in channels based on, safely and effectively, and performance is stablized, it is numb to the four limbs sensory disturbances of diabetes, send out cool, the symptoms such as pain have extraordinary effect.

Description

Treat Chinese medicine composition of diabete peripheral herve pathology and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine group for being used to treat diabete peripheral herve pathology Close object and its preparation method and application.
Background technology
Diabete peripheral herve pathology refers to that in the case where excluding other reasons diabetic occurs and peripheral nerve The relevant symptom of dysfunction.Clinic is in symmetry pain and cacesthesia, and symptoms of lower extremity is common compared with upper limb.
Cacesthesia has that numb, ant walks, worm climbs, generate heat, electric shock sample is felt, often from distal end toe uplink up to above-knee, Patient wears socks and wears gloves sample sensation.The serious case of sensory disturbance may occur in which joint of lower extremity disease and ulcer.Pain in shouting pain, Cusalgia, Drilling pain, it appears that have a pain in marrow deep, acute pain such as amputation pain is in daytime light night weight sometimes.Sometimes tactile allergy, very then It can't bear the pressure of cotton-wadded quilt, quilt must be supported.When kinesitherapy nerve involves, muscular strength often has different degrees of decline, and late period has Dystrophic amyotrophia.Peripheral neuropathy can bilateral, can be unilateral, can be symmetrical, can be asymmetric but more with bilateral symmetric property person See.Traditional Chinese medicine prevention diabetes have the history of nearly 2,000 years, have complete theoretical system and abundant clinical experience, there is to obtain day Solely thick natural resources of Chinese medicinal materials, TCM Treatment of Diabetes hold out broad prospects, especially to the prevention of chronic complicating diseases of diabetes more Tool advantage.But lack very much treat the sick tcm product at present, play Advantages of TCM, multipath research and development prevention should The Chinese medicine preparation of disease is still very necessary.
The content of the invention
An object of the present invention is to provide a kind of for treating the Chinese medicine composition of diabete peripheral herve pathology.
The Chinese medicine composition for being used to treat diabete peripheral herve pathology of the present invention includes the original of following parts by weight Material：15 parts~25 parts of Radix Astragali, 5 parts~15 parts of Radix Angelicae Sinensis, 5 parts~15 parts of corydalis tuber, 5 parts~15 parts of Radix Notoginseng, 15 parts~25 parts of Radix Salviae Miltiorrhizae, 10 parts~20 parts of Rhizoma Chuanxiong, 1 part~2 parts of safflower, 5 parts~15 parts of bush, 25 parts~35 parts of Caulis Spatholobi, caulis lonicerae 15 parts~25 Part, 3 parts~9 parts of Fructus Liquidambaris, 10 parts~20 parts of radix cyathulae, 10 parts~20 parts of the radix paeoniae rubrathe, 5 parts~15 parts of lopseed and 5 parts of carbon of Chinese mugwort~ 15 parts.
The present invention for treating the Chinese medicine composition of diabete peripheral herve pathology, Radix Notoginseng, Radix Astragali in formula etc. are There is certain blood pressure lowering, act synergistically with other drugs there is expansion blood vessel, improve microcirculation, inhibit blood platelet Aggegation improves blood viscosity, so as to improve motorial conduction of velocity.With supplementing qi and nourishing yin, it is promoting blood circulation and removing obstruction in channels based on, safely and effectively, And performance is stablized, it is numb to the four limbs sensory disturbances of diabetes, send out cool, the symptoms such as pain have extraordinary effect.
In addition, the Chinese medicine composition for being used to treat diabete peripheral herve pathology that the present invention is above-mentioned, can also have such as Under additional technical characteristic：
As the preferred embodiment of the present invention, the Chinese traditional medicine composition for being used to treat diabete peripheral herve pathology Object includes the raw material of following parts by weight：15 parts of Radix Astragali, 15 parts of Radix Angelicae Sinensis, 5 parts of corydalis tuber, 15 parts of Radix Notoginseng, 15 parts of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong 20 parts, 1 part of safflower, 15 parts of bush, 25 parts of Caulis Spatholobi, 25 parts of caulis lonicerae, 3 parts of Fructus Liquidambaris, 20 parts of radix cyathulae, 10 parts of the radix paeoniae rubrathe, 15 parts of lopseed and 5 parts of carbon of Chinese mugwort.
As the preferred embodiment of the present invention, the Chinese traditional medicine composition for being used to treat diabete peripheral herve pathology Object includes the raw material of following parts by weight：25 parts of Radix Astragali, 5 parts of Radix Angelicae Sinensis, 15 parts of corydalis tuber, 5 parts of Radix Notoginseng, 25 parts of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong 10 Part, 2 parts of safflower, 5 parts of bush, 35 parts of Caulis Spatholobi, 15 parts of caulis lonicerae, 9 parts of Fructus Liquidambaris, 10 parts of radix cyathulae, 20 parts of the radix paeoniae rubrathe are deep 5 parts of grass and 15 parts of carbon of Chinese mugwort.
As the preferred embodiment of the present invention, the Chinese traditional medicine composition for being used to treat diabete peripheral herve pathology Object includes the raw material of following parts by weight：20 parts of Radix Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of corydalis tuber, 10 parts of Radix Notoginseng, 20 parts of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong 15 parts, 1.5 parts of safflower, 10 parts of bush, 30 parts of Caulis Spatholobi, 20 parts of caulis lonicerae, 6 parts of Fructus Liquidambaris, 12 parts of radix cyathulae, the radix paeoniae rubrathe 12 Part, 10 parts of lopseed and 10 parts of carbon of Chinese mugwort.
It is another object of the present invention to propose the Chinese traditional medicine composition for being used to treat diabete peripheral herve pathology The preparation method of object.
The preparation method for being used to treat the Chinese medicine composition of diabete peripheral herve pathology, includes the following steps： S101：It is ground after first mixing the Radix Astragali, the Radix Angelicae Sinensis, the corydalis tuber, the Radix Notoginseng, the Radix Salviae Miltiorrhizae and the Rhizoma Chuanxiong It into powder, is then baked to and sieves, recycle supercritical CO2Fluid extracts the powder after sieving, is extracted Object, then the extract is centrifuged and collects centrifugate；S102：According to solid-liquid ratio it is 1g by surplus stock and water：550L It adds in water and is heated to seething with excitement, keep the temperature 4h~8h, then filter and collect filtrate；S103：By the step S101 obtain from The filtrate mixing that heart liquid and the step S102 are obtained obtains treating the Chinese medicine composition of diabete peripheral herve pathology.
Further, in the step S101, supercritical CO2The extracting pressure of fluid is 15MPa~20MPa, is extracted Temperature is 45 DEG C~60 DEG C, CO2Fluid flow is 24mL/min~33mL/min, and extraction time is 4h~8h.
Further, in the step S102, the aperture for the strainer that when filtering uses is 1 μm~10 μm.
Another object of the present invention is to propose that the Chinese medicine composition is preparing to treat Diabetic Peripheral god Application in drug through lesion.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description It obtains substantially or is recognized by the practice of the present invention.
Specific embodiment
The embodiment of the present invention is described below in detail, the embodiment is exemplary, it is intended to for explaining the present invention, and It is not considered as limiting the invention.
Embodiment 1
Embodiment 1 proposes a kind of Chinese medicine composition for being used to treat diabete peripheral herve pathology, including following weight The raw material of number：15 parts of Radix Astragali, 15 parts of Radix Angelicae Sinensis, 5 parts of corydalis tuber, 15 parts of Radix Notoginseng, 15 parts of Radix Salviae Miltiorrhizae, 20 parts of Rhizoma Chuanxiong, 1 part of safflower, 15 parts of bush, 25 parts of Caulis Spatholobi, 25 parts of caulis lonicerae, 3 parts of Fructus Liquidambaris, 20 parts of radix cyathulae, 10 parts of the radix paeoniae rubrathe, 15 parts of lopseed and Chinese mugwort carbon 5 parts.
The preparation method for being used to treat the Chinese medicine composition of diabete peripheral herve pathology of embodiment 1, including walking as follows Suddenly：
(1) Radix Astragali, the Radix Angelicae Sinensis, the corydalis tuber, the Radix Notoginseng, the Radix Salviae Miltiorrhizae and the Rhizoma Chuanxiong are mixed first Then grind into powder afterwards is baked to and sieves, recycle supercritical CO2Fluid extracts the powder after sieving, obtains To extract, then the extract is centrifuged and collects centrifugate.Wherein, supercritical CO2The extracting pressure of fluid is 15MPa, extraction temperature are 60 DEG C, CO2Fluid flow is 24mL/min, extraction time 8h.
(2) it is 1g according to solid-liquid ratio by surplus stock and water：550L adds in water and is heated to seething with excitement, and keeps the temperature 4h, Ran Houyong Aperture is 10 μm of strainer filtering and collects filtrate.
(3) the filtrate mixing that the centrifugate and the step (2) obtained the step (1) obtains, obtains treating The Chinese medicine composition of diabete peripheral herve pathology.
Embodiment 2
Embodiment 2 proposes a kind of Chinese medicine composition for being used to treat diabete peripheral herve pathology, including following weight The raw material of number：25 parts of Radix Astragali, 5 parts of Radix Angelicae Sinensis, 15 parts of corydalis tuber, 5 parts of Radix Notoginseng, 25 parts of Radix Salviae Miltiorrhizae, 10 parts of Rhizoma Chuanxiong, 2 parts of safflower, Soviet Union 5 parts of wood, 35 parts of Caulis Spatholobi, 15 parts of caulis lonicerae, 9 parts of Fructus Liquidambaris, 10 parts of radix cyathulae, 20 parts of the radix paeoniae rubrathe, 5 parts of lopseed and Chinese mugwort carbon 15 Part.
The preparation method for being used to treat the Chinese medicine composition of diabete peripheral herve pathology of embodiment 2, including walking as follows Suddenly：
(1) Radix Astragali, the Radix Angelicae Sinensis, the corydalis tuber, the Radix Notoginseng, the Radix Salviae Miltiorrhizae and the Rhizoma Chuanxiong are mixed first Then grind into powder afterwards is baked to and sieves, recycle supercritical CO2Fluid extracts the powder after sieving, obtains To extract, then the extract is centrifuged and collects centrifugate.Wherein, supercritical CO2The extracting pressure of fluid is 20MPa, extraction temperature are 45 DEG C, CO2Fluid flow is 33mL/min, extraction time 4h.
(2) it is 1g according to solid-liquid ratio by surplus stock and water：550L adds in water and is heated to seething with excitement, and keeps the temperature 8h, Ran Houyong Aperture is 1 μm of strainer filtering and collects filtrate.
(3) the filtrate mixing that the centrifugate and the step (2) obtained the step (1) obtains, obtains treating The Chinese medicine composition of diabete peripheral herve pathology.
Embodiment 3
Embodiment 3 proposes a kind of Chinese medicine composition for being used to treat diabete peripheral herve pathology, including following weight The raw material of number：20 parts of Radix Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of corydalis tuber, 10 parts of Radix Notoginseng, 20 parts of Radix Salviae Miltiorrhizae, 15 parts of Rhizoma Chuanxiong, safflower 1.5 Part, 10 parts of bush, 30 parts of Caulis Spatholobi, 20 parts of caulis lonicerae, 6 parts of Fructus Liquidambaris, 12 parts of radix cyathulae, 12 parts of the radix paeoniae rubrathe, 10 parts of lopseed and End 10 parts of carbon.
The preparation method for being used to treat the Chinese medicine composition of diabete peripheral herve pathology of embodiment 3, including walking as follows Suddenly：
(1) Radix Astragali, the Radix Angelicae Sinensis, the corydalis tuber, the Radix Notoginseng, the Radix Salviae Miltiorrhizae and the Rhizoma Chuanxiong are mixed first Then grind into powder afterwards is baked to and sieves, recycle supercritical CO2Fluid extracts the powder after sieving, obtains To extract, then the extract is centrifuged and collects centrifugate.Wherein, supercritical CO2The extracting pressure of fluid is 17MPa, extraction temperature are 53 DEG C, CO2Fluid flow is 29mL/min, extraction time 6h.
(2) it is 1g according to solid-liquid ratio by surplus stock and water：550L adds in water and is heated to seething with excitement, and keeps the temperature 6h, Ran Houyong Aperture is 5 μm of strainer filtering and collects filtrate.
(3) the filtrate mixing that the centrifugate and the step (2) obtained the step (1) obtains, obtains treating The Chinese medicine composition of diabete peripheral herve pathology.
Toxicity test
It is random to select the small white mouse 300 that weight is 18~22g, it is divided into 3 groups, every group of small white mouse back unhairing exposes appearance Skin, unhairing scope 2cm × 2cm smear the Chinese medicine composition that the embodiment of the present invention 1 is prepared to embodiment 3, to medicament respectively It measures as 0.5g, successive administration 30 days.When during administration and 1 week after drug withdrawal, white mouse growth conditions and activity and diet are observed, identifies blood Liquid, blood biochemical analysis, organ tissue structure and routine urinalysis etc..It turns out that the health existence of all small white mouses, without any Toxic side effect；Blood picture, liver function, each organs and tissues state, the indifference compared with normal small white mouse is dissected and observed.It is demonstrated experimentally that Chinese medicine composition provided by the invention is nontoxic, and drug safety is reliable.
The present invention for treating the Chinese medicine composition of diabete peripheral herve pathology, Radix Notoginseng, Radix Astragali in formula etc. are There is certain blood pressure lowering, act synergistically with other drugs there is expansion blood vessel, improve microcirculation, inhibit blood platelet Aggegation improves blood viscosity, so as to improve motorial conduction of velocity.With supplementing qi and nourishing yin, it is promoting blood circulation and removing obstruction in channels based on, safely and effectively, And performance is stablized, it is numb to the four limbs sensory disturbances of diabetes, send out cool, the symptoms such as pain have extraordinary effect.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show The description of example " or " some examples " etc. means specific features, structure, material or the spy for combining the embodiment or example description Point is contained at least one embodiment of the present invention or example.In the present specification, schematic expression of the above terms is not It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office It is combined in an appropriate manner in one or more embodiments or example.In addition, without conflicting with each other, the skill of this field Art personnel can tie the different embodiments described in this specification or example and different embodiments or exemplary feature It closes and combines.
Although the embodiment of the present invention has been shown and described above, it is to be understood that above-described embodiment is example Property, it is impossible to limitation of the present invention is interpreted as, those of ordinary skill in the art within the scope of the invention can be to above-mentioned Embodiment is changed, changes, replacing and modification.

Claims (8)

1. a kind of Chinese medicine composition for being used to treat diabete peripheral herve pathology, which is characterized in that including following parts by weight Raw material：15 parts~25 parts of Radix Astragali, 5 parts~15 parts of Radix Angelicae Sinensis, 5 parts~15 parts of corydalis tuber, 5 parts~15 parts of Radix Notoginseng, 15 parts of Radix Salviae Miltiorrhizae~ 25 parts, 10 parts~20 parts of Rhizoma Chuanxiong, 1 part~2 parts of safflower, 5 parts~15 parts of bush, 25 parts~35 parts of Caulis Spatholobi, 15 parts of caulis lonicerae ~25 parts, 3 parts~9 parts of Fructus Liquidambaris, 10 parts~20 parts of radix cyathulae, 10 parts~20 parts of the radix paeoniae rubrathe, 5 parts~15 parts of lopseed and Chinese mugwort carbon 5 Part~15 parts.
2. the Chinese medicine composition according to claim 1 for being used to treat diabete peripheral herve pathology, which is characterized in that bag Include the raw material of following parts by weight：15 parts of Radix Astragali, 15 parts of Radix Angelicae Sinensis, 5 parts of corydalis tuber, 15 parts of Radix Notoginseng, 15 parts of Radix Salviae Miltiorrhizae, 20 parts of Rhizoma Chuanxiong, 1 part of safflower, 15 parts of bush, 25 parts of Caulis Spatholobi, 25 parts of caulis lonicerae, 3 parts of Fructus Liquidambaris, 20 parts of radix cyathulae, 10 parts of the radix paeoniae rubrathe, lopseed 15 parts and 5 parts of carbon of Chinese mugwort.
3. the Chinese medicine composition according to claim 1 for being used to treat diabete peripheral herve pathology, which is characterized in that bag Include the raw material of following parts by weight：25 parts of Radix Astragali, 5 parts of Radix Angelicae Sinensis, 15 parts of corydalis tuber, 5 parts of Radix Notoginseng, 25 parts of Radix Salviae Miltiorrhizae, 10 parts of Rhizoma Chuanxiong are hidden 2 parts of safflower, 5 parts of bush, 35 parts of Caulis Spatholobi, 15 parts of caulis lonicerae, 9 parts of Fructus Liquidambaris, 10 parts of radix cyathulae, 20 parts of the radix paeoniae rubrathe, 5 parts of lopseed With 15 parts of carbon of Chinese mugwort.
4. the Chinese medicine composition according to claim 1 for being used to treat diabete peripheral herve pathology, which is characterized in that bag Include the raw material of following parts by weight：20 parts of Radix Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of corydalis tuber, 10 parts of Radix Notoginseng, 20 parts of Radix Salviae Miltiorrhizae, 15 parts of Rhizoma Chuanxiong, 1.5 parts of safflower, 10 parts of bush, 30 parts of Caulis Spatholobi, 20 parts of caulis lonicerae, 6 parts of Fructus Liquidambaris, 12 parts of radix cyathulae, 12 parts of the radix paeoniae rubrathe are deep 10 parts of grass and 10 parts of carbon of Chinese mugwort.
5. claim 1-4 any one of them is used to treat the preparation side of the Chinese medicine composition of diabete peripheral herve pathology Method includes the following steps：
S101：After the Radix Astragali, the Radix Angelicae Sinensis, the corydalis tuber, the Radix Notoginseng, the Radix Salviae Miltiorrhizae and the Rhizoma Chuanxiong are mixed first Then grind into powder is baked to and sieves, recycle supercritical CO2Fluid extracts the powder after sieving, obtains Extract, then the extract is centrifuged and collects centrifugate；
S102：According to solid-liquid ratio it is 1g by surplus stock and water：550L adds in water and is heated to seething with excitement, and keeps the temperature 4h~8h, then It filters and collects filtrate；
S103：The filtrate that the obtained centrifugates of the step S101 and the step S102 are obtained mixes, and obtains treating The Chinese medicine composition of diabete peripheral herve pathology.
6. it is according to claim 5 for treating the preparation method of the Chinese medicine composition of diabete peripheral herve pathology, In the step S101, supercritical CO2The extracting pressure of fluid is 15MPa~20MPa, and extraction temperature is 45 DEG C~60 DEG C, CO2 Fluid flow is 24mL/min~33mL/min, and extraction time is 4h~8h.
7. it is according to claim 5 for treating the preparation method of the Chinese medicine composition of diabete peripheral herve pathology, In the step S102, the aperture for the strainer that when filtering uses is 1 μm~10 μm.
8. claim 1-4 any one of them Chinese medicine composition is preparing to treat the drug of diabete peripheral herve pathology In application.
CN201810135737.2A 2018-02-09 2018-02-09 Treat Chinese medicine composition of diabete peripheral herve pathology and preparation method thereof Pending CN108057077A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114732843A (en) * 2022-03-10 2022-07-12 上海市浦东新区中医医院 Traditional Chinese medicine gel patch for treating DPN (dipeptidyl peptidase-IV) through medicine penetration and preparation method and application thereof
CN116898941A (en) * 2023-07-21 2023-10-20 首都医科大学附属北京中医医院 Traditional Chinese medicine composition and application thereof, traditional Chinese medicine preparation and preparation method and application thereof

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Publication number Priority date Publication date Assignee Title
CN1313119A (en) * 2001-03-22 2001-09-19 营口奥达制药有限公司 Medicinal particles for treating diabetic peripheral neuropathy
CN104127567A (en) * 2014-08-19 2014-11-05 厉惠 Traditional Chinese medicine composition for treating diabetic peripheral neuropathy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1313119A (en) * 2001-03-22 2001-09-19 营口奥达制药有限公司 Medicinal particles for treating diabetic peripheral neuropathy
CN104127567A (en) * 2014-08-19 2014-11-05 厉惠 Traditional Chinese medicine composition for treating diabetic peripheral neuropathy

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114732843A (en) * 2022-03-10 2022-07-12 上海市浦东新区中医医院 Traditional Chinese medicine gel patch for treating DPN (dipeptidyl peptidase-IV) through medicine penetration and preparation method and application thereof
CN116898941A (en) * 2023-07-21 2023-10-20 首都医科大学附属北京中医医院 Traditional Chinese medicine composition and application thereof, traditional Chinese medicine preparation and preparation method and application thereof
CN116898941B (en) * 2023-07-21 2024-04-30 首都医科大学附属北京中医医院 Traditional Chinese medicine composition and application thereof, traditional Chinese medicine preparation and preparation method and application thereof

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