CN102671102B - Traditional Chinese medicine composition for treating chronic hepatitis B - Google Patents
Traditional Chinese medicine composition for treating chronic hepatitis B Download PDFInfo
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- CN102671102B CN102671102B CN201210174726.8A CN201210174726A CN102671102B CN 102671102 B CN102671102 B CN 102671102B CN 201210174726 A CN201210174726 A CN 201210174726A CN 102671102 B CN102671102 B CN 102671102B
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Abstract
The invention relates to a Chinese medicinal composition for treating chronic hepatitis. The Chinese medicinal composition is prepared from the following Chinese herbal medicines by weight: 20g of girald pteroxygonum root, 20g of white paeony root, 15g of schisandra chinensis, 20g of dark plum fruit, 20g of fructus crataegi, 15g of prepared rehmannia rhizome, 10g of Chinese wolfberry, 30g of vinegar turtle shell, 10g of vinegar nutgrass galingale rhizome, 10g of roasted astragalus, 10g of tuckahoe, 10g of oriental waterplantain rhizome, 10g of Chinese date, 5g of amomum fruit and 5g of liquoric root. The Chinese medicinal composition is a pure Chinese medicinal preparation, does not have toxic or side effect, and has an obvious curative effect on chronic hepatitis.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of hepatitis, be specifically related to a kind of Chinese medicine composition for the treatment of chronic hepatitis B.
Background technology
Hepatic injury due to chronic hepatitis B, belongs to Liver of TCM through damp and hot disease, and patient is often with qi depression to blood stasis in various degree.Hepatopathy with the passing of time easily passes and spleen kidney, causes liver spleen kidney with sick, even develops into liver cirrhosis, occurs hepatic ascites.The quality of life that has a strong impact on patient even may cause life danger.
And in prior art, treatment to chronic hepatitis B, the general Therapeutic Method that adopts Integrative Chinese-Western, Western medicine is mainly with interferon etc., but problem is that its cost is high, side effect is large, Chinese medicine is main for the treatment of hepatitis mainly with nourishing the liver tonifying liver, and the course for the treatment of is long, and therapeutic effect is not good enough, cure rate is low, and its radical cure person is also few.
Summary of the invention
For solving the problems of the technologies described above, the invention provides the Chinese medicine composition of a kind of pure Chinese medicine treatment chronic hepatitis B that make, that therapeutic effect is good, toxic and side effects is little.
Technical scheme of the present invention is as follows:
The Chinese medicine composition for the treatment of chronic hepatitis B provided by the present invention, is prepared from by following weight crude drug: Radix Paeoniae Rubra 20g, Radix Paeoniae Alba 20g, Radix Schisandrae Bicoloris 15g, Fructus Mume 20g, Fructus Crataegi 20g, Radix Rehmanniae Preparata 15g, Fructus Lycii 10g, Carapax Trionycis (processed with vinegar) 30g, Rhizoma Cyperi (processed with vinegar) 10g, Radix Astragali Preparata 10g, Poria 10g, Rhizoma Alismatis 10g, Fructus Jujubae 10g, Fructus Amomi 5g, Radix Glycyrrhizae 5g.
The present invention adopts the method that is prepared as follows:
By above prescription, take ingredients, get Carapax Trionycis (processed with vinegar), pulverized 40 mesh sieves, add 6 times of water gagings to seethe with excitement half an hour, filter, concentrated decocting liquid is standby to 30-50ml; Get Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Schisandrae Bicoloris, Fructus Mume, Fructus Crataegi, Radix Rehmanniae Preparata, Fructus Lycii, Rhizoma Cyperi (processed with vinegar), Radix Astragali Preparata, Poria, Rhizoma Alismatis, Fructus Jujubae, Radix Glycyrrhizae warm water soaking 1 hour, be incorporated into Carapax Trionycis (processed with vinegar) medicinal residues, add respectively 8 times of amounts, 8 times of water gagings decoct twice, each 1 hour, after add Fructus Amomi to decoct 5 minutes, filter, be concentrated into 250-350ml.
Instructions of taking: concentrated solution and Carapax Trionycis (processed with vinegar) decocting liquid close clothes at twice, every day, potion, 28 days was a course for the treatment of.
Radix Paeoniae Alba sour and sweet drugs can transforme into YIN in side, nourishing blood to suppress the hyperactive liver; Radix Schisandrae Bicoloris, Fructus Mume, the nourishing kidney of astringing the lung, three medicines are same by the effect of playing altogether nourishing the liver and kidney.Radix Paeoniae Rubra promoting blood circulation and cooling blood; Carapax Trionycis (processed with vinegar) nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving; Rhizoma Cyperi depressed liver-energy dispersing and QI regulating and in reduce phlegm; Rhizoma Alismatis dampness removing, jaundice eliminating, expel the heat-evil; Radix Astragali Preparata has the effect of replenishing QI to invigorate the spleen, inducing diuresis to remove edema removing toxic substances.All medicines share and can make irritability bar reach above, liver nourishing YANG hyperactivity suppressing, and dampness removing expels the heat-evil, and subduing swelling and detoxicating plays the effect of antiinflammatory hepatoprotective jointly.Modern medicine study proves: the main chemical compositions of Radix Paeoniae is peoniflorin, has multiple biological activity, and all there is to sure pharmacological action the aspects such as immunity, cardiovascular, central nervous system and smooth muscle.The main chemical compositions of Radix Schisandrae Bicoloris has deoxyschizandrin, second element, the third element, alcohol first, alcohol second, SALLRSIPA SAL ADNF-9 schizronol schisanhenol, all has obvious function for protecting liver and reducing enzyme activity, is the main component of multiple the liver protecting and ALT lowering medicine.Radix Astragali saponin in Radix Astragali Preparata has anti-liver injury effect, can alleviate the pathological changes that liver poisoning causes.Triterpenoid compound in Rhizoma Cyperi (processed with vinegar) has obvious antiinflammatory action, and can significantly strengthen the function of promoting blood circulation to disperse blood clots of inrigorating qi and promoting blood circulation medicine.The present invention can significantly improve the liver function of chronic hepatitis B patient; reduce serum alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (Tbil); improve the ratio (A/G) of serum albumin and globulin; alleviate inflammation mobility, impaired liver is played to effective protective effect.After taking medicine of the present invention, can alleviate to a certain extent liver cirrhosis pathology state, promote liver cell regeneration.Medicine of the present invention is specially adapted to the treatment of the chronic hepatitis B of light moderate.
clinical data
1. diagnostic criteria:
Diagnosis meets " 2010 editions the guidelines " standard of Chinese Medical Association's hepatopathy credit meeting in 2010 and the revision of the sick credit of infection club.
2. clinical efficacy standard:
1). effective: except hepatic facies, liver palm, spider angioma, all the other sings and symptomses significantly take a turn for the better or approach and disappear; Liver function is significantly improved, and even approaches normal; Accompany or do not accompany the improvement of other chemical examinations and auxiliary examination project;
2). effectively: the treatment between effective and invalid lapses to;
3). invalid: the index in clinical symptoms, sign, lab testing and auxiliary examination more than 80% is without improvement, even increase the weight of.In practical operation, all between two-stage curative effect person, all include the good one-level of curative effect in, do not repeat to each other statistics.
3. clinical trial:
The chronic hepatitis B patient that we examine between year March in March, 2010 to 2012, choose chronic hepatitis B (light ~ moderate) 146 cases of agreeing to accept this research method, be divided into two groups.Treatment group 86 examples, male 69 examples, female's 17 examples, age 15-61 year, average 33.1 ± 11.2 years old.Matched group 60 examples, male 49 examples, female's 11 examples, age 16-59 year, average 34.6 ± 10.8 years old.Two groups of patients are learning processing by statistics aspect sex, age, the state of an illness and the course of disease, no significant difference, has comparability.
4. result of the test:
Before and after 4.1 liang of group patient treatments, liver functional testing the results are shown in Table 1.
Liver functional testing result comparison (x ± s) before and after table 1 liang group patient treatment
The comparison of 4.2 liang of group patient clinical curative effects, in Table 2
Table 2 liang group patient clinical curative effect comparison
Group | n | Effective | Effectively | Invalid | Total effective rate (%) |
Treatment group | 86 | 68 | 11 | 7 | 91.8 |
Matched group | 60 | 24 | 21 | 15 | 75 |
From above two tables, can find out, there were significant differences for the therapeutic effect of matched group and treatment group, illustrates that medication effect of the present invention is remarkable.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described further.
Embodiment 1
Get Carapax Trionycis (processed with vinegar) 30g, pulverized 40 mesh sieves, add 6 times of water gagings to seethe with excitement half an hour, filter, concentrated decocting liquid is standby to 30-50ml; Get Radix Paeoniae Rubra 20g, Radix Paeoniae Alba 20g, Radix Schisandrae Bicoloris 15g, Fructus Mume 20g, Fructus Crataegi 20g, Radix Rehmanniae Preparata 15g, Fructus Lycii 10g, Rhizoma Cyperi (processed with vinegar) 10g, Radix Astragali Preparata 10g, Poria 10g, Rhizoma Alismatis 10g, Fructus Jujubae 10g, Radix Glycyrrhizae 5g warm water soaking 1 hour, be incorporated into Carapax Trionycis (processed with vinegar) medicinal residues, add 8 times of amounts, 8 times of water gagings decoct twice, each 1 hour, after add Fructus Amomi to decoct 5 minutes, filter, be concentrated into 250-350ml.
Model case
?case 1
Pan, man, suffered from chronic hepatitis B before 10 years, weak, poor appetite, yellowish urine and abnormal liver function repeatedly, once seek medical advice diagnosis and treatment medication, all unsatisfactory curative effect of many places.San Nianlaiwo institute seeks medical advice after being ill, patient at that time weak, poor appetite symptom is obvious, accompanies slight yellowish urine, dim complexion, looks into liver function moderate abnormal, five index of hepatitis b is great three positive, HBV-DNA is positive, B ultrasonic prompting liver parenchyma lesion ultrasonogram.Patient takes decoction for the treatment of the present invention 1 month, and liver function is just basic recovers normal; After 3 months, HBV-DNA the moon turns; After 6 months, great three positive turns small three positive; Doctor's advice patient can stop treatment.But patient requires to continue to take, after 1 year patient unexpectedly HBsAg the moon turn, two positives of HBcAb and HBeAb only.After 6 years, follow up a case by regular visits to still healthy living of patient.
Case 2.
Teacher, man, the concealment of patient's onset, finds patient when within 6 years, cause is suffered from the treatment of dermatosis Zhu Ta institute and merges " chronic hepatitis B " simultaneously.The patient Hou Jilaiwo institute of leaving hospital seeks medical advice, and looks into liver function mile abnormality, and HbsAg, HbeAg, anti-HBc and HBV-DNA are all positive, B ultrasonic prompting liver parenchyma lesion ultrasonogram.Be diagnosed as chronic hepatitis B, and application of interference element 500Wan unit, the next day intramuscular injection once, continued treatment 1 year, poor effect.After use adefovir ester instead and add the medication combined anti-HBV of the present invention and liver protection treatment 2 years, liver function is completely normal, HBV-DNA the moon turns, great three positive turns small three positive.After 3 years, follow up a case by regular visits to, patient is stable disease still, works and rests as usual.
Case 3
Lee, man, patient's onset concealment, finds abnormal liver function while treating because of trauma surgery before 3 years, hepatitis B great three positive, but at that time patient without obvious subjective symptoms.Within 1 year, I sought medical advice at institute afterwards, looked into liver function moderate abnormal, HbsAg, HbeAg, the anti-HBc positive, and HBV-DNA:1.0E+06IU/ml, in B ultrasonic prompting liver, luminous point increases thick.Be diagnosed as " chronic hepatitis B (moderate) ", and application of interference element 500Wan unit, the next day intramuscular injection once, continued treatment half a year, liver function is mile abnormality still, HBV-DNA:1.0E+05IU/ml declines not obvious.Add subsequently treated with combined medication of the present invention half a year, liver function is normal, and HBV-DNA the moon turns, and great three positive turns small three positive.The interferon of stopping using, then continue to take Drug therapy of the present invention half a year, HBsAg the moon turns unexpectedly, but HbsAb not yet turns positive.After 1 year, follow up a case by regular visits to still working healthily.
Claims (1)
1. a Chinese medicine composition for the treatment of chronic hepatitis B, it is characterized in that, by following weight crude drug, be prepared from: Radix Paeoniae Rubra 20g, Radix Paeoniae Alba 20g, Radix Schisandrae Bicoloris 15g, Fructus Mume 20g, Fructus Crataegi 20g, Radix Rehmanniae Preparata 15g, Fructus Lycii 10g, Carapax Trionycis (processed with vinegar) 30g, Rhizoma Cyperi (processed with vinegar) 10g, Radix Astragali Preparata 10g, Poria 10g, Rhizoma Alismatis 10g, Fructus Jujubae 10g, Fructus Amomi 5g, Radix Glycyrrhizae 5g.
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CN103893674B (en) * | 2012-12-27 | 2016-07-06 | 刘药石 | A kind of Chinese medicinal pill for the treatment of the liver removing toxic substances |
CN103430903B (en) * | 2013-09-11 | 2015-01-07 | 桂林医学院 | Method for preparing non-human animal model with opportunistic infections and chronic wasting diseases and medicament screened by using same |
CN103549433B (en) * | 2013-11-15 | 2015-12-30 | 河南中医学院 | A kind of Chinese medicine and health food with liver protecting effect |
CN104127557A (en) * | 2014-08-19 | 2014-11-05 | 金先琦 | Traditional Chinese medicine for treating liver cirrhosis |
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