CN101549133B - Ablation and embolism extinguishing preparation of Chinese medicine - Google Patents
Ablation and embolism extinguishing preparation of Chinese medicine Download PDFInfo
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Abstract
The invention relates to an ablation and embolism extinguishing preparation of Chinese medicine which is designed aiming at the technical problems existing in the prior art that a plurality of medicaments have long taking time, large dosage, are slow in taking effect and do not have ideal clinical efficacy. The components of the preparation is as follows according to weight percentage: 10 to 30g of rhizoma gastrodiae, 50 to 70g of radix salviae miltiorrhizae, 60 to 80g of astragalus root, 20 to 40g of red peony root, 10 to 30g of dlbergia wood, 30 to 50g of turmeric, 20 to 30g of agkistrodon halys, 20 to 30g of earthworm and 30 to 50g of szechwan lovage rhizome. The preparation method comprises the steps of: putting the pure Chinese medicines of rhizoma gastrodiae, salviae miltiorrhizae, astragalus root, red peony root, dlbergia wood, turmeric and szechwan lovage rhizome in a container after classifying and purifying; drying the agkistrodon halys and earthworm by mild fire, and then preparing into grains and packing into capsule after being ground into powder, screened on 100 mesh sieve and being fully mixed and stirred with all the purified Chinese medicine; and irradiating conventionally by medical Co60 for later use. The preparation has the characteristics and beneficial effects that: after years of clinical observation, the preparation has reliable embolism resisting and ablation effects, effectively reduces the blood plasma and the whole blood contrast viscosity and reduces the cohesiveness of blood platelet, effectively recovers sequela caused by cardiovascular and cerebrovascular diseases, and especially has the double effects of stroke rehabilitation and preventing from second attack.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation, relate in particular to a kind of Chinese medicine ablation and embolism extinguishing preparation.Be mainly used in the treatment of cardiovascular and cerebrovascular disease.
Background technology:
Cardiovascular and cerebrovascular disease is commonly encountered diseases, the frequently-occurring disease of middle-aged and elderly people.In recent years, the Along with people's growth in the living standard, the patient of cardiovascular and cerebrovascular disease is rising year by year, and the trend of rejuvenation is arranged.Yet, though it is a variety of to treat the Chinese medicine and western medicine of this disease, find that in clinical practice most medicines exist that Time of Administration is long, dosage is big, drawback such as take effect slowly, clinical efficacy is also not ideal enough.
Summary of the invention:
The most drug administration times that the present invention is directed to the prior art existence are grown, dosage is big, it is slow to take effect, and the unfavorable technical problem of clinical efficacy provides a kind of Chinese medicine ablation and embolism extinguishing preparation; This ablation and embolism extinguishing preparation is processed by following weight Chinese medicinal raw materials medicine: Rhizoma Gastrodiae 10-30g, Radix Salviae Miltiorrhizae 50-70g, Radix Astragali 60-80g; Radix Paeoniae Rubra 20-40g, Lignum Dalbergiae Odoriferae 10-30g, Rhizoma Curcumae Longae 30-50g; Agkistrodon halys 20-30g, Pheretima 20-30g, Rhizoma Chuanxiong 30-50g.
Its preparation method is realized by following step:
By the weight proportion of this each component of ablation and embolism extinguishing preparation, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Rhizoma Curcumae Longae and Rhizoma Chuanxiong Chinese medicine are purified respectively;
The extraction of Rhizoma Chuanxiong: the alcohol reflux concentrating under reduced pressure, cross macroporous adsorptive resins, with washing, reuse 30% ethanol elution is collected 30% ethanol elution concentrating under reduced pressure and is got the Rhizoma Chuanxiong total extract earlier;
The extraction of Rhizoma Gastrodiae: the water heavy method of purifying is extracted, and goes out the water solublity crude polysaccharides, through sevag method deproteinization and the active carbon element that discolors, and mistake DEAE cellulose column, eluting salt gets gastrodia elata polysaccharide;
Radix Paeoniae Rubra, the Radix Astragali, Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae, Rhizoma Curcumae Longae are pressed the decocting cooking method and extract: decoct-concentrate-fluid extract-dry extract-pulverizing-fine powder;
With Agkistrodon halys, Pheretima oven dry, be ground into fine powder, fully mix in container with each tcm components of purifying behind 100 mesh sieves excessively, process granule after stirring; Use medical cobalt
60Conventional irradiation back is subsequent use.
Characteristics of the present invention and beneficial effect:
The present invention through clinically for many years have reliable anticoagulant, the molten curative effect that disappears, effectively reduce blood plasma and whole blood specific viscosity, reduction platelet aggregation power; Blood circulation promoting and blood stasis dispelling, microcirculation improvement, prevent thrombosis; Can prevent and the glutinous caused disease of treatment thrombosis, microthrombus and high blood; The effect of playing prevention and treatment cardiovascular and cerebrovascular disease and stoping its development; Efficient recovery so and cardiovascular and cerebrovascular disease that takes place and the dependency sequela of leaving over can be arranged.
The present invention also has remarkable prevention and therapeutic effect to hyperlipemia; Clinical proof; Use preparation 3-4 week of the present invention (course of treatment), just can significantly reduce serum cholesterol, low density lipoprotein, LDL, obviously high density lipoprotein increasing; Effectively prevent and treatment medicated porridge appearance arteriosclerosis and coronary heart disease, and cardiovascular and cerebrovascular vessel are had important protective effect.
The present invention not only has significant change blood biochemical function, and has the stroke rehabilitation of particular importance and the double effects of prevention secondary outbreak, and does not produce the brain and other organ hemorrhage after the apoplexy, does not therefore influence the treatment of " nearly anxious phase ".
The specific embodiment:
The Chinese medicine ablation and embolism extinguishing preparation, the weight proportion of this each component of ablation and embolism extinguishing preparation is: Rhizoma Gastrodiae 10-30g, Radix Salviae Miltiorrhizae 50-70g, Radix Astragali 60-80g, Radix Paeoniae Rubra 20-40g, Lignum Dalbergiae Odoriferae 10-30g, Rhizoma Curcumae Longae 30-50g, Agkistrodon halys 20-30g, Pheretima 20-30g, Rhizoma Chuanxiong 30-50g.
Its preparation method is realized by following step:
Process by following weight Chinese medicinal raw materials medicine by this ablation and embolism extinguishing preparation, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Rhizoma Curcumae Longae and Rhizoma Chuanxiong Chinese medicine are purified respectively;
The extraction of Rhizoma Chuanxiong: the alcohol reflux concentrating under reduced pressure, cross macroporous adsorptive resins, with washing, reuse 30% ethanol elution is collected 30% ethanol elution concentrating under reduced pressure earlier, crosses macroporous adsorptive resins, the Rhizoma Chuanxiong total extract;
The extraction of Rhizoma Gastrodiae: the water heavy method of purifying is extracted, and goes out the water solublity crude polysaccharides, through sevag method deproteinization and the active carbon element that discolors, and mistake DEAE cellulose column, eluting salt gets gastrodia elata polysaccharide;
Radix Paeoniae Rubra, the Radix Astragali, Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae, Rhizoma Curcumae Longae are pressed the decocting cooking method and extract: decoct-concentrate-fluid extract-dry extract-pulverizing-fine powder;
With Agkistrodon halys, Pheretima oven dry, be ground into fine powder, fully mix in container with each tcm components of purifying behind 100 mesh sieves excessively, process granule after stirring; Use medical cobalt
60Conventional irradiation back is subsequent use.
Embodiment 1 Chinese medicine melts fastens agent and is processed by following weight Chinese medicinal raw materials medicine: Rhizoma Gastrodiae 10g, Radix Salviae Miltiorrhizae 50g, Radix Astragali 60g, Radix Paeoniae Rubra 20g, Lignum Dalbergiae Odoriferae 10g, Rhizoma Curcumae Longae 30g, Agkistrodon halys 20g, Pheretima 20g, Rhizoma Chuanxiong 30g.
Its preparation technology realizes by following step:
By the weight proportion of this each component of ablation and embolism extinguishing preparation, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Rhizoma Curcumae Longae and Rhizoma Chuanxiong Chinese medicine are purified respectively;
The extraction of Rhizoma Chuanxiong: the alcohol reflux concentrating under reduced pressure, cross macroporous adsorptive resins, with washing, reuse 30% ethanol elution is collected 30% ethanol elution concentrating under reduced pressure and is got the Rhizoma Chuanxiong total extract earlier;
The extraction of Rhizoma Gastrodiae: the water heavy method of purifying is extracted, and goes out the water solublity crude polysaccharides, through sevag method deproteinization and the active carbon element that discolors, and mistake DEAE cellulose column, eluting salt gets gastrodia elata polysaccharide;
Radix Paeoniae Rubra, the Radix Astragali, Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae, Rhizoma Curcumae Longae are pressed the decocting cooking method and extract: decoct-concentrate-fluid extract-dry extract-pulverizing-fine powder;
With Agkistrodon halys, Pheretima oven dry, be ground into fine powder, fully mix in container with each tcm components of purifying behind 100 mesh sieves excessively, process granule after stirring; Use medical cobalt
60Conventional irradiation back is subsequent use.
Embodiment 2 Chinese medicines melt fastens agent and is processed by following weight Chinese medicinal raw materials medicine: Rhizoma Gastrodiae 30g, Radix Salviae Miltiorrhizae 70g, Radix Astragali 80g, Radix Paeoniae Rubra 40g, Lignum Dalbergiae Odoriferae 30g, Rhizoma Curcumae Longae 50g, Agkistrodon halys 30g, Pheretima 30g, Rhizoma Chuanxiong 50g.
The step that its preparation technology realizes is with embodiment 1.
Embodiment 3 Chinese medicines melt fastens agent and is processed by following weight Chinese medicinal raw materials medicine: Rhizoma Gastrodiae 20g, Radix Salviae Miltiorrhizae 60g, Radix Astragali 70g, Radix Paeoniae Rubra 30g, Lignum Dalbergiae Odoriferae 20g, Rhizoma Curcumae Longae 40g, Agkistrodon halys 25g, Pheretima 25g, Rhizoma Chuanxiong 40g.
The step that its preparation technology realizes is with embodiment 1.
Embodiment 4 Chinese medicines melt fastens agent and is processed by following weight Chinese medicinal raw materials medicine: Rhizoma Gastrodiae 15g, Radix Salviae Miltiorrhizae 55g, Radix Astragali 65g, Radix Paeoniae Rubra 25g, Lignum Dalbergiae Odoriferae 15g, Rhizoma Curcumae Longae 35g, Agkistrodon halys 22g, Pheretima 22g, Rhizoma Chuanxiong 35g.
The step that its preparation technology realizes is with embodiment 1.
Embodiment 5 Chinese medicines melt fastens agent and is processed by following weight Chinese medicinal raw materials medicine: Rhizoma Gastrodiae 10-25g, Radix Salviae Miltiorrhizae 65g, Radix Astragali 75g, Radix Paeoniae Rubra 35g, Lignum Dalbergiae Odoriferae 25g, Rhizoma Curcumae Longae 45g, Agkistrodon halys 28g, Pheretima 28g, Rhizoma Chuanxiong 45g.
The step that its preparation technology realizes is with embodiment 1.
The Chinese crude drug Rhizoma Gastrodiae that the present invention selects for use, Radix Salviae Miltiorrhizae, the Radix Astragali, Agkistrodon halys and Pheretima are monarch drug, Rhizoma Gastrodiae have relieve dizziness, high fever, infantile convulsions, epilepsy, etc., relieving convulsion (shying), mediation collateral dredging, pain relieving (ache), to numb limbs and tense tendons, hemiplegia, headache (ache), dizziness (dusk) are effectively; Radix Salviae Miltiorrhizae has the effect of blood vessel dilating, microcirculation improvement, reduction blood viscosity, especially changes the CHARGE DISTRIBUTION of erythrocyte, reduces hemocyte, hematoblastic coagulation; The Radix Astragali has QI invigorating, beneficial blood effect, to nervous breathe hard, limbs weakness, complexion Rong Youxiao not.Through clinical verification blood pressure also had dual regulation; Agkistrodon halys is thought from modern medicine, contains effectively electrolysis blood constituent of ophiotoxin, improves platelet, erythrocyte, fibrinous degree of safety; Pheretima has stronger opposing and reduces fibrinous effect.Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Rhizoma Curcumae Longae and Rhizoma Chuanxiong are ministerial drug, all play the effect of the blood circulation promoting and blood stasis dispelling of coordinating above-mentioned monarch drug, dredge the meridian passage, relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain.Through the reasonable compatibility of above-mentioned medical material and with above-mentioned technology manufacture method preparation, fully the effective ingredient of each flavor medical material is coordinated, make its efficacy of a drug performance the best use of and reached best effects.
Be the several representative instances in the clinical practice of the present invention below:
Case 1, Ma Chunying woman 86 years old.
Malfunctioning 6 years of right side limb activity, previously: migraine 30 years, hypertension 10 years.
Before the medication, blood pressure 20.0/12.0kpa.Mind is clear, and Chang Gu river intelligence scale (HBS) scoring is for serious dull-witted.The completeness motor aphasia.Right nasolabial fold shoals, the bicker left avertence, and right avertence lolls.Neck is soft, right upper extremity flexing spasm, 0 grade of muscular strength, tendon hyperreflexia, right Hoffimann ' s (+) .Bnurdzinski (-). head CT: show left side basal area low-density kitchen range; Ventricular system enlarges, ventricles of the brain periphery low-density, and Schizencephaly is deepened, is widened, and center line does not have displacement between two parties.
Diagnosis: 1, cerebral infarction; 2, arteriosclerotic leukoencephalopathy under the cortex; 3, hypertension.
Treatment: obey this medicament every day 3 times, each 2, through three courses of treatment (4 weeks of the course of treatment) after, aphasia alleviates, and the limbs motility improves, and reaches the II level through detection right lower extremity Myodynamia recovery.
Case 2, Pan Xiu cloud woman 73 years old.
Symptom: headache, nauseating, frequently vomiting in four hours.
Headache before patient's self-induction, increase the weight of in the left side, and that continues nausea and vomiting occurs, takes place frequently gradually; No aphasia.
The right side platycoria is seen in inspection, and photoreaction is dwindled, and neck is soft, the right upper extremity limitation of activity; Suddenly send capable emergency treatment head CT scanography to hospital, seeing has the tricorn opaque dark area of fluid, slight pressurized.Previously have surplus the history of hypertension 20 year.
Clinical diagnosis: 1, hypertension; 2, cerebral arteriosclerosis; 3, cerebral hemorrhage.Suggestion is hospitalized for treatment.
Through hospital's hemostasis and dehydration therapy, symptom disappears basically after one month, leaves hospital; But right upper extremity is unable, the time headache, giddy (unclear), dysphoria phenomenon arranged.
Afterwards, obey this medicament.Every day 3 times, each 3, after four courses of treatment (4 weeks of the course of treatment), the complete obiteration of patient's symptom, right upper extremity Myodynamia recovery.
Case 3, Li Zhiming man 65 years old.
Slurred speech companion left limb moving obstacle 6 months, previously: hypertension 15 years, diabetes 4 years.
Before the medication, blood pressure 21.0/13.3kpa.Left side nasolabial fold shoals, bicker right avertence, and left avertence lolls.Left upper extremity flexing spasm, muscular strength III level, tendon hyperreflexia, left Hoffimann ' s (+) .Bnurdzinski (-). head CT: show right side basal area low-density kitchen range; Ventricular system enlarges, ventricles of the brain periphery low-density, and Schizencephaly is deepened, is widened, and center line does not have displacement between two parties.
Diagnosis: 1, cerebral infarction; 2, hypertension; 3, type ii diabetes
Treatment: obey this medicament every day 3 times, each 2, after 5 courses of treatment (20 weeks of the course of treatment), the symptom of pronouncing indistinctly obviously alleviates, and the limb activity ill symptoms improves, right lower extremity muscular strength IV level.
Case 4, Zhang Xiaohong woman 51 years old.
Symptom: headache, nauseating, vomitted 2 hours, increase the weight of half an hour.
Patient's carrying heavy goods processus aboralis sense headache, the companion feels sick, vomiting, and half an hour, postemphasis was obvious.
The left side platycoria is seen in inspection, and photoreaction is dwindled, and neck is soft, the left upper extremity limitation of activity; After 120 simple process, suddenly send to hospital.Head CT scanography: ventriculus sinister cerebri opaque dark area of fluid, slight pressurized.Year surplus the past history of hypertension 5.
Clinical diagnosis: 1 cerebral hemorrhage; 2, hypertension.
Treatments such as the cranium pressure falls in emergency treatment, the support of suiting the medicine to the illness, the state of an illness are steady basically after 2 weeks, leave hospital after 1 month; Inspection left upper extremity muscular strength III level before leaving hospital, lower-limb muscular strength IV.
Afterwards, obey this medicament.Every day 3 times, each 3, after four courses of treatment (4 weeks of the course of treatment), the complete obiteration of patient's symptom, upper left, lower-limb muscular strength V level.
Case 5, Wang Guangya man 81 years old.
Malfunctioning 4 years of right side limb activity, previously: hypertension 21 years, coronary heart disease 5 years.
Before the medication, blood pressure 22.0/12.6kpa.The imperfection motor aphasia.Right nasolabial fold shoals, the bicker left avertence, and right avertence lolls.Neck is soft, right upper extremity flexing spasm, muscular strength II level, tendon hyperreflexia, right Hoffimann ' s (+) .Bnurdzinski (-). head CT: show left side basal area low-density kitchen range; Ventricular system enlarges, ventricles of the brain periphery low-density, and center line does not have displacement between two parties.
Diagnosis: 1, cerebral infarction; 2, hypertension; 3, coronary heart disease.
Treatment: obey this medicament every day 3 times, each 2, through three courses of treatment (4 weeks of the course of treatment) after, aphasia alleviates, and the limbs motility improves, and reaches the IV level through detection right lower extremity Myodynamia recovery.
Case 6, Zhang Meihui woman 82 years old.
Symptom: headache, the companion that feels sick vomit half an hour.
Before half an hour, quarrel should take place and bring out headache in this patient with other people, the companion's vomiting of feeling sick.Previously: hypertension history 14 years, diabetes 10 years.After emergency treatment is admitted to hospital, through the emergency treatment CT examination, prompting: cerebral hemorrhage.
Clinical diagnosis: 1, cerebral hemorrhage; 2, hypertension; 3, type ii diabetes.
Emergency treatment is admitted to hospital, and through systematic treating, leaves hospital after the state of an illness is steady.Have a medical check-up before leaving hospital: right nasolabial fold shoals, the bicker left avertence, and right avertence lolls.Neck is soft, right upper extremity flexing spasm, muscular strength III level, tendon hyperreflexia, right Hoffimann ' s (+) .Bnurdzinski (-).
Afterwards, obey this medicament.Every day 3 times, each 3, after four courses of treatment (4 weeks of the course of treatment), the complete obiteration of patient's symptom, right upper extremity Myodynamia recovery.
The method for using of this medicament: 3-4 week is a course of treatment, takes every day 3 times, each 2～3 oral, every 0.4g.Ordinary circumstance three months was a course of treatment, and 6～12 months effects of clinical treatment are remarkable.
The disease distribution situation of clinical case in recent years: male's 395 examples account for 65%; Women's 213 examples account for 35%.
The situation of clinical practice curative effect in recent years statistics:
Claims (6)
1. Chinese medicine ablation and embolism extinguishing preparation, it is characterized in that: this ablation and embolism extinguishing preparation is processed by following weight Chinese medicinal raw materials medicine: Rhizoma Gastrodiae 10-30g, Radix Salviae Miltiorrhizae 50-70g, Radix Astragali 60-80g; Radix Paeoniae Rubra 20-40g, Lignum Dalbergiae Odoriferae 10-30g, Rhizoma Curcumae Longae 30-50g; Agkistrodon halys 20-30g, Pheretima 20-30g, Rhizoma Chuanxiong 30-50g;
Its preparation method is realized by following step:
By the weight proportion of this each component of ablation and embolism extinguishing preparation, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Paeoniae Rubra, Lignum Dalbergiae Odoriferae, Rhizoma Curcumae Longae and Rhizoma Chuanxiong Chinese medicine are purified respectively;
The extraction of Rhizoma Chuanxiong: the alcohol reflux concentrating under reduced pressure, cross macroporous adsorptive resins, with washing, reuse 30% ethanol elution is collected 30% ethanol elution concentrating under reduced pressure and is got the Rhizoma Chuanxiong total extract earlier;
The extraction of Rhizoma Gastrodiae: the water heavy method of purifying is extracted, and goes out the water solublity crude polysaccharides, through sevag method deproteinization and the active carbon element that discolors, and mistake DEAE cellulose column, eluting salt gets gastrodia elata polysaccharide;
Radix Paeoniae Rubra, the Radix Astragali, Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae, Rhizoma Curcumae Longae are pressed the decocting cooking method and extract: decoct-concentrate-fluid extract-dry extract-pulverizing-fine powder;
With Agkistrodon halys, Pheretima oven dry, be ground into fine powder, fully mix in container with each tcm components of purifying behind 100 mesh sieves excessively, process granule after stirring; Use medical cobalt
60Conventional irradiation back is subsequent use.
2. Chinese medicine ablation and embolism extinguishing preparation according to claim 1 is characterized in that: the weight proportion of this each component of ablation and embolism extinguishing preparation is: Rhizoma Gastrodiae 10g, Radix Salviae Miltiorrhizae 50g, Radix Astragali 60g, Radix Paeoniae Rubra 20g, Lignum Dalbergiae Odoriferae 10g, Rhizoma Curcumae Longae 30g, Agkistrodon halys 20g, Pheretima 20g, Rhizoma Chuanxiong 30g.
3. Chinese medicine ablation and embolism extinguishing preparation according to claim 1 is characterized in that: the weight proportion of this each component of ablation and embolism extinguishing preparation is: Rhizoma Gastrodiae 30g, Radix Salviae Miltiorrhizae 70g, Radix Astragali 80g, Radix Paeoniae Rubra 40g, Lignum Dalbergiae Odoriferae 30g, Rhizoma Curcumae Longae 50g, Agkistrodon halys 30g, Pheretima 30g, Rhizoma Chuanxiong 50g.
4. Chinese medicine ablation and embolism extinguishing preparation according to claim 1 is characterized in that: the weight proportion of this each component of ablation and embolism extinguishing preparation is: Rhizoma Gastrodiae 20g, Radix Salviae Miltiorrhizae 60g, Radix Astragali 70g, Radix Paeoniae Rubra 30g, Lignum Dalbergiae Odoriferae 20g, Rhizoma Curcumae Longae 40g, Agkistrodon halys 25g, Pheretima 25g, Rhizoma Chuanxiong 40g.
5. Chinese medicine ablation and embolism extinguishing preparation according to claim 1 is characterized in that: the weight proportion of this each component of ablation and embolism extinguishing preparation is: Rhizoma Gastrodiae 15g, Radix Salviae Miltiorrhizae 55g, Radix Astragali 65g, Radix Paeoniae Rubra 25g, Lignum Dalbergiae Odoriferae 15g, Rhizoma Curcumae Longae 35g, Agkistrodon halys 22g, Pheretima 22g, Rhizoma Chuanxiong 35g.
6. Chinese medicine ablation and embolism extinguishing preparation according to claim 1 is characterized in that: the weight proportion of this each component of ablation and embolism extinguishing preparation is: Rhizoma Gastrodiae 10-25g, Radix Salviae Miltiorrhizae 65g, Radix Astragali 75g, Radix Paeoniae Rubra 35g, Lignum Dalbergiae Odoriferae 25g, Rhizoma Curcumae Longae 45g, Agkistrodon halys 28g, Pheretima 28g, Rhizoma Chuanxiong 45g.
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