CN1259085C - Sapid invigorating yang five-recouping capsule and the preparation thereof - Google Patents

Abstract

The present invention belongs to a Chinese medical preparation for treating apoplexy and nerval and digestive system diseases and a preparing process thereof. The prescription of the Chinese medical preparation comprises 450 to 500g of astragalus root, 225 to 250g of red sage root, 90 to 120g of tangkuei tail, 150 to 180g of radix paeoniae rubra, 135 to 165g of earthworm, 135 to 165g of hemlock parsley, 90 to 120g of safflower, 90 to 120g of peach kernel, 90 to 120g of scorpion, 90 to 120g of notoginseng, 135 to 165g of grassleaf sweetflag rhizome, 90 to 120g of achyranthes root and 30 to 45g of borneol. According to the properties of different medicinal chemistry ingredients, the efficient ingredients are sufficiently leached out by adopting corresponding methods of extraction, such as the water lift method, the ethanol back flow method, the distillation method, etc., the utilization rate of the medicinal materials is enhanced furthest, and the curative effects of the whole prescription achieves the best.

Description

Add also five capsules and preparation method thereof of flavor YANG invigorating

Technical field: the invention belongs to a kind of Chinese medicine preparation of treatment apoplexy and nerve, digestive system disease and preparation method thereof.

Background technology: BUYANG HUANWU TANG is that the well-known doctor of Qing Dynasty Wang Qingren treatment is dizzy because of the headache that apoplexy causes, the prescription of the disease of aphasia, the birth of bicker stream, facial hemiparalysis, hemiplegia, and its curative effect is reasonable in this class medicine.CN1033934A " method for making of embolism extinguishing oral (liquid, sheet, electuary) ", CN1044907A " manufacture method of fast-dissolved embolism-eliminating pulvis " are on BUYANG HUANWU TANG prescription basis, the improvement of the pharmaceutical methods of being done.Wherein " method for making of embolism extinguishing oral (liquid, sheet, electuary) " is to adopt all medicine chopping backs in the prescription are decocted, the gained medicinal liquid is concentrated back with pure precipitation method decontamination, the result of water decoction-alcohol sedimentation can lose active substance such as polysaccharide, flavone, aminoacid, trace element, thereby affects the treatment.And " manufacture method of fast-dissolved embolism-eliminating pulvis " is by the compatibility of medicines in a prescription, decocts with water, and will decoct medical filtration, concentrates, and is spray dried to granule, and this decocting method of boiling can make the part liposoluble constituent leach, and has reduced bioavailability.

Goal of the invention: the invention provides a kind of also five capsules and preparation method thereof of flavor YANG invigorating that add, on original prescription basis, increase blood circulation promoting and blood stasis dispelling and causing resuscitation with aromatic drugs medicine, to improve its curative effect, and according to the character of different pharmaceutical chemical analysis, adopt corresponding extracting method, active ingredient is fully leached, improve the utilization rate of medical material to greatest extent, make the curative effect of whole prescription reach best.

Technical scheme: for this reason, the present invention adopts following technical scheme:

Per thousand capsules are to make with the raw material of following consumption: Radix Astragali 450-500 gram, Radix Salviae Miltiorrhizae 225-250 gram, Radix Angelicae Sinensis 90-120 gram, Radix Paeoniae Rubra 150-180 gram, Pheretima 135-165 gram, Rhizoma Chuanxiong 135-165 gram, Flos Carthami 90-120 gram, Semen Persicae 90-120 gram, Scorpio 90-120 gram, Radix Notoginseng 90-120 gram, Rhizoma Acori Graminei 135-165 gram, Radix Achyranthis Bidentatae 90-120 gram, Borneolum Syntheticum 30-45 gram.

Compound method is for to be broken into fine powder with Borneolum Syntheticum porphyrize, Radix Notoginseng powder, and Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong is cataclasm, with 90% above alcohol reflux three times, and 2 hours for the first time, second and third time each 1 hour left standstill a period of time after-filtration, merging filtrate, reclaim ethanol, medicinal liquid is collected separately, and medicinal residues are standby; Get Radix Angelicae Sinensis, Flos Carthami, Rhizoma Acori Graminei distillating extracting oil, the aqueous solution after the distillation is collected separately; All the other Radixs Astragali, Pheretima, Scorpio, Radix Paeoniae Rubra, pink, Radix Achyranthis Bidentatae Six-element medicine, and Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami, Rhizoma Acori Graminei medicinal residues merge and decoct with water twice, three hours for the first time, 2 hours for the second time, merge decoction liquor, filter, filtrate and aforementioned medicinal liquid merge, be evaporated to the clear paste of relative density 1.32～1.35, temperature is surveyed 50 ℃ of heat; Qinghuo reagent adds Radix Notoginseng fine powder and appropriate amount of auxiliary materials (as conventional adjuvants such as dextrin), and drying with the Borneolum Syntheticum facing-up that is ground into fine powder, adds the volatile oil that is extracted again, and mixing incapsulates promptly.

In the above-mentioned method for making, in the ethanol extraction of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, contain TANSHINONES and ligustrazine, inhibited to thrombosis, platelet coagulation function, contain danshensu and ferulic acid alkaloid in the water extract, have coronary artery dilating and blood vessel, coronary blood flow increasing improves the effect of myocardial ischemia situation.

The Radix Angelicae Sinensis volatile oil main component is butylidenephthalide and ligustilide, all is cholinolytic (spasmolytic) active ingredients; And the safflower oil Main Ingredients and Appearance is a polyacetylene class mixture, also contains the xylan class, fatty oil, Flos Carthami polysaccharide, 16 seed amino acids, energy blood fat reducing; The Rhizoma Acori Graminei volatile oil Main Ingredients and Appearance is beta-Asarone, asaricin, also contains the function that caryophyllene, α-Humuleno, sekishone etc. have convulsion, stable, spasmolytic, promotion memory.Contain cardiac nutrition in the water extract of Radix Angelicae Sinensis, the antagonism arrhythmia significantly promotes hemoglobin and erythropoietic effect, and the Flos Carthami water extract has blood pressure lowering and antithrombotic effect, can coronary blood flow increasing and the heart-nutriment blood flow of nourishing one's nature.So the distilled water solution behind the distillating extracting oil is also collected, do medicinal liquid and use.The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis detoxification, evacuation of pus, expelling pus and promoting granulation effect; That Pheretima has is analgesic, Dingchuan, blood pressure lowering, spasmolytic, the active effect of diuresis; Scorpio has convulsion, hypotensive activity; Radix Paeoniae Rubra energy clearing away heat and cooling blood, eliminating stasis to stop pain; Semen Persicae energy blood stasis dispelling blood, antiinflammatory, antiallergic; Effects such as Radix Achyranthis Bidentatae energy anti-inflammatory and antalgic, cholesterol reducing, diuresis.

Add also five capsular pharmacological researches of flavor YANG invigorating:

1, microcirculation improvement effect.But add flavor YANG invigorating also vascular morphology, the blood flow form of five capsule microcirculation improvement obstacles, and make vascularity normal.Also expansible Mice Auricle arteriole and thin vein network increase the open quantity of blood capillary.

2, to the influence of hemorheological property.Add the flavor YANG invigorating also five capsules obviously improve dense, sticking, the state of aggregation of blood, to the effect that all is significantly improved of hemorheology many index.The observation of rabbit apoplexy mice is shown, but add also five capsule blood viscosity lowering of flavor YANG invigorating, packed cell volume and PAR, and can obviously prolong thrombinogen clotting time and thromboplastin action time, has inside and outside anti-platelet aggregation effect, can suppress inside and outside thrombosis, and have thrombolytic effect in the body, collagen-induced platelet aggregation is had remarkable inhibitory action.

3, to hemodynamic influence.Add the flavor YANG invigorating also five capsules can increase myocardial contraction, improve myocardial metabolism, coronary circulation and microcirculation, and expansible peripheral blood vessel, bring high blood pressure down also expansible cerebrovascular, reduce cerebral vascular resistance, the cerebral blood flow increasing amount is to the hemodynamics effect of having clear improvement.

4, antioxidation.Add the flavor YANG invigorating also five capsules can reduce rat cerebral ischemia, perfusion and the heart, patients with cerebral ischemic blood plasma lipide peroxide level again; and superoxide dismutase, activity of glutathione peroxidase are increased; can suppress tissue ischemia and pour into the lipid peroxidation that the back free radical causes again; the protection activities of antioxidant enzymes has antioxidation.

5, antiinflammatory and immunoregulation effect.Add the flavor YANG invigorating also five capsules proliferative inflammation and exudative inflammation are all had antagonism, human body specific immune function and non-specific immunity are all had obvious potentiation.The posthepatitic cirrhosis patient adopted add the flavor YANG invigorating also behind five capsule for treating, serum IgA, IgG, IgM level all have decline, can improve complement level in the serum simultaneously, have the effect of regulating and improving body immune function, and Ig refers to immunoglobulin.Can blood fat reducing, anti-arteriosclerosis, anoxia enduring, resisting fatigue improves the human body survival ability, promotes neural the reparation and effects such as regeneration.

Add the also five capsular clinical researches of flavor YANG invigorating:

1, treatment diseases of cardiovascular and cerebrovascular systems.Cardiovascular and cerebrovascular disease mostly is deficiency in origin greatly and marks real deficiency of vital energy syndrome of deficiency of blood, adopt add the flavor YANG invigorating also five capsules can improve the cardiac function of patients with cor pulmonale, increase myocardial contraction, and do not increase myocardial oxygen consumption and heart burden.Can make slow arrhythmia patient heart rate recover normal, coronary heart disease is also had better curative effect.

2, treatment nervous system disease.Add the flavor YANG invigorating also five capsules be usually used in treating ischemic cerebrovascular.Treatment back human body obviously recovers, and clinical card shape obviously improves, to dementia patients behind alzheimer disease or the cerebral thrombosis, add the flavor YANG invigorating also five capsules can improve the brain blood circulation, promote the brain cell metabolism; To the craniocerebral trauma patient add the flavor YANG invigorating also five capsules can improve the brain blood circulation, promote the cranial nerve cell reparation, promote the recovery of injured brain cell tissue healing and brain function, to premonitory apoplexy and apoplexy sequela as: hemiplegia, aphasia, the enuresis be can't help, and better curative effect is also arranged.

3, treatment digestive system disease.Cirrhotic ascites and Patients with Cirrhosis After Hepatitis, with adding the flavor YANG invigorating also behind five capsule for treating, clinical card shape is clearly better, and ascites reduces, and Most patients ascites disappears, and liver function is obviously improved.The liver cirrhosis patient blood flow state is improved, regulate its immunologic function, control and delay disease progression, prolong life cycle, prevent canceration, liver cirrhosis is played treatment and protective effect.Atrophic gastritis is many by deficiency of spleen-QI and stomach-QI, and unable promotion blood is capable, and blood stasis hinders in the stomach abdomen, due to the pathogen usually intruding into collateral in protracted disease, with adding the also five capsule benefiting QI for activating blood circulation of YANG invigorating of distinguishing the flavor of, can obtain excellent curative.

4, treatment peripheral neuropathy.How simple peripheral facial paralysis goes into apoplex involving the channels and collaterals by ailment said due to cold or exposure, and gas reaches due to the women's head-ornaments on not, available also five capsule for treating of flavor YANG invigorating that add, for common peroneal nerve injury, motorial conduction velocity and damage conduction velocity in nerve fiber recovery rate afterwards around adding the flavor YANG invigorating also five capsules being accelerated.Add the flavor YANG invigorating also five capsules repair neuromechanism may with improve local microcirculation, promote damage location inflammation edema extinction, improve the coefficient of oxygen utilization of neural Schwann cell, promote that neuranagenesis is relevant.

Above-mentioned four kinds of diseases, how because of due to blood stasis due to qi deficiency, the deficiency of both the liver and kidney, blood stasis is detained, blood vessels freely do not reach and attack on the liver-yang that can to cause headache dizzy; Venation block, muscle arteries and veins lose supports, so see hemiplegia, facial hemiparalysis; Blood stagnancy due to deficiency of QI, this mistake of tongue are supported, so aphasia, slobbering; Stagnation of heart-blood, the motive is lost empty, and visible chest is felt oppressed pained cardiopalmus.

Reuse the Radix Astragali, Radix Salviae Miltiorrhizae in the prescription, inrigorating qi and promoting blood circulation makes the prosperous and short blood of gas capable, and blood stasis dispelling and just not hindering is monarch drug; Be equipped with Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Flos Carthami, Semen Persicae, Radix Notoginseng, blood circulation promoting and blood stasis dispelling can be led down and smooth QI and blood in drop-down, and the effect of blood circulation promoting and blood stasis dispelling tissue regeneration promoting is arranged, and is ministerial drug; Pheretima, Scorpio all have the endogenous wind stopping relieving convulsion, the removing obstruction in the collateral to relieve pain effect, and Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening, conducting blood to flow downwards with the suppressing the hyperactive liver sun, are supplementary drug; The Rhizoma Acori Graminei removing dampness is amusing, is eliminated phlegm for resuscitation; Borneolum Syntheticum is hot to loose that hardship is let out, fragrance is walked to scurry, the part of the body cavity above the diaphragm housing the heart and lungs that can loose, stagnated fire and the refreshment of having one's ideas straightened out is messenger drug.All medicines share, and make the prosperous blood of gas capable, promoting tissue regeneration by removing blood stasis, and liver-wind can be put down, but all diseases are from convalesce.

Beneficial effect: owing to adopt technique scheme, the present invention add the flavor YANG invigorating also five capsules overcome the shortcoming of decoction decocting, be easier to take, be easy to carry.And the prescription that has improved has enlarged attending scope, increases activating blood and removing stasis drug, has strengthened the speed that blood stasis is eliminated, have the effect of several arteriosclerosis of blood pressure lowering simultaneously concurrently, the causing resuscitation with aromatic drugs medicine can play the refreshment effect, and Borneolum Syntheticum can be worked in coordination with other compositions by blood brain barrier, has improved curative effect.And preparation method is scientific and reasonable, according to the character of different pharmaceutical active ingredient, adopts different solvents, different extracting method, and active ingredient is fully leached, and has improved the utilization rate of medical material greatly.And a BUYANG HUANWU TANG water decocts, and the part liposoluble constituent is difficult for leaching, and bioavailability is low.

Embodiment:

Get the Radix Astragali 450 grams, Radix Salviae Miltiorrhizae 225 grams, Radix Angelicae Sinensis 90 grams, Radix Paeoniae Rubra 150 grams, Pheretima 135 grams, Rhizoma Chuanxiong 135 grams, Flos Carthami 90 grams, Semen Persicae 90 grams, Scorpio 90 grams, Radix Notoginseng 90 grams, Rhizoma Acori Graminei 135 grams, Radix Achyranthis Bidentatae 90 grams, Borneolum Syntheticum 30 grams.Borneolum Syntheticum porphyrize, Radix Notoginseng powder are broken into fine powder, and Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong is cataclasm, and with 90% above alcohol reflux three times, 2 hours for the first time, a period of time after-filtration was left standstill in second and third time each 1 hour, and merging filtrate reclaims ethanol, and medicinal liquid is collected separately, and medicinal residues are standby; Get Radix Angelicae Sinensis, Flos Carthami, Rhizoma Acori Graminei distillating extracting oil, the aqueous solution after the distillation is collected separately; All the other Radixs Astragali, Pheretima, Scorpio, Radix Paeoniae Rubra, Semen Persicae, Radix Achyranthis Bidentatae Six-element medicine, and Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami, Rhizoma Acori Graminei medicinal residues merge and decoct with water twice, three hours for the first time, 2 hours for the second time, merge decoction liquor, filter, filtrate and aforementioned medicinal liquid merge, be evaporated to the clear paste of relative density 1.32～1.35, temperature is surveyed 50 ℃ of heat; Qinghuo reagent adds Radix Notoginseng fine powder and appropriate amount of auxiliary materials, and drying with the Borneolum Syntheticum facing-up that is ground into fine powder, adds the volatile oil that is extracted again, mixing, and 1000 capsules of packing into get final product.

Claims (2)

1, add also five capsules of flavor YANG invigorating, it is characterized in that: per thousand capsules are to make with the raw material of following consumption: Radix Astragali 450-500 gram, Radix Salviae Miltiorrhizae 225-250 gram, Radix Angelicae Sinensis 90-120 gram, Radix Paeoniae Rubra 150-180 gram, Pheretima 135-165 gram, Rhizoma Chuanxiong 135-165 gram, Flos Carthami 90-120 gram, Semen Persicae 90-120 gram, Scorpio 90-120 gram, Radix Notoginseng 90-120 gram, Rhizoma Acori Graminei 135-165 gram, Radix Achyranthis Bidentatae 90-120 gram, Borneolum Syntheticum 30-45 gram.

2, the also five capsular preparation methoies of flavor YANG invigorating that add according to claim 1 is characterized in that: with the Borneolum Syntheticum porphyrize; Radix Notoginseng powder is broken into fine powder; Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong is cataclasm, and with 90% above alcohol reflux three times, 2 hours for the first time, a period of time after-filtration was left standstill in second and third time each 1 hour, and merging filtrate reclaims ethanol, and medicinal liquid is collected separately, and medicinal residues are standby; Get Radix Angelicae Sinensis, Flos Carthami, Rhizoma Acori Graminei distillating extracting oil, the aqueous solution after the distillation is collected separately; All the other Radixs Astragali, Pheretima, Scorpio, Radix Paeoniae Rubra, Semen Persicae, Radix Achyranthis Bidentatae Six-element medicine, and Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami, Rhizoma Acori Graminei medicinal residues merge and decoct with water twice, 3 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, filtrate and aforementioned medicinal liquid merge, and are evaporated to the clear paste of surveying relative density 1.32-1.35 50 ℃ of heat; Qinghuo reagent adds Radix Notoginseng fine powder and appropriate amount of auxiliary materials, and drying with the Borneolum Syntheticum facing-up that is ground into fine powder, adds the volatile oil that is extracted again, and mixing incapsulates and gets final product.