CN106421474A - Formula for traditional Chinese medicines capable of lowering blood lipid - Google Patents
Formula for traditional Chinese medicines capable of lowering blood lipid Download PDFInfo
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Abstract
The invention discloses a formula for traditional Chinese medicines capable of lowering blood lipid. The traditional Chinese medicines comprise, by weight, 15-23 parts of folium nelumbinis, 12-20 parts of radix salviae miltiorrhizae, 10-16 parts of cortex moutan, 8-12 parts of ganoderma, 10-14 parts of rhizoma phragmitis, 12-16 parts of radix ginseng, 16-22 parts of poria, 15-23 parts of pericarpium citri reticulatae, 12-16 parts of radix rehmanniae, 14-18 parts of herba leonuri, 10-16 parts of caulis lonicerae, 14-20 parts of radix et rhizoma rhei and 12-16 parts of herba taraxaci. The formula has the advantages that the formula is based on knowledge and treatment principles for high blood lipid symptoms and mechanisms, the traditional Chinese medicines are directly orally taken, accordingly, effects of lowering serum triglyceride and cholesterol and effectively preventing and treating cardiovascular and cerebrovascular diseases can be realized, obvious curative effects can be realized, the quality of the traditional Chinese medicines is easy to control, and the traditional Chinese medicines are good in stability and basically free of adverse reaction.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, it is a kind of Chinese medicine preparation being capable of reduction blood fat.
Background technology
The cardiovascular and cerebrovascular diseases such as coronary heart disease, myocardial infarction, headstroke are clinically common class diseases, the incidence of disease and dead
The rate of dying is first of various diseases, the serious harm life and health of the mankind.And hyperlipemia is atherosclerotic, coronary disease
Disease, headstroke, the inducement of myocardial infarction, therefore reduce plasma cholesterol, triglyceride, low-density lipoprotein to the above-mentioned disease of preventing and treating
Disease is particularly significant.Myocardial infarction and coronary artery blood vessel and its microcirculatory vascular tension force are too high also relevant, and antiotasis is too high and blood
In slurry, triglyceride, cholesterol level are too high also relevant, it is now recognized that the above-mentioned and too strong close relation of activity of calcium channels, therefore anti-
Control myocardial infarction particularly important with cholesterol and triglyceride in anticalcium and reduction blood plasma.Clinical proof, reduces plasma cholesterol
And triglyceride levels, the danger of myocardial infarction can be reduced.
The lipid lowerers clinically using at present are such as：Meglutol list acyl coenzyme A (HMG-CoA) reductase inhibitor, algae
Though the double Western medicine such as fat sodium, clofibrate, nicotinic acid, Cholestyramine of acid has preferable curative effect, it is respectively provided with stronger toxic and side effect, uncomfortable
The prolonged application of patient Yu is to prevent and treat cardiovascular and cerebrovascular disease.
Content of the invention
It is an object of the invention to provide a kind of Small side effects, curative effect be fast, the Chinese medicine being capable of reduction blood fat of effect is significant
Formula.
The present invention is achieved through the following technical solutions：A kind of Chinese medicine preparation being capable of reduction blood fat, including in parts by weight
15 ~ 23 parts of lotus leaf, 12 ~ 20 parts of the red sage root, 10 ~ 16 parts of the root bark of tree peony, 8 ~ 12 parts of glossy ganoderma, 10 ~ 14 parts of reed rhizome, 12 ~ 16 parts of ginseng, Poria cocos
16 ~ 22 parts, 15 ~ 23 parts of dried orange peel, 12 ~ 16 parts of glutinous rehmannia, 14 ~ 18 parts of motherwort, 10 ~ 16 parts of caulis lonicerae, 14 ~ 20 parts of rheum officinale, Pu Gong
12 ~ 16 parts of English.
A kind of bulk drug pharmacology of Chinese medicine composition being capable of reduction blood fat of the present invention：
Lotus leaf：Mild-natured, bitter.Return liver warp, the spleen channel, stomach.Clearing away summer-heat and eliminating dampness, sending up the lucid yang, cooling blood and hemostasis.Belong to and classifying under antipyretic
Heat-clearing drug.
The red sage root：Cold nature, bitter.Thoughts of returning home warp, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation dysmenorrhoea, relieving restlessness that clears away heart-fire.Belong to drug for invigorating blood circulation and eliminating stasis
The blood-activating and menstruation-regulating medicinal of lower classification.
The root bark of tree peony：Cold nature, bitter, pungent.Thoughts of returning home warp, Liver Channel, kidney channel.Clearing heat and cooling blood, promoting blood circulation and removing blood stasis.Belong to antipyretic subordinate to divide
The heat-clearing drug of class.
Glossy ganoderma：Mild-natured, sweet.Thoughts of returning home warp, lung channel, Liver Channel, kidney channel.Invigorating qi for tranquilization, relieving cough and asthma.Belong to qi-restoratives medicine subordinate to divide
The Qi-tonifying drug of class.
Reed rhizome：Cold in nature, sweet.Return lung warp, stomach.Clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Under genus antipyretic, classification is clear
Hot Chinese laxative drugs for removing fire factor.
Ginseng：Warm in nature, sweet, slight bitter.Thoughts of returning home warp, lung channel, the spleen channel, kidney channel.Reinforce vital energy, veins takes off admittedly, reinforce the spleen to benefit the lung,
Promoting production of body fluid and inducing sedation of the mind.Belong to the Qi-tonifying drug of classification under qi-restoratives medicine.
Poria cocos：Mild-natured, sweet, light.Thoughts of returning home warp, lung channel, the spleen channel, kidney channel.Clearing damp and promoting diuresis, invigorating the spleen calming heart.Belong to clearing damp and promoting diuresis
The edema-alleviating diuretic of medicine subordinate classification.
Dried orange peel：Taste is pungent, bitter, warm in nature.Returns spleen warp, lung channel.Qi-regulating is whetted the appetite, eliminating dampness and eliminating phlegm, controls the spleen-stomach diseases.Belong to qi-regulating drug.
Glutinous rehmannia：Radix rehmanniae recen：Cold in nature, sweet.Thoughts of returning home warp, Liver Channel, kidney channel.Fresh rehmannia root：Cold in nature, sweet, bitter.Thoughts of returning home warp, liver
Warp, kidney channel.Radix rehmanniae recen：Clearing heat and cooling blood, yin-nourishing, promote the production of body fluid.Fresh rehmannia root：Clearing heat and promoting fluid, cool blood, hemostasis.Belong to antipyretic subordinate classification
Heat-clearing drug.
Motherwort：Cold nature, bitter, pungent.Return liver warp, the heart channel of Hang-Shaoyin, bladder warp.Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema.Belong to promoting blood circulation and removing blood stasis
Blood-activating and menstruation-regulating medicinal under medicine classification.
Caulis lonicerae：Cold in nature, sweet.Return lung warp, stomach.Clearing heat and detoxicating, dispelling wind dredging collateral.Belong to the heat-clearing of antipyretic subordinate classification
Antidote.
Rheum officinale：Cold in nature, bitter.Returns spleen warp, stomach, large intestine channel, Liver Channel, pericardium channel.Purgating heat and bowels, removing pattogenic heat from the blood and toxic material from the body, by the stasis of blood
Stimulate the menstrual flow.Belong to the cathartic drug of purgatives medicine subordinate classification.
Dandelion：Cold in nature, bitter, sweet.Return liver warp, stomach.Clearing heat and detoxicating, diuresis dissipating bind.Under genus antipyretic, classification is clear
Pyrolysis poison.
Including 15 parts of lotus leaf by weight, 12 parts of the red sage root, 16 parts of the root bark of tree peony, 12 parts of glossy ganoderma, 14 parts of reed rhizome, 12 parts of ginseng,
16 parts of Poria cocos, 15 parts of dried orange peel, 16 parts of glutinous rehmannia, 14 parts of motherwort, 10 parts of caulis lonicerae, 14 parts of rheum officinale, 12 parts of dandelion.
Including 18 parts of lotus leaf by weight, 18 parts of the red sage root, 10 parts of the root bark of tree peony, 9 parts of glossy ganoderma, 10 parts of reed rhizome, 16 parts of ginseng, Fu
22 parts of Siberian cocklebur, 23 parts of dried orange peel, 12 parts of glutinous rehmannia, 18 parts of motherwort, 16 parts of caulis lonicerae, 20 parts of rheum officinale, 16 parts of dandelion.
Including 23 parts of lotus leaf by weight, 20 parts of the red sage root, 3 parts of the root bark of tree peony, 8 parts of glossy ganoderma, 12 parts of reed rhizome, 14 parts of ginseng, Fu
20 parts of Siberian cocklebur, 18 parts of dried orange peel, 14 parts of glutinous rehmannia, 16 parts of motherwort, 13 parts of caulis lonicerae, 17 parts of rheum officinale, 16 parts of dandelion.
Described lotus leaf, the red sage root, the root bark of tree peony, glossy ganoderma, reed rhizome, ginseng, Poria cocos, dried orange peel, glutinous rehmannia, motherwort, caulis lonicerae, big
Yellow, dandelion decocts and takes.
The present invention compared with prior art, has advantages below and beneficial effect：
The present invention is based on to the understanding of hyperlipidemic conditions mechanism and principle of reatment, the method using being directly administered orally, and has reduction
Serum levels of triglyceride and cholesterol simultaneously effectively prevent and treat the effect of cardiovascular and cerebrovascular disease, and evident in efficacy, quality is easily controlled, stable
Property is good, substantially has no adverse reaction.
Specific embodiment
With reference to embodiment, the present invention is described in further detail, but embodiments of the present invention not limited to this.
Embodiment 1：
A kind of Chinese medicine preparation being capable of reduction blood fat, including 15 ~ 23 parts of lotus leaf in parts by weight, 12 ~ 20 parts of the red sage root, the root bark of tree peony 10
~ 16 parts, 8 ~ 12 parts of glossy ganoderma, 10 ~ 14 parts of reed rhizome, 12 ~ 16 parts of ginseng, 16 ~ 22 parts of Poria cocos, 15 ~ 23 parts of dried orange peel, 12 ~ 16 parts of glutinous rehmannia,
14 ~ 18 parts of motherwort, 10 ~ 16 parts of caulis lonicerae, 14 ~ 20 parts of rheum officinale, 12 ~ 16 parts of dandelion.
The method of the present embodiment medicine preparation, including following step：
Step S1：In parts by weight, 15 ~ 23 parts of lotus leaf, 12 ~ 20 parts of the red sage root, 10 ~ 16 parts of the root bark of tree peony, 8 ~ 12 parts of glossy ganoderma, reed rhizome are weighed
10 ~ 14 parts, 12 ~ 16 parts of ginseng, 16 ~ 22 parts of Poria cocos, 15 ~ 23 parts of dried orange peel, 12 ~ 16 parts of glutinous rehmannia, 14 ~ 18 parts of motherwort, caulis lonicerae
10 ~ 16 parts, 14 ~ 20 parts of rheum officinale, 12 ~ 16 parts of dandelion；
Step S2：By above-mentioned whole Chinese medicine material medicines, clear water or pure water is used in advance to soak 30 minutes, water consumption for immersion is 1 ~
1.2L；
Step S3：The liquid medicine of the Chinese medicine material medicine after soaking and its immersion is added in decocting container, adds a cover and jointly decoct
Two hours, dosing included following step：
Step S301：First lotus leaf, the red sage root, the root bark of tree peony, glossy ganoderma, reed rhizome are added in decocting container and are decocted 10 minutes with small fire；
Step S302：Again ginseng, Poria cocos, dried orange peel, glutinous rehmannia, motherwort are added in decocting container and are decocted 10 minutes with small fire；
Step S303：Again caulis lonicerae, rheum officinale, dandelion are added in decocting container；
Step S4：So that decocting container Chinese medicine liquid is seethed with excitement with high heat, reuse slow fire and boil 20 ~ 25 minutes, 2 when boiling medicine, need to be stirred
~ 3 times；
Step S5：After the completion of decoction, leach liquid, obtained liquid is endo-medicine.
Step S6：Second decoction is carried out one hour using 0.7 ~ 0.8L clear water or pure water repeat step S3 ~ S5；
Third time is carried out using 0.5 ~ 0.6L clear water or pure water repeat step S3 ~ S5 and decocts one hour.
Embodiment 2：
Including 15 parts of lotus leaf by weight, 12 parts of the red sage root, 16 parts of the root bark of tree peony, 12 parts of glossy ganoderma, 14 parts of reed rhizome, 12 parts of ginseng, Poria cocos
16 parts, 15 parts of dried orange peel, 16 parts of glutinous rehmannia, 14 parts of motherwort, 10 parts of caulis lonicerae, 14 parts of rheum officinale, 12 parts of dandelion.
Embodiment 3：
Including 18 parts of lotus leaf by weight, 18 parts of the red sage root, 10 parts of the root bark of tree peony, 9 parts of glossy ganoderma, 10 parts of reed rhizome, 16 parts of ginseng, Poria cocos 22
Part, 23 parts of dried orange peel, 12 parts of glutinous rehmannia, 18 parts of motherwort, 16 parts of caulis lonicerae, 20 parts of rheum officinale, 16 parts of dandelion.
Embodiment 4：
Including 23 parts of lotus leaf by weight, 20 parts of the red sage root, 3 parts of the root bark of tree peony, 8 parts of glossy ganoderma, 12 parts of reed rhizome, 14 parts of ginseng, Poria cocos 20
Part, 18 parts of dried orange peel, 14 parts of glutinous rehmannia, 16 parts of motherwort, 13 parts of caulis lonicerae, 17 parts of rheum officinale, 16 parts of dandelion.
Toxicology test：
Acute toxicity test：
Experimental observation, because measuring LD50, therefore has carried out the mensure of maximum dosage-feeding.Chinese medicine compound prescription prepared by embodiment 1
Mixture is dissolved in sterile saline, is configured to solution gavage mouse, and result shows, raw with medicine maximum administration concentration 9.65
Medicine/ml, maximum administered volume 50ml/kg was administered twice to mouse stomach in 24 hours, and mouse maximum dosage-feeding is 763.25g
Crude drug/kg, bad reaction and death in animal, anatomic observation each internal organs no abnormality seen.
Long term toxicity test：
SD rat 80 is applied in this test, and Chinese medicine compound prescription mixture prepared by embodiment 1 is dissolved in sterile saline, configuration
Become solution gavage, if control group and 24g, 35g, 49g crude drug/kg dosage group, continuous gavage is administered 12 weeks, observes in the present invention
The impact to animal indices for the drug composition.Result of the test shows, successive administration 12 weeks, and the Chinese medicine composition of the present invention is to big
The body weight of mouse, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index etc. all have no significant effect；Blood biochemical 12
Item index determining result, 12 weeks low dose group BiLi values of administration are higher than control group（P<0.05)；Low dose group, middle dose group TP value
Higher than control group（P<0.05), but all within normal physiologic range, other indexs compare no significant difference with control group.Recover
Phase each administration group indices measured value compares equal no significant difference with control group.Each group each internal organs gross examination of skeletal muscle no abnormality seen.
It is directed to the clinical statisticses data of various hyperlipemic patients using medicine of the present invention：
Through the Clinical practice of 300 patients, wherein male patient 173, female patient 127, medication age object 30 ~ 60 years old.Its
Middle minimum 30 years old, maximum 60 years old, average age 45 years old.
Lee, man, 54 years old.Dizzy alliteration blurring of vision, high pressure, high fat 4 years, before medication, blood pressure 180/110 mmHg, sweet
Oily three ester 4.8mmol/L, after two months, blood pressure is steadily 135/85mmHg, blood fat 1.4mmol/L, and dizzy alliteration is delayed for medication
Solution is clear depending on thing.
Wang, man, 67 years old, the high fat of high pressure 6 years, before medication, blood pressure 190/100mmHg, triglycerides 5.3mmol/L, the heart
Angina, shortness of breath uncomfortable in chest, medication three months, blood pressure is down to 138/80mmHg, triglycerides 1.6mmol/L, simultaneously shortness of breath uncomfortable in chest,
Angina pectoris relative remission.
The above, be only presently preferred embodiments of the present invention, and not the present invention is done with any pro forma restriction, every according to
Any simple modification above example made according to the technical spirit of the present invention, equivalent variations, each fall within the protection of the present invention
Within the scope of.
Claims (5)
1. a kind of Chinese medicine preparation being capable of reduction blood fat it is characterised in that：Including 15 ~ 23 parts of lotus leaf in parts by weight, the red sage root
12 ~ 20 parts, 10 ~ 16 parts of the root bark of tree peony, 8 ~ 12 parts of glossy ganoderma, 10 ~ 14 parts of reed rhizome, 12 ~ 16 parts of ginseng, 16 ~ 22 parts of Poria cocos, dried orange peel 15 ~ 23
Part, 12 ~ 16 parts of glutinous rehmannia, 14 ~ 18 parts of motherwort, 10 ~ 16 parts of caulis lonicerae, 14 ~ 20 parts of rheum officinale, 12 ~ 16 parts of dandelion.
2. a kind of Chinese medicine preparation being capable of reduction blood fat according to claim 1 it is characterised in that：Including by weight
15 parts of lotus leaf, 12 parts of the red sage root, 16 parts of the root bark of tree peony, 12 parts of glossy ganoderma, 14 parts of reed rhizome, 12 parts of ginseng, 16 parts of Poria cocos, 15 parts of dried orange peel, glutinous rehmannia
16 parts, 14 parts of motherwort, 10 parts of caulis lonicerae, 14 parts of rheum officinale, 12 parts of dandelion.
3. a kind of Chinese medicine preparation being capable of reduction blood fat according to claim 1 it is characterised in that：Including by weight
18 parts of lotus leaf, 18 parts of the red sage root, 10 parts of the root bark of tree peony, 9 parts of glossy ganoderma, 10 parts of reed rhizome, 16 parts of ginseng, 22 parts of Poria cocos, 23 parts of dried orange peel, glutinous rehmannia 12
Part, 18 parts of motherwort, 16 parts of caulis lonicerae, 20 parts of rheum officinale, 16 parts of dandelion.
4. a kind of Chinese medicine preparation being capable of reduction blood fat according to claim 1 it is characterised in that：Including by weight
23 parts of lotus leaf, 20 parts of the red sage root, 3 parts of the root bark of tree peony, 8 parts of glossy ganoderma, 12 parts of reed rhizome, 14 parts of ginseng, 20 parts of Poria cocos, 18 parts of dried orange peel, glutinous rehmannia 14
Part, 16 parts of motherwort, 13 parts of caulis lonicerae, 17 parts of rheum officinale, 16 parts of dandelion.
5. a kind of Chinese medicine preparation being capable of reduction blood fat according to claim 1 it is characterised in that：Described lotus leaf, pellet
Ginseng, the root bark of tree peony, glossy ganoderma, reed rhizome, ginseng, Poria cocos, dried orange peel, glutinous rehmannia, motherwort, caulis lonicerae, rheum officinale, dandelion decoct and take.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610974833.7A CN106421474A (en) | 2016-11-07 | 2016-11-07 | Formula for traditional Chinese medicines capable of lowering blood lipid |
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| CN201610974833.7A CN106421474A (en) | 2016-11-07 | 2016-11-07 | Formula for traditional Chinese medicines capable of lowering blood lipid |
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| CN106421474A true CN106421474A (en) | 2017-02-22 |
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| CN201610974833.7A Withdrawn CN106421474A (en) | 2016-11-07 | 2016-11-07 | Formula for traditional Chinese medicines capable of lowering blood lipid |
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| CN (1) | CN106421474A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107469000A (en) * | 2017-08-29 | 2017-12-15 | 成都泠汐尚品科技有限公司 | A kind of Chinese medicinal preparation method for reducing blood lipid hypotensive |
| CN107715051A (en) * | 2017-08-29 | 2018-02-23 | 成都泠汐尚品科技有限公司 | A kind of Chinese medicine preparation for reducing blood lipid hypotensive |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682837A (en) * | 2005-03-11 | 2005-10-19 | 哈尔滨医科大学 | Medicine for regulating blood fat and its preparing method |
| CN101181550A (en) * | 2007-11-28 | 2008-05-21 | 荣玉明 | Chinese medicine prescription for dropping blood fat and preparation method |
| CN101721563A (en) * | 2009-11-09 | 2010-06-09 | 徐兆云 | Three high rehabilitation tea |
-
2016
- 2016-11-07 CN CN201610974833.7A patent/CN106421474A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682837A (en) * | 2005-03-11 | 2005-10-19 | 哈尔滨医科大学 | Medicine for regulating blood fat and its preparing method |
| CN101181550A (en) * | 2007-11-28 | 2008-05-21 | 荣玉明 | Chinese medicine prescription for dropping blood fat and preparation method |
| CN101721563A (en) * | 2009-11-09 | 2010-06-09 | 徐兆云 | Three high rehabilitation tea |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107469000A (en) * | 2017-08-29 | 2017-12-15 | 成都泠汐尚品科技有限公司 | A kind of Chinese medicinal preparation method for reducing blood lipid hypotensive |
| CN107715051A (en) * | 2017-08-29 | 2018-02-23 | 成都泠汐尚品科技有限公司 | A kind of Chinese medicine preparation for reducing blood lipid hypotensive |
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Application publication date: 20170222 |