CN108904739A - A kind of Chinese and Western compound preparation and preparation method thereof for treating senile dementia - Google Patents

A kind of Chinese and Western compound preparation and preparation method thereof for treating senile dementia Download PDF

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CN108904739A
CN108904739A CN201811120481.4A CN201811120481A CN108904739A CN 108904739 A CN108904739 A CN 108904739A CN 201811120481 A CN201811120481 A CN 201811120481A CN 108904739 A CN108904739 A CN 108904739A
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chinese
senile dementia
western
piracetam
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苗琦
张敏
白永胜
惠建荣
王郁金
贾妮
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Shaanxi University of Chinese Medicine
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Shaanxi University of Chinese Medicine
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Abstract

The invention discloses a kind of Chinese and Western compound preparation and preparation method thereof for treating senile dementia, which is compounded by traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are prepared by the raw material of following parts by weight：10-20 parts of Rhizoma Gastrodiae, 10-15 parts of Radix Salviae Miltiorrhizae, 10-15 parts of ginkgo leaf, 5-10 parts of cortex albiziae, 5-10 parts of fructus alpiniae oxyphyllae, 2-5 parts of dark plum, 5-10 parts of pheretima；The Western medicine is composed of the following components：1-1.5 parts of piracetam, 1-1.5 parts of Doneppezil Hydrochloride, 0.5-1 parts of vitamin B1.The present invention takes the method that Chinese and Western medicine combines, it can effectively improve cranial nerve, the cerebrovascular and brain blood circulation function, improve and treat insomnia forgetfulness caused by senile dementia, failure of memory, cognitive ability decline etc., short treating period, quick, side effect is low, has wide medical application prospect.

Description

A kind of Chinese and Western compound preparation and preparation method thereof for treating senile dementia
Technical field
The present invention relates to field of medicaments, and in particular to a kind of Chinese and Western compound preparation for treating senile dementia and its preparation side Method.
Background technique
Senile dementia can be divided into Alzheimer disease (AD), vascular dementia (VD), Mixed dementia (AD+VD) and other Dementia betides a kind of primary degenerative encephalopathy of Senectitude and presenium, is that a kind of duration higher nerve function is living Dynamic obstacle is that cognition and memory function constantly deteriorate in clinical manifestation, the decline of activity of daily living progressive, and has various nerves The symptoms such as mental symptom and behavior disorder.Senile dementia is the relatively high disease of disease incidence, the data sheet of the World Health Organization Bright, the elderly about 20,000,000 of senile dementia is suffered from the current whole world, it is contemplated that arrives the year two thousand twenty, global patients of senile dementia will More than 30,000,000 people.Therefore, exploitation improves cognition dysfunction, and the drug for treating senile dementia becomes world community medical treatment work The research emphasis of author receives the great attention of Chinese and western medical field.
Currently, treatment senile dementia Western medicine have very much, these drugs can only respite patient's recognizing ability decline, But disease cannot be delayed to develop, and Western medicine has the adverse reactions such as serious liver renal toxicity, and expensive.In recent years, state Inside and outside experts and scholars begin to focus on natural traditional Chinese medicine, and Chinese medicine has long-term effect strong, and drug resistance is strong, safe and non-toxic advantage, very suitable It closes patients of senile dementia to take for a long time, but curative effect is not significant, it is therefore desirable to continue to explore and develop new treatment senile dementia Drug.
Summary of the invention
To solve the above problems, the present invention provides a kind of Chinese and Western compound preparation for treating senile dementia and its preparation sides Method.
To achieve the above object, the technical scheme adopted by the invention is as follows：
A kind of Chinese and Western compound preparation for treating senile dementia, is compounded by traditional Chinese medicinal components and western medicine component, it is described in Medicine component is prepared by the raw material of following parts by weight：
10-20 parts of Rhizoma Gastrodiae, 10-15 parts of Radix Salviae Miltiorrhizae, 10-15 parts of ginkgo leaf, 5-10 parts of cortex albiziae, 5-10 parts of fructus alpiniae oxyphyllae, dark plum 2-5 parts, 5-10 parts of pheretima；
The Western medicine is composed of the following components：
1-1.5 parts of piracetam, 1-1.5 parts of Doneppezil Hydrochloride, 0.5-1 parts of vitamin B1.
Preferably, the traditional Chinese medicinal components are prepared by the raw material of following parts by weight：
10 parts of Rhizoma Gastrodiae, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of ginkgo leaf, 5 parts of cortex albiziae, 5 parts of fructus alpiniae oxyphyllae, 2 parts of dark plum, 5 parts of pheretima；
The Western medicine is composed of the following components：
1 part of piracetam, 1 part of Doneppezil Hydrochloride, 1 part of vitamin B1.
Preferably, the traditional Chinese medicinal components are prepared by the raw material of following parts by weight：
20 parts of Rhizoma Gastrodiae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of ginkgo leaf, 10 parts of cortex albiziae, 10 parts of fructus alpiniae oxyphyllae, 5 parts of dark plum, 10 parts of pheretima；
The Western medicine is composed of the following components：
1.5 parts of piracetam, Doneppezil Hydrochloride 1.5,1 part of vitamin B1.
Preferably, the traditional Chinese medicinal components are prepared by the raw material of following parts by weight：
15 parts of Rhizoma Gastrodiae, 12.5 parts of Radix Salviae Miltiorrhizae, 12.5 parts of ginkgo leaf, 7.5 parts of cortex albiziae, 7.5 parts of fructus alpiniae oxyphyllae, 3.5 parts of dark plum, 7.5 parts of dragon；
The Western medicine is composed of the following components：
1.25 parts of piracetam, 1.25 parts of Doneppezil Hydrochloride, 0.75 part of vitamin B1.
The present invention also provides a kind of preparation methods of Chinese and Western compound preparation for treating senile dementia, including walk as follows Suddenly：
S1, each component is weighed by above-mentioned formula；
S2, after cleaning weighed Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, ginkgo leaf, cortex albiziae, fructus alpiniae oxyphyllae, dark plum, pheretima, it is placed in flash mention It takes in device, the water of 6-8 times of volume is added, after handling 30-60S, lignin degradation is added for the ratio of 2-3% by mass percentage Enzyme digests 1-2h at 30-50 DEG C, filters, obtains enzymolysis liquid；
S3, by natural thaw again after resulting enzymolysis liquid quick freeze, precipitate age of starch in extract；Collect supernatant Liquid, remainder centrifugation are collected centrifugal liquid and are incorporated in supernatant, be spray-dried, obtain powder；
S4, after resulting powder and weighed piracetam, Doneppezil Hydrochloride, vitamin B1 are mixed evenly, Microwave disinfection, it is encapsulated by 0.2-0.25/ specification, packaging to get.
The invention has the advantages that：
Take the method that Chinese and Western medicine combines, can effectively improve cranial nerve, the cerebrovascular and brain blood circulation function, improve and Treat insomnia forgetfulness caused by senile dementia, failure of memory, cognitive ability decline etc., short treating period, quick, side effect It is low, there is wide medical application prospect.
Specific embodiment
The present invention is described in detail combined with specific embodiments below.Following embodiment will be helpful to the technology of this field Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill of this field For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention Protection scope.
Embodiment 1
A kind of Chinese and Western compound preparation for treating senile dementia, is compounded by traditional Chinese medicinal components and western medicine component, it is described in Medicine component is prepared by the raw material of following parts by weight：
10 parts of Rhizoma Gastrodiae, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of ginkgo leaf, 5 parts of cortex albiziae, 5 parts of fructus alpiniae oxyphyllae, 2 parts of dark plum, 5 parts of pheretima；
The Western medicine is composed of the following components：
1 part of piracetam, 1 part of Doneppezil Hydrochloride, 1 part of vitamin B1.
Embodiment 2
A kind of Chinese and Western compound preparation for treating senile dementia, is compounded by traditional Chinese medicinal components and western medicine component, it is described in Medicine component is prepared by the raw material of following parts by weight：
20 parts of Rhizoma Gastrodiae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of ginkgo leaf, 10 parts of cortex albiziae, 10 parts of fructus alpiniae oxyphyllae, 5 parts of dark plum, 10 parts of pheretima；
1.5 parts of piracetam, Doneppezil Hydrochloride 1.5,1 part of vitamin B1.
Embodiment 3
A kind of Chinese and Western compound preparation for treating senile dementia, is compounded by traditional Chinese medicinal components and western medicine component, it is described in Medicine component is prepared by the raw material of following parts by weight：
15 parts of Rhizoma Gastrodiae, 12.5 parts of Radix Salviae Miltiorrhizae, 12.5 parts of ginkgo leaf, 7.5 parts of cortex albiziae, 7.5 parts of fructus alpiniae oxyphyllae, 3.5 parts of dark plum, 7.5 parts of dragon
The Western medicine is composed of the following components：
1.25 parts of piracetam, 1.25 parts of Doneppezil Hydrochloride, 0.75 part of vitamin B1.
Embodiment 4
S1, each component is weighed by formula described in embodiment 1, embodiment 2 or implementation 3；
S2, after cleaning weighed Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, ginkgo leaf, cortex albiziae, fructus alpiniae oxyphyllae, dark plum, pheretima, it is placed in flash mention It takes in device, the water of 6-8 times of volume is added, after handling 30-60S, lignin degradation is added for the ratio of 2-3% by mass percentage Enzyme digests 1-2h at 30-50 DEG C, filters, obtains enzymolysis liquid；
S3, by natural thaw again after resulting enzymolysis liquid quick freeze, precipitate age of starch in extract；Collect supernatant Liquid, remainder centrifugation are collected centrifugal liquid and are incorporated in supernatant, be spray-dried, obtain powder；
S4, after resulting powder and weighed piracetam, Doneppezil Hydrochloride, vitamin B1 are mixed evenly, Microwave disinfection, it is encapsulated by 0.2-0.25/ specification, packaging to get.
Specific embodiments of the present invention are described above.It is to be appreciated that the invention is not limited to above-mentioned Particular implementation, those skilled in the art can make a variety of changes or modify within the scope of the claims, this not shadow Ring substantive content of the invention.In the absence of conflict, the feature in embodiments herein and embodiment can any phase Mutually combination.

Claims (5)

1. a kind of Chinese and Western compound preparation for treating senile dementia, is compounded, feature exists by traditional Chinese medicinal components and western medicine component In：The traditional Chinese medicinal components are prepared by the raw material of following parts by weight：
10-20 parts of Rhizoma Gastrodiae, 10-15 parts of Radix Salviae Miltiorrhizae, 10-15 parts of ginkgo leaf, 5-10 parts of cortex albiziae, 5-10 parts of fructus alpiniae oxyphyllae, dark plum 2-5 Part, 5-10 parts of pheretima；
The Western medicine is composed of the following components：
1-1.5 parts of piracetam, 1-1.5 parts of Doneppezil Hydrochloride, 0.5-1 parts of vitamin B1.
2. a kind of Chinese and Western compound preparation for treating senile dementia as described in claim 1, it is characterised in that：The Chinese medicine group Divide and is prepared by the raw material of following parts by weight：
10 parts of Rhizoma Gastrodiae, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of ginkgo leaf, 5 parts of cortex albiziae, 5 parts of fructus alpiniae oxyphyllae, 2 parts of dark plum, 5 parts of pheretima；
The Western medicine is composed of the following components：
1 part of piracetam, 1 part of Doneppezil Hydrochloride, 1 part of vitamin B1.
3. a kind of Chinese and Western compound preparation for treating senile dementia as described in claim 1, it is characterised in that：The Chinese medicine group Divide and is prepared by the raw material of following parts by weight：
20 parts of Rhizoma Gastrodiae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of ginkgo leaf, 10 parts of cortex albiziae, 10 parts of fructus alpiniae oxyphyllae, 5 parts of dark plum, 10 parts of pheretima；
The Western medicine is composed of the following components：
1.5 parts of piracetam, Doneppezil Hydrochloride 1.5,1 part of vitamin B1.
4. a kind of Chinese and Western compound preparation for treating senile dementia as described in claim 1, it is characterised in that：The Chinese medicine group Divide and is prepared by the raw material of following parts by weight：
15 parts of Rhizoma Gastrodiae, 12.5 parts of Radix Salviae Miltiorrhizae, 12.5 parts of ginkgo leaf, 7.5 parts of cortex albiziae, 7.5 parts of fructus alpiniae oxyphyllae, 3.5 parts of dark plum, pheretima 7.5 part；
The Western medicine is composed of the following components：
1.25 parts of piracetam, 1.25 parts of Doneppezil Hydrochloride, 0.75 part of vitamin B1.
5. a kind of preparation method for the Chinese and Western compound preparation for treating senile dementia, it is characterised in that：Include the following steps：
S1, each component is weighed by the described in any item formulas of claim 1-4；
S2, after cleaning weighed Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, ginkgo leaf, cortex albiziae, fructus alpiniae oxyphyllae, dark plum, pheretima, it is placed in flash extracter It is interior, the water of 6-8 times of volume is added, after handling 30-60S, lignin-degrading enzymes are added for the ratio of 2-3% by mass percentage, 1-2h is digested at 30-50 DEG C, is filtered, is obtained enzymolysis liquid；
S3, by natural thaw again after resulting enzymolysis liquid quick freeze, precipitate age of starch in extract；Supernatant is collected, Remainder centrifugation is collected centrifugal liquid and is incorporated in supernatant, is spray-dried, obtains powder；
S4, after resulting powder and weighed piracetam, Doneppezil Hydrochloride, vitamin B1 are mixed evenly, microwave Sterilization, it is encapsulated by 0.2-0.25/ specification, packaging to get.
CN201811120481.4A 2018-09-13 2018-09-13 A kind of Chinese and Western compound preparation and preparation method thereof for treating senile dementia Pending CN108904739A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022007982A3 (en) * 2020-07-10 2022-03-03 上海日馨医药科技股份有限公司 Pharmaceutical composition and application thereof
WO2023036105A1 (en) * 2021-09-09 2023-03-16 上海日馨医药科技股份有限公司 Method for treating neurodegenerative disease

Citations (4)

* Cited by examiner, † Cited by third party
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