CN102764337B

CN102764337B - Traditional Chinese medicine composition for curing hepatitis B

Info

Publication number: CN102764337B
Application number: CN201210295661.2A
Authority: CN
Inventors: 马弛; 马丽华; 高文旭
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-08-20
Filing date: 2012-08-20
Publication date: 2014-04-09
Anticipated expiration: 2032-08-20
Also published as: CN102764337A

Abstract

The invention provides a traditional Chinese medicine composition for curing hepatitis B. The traditional Chinese medicine composition includes, by weight, 12 parts of polygonum cuspidatum, 12 parts of artemisia scoparia waldst, 10 parts of radix scutellariae, 10 parts of oldenlandia, 10 parts of radix paeoniae alba, 8 parts of epimedium herb, 10 parts of rehmannia glutinosa, 12 parts of flos chrysanthemi indici, 8 parts of red tangerine peel and 3 parts of licorice. The traditional Chinese medicine composition has effects of clearing heat and removing toxicity, norishing blood and liver, nourishing Yin and tonifying Yang, and regulating vital energy and removing stasis; and has remarkable efficacy on the hepatitis B.

Description

A kind of Chinese medicine composition for the treatment of chronic hepatitis B

Technical field

The present invention relates to a kind of medicine for the treatment of hepatitis B, particularly relate to a kind of compositions of the treatment chronic viral hepatitis B being prepared from by Chinese herbal medicine.

Background technology

Motherland's medical science thinks, the main pathological factor of hepatitis B is hot and humid ecchymosis, and hepatopathy with the passing of time easily passes and spleen kidney, causes liver spleen kidney with sick, even develops into liver cirrhosis, occurs hepatic ascites.The quality of life that has a strong impact on patient even may cause life danger.

Treatment with respect to western modern medicine to hepatitis B, the advantage such as it is low that Chinese medicine has expense, and untoward reaction is few, but the problem such as existing clinical treatment medicine also exists treatment time long, and uncertain therapeutic efficacy is cut, and cure rate is low.

Summary of the invention

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of hepatitis B.

Technical scheme of the present invention is as follows:

Treat a Chinese medicine composition for chronic hepatitis B, by the Chinese crude drug of following weight portion, be prepared from: Rhizoma Polygoni Cuspidati 12, Herba Artemisiae Scopariae 12, Radix Scutellariae 10, Herba Hedyotidis Diffusae 10, the Radix Paeoniae Alba 10, Herba Epimedii 8, Radix Rehmanniae Preparata 10, Flos Chrysanthemi Indici 12, Exocarpium Citri Rubrum 8, Radix Glycyrrhizae 3.

The present invention adopts following preparation method: by proportioning, takes above each taste, adds the water extraction 3 times of 10 times, 8 times, 8 times amounts, and each two hours, merging filtrate, concentrated, dry, pulverize, standby.

Rhizoma Polygoni Cuspidati dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain; Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis, promoting the function of the gallbladder to alleviate jaundice; Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication; Herba Hedyotidis Diffusae heat-clearing and toxic substances removing; Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, suppressing liver-YANG; Herba Epimedii kidney-replenishing; The Radix Rehmanniae Preparata YIN nourishing of enriching blood; Flos Chrysanthemi Indici heat-clearing and toxic substances removing, pathogenic fire purging suppressing the hyperactive liver; Exocarpium Citri Rubrum regulating the flow of QI to ease the stomach, drying dampness to eliminate phlegm; Radix Glycyrrhizae invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription.All medicine phases 5, play heat-clearing and toxic substances removing, nourishing blood to suppress the hyperactive liver, YIN nourishing and YANG strengthening, the effect of the dissipating blood stasis of regulating the flow of vital energy altogether above.

Clinical data

clinical data

1. diagnostic criteria:

Diagnosis meets " 2010 editions the guidelines " standard of Chinese Medical Association's hepatopathy credit meeting in 2010 and the revision of the sick credit of infection club.

2. clinical efficacy standard:

1). effective: except hepatic facies, liver palm, spider angioma, all the other sings and symptomses significantly take a turn for the better or approach and disappear; Liver function is significantly improved, and even approaches normal; Accompany or do not accompany the improvement of other chemical examinations and auxiliary examination project;

2). effectively: the treatment between effective and invalid lapses to;

3). invalid: the index in clinical symptoms, sign, lab testing and auxiliary examination more than 80% is without improvement, even increase the weight of.In practical operation, all between two-stage curative effect person, all include the good one-level of curative effect in, do not repeat to each other statistics.

3. clinical trial:

The chronic hepatitis B patient that we examine between year July in July, 2010 to 2012, choose chronic hepatitis B (light ~ moderate) patient's 186 examples of agreeing to accept this research method, man's 121 examples, female's 65 examples, in age 15-61 year, take medicine of the present invention and after 6 courses for the treatment of, investigate therapeutic effect, wherein effective 107 examples, effective 67 examples, invalid 12 examples, total effective rate reaches 93.5%, illustrates that medicine of the present invention has significant curative effect to chronic hepatitis B.

the specific embodiment

Below in conjunction with specific embodiment, the present invention is described further.

Embodiment 1

Get Rhizoma Polygoni Cuspidati 12 g, Herba Artemisiae Scopariae 12g, Radix Scutellariae 10g, Herba Hedyotidis Diffusae 10g, Radix Paeoniae Alba 10g, Herba Epimedii 8g, Radix Rehmanniae Preparata 10g, Flos Chrysanthemi Indici 12g, Exocarpium Citri Rubrum 8g, Radix Glycyrrhizae 3g; The water extraction 3 times that adds 10 times, 8 times, 8 times amounts, each two hours, merging filtrate, concentrated, dry, pulverize, standby.

model case

Case 1

Pan, man, suffered from chronic hepatitis B before 10 years, weak, poor appetite, yellowish urine and abnormal liver function repeatedly, once seek medical advice diagnosis and treatment medication, all unsatisfactory curative effect of many places.San Nianlaiwo institute seeks medical advice after being ill, patient at that time weak, poor appetite symptom is obvious, accompanies slight yellowish urine, dim complexion, looks into liver function moderate abnormal, five index of hepatitis b is great three positive, HBV-DNA is positive, B ultrasonic prompting liver parenchyma lesion ultrasonogram.Patient takes decoction for the treatment of the present invention 1 month, and liver function is just basic recovers normal; After 3 months, HBV-DNA the moon turns; After 6 months, great three positive turns small three positive; Doctor's advice patient can stop treatment.But patient requires to continue to take, after 1 year patient unexpectedly HBsAg the moon turn, two positives of HBcAb and HBeAb only.After 6 years, follow up a case by regular visits to still healthy living of patient.

Case 2

Teacher, man, the concealment of patient's onset, finds patient when within 6 years, cause is suffered from the treatment of dermatosis Zhu Ta institute and merges " chronic hepatitis B " simultaneously.The patient Hou Jilaiwo institute of leaving hospital seeks medical advice, and looks into liver function mile abnormality, and HbsAg, HbeAg, anti-HBc and HBV-DNA are all positive, B ultrasonic prompting liver parenchyma lesion ultrasonogram.Be diagnosed as chronic hepatitis B, and application of interference element 500Wan unit, the next day intramuscular injection once, continued treatment 1 year, poor effect.After use adefovir ester instead and add the medication combined anti-HBV of the present invention and liver protection treatment 2 years, liver function is completely normal, HBV-DNA the moon turns, great three positive turns small three positive.After 3 years, follow up a case by regular visits to, patient is stable disease still, works and rests as usual.

Case 3

Lee, man, patient's onset concealment, finds abnormal liver function while treating because of trauma surgery before 3 years, hepatitis B great three positive, but at that time patient without obvious subjective symptoms.Within 1 year, I sought medical advice at institute afterwards, looked into liver function moderate abnormal, HbsAg, HbeAg, the anti-HBc positive, and HBV-DNA:1.0E+06IU/ml, in B ultrasonic prompting liver, luminous point increases thick.Be diagnosed as " chronic hepatitis B (moderate) ", and application of interference element 500Wan unit, the next day intramuscular injection once, continued treatment half a year, liver function is mile abnormality still, HBV-DNA:1.0E+05IU/ml declines not obvious.Add subsequently treated with combined medication of the present invention half a year, liver function is normal, and HBV-DNA the moon turns, and great three positive turns small three positive.The interferon of stopping using, then continue to take Drug therapy of the present invention half a year, HBsAg the moon turns unexpectedly, but HbsAb not yet turns positive.After 1 year, follow up a case by regular visits to still working healthily.

Claims

1. a Chinese medicine composition for the treatment of chronic hepatitis B, it is characterized in that, by the Chinese crude drug of following weight portion, be prepared from: Rhizoma Polygoni Cuspidati 12, Herba Artemisiae Scopariae 12, Radix Scutellariae 10, Herba Hedyotidis Diffusae 10, the Radix Paeoniae Alba 10, Herba Epimedii 8, Radix Rehmanniae Preparata 10, Flos Chrysanthemi Indici 12, Exocarpium Citri Rubrum 8, Radix Glycyrrhizae 3.