CN102772575A

CN102772575A - Traditional Chinese medicine composition for treating chronic hepatitis B

Info

Publication number: CN102772575A
Application number: CN2012102936375A
Authority: CN
Inventors: 刘海霞; 张守潘; 王晴文
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-08-17
Filing date: 2012-08-17
Publication date: 2012-11-14
Anticipated expiration: 2032-08-17
Also published as: CN102772575B

Abstract

The invention provides a traditional Chinese medicine composition for treating chronic hepatitis B. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 parts of radix bupleuri, 10 parts of radix paeoniae rubra, 10 parts of radix paeoniae alba, 5 parts of radix aucklandiae, 5 parts of fructus schisandrae chinensis, 10 parts of rhubarb, 10 parts of herba artemisiae scopariae, 10 parts of fructus lycii, 10 parts of pangolin scales and 15 parts of turtle shell. The traditional Chinese medicine composition provided by the invention has the effects of dispelling pathogen, reinforcing healthy qi and emolliating liver, thus having an obvious curative effect on the chronic hepatitis B.

Description

A kind of Chinese medicine composition of treating chronic hepatitis B

Technical field

The present invention relates to a kind of medicine of treating chronic hepatitis B, be specifically related to a kind of Chinese medicine composition of treating chronic hepatitis B.

Background technology

Chronic hepatitis B is that a kind of sickness rate is high, and the course of disease is long, and refractory is healed, is prone to commonly encountered diseases repeatedly, seriously influences health.Doctor trained in Western medicine adopts antiviral, immunomodulating at present, protects the liver, falls comprehensive drug treatment such as enzyme, antiinflammatory and fibrosis the treatment of primary disease, still, and problem such as the western modern medicine treatment exists the expense height, and untoward reaction is many, and therapeutic effect is undesirable; Chinese medicine has outstanding advantage aspect the treatment hepatitis B, but the medicine of existing clinically treatment chronic hepatitis B is fewer, more and more can not satisfy clinical demand.

Summary of the invention

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition of treating chronic hepatitis B.

Technical scheme of the present invention is following:

A kind of Chinese medicine composition of treating chronic hepatitis B; It is characterized in that, be prepared from the crude drug of following weight portion: Radix Bupleuri 10, Radix Paeoniae Rubra 10, the Radix Paeoniae Alba 10, the Radix Aucklandiae 5, Fructus Schisandrae Chinensis 5, Radix Et Rhizoma Rhei 10, Herba Artemisiae Scopariae 10, Fructus Lycii 10, Squama Manis 10, Carapax Trionycis 15.

Take by weighing above each flavor by proportioning, get 60% ethanol extraction 2 times that Squama Manis, Carapax Trionycis add 8 times, 6 times amounts, each 2 hours, merging filtrate; Filter, concentrate, drying, pulverize alcohol extract; The water extraction of 8 times, 8 times amounts of all the other each flavor addings 2 times, each 2 hours, merging filtrate filtered; Concentrate, drying is pulverized the back and is mixed with alcohol extract.

Radix Bupleuri is evacuated and is brought down a fever dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy in the side; The Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain; Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, Radix Aucklandiae promoting the circulation of QI to relieve pain, invigorating the spleen and regulating the stomach; The Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming; Radix Et Rhizoma Rhei has removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, the effect of dampness removing jaundice eliminating; The Herba Artemisiae Scopariae eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice; The Fructus Lycii nourishing the liver and kidney; The Squama Manis promoting blood circulation to remove obstruction in the collateral; The Carapax Trionycis nourishing YIN for suppressing the hyperactive YANG is brought down a fever to remove and is steamed hard masses softening and resolving.All medicine phases 5 have and get rid of evils, and set upright the effect of easing the affected liver.

Clinical data

Clinical data

1. diagnostic criteria:

Diagnosis meets " 2010 editions prevention and treatment for chronic hepatitis B guides " standard of Chinese Medical Association's hepatopathy credit meeting in 2010 and the revision of the sick credit of infection club.

2. clinical efficacy standard:

1) produce effects: except that hepatic facies, liver palm, the spider angioma, all the other sings and symptomses significantly take a turn for the better or near disappearing; Liver function is significantly improved, even near normal; Accompany or do not accompany the improvement of other chemical examinations and auxiliary examination project;

2) effective: between produce effects and invalid between treatment lapse to;

3) invalid: the index in clinical symptoms, sign, lab testing and the auxiliary examination more than 80% does not have improvement, even increase the weight of.In the practical operation, all between the two-stage curative effect person, all include curative effect one-level preferably in, do not repeat to each other the statistics.

3. clinical trial:

Choose chronic hepatitis B (light ~ moderate) patient's 126 examples of agreeing to accept this research method the chronic hepatitis B patient that we examine between year June in March, 2010 to 2012, take medicine of the present invention, wherein a weight portion is 1 dose; Every day potion, one month is 1 course of treatment, observes therapeutic effect after 6 courses of treatment; Produce effects 88 examples wherein, effective 26 examples, invalid 12 examples; Total effective rate reaches 90.5%, proves that medicine of the present invention has significant curative effect to chronic hepatitis B.

The specific embodiment

Below in conjunction with specific embodiment the present invention is done further explanation.

Embodiment 1

Take by weighing Radix Bupleuri 10 g, Radix Paeoniae Rubra 10g, Radix Paeoniae Alba 10g, Radix Aucklandiae 5g, Fructus Schisandrae Chinensis 5g, Radix Et Rhizoma Rhei 10g, Herba Artemisiae Scopariae 10g, Fructus Lycii 10g, Squama Manis 10g, Carapax Trionycis 15g; Get 60% ethanol extraction 2 times that Squama Manis, Carapax Trionycis add 8 times, 6 times amounts, each 2 hours, merging filtrate filtered; Concentrate, drying, pulverize alcohol extract, all the other each flavors add the water extraction 2 times of 8 times, 8 times amounts; Each 2 hours, merging filtrate filtered; Concentrate, drying is pulverized the back and is mixed with alcohol extract.

Model case

Case 1

Deng, the man suffered from chronic hepatitis B before 10 years, weak repeatedly, poor appetite, yellowish urine and abnormal liver function, once seek medical advice diagnosis and treatment medication, all unsatisfactory curative effect of many places.I seek medical advice at institute over 3 years after being ill, and the patient was weak at that time, the poor appetite symptom is obvious, accompanied slight yellowish urine, dim complexion, and it is unusual to look into the liver function moderate, and five index of hepatitis b is great three positive, and HBV-DNA is positive, B ultrasonic prompting liver parenchyma infringement ultrasonogram.The patient took decoction for the treatment of the present invention 1 month, and liver function is just basic recovers normal; HBV-DNA is cloudy after 3 months changes; Great three positive changes small three positive after 6 months.Follow up a case by regular visits to still healthy living of patient after 6 years.

Case 2

The teacher, the male, main cause is weak, poor appetite 1 year, big belly meets the eye on every side Huang, day is admitted to hospital surplus the yellowish urine 10.The patient is at local hospital chemical examination five indexes of hepatitis b before 1 year, and HbsAg+, HbeAb+, HbcAb+, liver function transaminase are higher than normally, and at local hospital symptomatic treatment, the transaminase is unusual repeatedly, and check liver function ALT1036u/L comes the further diagnosis and treatment of my institute before 10 days.Existing disease: dim complexion, white of the eye xanthochromia, abdominal distention poor appetite, yellowish urine icteric sclera, liver palm spider angioma, red tongue, yellow fur, stringy pulse.Human health screening: the chronic hepatopathy face, whole skin, the slight xanthochromia of mucosa, sclera moderate xanthochromia, the cardiopulmonary no abnormality seen does not reach under the liver spleen rib, and shifting dullness is negative, and two lower limb do not have edema, and asterixis is negative, red tongue, yellow fur, stringy pulse.Lab testing: six of hepatitis B, HbsAg+, HbeAb+, HbcAb+, liver function: AST728u/L; ALT1069u/L, TbiL54.2ummol/L, anti--HBV-IgM is negative, and HEV-IgG is negative; HEV-IgM is negative, and HCV-IgG is negative, and HCV-IgM is negative, is diagnosed as chronic hepatitis B.The patient takes medicine of the present invention after 6 courses of treatment, and it is normal that liver function is recovered basically: AST26u/L, ALT36u/L, TbiL23.1mmol/L.After follow up a case by regular visits to the check liver function all normal.

Case 3

Normal certain, the man, the patient is weak with repeatability, inappetence 3 years, increases the weight of to be chief complaint in 1 year and examines lab testing: hepatitis b virus marker: HbsAg (+), HbeAg (+), anti--HBc (+).2, liver function: ALT171u/L, AST120u/L.Be diagnosed as chronic hepatitis B.Take medicine of the present invention subsequently, took medicine continuously 3 months, ultrasound diagnosis liver morphosis is all normal.Took medicine continuously 4 months, except that liver function was normal already, five indexes of hepatitis b: HbeAg was transferred to feminine gender and is produced antibody by the positive, and HBV-DNA also firmly turns out cloudy.This patient followed up a case by regular visits at 6 months, 12 months and 18 months respectively after stopping treatment, and the patient returns to one's perfect health.

Claims

1. Chinese medicine composition of treating chronic hepatitis B; It is characterized in that, be prepared from the crude drug of following weight portion: Radix Bupleuri 10, Radix Paeoniae Rubra 10, the Radix Paeoniae Alba 10, the Radix Aucklandiae 5, Fructus Schisandrae Chinensis 5, Radix Et Rhizoma Rhei 10, Herba Artemisiae Scopariae 10, Fructus Lycii 10, Squama Manis 10, Carapax Trionycis 15.

2. the method for preparing of Chinese medicine composition according to claim 1 is characterized in that, adopts the method that is prepared as follows: take by weighing above each flavor by proportioning, get 60% ethanol extraction 2 times that Squama Manis, Carapax Trionycis add 8 times, 6 times amounts, each 2 hours; Merging filtrate filters, and concentrates drying; Pulverize alcohol extract, all the other each flavor adds the water extraction 2 times of 8 times, 8 times amounts, each 2 hours, merging filtrate; Filter, concentrate, drying is pulverized the back and is mixed with alcohol extract.