CN108465059A - Treat the Chinese medicine composition of wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, the preparation method of Chinese medicine preparation and pill - Google Patents
Treat the Chinese medicine composition of wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, the preparation method of Chinese medicine preparation and pill Download PDFInfo
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Abstract
The invention discloses the preparation method of a kind of Chinese medicine composition for treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, Chinese medicine preparation and pill, which includes the raw material of following parts by weight：5~30 parts of 5~50 parts of Rhizoma Gastrodiae, 10~50 parts of pueraria lobata, 10~50 parts of Radix Astragali, 5~35 parts of rhizome of chuanxiong, 5~50 parts of Radix Angelicae Sinensis, 5~35 parts of vinegar corydalis tuber, 5~50 parts of Radix Paeoniae Alba, 5~30 parts of earthworm, 5~30 parts of stiff silkworm, 5~30 parts of Rhizoma Et Radix Notopterygii and cassia twig.The Chinese medicine composition of the present invention selects natural Chinese traditional medicines raw material, using Rhizoma Gastrodiae as monarch drug in a prescription, using vinegar corydalis tuber, Rhizoma Et Radix Notopterygii, cassia twig as ministerial drug, using Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Alba, rhizome of chuanxiong, earthworm and stiff silkworm as adjutant, comprehensively utilize the Action advantage and synergistic effect of above-mentioned Chinese herb, with dispelling wind and removing obstruction in the meridians, neck and shoulder part arthralgia pain due to rheumatism of dispelling, regulating qi-flowing for relieving pain, dispelling cold and removing dampness, temperature are significant in efficacy for wind chill blockage and qi stagnation and blood stasis type cervical spondylosis through expelling pathogenic factors from muscles and skin, promoting blood circulation and removing blood stasis and other effects.
Description
Technical field
The present invention relates to Chinese medicine compound prescription technical fields, and wind chill blockage and qi stagnation and blood stasis type are treated in particular to a kind of
The Chinese medicine composition of cervical spondylosis, the preparation method of Chinese medicine preparation and pill.
Background technology
Cervical spondylosis is a kind of illness for changing into basis with degeneration pathology, is strained for a long time mainly due to cervical vertebra, hyperostosis
Raw or Disc herniation, ligament thicken, and cause cervical vertebra spinal cord, nerve root or vertebral artery to be pressurized, a series of dysfunctions occur
Clinical syndrome.Chinese medicine thinks cervical vertebra disease located in liver kidney, closely related with qi and blood, characteristic of disease category asthenia in origin and asthenia in superficiality；It is lost with liver kidney, qi and blood
Void is this, is mark with wet, qi depression to blood stasis of catching cold, phlegm wet, and wherein caused by liver and kidney deficiency is morbidity root, and cold-dampness, blood stasis, phlegm are turbid to be
Important pathogenic factor.
Drug therapy is relied primarily on to the treatment of cervical spondylosis at present, generally include nonsteroidal anti-inflammatory drug (aspirin, to second
Acylamino- phenol, Indomethacin, naproxen, Nabumetone, Diclofenac, brufen, aulin, rofecoxib, celecoxib
Deng), Chinese patent drug (such as red deer logical superintends and directs piece, JINGFUKANG KELI, XIANLING GUBAO JIAONANG, Jingtong KeLi).The most price of these drugs
Costliness, and have obvious side effect.And according to recent external in relation to aspirin can inhibit activity and the reduction of epoxidase
The formation of thromboxane A2 prevents platelet aggregation, makes it be not easy to release coagulation factor, easily cause bleeding, haemolysis, hematopoiesis function
Obstacle；And Diclofenac class easily causes gastrointestinal reaction or even gastroenteritic ulcer, perforation bleeding etc..And some existing physics are controlled
Auxiliary treatment can only be used as by treating such as micro-wave therapeutic, infrared ray, low frequency, ultrasound.
Invention content
In view of this, a kind of Chinese medicine composition for treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis provided by the invention,
The preparation method of Chinese medicine preparation and pill, preferably overcomes the above-mentioned problems of the prior art and defect, the treatment chill
Numbness hinders and the Chinese medicine composition of qi stagnation and blood stasis type cervical spondylosis selects natural Chinese traditional medicines raw material, using Rhizoma Gastrodiae as monarch drug in a prescription, is prolonged recklessly with vinegar
Rope, Rhizoma Et Radix Notopterygii, cassia twig are ministerial drug, using Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Alba, rhizome of chuanxiong, earthworm and stiff silkworm as adjutant, comprehensively utilize above-mentioned each Chinese medicine
The Action advantage of raw material and mutually synergistic effect, have dispelling wind and removing obstruction in the meridians, neck and shoulder part arthralgia pain due to rheumatism of dispelling, regulating qi-flowing for relieving pain, cold dispelling remove
It is wet, warm to hold back cloudy, flourish muscle analgesic, promoting blood circulation and removing blood stasis and other effects through expelling pathogenic factors from muscles and skin, blood-nourishing, wind chill blockage and qi stagnation and blood stasis type cervical spondylosis are treated
Effect is notable, easy to use, and low in raw material price, without any side effects.
A kind of Chinese medicine composition for treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, includes the original of following parts by weight
Material：5~50 parts of Rhizoma Gastrodiae, 10~50 parts of pueraria lobata, 10~50 parts of Radix Astragali, 5~35 parts of rhizome of chuanxiong, 5~50 parts of Radix Angelicae Sinensis, vinegar corydalis tuber 5~
5~30 parts of 35 parts, 5~50 parts of Radix Paeoniae Alba, 5~30 parts of earthworm, 5~30 parts of stiff silkworm, 5~30 parts of Rhizoma Et Radix Notopterygii and cassia twig.
Further, the Chinese medicine composition includes the raw material of following parts by weight：5~30 parts of Rhizoma Gastrodiae, pueraria lobata 5~35
Part, 5~35 parts of Radix Astragali, 5~30 parts of rhizome of chuanxiong, 5~30 parts of Radix Angelicae Sinensis, 5~25 parts of vinegar corydalis tuber, 5~30 parts of Radix Paeoniae Alba, earthworm 5~20
5~20 parts of part, 5~20 parts of stiff silkworm, 5~20 parts of Rhizoma Et Radix Notopterygii and cassia twig.
Further, the Chinese medicine composition includes the raw material of following parts by weight：10~15 parts of Rhizoma Gastrodiae, pueraria lobata 20~30
Part, 20~30 parts of Radix Astragali, 10~15 parts of rhizome of chuanxiong, 10~15 parts of Radix Angelicae Sinensis, 10~15 parts of vinegar corydalis tuber, 5~10 parts of Radix Paeoniae Alba, earthworm 5
5~10 parts of~10 parts, 5~10 parts of stiff silkworm, 5~10 parts of Rhizoma Et Radix Notopterygii and cassia twig.
The present invention also provides a kind of Chinese medicine preparation for treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, the Chinese medicines
Preparation includes the Chinese medicine composition of above-mentioned treatment wind chill blockage and qi stagnation and blood stasis type cervical spondylosis.
Further, the dosage form of the Chinese medicine preparation is pill, granule or decoction.
Further, the dosage form of the Chinese medicine preparation is pill.
It is described the present invention also provides a kind of preparation method of pill that treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis
Pill includes the Chinese medicine composition of above-mentioned treatment wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, and the preparation method includes：
Rhizoma Gastrodiae, Radix Angelicae Sinensis and rhizome of chuanxiong are ground into fine powder；
Pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig are mixed, added water to cook, is filtered, then
Obtained filtrate is condensed into thick paste；
By the thick paste and the fine powder mixing, pill.
Further, the grain size of the fine powder is 100~200 mesh.
Further, the number added water to cook is 2 times, and it is total to be respectively the Chinese medicine material for described plus water the amount every time
3~6 times of weight；The time of the decoction is 1.5~2.5h for the first time, and the time of second of decoction is 1.5~2.5h.
Further, the pelletizing process includes：The mixture of the thick paste and the fine powder is first made to wet ball, then
It is dried to obtain vegetable pill, then the vegetable pill is coated with activated carbon and uses talcum powder polishing.
Compared with prior art, a kind of Chinese traditional medicine composition for treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis of the invention
The advantageous effect of the preparation method of object, Chinese medicine preparation and pill is：
(1) treatment wind chill blockage of the invention and the Chinese medicine composition of qi stagnation and blood stasis type cervical spondylosis select natural Chinese traditional medicines former
Material, using Rhizoma Gastrodiae as monarch drug in a prescription, using vinegar corydalis tuber, Rhizoma Et Radix Notopterygii, cassia twig as ministerial drug, with Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Alba, rhizome of chuanxiong, earthworm and stiff silkworm
For adjutant, comprehensively utilizes the Action advantage of above-mentioned each Chinese herb and mutually act synergistically, there is dispelling wind and removing obstruction in the meridians, neck and shoulder part of dispelling
Arthralgia pain due to rheumatism, regulating qi-flowing for relieving pain, dispelling cold and removing dampness, temperature hold back cloudy, flourish muscle analgesic, promoting blood circulation and removing blood stasis and other effects through expelling pathogenic factors from muscles and skin, blood-nourishing, for chill
Numbness hinders and qi stagnation and blood stasis type cervical spondylosis is significant in efficacy, easy to use, and low in raw material price, without any side effects.
(2) the Chinese medicine system that the present invention is prepared using the treatment wind chill blockage and the Chinese medicine composition of qi stagnation and blood stasis type cervical spondylosis
Agent, safe to use, no pain have no toxic side effect.
(3) pill that the present invention is prepared using the treatment wind chill blockage and the Chinese medicine composition of qi stagnation and blood stasis type cervical spondylosis is logical
It crosses and Rhizoma Gastrodiae, Radix Angelicae Sinensis and rhizome of chuanxiong is ground into fine powder；By pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig
Mixing, adds water to cook, and filters, obtained filtrate is then condensed into thick paste；The ball for again obtaining thick paste and fine powder mixing, pill
The effect of agent is more preferable, and preparation method is simple.
To enable the above objects, features and advantages of the present invention to be clearer and more comprehensible, preferred embodiment cited below particularly is made detailed
It is described as follows.
Specific implementation mode
To facilitate the understanding of the present invention, it elaborates to technical scheme of the present invention with reference to the mode of embodiment,
Many details are elaborated in the following description in order to fully understand the present invention.
But the invention can be embodied in many other ways as described herein, those skilled in the art can be with
Similar improvement is done without violating the connotation of the present invention, therefore the present invention is not limited to the specific embodiments disclosed below.
A kind of Chinese medicine composition for treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, includes the original of following parts by weight
Material：
Such as 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts of 5~50 parts of Rhizoma Gastrodiae or
50 parts etc.；
Such as 10 parts, 12 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts of 10~50 parts of pueraria lobata；
Such as 10 parts, 12 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts of 10~50 parts of Radix Astragali
5~35 parts of rhizome of chuanxiong is such as 5 parts, 10 parts, 12 parts, 15 parts, 20 parts, 25 parts, 30 parts or 35 parts；
5~50 parts of Radix Angelicae Sinensis is such as 5 parts, 10 parts, 12 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts
Deng；
5~35 parts of vinegar corydalis tuber is such as 5 parts, 10 parts, 12 parts, 15 parts, 20 parts, 25 parts, 30 parts or 35 parts
5~50 parts of Radix Paeoniae Alba is such as 5 parts, 10 parts, 12 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts
Deng
5~30 parts of earthworm is such as 5 parts, 10 parts, 12 parts, 15 parts, 20 parts, 25 parts or 30 parts；
5~30 parts of stiff silkworm is such as 5 parts, 10 parts, 12 parts, 15 parts, 20 parts, 25 parts or 30 parts；
5~30 parts of Rhizoma Et Radix Notopterygii is such as 5 parts, 10 parts, 12 parts, 15 parts, 20 parts, 25 parts or 30 parts；
5~30 parts of cassia twig is such as 5 parts, 10 parts, 12 parts, 15 parts, 20 parts, 25 parts or 30 parts.
Above-mentioned, theory of traditional Chinese medical science thinks：
Rhizoma Gastrodiae also known as rhizoma gastrodiae, solely shake sesame, from it is female, close from grass, god grass, yellow moccasin flower, Mokpo, RHIZONA GASTRODIAE, wind grass, Bai Long
Skin etc., is orchid family Gastrodia herbaceos perennial, and rhizome enters medicinal, and property is pungent, warm, nontoxic, has anti-epileptic, anti-throbs with fear
Faint, antirheumatic, calmness, antispastic, analgesia, qi-restoratives, suppressing hyperactive liver for calming endogenous wind and other effects, can be used to treat have a dizzy spell, extremity numbness, children
The diseases such as infantile convulsion.
Pueraria lobata, it is cool in nature, it is sweet in flavor, pungent.Pueraria lobata isoflavone-containing ingredient, Puerarin, Puerarin xyloside, daizeol, soybean
Glycosides displayed and cupreol, arachidic acid, and starch containing volume (content is 19~20% in fresh pueraria lobata)；Pueraria Flavonid and Pueraria lobota
Root element can improve the oxygen metabolism of cardiac muscle, generate beneficial effect to myocardial metabolism, while can expand blood vessel, improve microcirculation, reduce
Vascular resistence makes blood flow increase；Pueraria lobata is known as the apparent effect for reducing blood glucose, and the flavone compound contained by pueraria lobata has drop
Blood fat can reduce serum cholesterol, reduce oily three esters.The work(such as there is pueraria lobata inducing diaphoresis to bring down a fever, promote the production of body fluid, promoting eruption and Shengyang Zhixie
Effect.
Radix Astragali also known as cotton stilbene, astragalus, only mulberry, another name for Sichuan Province fat, hundred, hundred absorbent cotton, kurarinone etc., sweet in flavor, tepor.Radix Astragali contains flavones
Constituents calycosin also contains sucrose, glucuronic acid, astragalus polyose (A, B, C, D), lymphatic temperament, a variety of amino acid, hardship
Monosodium glutamate, astragaloside, glycine betaine, choline, folic acid, flavane compound and contain the lot of trace member such as selenium, silicon, zinc, cobalt, copper, molybdenum
Element；The effect of with invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic and inducing diuresis for removing edema
Rhizome of chuanxiong, also known as big rhizome of chuanxiong, comfort vault, wine rhizome of chuanxiong；It is with promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, dispelling wind and removing obstruction in the meridians, sensible qi and blood
And other effects.
Radix Angelicae Sinensis also known as it is dry return, the Qin which, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, Radix Angelicae Sinensis, when angelica body, contain angelica tail, Radix Angelicae Sinensis song etc., it is sweet in flavor,
It is pungent, warm.Radix Angelicae Sinensis have benefiting blood and regulating blood circulation, regulating menstruation and activating blood, moisturize laxation, blood-supplementing blood-nourishing, anticancer, it is anti-ageing anti-old and immune the effect of.
Vinegar corydalis tuber has promoting blood circulation and promoting qi circulation and relieving pain and other effects.
Radix Paeoniae Alba also known as auricledleaf swallowwort root have smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating and other effects.
Earthworm, also known as earthworm, the protein content of earthworm account for about the 53.5%~65.1% of dry weight, and fat content is about
4.4%~17.38%, carbohydrate is about 11%~17.4%, ash content 7.8%~23%.Also contain in earthworm body abundant
Vitamin D (account for about fresh weight 0.04%~0.073%) and calcium and phosphorus (account for about fresh weight 0.124%~
0.188%) mineral matter elements such as.Contain earthworm element, earthworm toxolysin, xanthine, antihistaminicum and vitamin B etc. in earthworm body
A variety of medicinal ingredients.Earthworm has heat-clearing, soothing the liver, Zhichuan, dredging collateral and other effects.
Stiff silkworm also known as flying worm have effects that expel endogenous wind to relieve convulsion, reducing phlegm and resolving masses.
Rhizoma Et Radix Notopterygii also known as Qiang are green, shield Qiang envoy, Hu king envoy, Qiang is sliding, move back wind envoy, and root and rhizome is medicinal part, taste
It is pungent；It is bitter；Property, temperature, dissipate exterior cold；Wind-damp dispelling；Sharp joint；Analgesic
Cassia twig also known as Liu Gui, pungent-warm have cold-dispelling, sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, helps yang transforming qi and eliminating cold to stop pain etc.
Effect.
The treatment wind chill blockage of the present invention and the Chinese medicine composition of qi stagnation and blood stasis type cervical spondylosis select natural Chinese traditional medicines former material
Material, using Rhizoma Gastrodiae as monarch drug in a prescription, have dispelling wind and removing obstruction in the meridians, dispel neck and shoulder part arthralgia pain due to rheumatism the effect of；Using vinegar corydalis tuber, Rhizoma Et Radix Notopterygii and cassia twig as minister
Medicine, has effects that regulating qi-flowing for relieving pain, dispelling cold and removing dampness, temperature through expelling pathogenic factors from muscles and skin, can principal drug assistance dissipate the exterior cold of neck and shoulder part, the numbness pain of dispellieg cold and dampness；
Assistant has effects that nourishing qi and blood, holds back cloudy, flourish muscle analgesic with Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Alba；Assistant has promoting blood circulation and removing blood stasis and dispels with Rhizoma Chuanxiong
The effect of wind relieves pain；Assistant has effects that blood-breaking is invigorated blood circulation by becoming silted up and increasing with animal drugs earthworm and stiff silkworm.Comprehensively utilize it is above-mentioned it is each in
The Action advantage of medicine raw material and mutually synergistic effect have very strong clearing damp eliminating impediment and promoting blood circulation and removing blood stasis and other effects, for chill
Numbness hinders and qi stagnation and blood stasis type cervical spondylosis is significant in efficacy, easy to use, and low in raw material price, without any side effects.
Preferably, the Chinese medicine composition also includes the raw material of following parts by weight：5~30 parts of Rhizoma Gastrodiae, pueraria lobata 5~35
Part, 5~35 parts of Radix Astragali, 5~30 parts of rhizome of chuanxiong, 5~30 parts of Radix Angelicae Sinensis, 5~25 parts of vinegar corydalis tuber, 5~30 parts of Radix Paeoniae Alba, earthworm 5~20
5~20 parts of part, 5~20 parts of stiff silkworm, 5~20 parts of Rhizoma Et Radix Notopterygii and cassia twig.
Preferably, the Chinese medicine composition includes the raw material of following parts by weight：10~15 parts of Rhizoma Gastrodiae, pueraria lobata 20~30
Part, 20~30 parts of Radix Astragali, 10~15 parts of rhizome of chuanxiong, 10~15 parts of Radix Angelicae Sinensis, 10~15 parts of vinegar corydalis tuber, 5~10 parts of Radix Paeoniae Alba, earthworm 5
5~10 parts of~10 parts, 5~10 parts of stiff silkworm, 5~10 parts of Rhizoma Et Radix Notopterygii and cassia twig.
The present invention also provides a kind of Chinese medicine preparation for treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, the Chinese medicines
Preparation includes the Chinese medicine composition of above-mentioned treatment wind chill blockage and qi stagnation and blood stasis type cervical spondylosis.
Preferably, the dosage form of the Chinese medicine preparation is pill, granule or decoction.Certainly, the embodiment of the present invention and unlimited
The dosage form of the treatment wind chill blockage and the Chinese medicine preparation of qi stagnation and blood stasis type cervical spondylosis is made, dosage form can also be pulvis, capsule
Deng.
It is highly preferred that the dosage form of the Chinese medicine preparation is pill.
The Chinese medicine preparation that the present invention is prepared using the treatment wind chill blockage and the Chinese medicine composition of qi stagnation and blood stasis type cervical spondylosis,
Safe to use, no pain has no toxic side effect.
It is described the present invention also provides a kind of preparation method of pill that treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis
Pill includes the Chinese medicine composition of above-mentioned treatment wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, and the preparation method includes：
Rhizoma Gastrodiae, Radix Angelicae Sinensis and rhizome of chuanxiong are ground into fine powder；
Pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig are mixed, added water to cook, is filtered, then
Obtained filtrate is condensed into thick paste；
By the thick paste and the fine powder mixing, pill.
Preferably, the grain size of the fine powder is 100~200 mesh.
Preferably, the number added water to cook is 2 times.Described plus water the amount is respectively the Chinese medicine material gross weight every time
3~6 times such as 3 times, 4 times, 5 times or 6 times of amount.Wherein, the time of the decoction is 1.5~2.5h such as 1.5h, 2h for the first time
Or 2.5h etc., the time of second of decoction is 1.5~2.5h such as 1.5h, 2h or 2.5h etc..
Preferably, the pelletizing process includes：The mixture of the thick paste and the fine powder is first made to wet ball, is then done
It is dry to obtain vegetable pill, then the vegetable pill is coated with activated carbon and uses talcum powder polishing.Wherein, the every 100 parts vegetable pills use
0.45~0.55 part of activated carbon and 0.45~0.55 part of talcum powder.
Wherein, every 100 parts of vegetable pills using 0.45~0.55 part such as 0.45 part, 0.48 part, 0.5 part, 0.52 part or
0.55 part of activated carbon and 0.45~0.55 part such as 0.45 part, 0.48 part, 0.5 part, 0.52 part or 0.55 part talcum powder.
The present invention is passed through using pill prepared by the treatment wind chill blockage and the Chinese medicine composition of qi stagnation and blood stasis type cervical spondylosis
Rhizoma Gastrodiae, Radix Angelicae Sinensis and rhizome of chuanxiong are ground into fine powder；Pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig are mixed
It closes, adds water to cook, filter, obtained filtrate is then condensed into thick paste；The pill for again obtaining thick paste and fine powder mixing, pill
Effect it is more preferable, and preparation method is simple
To facilitate the understanding of the present invention, the technical side further illustrated the present invention with reference to embodiment and specific case
Case.
Embodiment 1
(1) Chinese medicine material is weighed：5 parts of Rhizoma Gastrodiae, 10 parts of pueraria lobata, 10 parts of Radix Astragali, 35 parts of rhizome of chuanxiong, 50 parts of Radix Angelicae Sinensis, vinegar corydalis tuber 5
5 parts of part, 5 parts of Radix Paeoniae Alba, 5 parts of earthworm, 5 parts of stiff silkworm, 5 parts of Rhizoma Et Radix Notopterygii and cassia twig.
(2) three kinds of above-mentioned Rhizoma Gastrodiae, Radix Angelicae Sinensis and rhizome of chuanxiong Chinese medicine materials are ground into 100~200 mesh with using pulverizer respectively
Fine powder, be subsequently placed in mixing machine be uniformly mixed to get fine powder material.
(3) eight kinds of above-mentioned pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig Chinese medicine materials are mixed
It closes, the water of 3 times of amounts of eight kinds of Chinese medicine material total weights, after decocting 1.5h, filtering, to the dregs of a decoction being obtained by filtration then is added
The water of 5 times of amounts of eight kinds of Chinese medicine material total weights is added, continues to decoct 1.5h, refilters, merge filtrate twice.
(4) above-mentioned filtrate is condensed into the thick paste that relative density is 1.2.
(5) thick paste prepared by fine powder material and step (4) prepared by above-mentioned steps (2) is uniformly mixed, is then made
Wet ball, then be dried using microwave drying sterilization case, moisture is obtained in 5% vegetable pill below.
(6) above-mentioned vegetable pill is first coated with activated carbon, then uses talcum powder polishing, every 100 parts of vegetable pills that work can be added
Property charcoal, each 0.45 part of talcum powder, obtain pill.
Embodiment 2
(1) Chinese medicine material is weighed：50 parts of Rhizoma Gastrodiae, 50 parts of pueraria lobata, 50 parts of Radix Astragali, 35 parts of rhizome of chuanxiong, 50 parts of Radix Angelicae Sinensis, vinegar corydalis tuber
30 parts of 35 parts, 50 parts of Radix Paeoniae Alba, 30 parts of earthworm, 30 parts of stiff silkworm, 30 parts of Rhizoma Et Radix Notopterygii and cassia twig.
(2) three kinds of above-mentioned Rhizoma Gastrodiae, Radix Angelicae Sinensis and rhizome of chuanxiong Chinese medicine materials are ground into 100~200 mesh with using pulverizer respectively
Fine powder, be subsequently placed in mixing machine be uniformly mixed to get fine powder material.
(3) eight kinds of above-mentioned pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig Chinese medicine materials are mixed
It closes, the water of 6 times of amounts of eight kinds of Chinese medicine material total weights, after decocting 2.5h, filtering, to the dregs of a decoction being obtained by filtration then is added
The water of 5 times of amounts of eight kinds of Chinese medicine material total weights is added, continues to decoct 2h, refilters, merge filtrate twice.
(4) above-mentioned filtrate is condensed into the thick paste that relative density is 1.2.
(5) thick paste prepared by fine powder material and step (4) prepared by above-mentioned steps (2) is uniformly mixed, is then made
Wet ball, then be dried using microwave drying sterilization case, moisture is obtained in 5% vegetable pill below.
(6) above-mentioned vegetable pill is first coated with activated carbon, then uses talcum powder polishing, every 100 parts of vegetable pills that work can be added
Property charcoal, each 0.45 part of talcum powder, obtain pill.
Embodiment 3
(1) Chinese medicine material is weighed：40 parts of Rhizoma Gastrodiae, 40 parts of pueraria lobata, 40 parts of Radix Astragali, 25 parts of rhizome of chuanxiong, 40 parts of Radix Angelicae Sinensis, vinegar corydalis tuber
20 parts of 20 parts, 20 parts of Radix Paeoniae Alba, 20 parts of earthworm, 20 parts of stiff silkworm, 20 parts of Rhizoma Et Radix Notopterygii and cassia twig.
(2) three kinds of above-mentioned Rhizoma Gastrodiae, Radix Angelicae Sinensis and rhizome of chuanxiong Chinese medicine materials are ground into 100~200 mesh with using pulverizer respectively
Fine powder, be subsequently placed in mixing machine be uniformly mixed to get fine powder material.
(3) eight kinds of above-mentioned pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig Chinese medicine materials are mixed
It closes, the water of 5 times of amounts of eight kinds of Chinese medicine material total weights, after decocting 2.5h, filtering, to the dregs of a decoction being obtained by filtration then is added
The water of 4 times of amounts of eight kinds of Chinese medicine material total weights is added, continues to decoct 2h, refilters, merge filtrate twice.
(4) above-mentioned filtrate is condensed into the thick paste that relative density is 1.2.
(5) thick paste prepared by fine powder material and step (4) prepared by above-mentioned steps (2) is uniformly mixed, is then made
Wet ball, then be dried using microwave drying sterilization case, moisture is obtained in 5% vegetable pill below.
(6) above-mentioned vegetable pill is first coated with activated carbon, then uses talcum powder polishing, every 100 parts of vegetable pills that work can be added
Property charcoal, each 0.45 part of talcum powder, obtain pill.
Embodiment 4
(1) Chinese medicine material is weighed：10 parts of Rhizoma Gastrodiae, 20 parts of pueraria lobata, 20 parts of Radix Astragali, 15 parts of rhizome of chuanxiong, 15 parts of Radix Angelicae Sinensis, vinegar corydalis tuber
5 parts of 5 parts, 5 parts of Radix Paeoniae Alba, 5 parts of earthworm, 5 parts of stiff silkworm, 5 parts of Rhizoma Et Radix Notopterygii and cassia twig.
(2) three kinds of above-mentioned Rhizoma Gastrodiae, Radix Angelicae Sinensis and rhizome of chuanxiong Chinese medicine materials are ground into 100~200 mesh with using pulverizer respectively
Fine powder, be subsequently placed in mixing machine be uniformly mixed to get fine powder material.
(3) eight kinds of above-mentioned pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig Chinese medicine materials are mixed
It closes, the water of 3 times of amounts of eight kinds of Chinese medicine material total weights, after decocting 1.5h, filtering, to the dregs of a decoction being obtained by filtration then is added
The water of 3 times of amounts of eight kinds of Chinese medicine material total weights is added, continues to decoct 1.5h, refilters, merge filtrate twice.
(4) above-mentioned filtrate is condensed into the thick paste that relative density is 1.2.
(5) thick paste prepared by fine powder material and step (4) prepared by above-mentioned steps (2) is uniformly mixed, is then made
Wet ball, then be dried using microwave drying sterilization case, moisture is obtained in 5% vegetable pill below.
(6) above-mentioned vegetable pill is first coated with activated carbon, then uses talcum powder polishing, every 100 parts of vegetable pills that work can be added
Property charcoal, each 0.45 part of talcum powder, obtain pill.
Embodiment 5
(1) Chinese medicine material is weighed：15 parts of Rhizoma Gastrodiae, 30 parts of pueraria lobata, 30 parts of Radix Astragali, 15 parts of rhizome of chuanxiong, 15 parts of Radix Angelicae Sinensis, vinegar corydalis tuber
5 parts of 15 parts, 10 parts of Radix Paeoniae Alba, 10 parts of earthworm, 10 parts of stiff silkworm, 10 parts of Rhizoma Et Radix Notopterygii and cassia twig.
(2) three kinds of above-mentioned Rhizoma Gastrodiae, Radix Angelicae Sinensis and rhizome of chuanxiong Chinese medicine materials are ground into 100~200 mesh with using pulverizer respectively
Fine powder, be subsequently placed in mixing machine be uniformly mixed to get fine powder material.
(3) eight kinds of above-mentioned pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig Chinese medicine materials are mixed
It closes, the water of 4 times of amounts of eight kinds of Chinese medicine material total weights is then added, after decocting 2h, filtering adds to the dregs of a decoction being obtained by filtration
The water for entering 4 times of amounts of eight kinds of Chinese medicine material total weights continues to decoct 1.5h, refilters, merge filtrate twice.
(4) above-mentioned filtrate is condensed into the thick paste that relative density is 1.2.
(5) thick paste prepared by fine powder material and step (4) prepared by above-mentioned steps (2) is uniformly mixed, is then made
Wet ball, then be dried using microwave drying sterilization case, moisture is obtained in 5% vegetable pill below.
(6) above-mentioned vegetable pill is first coated with activated carbon, then uses talcum powder polishing, every 100 parts of vegetable pills that work can be added
Property charcoal, each 0.45 part of talcum powder, obtain pill.
Embodiment 6
(1) Chinese medicine material is weighed：12 parts of Rhizoma Gastrodiae, 25 parts of pueraria lobata, 25 parts of Radix Astragali, 12 parts of rhizome of chuanxiong, 12 parts of Radix Angelicae Sinensis, vinegar corydalis tuber
8 parts of 8 parts, 8 parts of Radix Paeoniae Alba, 8 parts of earthworm, 8 parts of stiff silkworm, 8 parts of Rhizoma Et Radix Notopterygii and cassia twig.
(2) three kinds of above-mentioned Rhizoma Gastrodiae, Radix Angelicae Sinensis and rhizome of chuanxiong Chinese medicine materials are ground into 100~200 mesh with using pulverizer respectively
Fine powder, be subsequently placed in mixing machine be uniformly mixed to get fine powder material.
(3) eight kinds of above-mentioned pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig Chinese medicine materials are mixed
It closes, the water of 5 times of amounts of eight kinds of Chinese medicine material total weights, after decocting 2.5h, filtering, to the dregs of a decoction being obtained by filtration then is added
The water of 4 times of amounts of eight kinds of Chinese medicine material total weights is added, continues to decoct 2h, refilters, merge filtrate twice.
(4) above-mentioned filtrate is condensed into the thick paste that relative density is 1.2.
(5) thick paste prepared by fine powder material and step (4) prepared by above-mentioned steps (2) is uniformly mixed, is then made
Wet ball, then be dried using microwave drying sterilization case, moisture is obtained in 5% vegetable pill below.
(6) above-mentioned vegetable pill is first coated with activated carbon, then uses talcum powder polishing, every 100 parts of vegetable pills that work can be added
Property charcoal, each 0.45 part of talcum powder, obtain pill.
Comparative example 1
With embodiment 5 difference lies in：Remove the Rhizoma Gastrodiae in Chinese medicine material, the other the same as in Example 5.
Comparative example 2
With embodiment 5 difference lies in：Remove the vinegar corydalis tuber in Chinese medicine material, the other the same as in Example 5.
Comparative example 3
With embodiment 5 difference lies in：Remove the Rhizoma Et Radix Notopterygii in Chinese medicine material, the other the same as in Example 5.
Comparative example 4
With embodiment 5 difference lies in：Remove the cassia twig in Chinese medicine material, the other the same as in Example 5.
Comparative example 5
5 identical Chinese medicine material of logical embodiment is weighed, is then prepared into using the preparation method of conventional Chinese herbal granules
To granule.
Comparative example 6
5 identical Chinese medicine material of logical embodiment is weighed, is then prepared using the preparation method of conventional traditional Chinese herbal decoction
Decoction.
Comparative example 7
(1) Chinese medicine material is weighed：12 parts of Rhizoma Gastrodiae, 25 parts of pueraria lobata, 25 parts of Radix Astragali, 12 parts of rhizome of chuanxiong, 12 parts of Radix Angelicae Sinensis, vinegar corydalis tuber
8 parts of 8 parts, 8 parts of Radix Paeoniae Alba, 8 parts of earthworm, 8 parts of stiff silkworm, 8 parts of Rhizoma Et Radix Notopterygii and cassia twig.
(2) by above-mentioned Rhizoma Gastrodiae, Radix Angelicae Sinensis, rhizome of chuanxiong, pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig
11 kinds of Chinese medicine material mixing, are then added the water of 4 times of amounts of eight kinds of Chinese medicine material total weights, after decocting 2h, filtering, to mistake
The water that 4 times of amounts of eight kinds of Chinese medicine material total weights are added in the obtained dregs of a decoction is filtered, continues to decoct 1.5h, refilter, merge twice
Filtrate.
(3) above-mentioned filtrate is condensed into the thick paste that relative density is 1.2.
(4) thick paste prepared by fine powder material and step (4) prepared by above-mentioned steps (2) is uniformly mixed, is then made
Wet ball, then be dried using microwave drying sterilization case, moisture is obtained in 5% vegetable pill below.
(5) above-mentioned vegetable pill is first coated with activated carbon, then uses talcum powder polishing, every 100 parts of vegetable pills that work can be added
Property charcoal, each 0.45 part of talcum powder, obtain pill.
Comparative example 8
5 identical Chinese medicine material of logical embodiment is weighed, is then prepared using the preparation method of conventional traditional Chinese herbal decoction
Decoction.
(1) 90 parts of pueraria lobata, 40 parts of Caulis Spatholobi, 70 parts of Radix Astragali, 40 parts of Radix Angelicae Sinensis, 40 parts of Rhizoma Chuanxiong, 40 parts of safflower, peach kernel 40 are taken
Part, 40 parts of turmeric, 40 parts of Artemisia anomala, 20 parts of Fructus Liquidambaris, 40 parts of the root of Chinese clematis, 20 parts of ramulus mori, 20 parts of aconiti preparata,radix, 20 parts of wild aconite root,
20 parts of semen brassicae, 40 parts of Rhizoma Gastrodiae, 20 parts of scorpio, 40 parts of earthworm, 7 parts of cornu cerve degelatinatum, 20 parts of dogwood fruit, 20 parts of HERBA EPIMEDII, Rhizoma Et Radix Notopterygii 20
Part, 20 parts of Radix Angelicae Pubescentis, 20 parts of lycopodium calvatum, 20 parts of uncaria, 20 parts of stiff silkworm, 20 parts of pyrola, 20 parts of Radix Salviae Miltiorrhizae, 20 parts of radix rehmanniae preparata, Radix Paeoniae Alba 20
Part, 20 parts of coix seed, 20 parts of psoralea corylifolia, 20 parts of RADIX ACONITILATERALIS PREPARATA, 20 parts of Chinese cassia tree, 20 parts of root of Aucklandia lappa Decne, 20 parts of corydalis tuber, 20 parts of Fructus Aurantii, system
After 20 parts of 20 parts of frankincense, 20 parts of myrrh, 20 parts of bark of ash, 20 parts of cassia twig, 20 parts of Radix Glycyrrhizae, Cortex Eucommiae removal impurity, it is uniformly mixed,
Then high pressure sterilization after progress ultramicro grinding, the 0.5g water-bindered pills are made by powder.
Clinical test
It now collects 450 famous physicians and is diagnosed as qi depression to blood stasis and the sluggish myelopathy of cold-dampness, doctor trained in Western medicine is diagnosed as spondylotic radiculopathy neck
Vertebra patient is randomly divided into 15 groups by random digits table, and every group 30, the age is 25~65 years old, is implemented respectively with the present invention
The Chinese medicine preparation and conventional western medicine of pill, the preparation of comparative example 1~8 prepared by example 1~6 are treated.
Application method：Pill, granule and decoction are directly for oral administration, pill and each 5g of granule；One bowl every time of decoction,
Medication is 3 times a day.
Observation index：Neck and shoulder ache visual analogue scales (VAS)：
0 point, without apparent neck and shoulder ache；
1~3 point, there is slight neck and shoulder ache, can endure；
4~6 points, neck and shoulder ache influences sleep, can endure；
7~10 points, there is the neck and shoulder ache that progressive aggravates, and can not endure, influence appetite and sleep.
Cervical vertebra improves JOA scorings：JOA score values are up to 29 points, minimum 0 point, and the lower expression dysfunction of score is more
Obviously.
Cervical functional impairment index (NDI indexes)：NDI indexes are divided by score value domain section:10~29% score value is
Slightly；30~49% be moderate；50~68% be serious, is complete more than or equal to 72%.
MacNab curative effects judge：
It cures：Symptom and sign disappears substantially.
Effectively：Symptom and sign is alleviated.
In vain：Symptom and sign is preceding without improvement with treatment.
10 days as a treatment course, after the Chinese medicine composition of 3 course for the treatment of present invention is used continuously, statistical result is as follows：
1. pretherapy and post-treatment VAS of table scorings, JOA scorings, NDI indexes compare (x+s, n=450)
Note：VAS scores：Before VS treatments▲P=0.00, embodiment 5VS comparative example 7#P=0.00, VS comparative example 8★P=
0.13, VS conventional western medicine●P=0.00；JOA scores：Before VS treatments▲P=0.00, embodiment 5VS comparative example 7#P=0.00, VS
Comparative example 8★P=0.38, VS conventional western medicine●P=0.00；NDI indexes：Before VS treatments▲P=0.00, embodiment 5VS comparative examples
7#P=0.00, VS comparative example 8★P=0.06, VS conventional western medicine●P=0.00.
By 1 result of upper table it is found that the pill of the preparation of the embodiment of the present invention 1~6 is to qi depression to blood stasis and the sluggish type cervical vertebra of cold-dampness
The therapeutic effect of disease is more preferable.
Table 2.MacNab curative effects compare
| Group | Total number of persons | It cures | Effectively | In vain | Total effective rate |
| Embodiment 1 | 30 | 20 | 3 | 7 | 77% |
| Embodiment 2 | 30 | 19 | 5 | 6 | 80% |
| Embodiment 3 | 30 | 20 | 4 | 8 | 80% |
| Embodiment 4 | 30 | 23 | 4 | 3 | 90% |
| Embodiment 5 | 30 | 26 | 3 | 1 | 97% |
| Embodiment 6 | 30 | 24 | 4 | 2 | 93% |
| Comparative example 1 | 30 | 1 | 8 | 21 | 30% |
| Comparative example 2 | 30 | 1 | 6 | 23 | 23% |
| Comparative example 3 | 30 | 0 | 6 | 24 | 20% |
| Comparative example 4 | 30 | 2 | 9 | 19 | 37% |
| Comparative example 5 | 30 | 16 | 8 | 6 | 80% |
| Comparative example 6 | 30 | 15 | 7 | 8 | 73% |
| Comparative example 7 | 30 | 13 | 8 | 9 | 70% |
| Comparative example 8 | 30 | 19 | 8 | 3 | 90% |
| Conventional western medicine | 30 | 13 | 8 | 9 | 70% |
By upper table 2 it is found that the pill through the embodiment of the present invention 1~6 controls qi depression to blood stasis and the sluggish myelopathy of cold-dampness
Effective percentage is treated 77% or more, cure rate is above effective percentage and the healing of comparative example 1~7 and conventional western medicine up to 63% or more
Rate, and it is suitable with the therapeutic effect of comparative example 8, it can be seen that, pill of the invention is to qi depression to blood stasis and the sluggish type cervical vertebra of cold-dampness
The therapeutic effect of disease is notable.In addition, in general from cure rate and effective percentage, the therapeutic effect in embodiment 4~6 is more preferable,
The therapeutic effect of middle embodiment 5 is best.
Clinical case
Case 1：Flood certain, man, 50 years old, neck-shoulder pain 8 years, aggravate 1 month, have no apparent through Dressed plaster, acupuncture etc.
Curative effect.Neck-shoulder pain feels that decline, physical examination are shown in that neck physiological camber straightens at right upper extremity deltoid muscle, and intervertebral foramen squeezes
Separation test is positive, and right arm clump distraction test is positive, and right deltoid region feels that decline, deltoid muscle muscular strength weaken, and pale tongue is dark, tongue
In vain, deep thready pulse, CT film makings are diagnosed as nerve root cervical vertebra sickness, and Minor articulus hypertrophy cohesion, the purple dark, tongue of tongue is greasy in vain, arteries and veins is tight,
The past superficial atrophic gastritis, 2 grades of high blood pressure took the pill of the embodiment of the present invention 5 after 10 days, and neck-shoulder pain is apparent
Mitigate, be further continued for taking the pill half a month of the embodiment of the present invention 1, neck and shoulder part and right upper arm symptom are relieved, life of taking care of oneself, extensive
It is good to visit curative effect for many years for recovery operation.
Case 2：Cao, female, 43 years old, neck-shoulder pain companion upper left acroanesthesia 5 years aggravated 12 days, no trauma history, physique inspection
It looks into neck physiological camber to straighten, intervertebral foramen squeezes the separation test positive, and right arm clump distraction test is positive, and left tiger's jaw area feels to subtract
It moves back, wrist dorsiflexion muscular strength disaccommodation, pale tongue is dark, tongue is white, deep thready pulse, and CT film makings are diagnosed as nerve root cervical vertebra sickness, Minor articulus hyperplasia fertilizer
Big cohesion.Take pill of the invention after a week, neck-shoulder pain is substantially reduced, is further continued for taking the ball of the embodiment of the present invention 1
Agent 1 month, neck-shoulder pain disappears substantially, and upper limb is felt to be clearly better before muscular strength is relatively treated, and spirit is preferable, life of taking care of oneself,
Extensive recovery operation, follow-up are not recurred for 1 year.
Case 3：Side certain, female, 49 years old, more than 10 years of neck-shoulder pain.Private prosecution walks and steps on cotton sense more than 1 year, holds object shakiness.
Through physical examination, neck physiological camber straightens, and intervertebral foramen squeezes the separation test positive, and left and right brachial plexus distraction test is positive, left,
Right Hoffmann sign (+), muscular strength have no apparent decrease, and pale tongue is dark, tongue is white, deep thready pulse, and CT film makings are diagnosed as nerve root cervical vertebra sickness,
Minor articulus hypertrophy cohesion.5/6 neck of cervical vertebra MRI prompt 4/5 necks of neck, 6/7 intervertebral foramen narrows, root compression, in conjunction with symptom body
It is diagnosed as nerve root cervical vertebra sickness after sign, takes the pill of the present invention after 2 weeks, neck-shoulder pain is substantially reduced, and mobility increases,
It is further continued for that 1 half a month of Chinese prescription of the present invention, neck-shoulder pain is used to disappear substantially, on foot steadily, the extensive recovery operation of energy, follow-up
It does not recur within 1 year.
Animal experiment
The pill for the sluggish myelopathy for the treatment of qi depression to blood stasis and cold-dampness prepared using the embodiment of the present invention 1 is directed to below
BBB scorings, hemorheology detection and the inflammation and immune factor test experience that animal carries out.
This animal experiment is quasi- to merge Writhing test rat model by establishing mechanical pressure, by modern Histopathology
The methods of inspection, biochemistry, molecular biology and means, system observe the Chinese medicinal granule to qi depression to blood stasis and the sluggish type of cold-dampness
The action pathway and the mechanism of action of cervical spondylosis, the mechanism of desk study medicine prevention qi depression to blood stasis and the sluggish myelopathy of cold-dampness.
1, mechanical pressure merges the foundation of Writhing test rat model
Reference literature method takes the clean type female sd inbred rats 50 of 150~200g of weight, and fasting 12 hours, abdomen is gone
Hair 2*4cm, conventional 75% alcohol or 0.5% iodophor disinfection, fiber crops are injected intraperitoneally with using ketamine (0.1g/kg weights)
It is liquor-saturated.Rat prostrate is fixed on operating table after anesthesia onset, and nape skin unhairing cuts off nape skin, takes stringer notch,
Notch about 2~3cm.Exposure vertebral plate cuts C6, C7 both sides vertebral plate, and exposing spinal cord pushes spinal cord to right side, expose left side C6,
The quantitative filter paper piece for being soaked with formalin is placed on C7 nerve root shoulders, sews up the incision by C7 nerve roots, model foundation success.
2, grouping and medication
The successful nerve root cervical vertebra sickness rat model of modeling is randomly divided into 5 groups, every group 10 using random digits table
Only, i.e. blank group (physiological saline), positive controls (Jingtong KeLi), pill low, middle and high dose groups of the invention.Separately take 10
Only set up pseudo- operation group (physiological saline).Positive controls give Jingtong KeLi 6g/Kg/d, low middle high dose group 4g/kg/d,
6g/kg/d, 8g/kg/d, blank group and pseudo- operation group give normal saline, successive administration 3 months.
3, Testing index
Before experiment, month after operation, 3 months after operation to rat carry out BBB scoring measure；Postoperative 3 monthly with ketamine
Rat is put to death in the excessive anesthesia of (0.1g/kg weights) intraperitoneal injection.Venous blood is acquired, is placed in anticoagulant tube and measures hemorheology
Index (packed cell volume, whole blood undercut/high shear viscosity, erythrocyte aggregation index)；Rat neck backbone is taken carefully to pick out spinal cord,
Myeloid tissue carries out homogenate and takes supernatant, using ELISA kit detection inflammatory factor prostaglandin E2 (prostaglandin
E2, PGE2) and phospholipase A2 (phospholipase A2, PLA2).
3.1, BBB scores
Animal is put into opening basin, tapping tub wall makes it creep, and observes the stern of animal, SCID Mice is walked, torso exercise
And its coordinate situation.Under the complete waking state of animal, its myodynamia is carried out by observing lower limb exercise and load-bearing capacity
Assessment, two trained experimenters are independent separately to carry out blind assessment.
3.2, hemorheology detects
Sample collection method：Above-mentioned rat, after anaesthetizing successfully, jugular vein blood collection is placed in be measured in anticoagulant tube.
Packed cell volume (PCV)：Using wynn's method.The anticoagulation being mixed is drawn with elongated capillary burette, is inserted into Wen Shi pipes
Then anticoagulation is slowly injected into scale " 10 " by bottom, place pays attention to preventing bubble from generating.With horizontal centrifuge with it is opposite from
3000r/min centrifuges 30min when mental and physical efforts (RCF) 2246g, i.e. effective radius 22.5cm.Read the pillar height millimeter of red blood cell layer
Number, is multiplied by 1%, the amount of as every liter blood rbc volume reports result as unit of percentage.
Whole blood undercut/high shear viscosity：Extracting vein blood 5ml constant temperature 5min under measuring temperature, are loaded after mixing well, with
The full-automatic blood viscosity analyzer row whole blood viscosity of ZL-6000 measures, and record height cuts (200s-1), undercut (1s-1) whole blood respectively
Viscosity number.
Erythrocyte aggregation index (red blood cell aggregation index, AI)：Erythrocyte aggregation index=
Low shear viscosity/high shear viscosity.
3.3 inflammation and immune factor detection
Prostaglandin E2 (prostaglandin E2, PGE2), phospholipase A2 (phospholipase A2, PLA2) are surveyed
It is fixed：It is detected using ELISA kit.Appropriate physiological saline is added in tissue to smash to pieces.3000r/min is centrifuged 10 minutes, takes supernatant
Liquid.1, it is coated with：It is 1-10 μ g/ml that antibody, which is diluted to protein content, with 0.05MPH9. You carbonate coating buffer solution.Every
Add 0.1ml in the reacting hole of a polystyrene board, 4 DEG C overnight.Next day discards solution in hole, washes 3 times with washing buffer, often
3 minutes secondary (referred to as washing, similarly hereinafter).2, it is loaded：In addition clear liquid 0.1ml, which in the above-mentioned reacting hole being coated with, sets 37 DEG C, is incubated 1
Hour.It is washed out.(while doing blank well, negative control hole and Positive control wells).3, enzyme labeling antibody：In each reacting hole
In, enzyme labelled antibody (dilution after titration) 0.1ml of diluted fresh is added.37 DEG C are incubated 0.5~1 hour, washing.4、
Substrate solution is added to develop the color：Be added the tmb substrate solution 0.1ml of Extemporaneous in each reacting hole, 37 DEG C 10~30 minutes.5, it terminates
Reaction：2M sulfuric acid 0.05ml is added in each reacting hole.6, result judgement：It can be in the knot that in white background, directly detects by an unaided eye
Fruit:Color is deeper in reacting hole, and positive degree is stronger, and negative reaction is colourless or extremely shallow, the depth of the be in color of foundation, with
"+", "-" number indicate.Also OD values can be surveyed:On ELISA detectors, at 450nm (if being developed the color with ABTS, 410nm), with
Each hole OD values are surveyed after blank control wells zeroing, it is as positive if more than 2.1 times of defined negative control OD value.
Test result：As the time pushes away length after blank group modeling, BBS scorings increase, Jingtong KeLi group and low middle height
3 months BBS scorings apparent increase (P after dosage group modeling<0.05), wherein high dose group increases most apparent (P<0.05) (see
Table 1)；Compared to other group blank group packed cell volume, erythrocyte aggregation index, whole blood low shear viscosity highest, and whole blood height is cut
Then minimum (the P of viscosity<0.05)；Packed cell volume, erythrocyte aggregation index, whole blood low shear viscosity each group compare, Jingtong KeLi
Group<Low dose group<Middle dose group<High dose group, whole blood high shear viscosity each group compare, Jingtong KeLi group>Low dose group>Middle dose
Amount group>High dose group (P<0.05) (2 are shown in Table)；PGE2 and PLA2 contents blank group is apparently higher than other groups (P in myeloid tissue<
0.05), other each groups compare, Jingtong KeLi group>Low dose group>Middle dose group>High dose group (P<0.05) (3 are shown in Table).
1 preoperative and postoperative rat BBB scorings of table are compared
Note：Compared with blank group●P<0.05；Compared with Jingtong KeLi group◆P>0.05；Compared with Jingtong KeLi group▲P<
0.05；Compared with Jingtong KeLi group★P<0.05。
23 months after operation hemorheology of table compares
Note：Compared with blank group●P<0.05；Compared with Jingtong KeLi group◆P>0.05；Compared with Jingtong KeLi group▲P<
0.05；Compared with Jingtong KeLi group★P<0.05。
33 months after operation PGE of table2And PLA2Comparision contents
Note：Compared with blank group●P<0.05；Compared with Jingtong KeLi group◆P>0.05；Compared with Jingtong KeLi group▲P<
0.05；Compared with Jingtong KeLi group★P<0.05。
To sum up, the pill high dose group of the embodiment of the present invention 1 can improve qi depression to blood stasis to the greatest extent and cold-dampness stagnates
The BBS of the rat model of myelopathy scores, and improves hemorheology, accelerates blood flow, reduces the cervical vertebra local inflammation factor
Aggregation.
It should be noted that the pill for the treatment of syringomyelia prepared by the embodiment of the present invention 1 is replaced with of the invention real
The pill for applying the treatment qi depression to blood stasis and the sluggish myelopathy of cold-dampness of the preparation of example 2~6, can reach above-mentioned same experiment effect.
The preferred embodiment of the present invention is above are only, is not intended to restrict the invention, for those skilled in the art
For member, inventive formulation and preparation process can have various modifications and variations.All within the spirits and principles of the present invention, institute
Any modification, equivalent substitution, improvement and etc. of work, should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, it is characterised in that：Including following weight
The raw material of number：5~50 parts of Rhizoma Gastrodiae, 10~50 parts of pueraria lobata, 10~50 parts of Radix Astragali, 5~35 parts of rhizome of chuanxiong, 5~50 parts of Radix Angelicae Sinensis, vinegar prolong
5~30 parts of 5~35 parts of Hu rope, 5~50 parts of Radix Paeoniae Alba, 5~30 parts of earthworm, 5~30 parts of stiff silkworm, 5~30 parts of Rhizoma Et Radix Notopterygii and cassia twig.
2. the Chinese medicine composition for the treatment of wind chill blockage and qi stagnation and blood stasis type cervical spondylosis according to claim 1, feature exist
In：Include the raw material of following parts by weight：5~30 parts of Rhizoma Gastrodiae, 5~35 parts of pueraria lobata, 5~35 parts of Radix Astragali, 5~30 parts of rhizome of chuanxiong, when
Return 5~30 parts, 5~25 parts of vinegar corydalis tuber, 5~30 parts of Radix Paeoniae Alba, 5~20 parts of earthworm, 5~20 parts of stiff silkworm, 5~20 parts of Rhizoma Et Radix Notopterygii and osmanthus
5~20 parts of branch.
3. the Chinese medicine composition for the treatment of wind chill blockage and qi stagnation and blood stasis type cervical spondylosis according to claim 1, feature exist
In：Include the raw material of following parts by weight：10~15 parts of Rhizoma Gastrodiae, 20~30 parts of pueraria lobata, 20~30 parts of Radix Astragali, rhizome of chuanxiong 10~15
Part, 10~15 parts of Radix Angelicae Sinensis, 10~15 parts of vinegar corydalis tuber, 5~10 parts of Radix Paeoniae Alba, 5~10 parts of earthworm, 5~10 parts of stiff silkworm, Rhizoma Et Radix Notopterygii 5~
10 parts and 5~10 parts of cassia twig.
4. a kind of Chinese medicine preparation for treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, it is characterised in that：The Chinese medicine preparation packet
Include the Chinese medicine composition for the treatment of wind chill blockage and qi stagnation and blood stasis type cervical spondylosis according to any one of claims 1 to 3.
5. the Chinese medicine preparation for the treatment of wind chill blockage and qi stagnation and blood stasis type cervical spondylosis according to claim 4, it is characterised in that：
The dosage form of the Chinese medicine preparation is pill, granule or decoction.
6. the Chinese medicine preparation for the treatment of wind chill blockage and qi stagnation and blood stasis type cervical spondylosis according to claim 5, it is characterised in that：
The dosage form of the Chinese medicine preparation is pill.
7. a kind of preparation method of pill that treating wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, it is characterised in that：The pill
Include the Chinese medicine composition for the treatment of wind chill blockage and qi stagnation and blood stasis type cervical spondylosis according to any one of claims 1 to 3, it is described
Preparation method includes：
Rhizoma Gastrodiae, Radix Angelicae Sinensis and rhizome of chuanxiong are ground into fine powder；
Pueraria lobata, Radix Astragali, vinegar corydalis tuber, Radix Paeoniae Alba, earthworm, stiff silkworm, Rhizoma Et Radix Notopterygii and cassia twig are mixed, added water to cook, is filtered, is then incited somebody to action
To filtrate be condensed into thick paste；
By the thick paste and the fine powder mixing, pill.
8. the preparation method for the treatment of wind chill blockage according to claim 7 and the pill of qi stagnation and blood stasis type cervical spondylosis, special
Sign is：The grain size of the fine powder is 100~200 mesh.
9. the preparation method for the treatment of wind chill blockage according to claim 7 and the pill of qi stagnation and blood stasis type cervical spondylosis, special
Sign is：The number added water to cook is 2 times, and described plus water the amount is respectively the 3~6 of the Chinese medicine material total weight every time
Times；The time of the decoction is 1.5~2.5h for the first time, and the time of second of decoction is 1.5~2.5h.
10. the preparation method for the treatment of wind chill blockage according to claim 7 and the pill of qi stagnation and blood stasis type cervical spondylosis, special
Sign is：The pelletizing process includes：The mixture of the thick paste and the fine powder is first made to wet ball, is then dried to obtain element
Ball, then the vegetable pill is coated with activated carbon and uses talcum powder polishing.
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| CN110731953A (en) * | 2019-11-01 | 2020-01-31 | 深圳市中医院 | Traditional Chinese medicine compound cataplasm for treating qi-stagnation and blood stasis type cervical spondylosis and preparation method thereof |
| CN116920017A (en) * | 2023-04-14 | 2023-10-24 | 北京羚锐伟业科技有限公司 | Application of Danlu Tongdu tablet in preparing product for treating or assisting in treating cervical spondylosis |
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