CN102772575B

CN102772575B - Traditional Chinese medicine composition for treating chronic hepatitis B

Info

Publication number: CN102772575B
Application number: CN201210293637.5A
Authority: CN
Inventors: 刘海霞; 张守潘; 王晴文
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-08-17
Filing date: 2012-08-17
Publication date: 2014-06-11
Anticipated expiration: 2032-08-17
Also published as: CN102772575A

Abstract

The invention provides a traditional Chinese medicine composition for treating chronic hepatitis B. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 parts of radix bupleuri, 10 parts of radix paeoniae rubra, 10 parts of radix paeoniae alba, 5 parts of radix aucklandiae, 5 parts of fructus schisandrae chinensis, 10 parts of rhubarb, 10 parts of herba artemisiae scopariae, 10 parts of fructus lycii, 10 parts of pangolin scales and 15 parts of turtle shell. The traditional Chinese medicine composition provided by the invention has the effects of dispelling pathogen, reinforcing healthy qi and emolliating liver, thus having an obvious curative effect on the chronic hepatitis B.

Description

A kind of Chinese medicine composition for the treatment of chronic hepatitis B

Technical field

The present invention relates to a kind of medicine for the treatment of chronic hepatitis B, be specifically related to a kind of Chinese medicine composition for the treatment of chronic hepatitis B.

Background technology

Chronic hepatitis B is that a kind of sickness rate is high, and the course of disease is long, refractory more, easy commonly encountered diseases repeatedly, the serious health that affects.Doctor trained in Western medicine adopts at present antiviral, immunomodulating, protects the liver, falls the comprehensive drug treatment such as enzyme, antiinflammatory and fibrosis the treatment of primary disease, still, and the problem such as it is high that western modern medicine treatment exists expense, and untoward reaction is many, and therapeutic effect is undesirable; Chinese medicine has outstanding advantage aspect treatment hepatitis B, but the medicine of existing treatment chronic hepatitis B is fewer clinically, more and more can not meet clinical demand.

Summary of the invention

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of chronic hepatitis B.

Technical scheme of the present invention is as follows:

A kind of Chinese medicine composition for the treatment of chronic hepatitis B, it is characterized in that, be prepared from by the crude drug of following weight portion: Radix Bupleuri 10, Radix Paeoniae Rubra 10, the Radix Paeoniae Alba 10, the Radix Aucklandiae 5, Fructus Schisandrae Chinensis 5, Radix Et Rhizoma Rhei 10, Herba Artemisiae Scopariae 10, Fructus Lycii 10, Squama Manis 10, Carapax Trionycis 15.

Take above each taste by proportioning, get 60% ethanol extraction 2 times that Squama Manis, Carapax Trionycis add 8 times, 6 times amounts, each 2 hours, merging filtrate, filters, concentrated, dry, pulverize to obtain alcohol extract, all the other each tastes add the water extraction 2 times of 8 times of amounts at every turn, each 2 hours, merging filtrate, filters, concentrated, after dry, pulverize, mix with alcohol extract.

In side, Radix Bupleuri is evacuated and is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy; Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain; Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, Radix Aucklandiae promoting the circulation of QI to relieve pain, invigorating the spleen and regulating the stomach; Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming; Radix Et Rhizoma Rhei has removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, effect of dampness removing jaundice eliminating; Herba Artemisiae Scopariae eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice; Fructus Lycii nourishing the liver and kidney; Squama Manis promoting blood circulation to remove obstruction in the collateral; Carapax Trionycis nourishing YIN for suppressing the hyperactive YANG, brings down a fever except steaming, hard masses softening and resolving.All medicine phases 5, have and get rid of evils, righting, the effect of easing the affected liver.

Clinical data

clinical data

1. diagnostic criteria:

Diagnosis meets " 2010 editions the guidelines " standard of Chinese Medical Association's hepatopathy credit meeting in 2010 and the revision of the sick credit of infection club.

2. clinical efficacy standard:

1) effective: except hepatic facies, liver palm, spider angioma, all the other sings and symptomses significantly take a turn for the better or approach and disappear; Liver function is significantly improved, and even approaches normal; Accompany or do not accompany the improvement of other chemical examinations and auxiliary examination project;

2) effective: the treatment between effective and invalid lapses to;

3) invalid: the index in clinical symptoms, sign, lab testing and auxiliary examination more than 80% is without improvement, even increase the weight of.In practical operation, all between two-stage curative effect person, all include the good one-level of curative effect in, do not repeat to each other statistics.

3. clinical trial:

The chronic hepatitis B patient that we examine between year June in March, 2010 to 2012, choose chronic hepatitis B (light ~ moderate) patient's 126 examples of agreeing to accept this research method, take medicine of the present invention, wherein a weight portion is 1 dose, and every day, potion, one month was 1 course for the treatment of, after 6 courses for the treatment of, observe therapeutic effect, wherein effective 88 examples, effective 26 examples, invalid 12 examples, total effective rate reaches 90.5%, proves that medicine of the present invention has significant curative effect to chronic hepatitis B.

The specific embodiment

Below in conjunction with specific embodiment, the present invention is described further.

Embodiment 1

Take Radix Bupleuri 10 g, Radix Paeoniae Rubra 10g, Radix Paeoniae Alba 10g, Radix Aucklandiae 5g, Fructus Schisandrae Chinensis 5g, Radix Et Rhizoma Rhei 10g, Herba Artemisiae Scopariae 10g, Fructus Lycii 10g, Squama Manis 10g, Carapax Trionycis 15g; Get 60% ethanol extraction 2 times that Squama Manis, Carapax Trionycis add 8 times, 6 times amounts, each 2 hours, merging filtrate, filter, concentrated, dry, pulverize to obtain alcohol extract, all the other each tastes add the water extraction 2 times of 8 times of amounts, each 2 hours, merging filtrate at every turn, filter, concentrated, after dry, pulverize, mix with alcohol extract.

Model case

?case 1

Deng, man, suffered from chronic hepatitis B before 10 years, weak, poor appetite, yellowish urine and abnormal liver function repeatedly, once seek medical advice diagnosis and treatment medication, all unsatisfactory curative effect of many places.Three Nian Laiwo institutes seek medical advice after being ill, patient at that time weak, poor appetite symptom is obvious, accompanies slight yellowish urine, dim complexion, looks into liver function moderate abnormal, five index of hepatitis b is great three positive, the HBV-DNA positive, B ultrasonic prompting liver parenchyma lesion ultrasonogram.Patient takes decoction for the treatment of the present invention 1 month, and liver function is just basic recovers normal; After 3 months, HBV-DNA the moon turns; After 6 months, great three positive turns small three positive.After 6 years, follow up a case by regular visits to still healthy living of patient.

Case 2

Teacher, male, main cause is weak, poor appetite 1 year, big belly meets the eye on every side Huang, and yellowish urine is admitted to hospital for more than 10 days.Before 1 year, patient chemically examines five indexes of hepatitis b at local hospital, HbsAg+, HbeAb+, HbcAb+, and liver function transaminase is higher than normally, and at local hospital symptomatic treatment, transaminase is repeatedly abnormal, checks liver function ALT1036u/L before 10 days, the further diagnosis and treatment of Lai Wo institute.Existing disease: dim complexion, white of the eye xanthochromia, abdominal distention poor appetite, yellowish urine icteric sclera, liver palm spider angioma, red tongue, yellow fur, stringy pulse.Human health screening: chronic hepatopathy face, whole skin, mucosa is slight xanthochromia, sclera moderate xanthochromia, cardiopulmonary no abnormality seen, under liver spleen rib not and, shifting dullness feminine gender, two lower limb are without edema, asterixis feminine gender, red tongue, yellow fur, stringy pulse.Lab testing: six of hepatitis B, HbsAg+, HbeAb+, HbcAb+, liver function: AST728u/L, ALT1069u/L, TbiL54.2ummol/L, anti-HBV-IgM feminine gender, HEV-IgG feminine gender, HEV-IgM feminine gender, HCV-IgG feminine gender, HCV-IgM feminine gender, is diagnosed as chronic hepatitis B.Patient took after 6 courses for the treatment of of medicine of the present invention, and it is normal that liver function is recovered substantially: AST26u/L, ALT36u/L, TbiL23.1mmol/L.After follow up a case by regular visits to check liver function all normal.

Case 3

Normal certain, man, patient is weak with repeatability, inappetence 3 years, increases the weight of to be chief complaint to examine for 1 year lab testing: hepatitis b virus marker: HbsAg (+), HbeAg (+), anti-HBc (+).2, liver function: ALT171u/L, AST120u/L.Be diagnosed as chronic hepatitis B.Take subsequently medicine of the present invention, take medicine continuously 3 months, ultrasound diagnosis liver morphosis is all normal.Take medicine continuously 4 months, except liver function is normal already, five indexes of hepatitis b: HbeAg is transferred to feminine gender and is produced antibody by the positive, and HBV-DNA also firmly turns out cloudy.This patient stop treatment after, followed up a case by regular visits at 6 months, 12 months and 18 months respectively, patient returns to one's perfect health.

Claims

1. treat the Chinese medicine composition of chronic hepatitis B for one kind, it is characterized in that, be prepared from by the crude drug of following weight portion: Radix Bupleuri 10, Radix Paeoniae Rubra 10, the Radix Paeoniae Alba 10, the Radix Aucklandiae 5, Fructus Schisandrae Chinensis 5, Radix Et Rhizoma Rhei 10, Herba Artemisiae Scopariae 10, Fructus Lycii 10, Squama Manis 10, Carapax Trionycis 15.

2. the preparation method of Chinese medicine composition according to claim 1, is characterized in that, adopts and is prepared as follows method: take above each taste by proportioning, get 60% ethanol extraction 2 times that Squama Manis, Carapax Trionycis add 8 times, 6 times amounts, each 2 hours, merging filtrate, filter, concentrated, dry, pulverize to obtain alcohol extract, all the other each tastes add the water extraction 2 times of 8 times of amounts, each 2 hours at every turn, merging filtrate, filters, concentrated, after dry, pulverize, mix with alcohol extract.