CN106309749A - Traditional Chinese medicine for treating cervical cancer - Google Patents

Traditional Chinese medicine for treating cervical cancer Download PDF

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Publication number
CN106309749A
CN106309749A CN201610889602.6A CN201610889602A CN106309749A CN 106309749 A CN106309749 A CN 106309749A CN 201610889602 A CN201610889602 A CN 201610889602A CN 106309749 A CN106309749 A CN 106309749A
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CN
China
Prior art keywords
herba
parts
cervical cancer
chinese medicine
traditional chinese
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Pending
Application number
CN201610889602.6A
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Chinese (zh)
Inventor
蒋敏捷
蓝彬
蒋伟哲
付书婕
巫玲玲
郭为
蓝献丽
植国繁
许立拔
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NANNING DUOLING BIOTECHNOLOGY CO Ltd
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NANNING DUOLING BIOTECHNOLOGY CO Ltd
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Priority to CN201610889602.6A priority Critical patent/CN106309749A/en
Publication of CN106309749A publication Critical patent/CN106309749A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533Leonurus (motherwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/748Oldenlandia or Hedyotis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/84Valerianaceae (Valerian family), e.g. valerian
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a traditional Chinese medicine for treating cervical cancer. The traditional Chinese medicine is prepared from sarcandra glabra, mother chrysanthemum, sweet wormwood, radix sophorae flavescentis, fructus akebiae, spicate clerodendranthus herb, patrinia, hairyvein agrimony, oldenlandia diffusa, motherwort and scutellaria baicalensis. The medicine can achieve the aims of effectively improving the immunologic functions of patients suffering from cervical cancer, improving the constitution, inhibiting and killing cancer cells, softening and reducing tumors and increasing endurance of the patients suffering from cervical cancer; and moreover, reoccurrence and metastasis of the cervical cancer can be prevented, and the opportunity of treatment is increased.

Description

A kind of Chinese medicine treating cervical cancer
Technical field
The invention mainly relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine treating cervical cancer.
Background technology
Cervical cancer has generation all over the world, is one of modal carcinoma of human body, not only in female sex organ cancer Tumor accounts for first place, and is carcinoma the most common in the various malignant tumor of women, but its sickness rate has obvious regional difference.I The generation of state's cervical cancer, the feature in geographical distribution is that district occurred frequently often connects in flakes.Each province's cervical cancer relative to district occurred frequently city, The most often there is interconnection phenomenon in county.Total trend is that rural area is higher than city, mountain area higher than Plain.According to 29 provinces, municipalities and autonomous regions Retrospective survey China Mortality of cervix cancer accounts for the 4th of total cancer mortality, accounts for the second of women cancer.Cervical cancer patient Average age of onset, various countries, various places report are the most variant, and China's age of onset is most with 40~50 years old, and 60~have again for 70 years old One peak occurs, rare before 20 years old.
The western medical treatment mode of cervical cancer is our known operative treatment, radiotherapy, chemotherapy.Western medical treatment Although instant effect, but easily recur, side effect is big.So in for, the expectant treatment in late period, or the Radiotherapy chemotherapy after early operation Auxiliary treatment, the traditional Chinese medical science plays an important role, but the most uncertain therapeutic efficacy of existing Chinese medicine formula is cut.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine treating cervical cancer, all select natural Chinese medicinal herb, it is possible to effectively Treatment cervical cancer.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine treating cervical cancer, is made up of the crude drug of following parts by weight: Herba Sarcandrae 30 parts, Flos Chrysanthemi Indici 60 parts, green grass or young crops Artemisia 90 parts, Radix Sophorae Flavescentis 30 parts, Fructus Akebiae 60 parts, Herba clerodendranthi spicati 30 parts, Herba Patriniae 60 parts, Herba Agrimoniae 60 parts, Herba Hedyotidis Diffusae 60 parts, benefit Herba Linderniae Crustaceae 30 parts, Radix Scutellariae 15 parts.
The invention have the advantage that
Chinese medicine of the present invention has heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating, detumescence and promoting granulation, effect of inrigorating qi and promoting blood circulation, and it uses treating both the principal and secondary aspects of a disease Method, strengthening vital QI to eliminate pathogenic factors, alleviating pain, body immunity, the growth of suppression cancer cell can be strengthened, and it is thin to kill cancer further Born of the same parents, reach to cure the purpose of cervical cancer.
Detailed description of the invention:
A kind of Chinese medicine treating cervical cancer, the weight (g) of its each raw material components is: Herba Sarcandrae 30, Flos Chrysanthemi Indici 60, Herba Artemisiae Annuae 90, hardship Ginseng 30, Fructus Akebiae 60, Herba clerodendranthi spicati 30, Herba Patriniae 60, Herba Agrimoniae 60, Herba Hedyotidis Diffusae 60, Herba Leonuri 30, Radix Scutellariae 15.
By proportioning weigh Herba Sarcandrae, Flos Chrysanthemi Indici, Radix Sophorae Flavescentis, Fructus Akebiae, Herba clerodendranthi spicati, Herba Patriniae, Herba Agrimoniae, Herba Hedyotidis Diffusae, Radix Scutellariae, the 100 DEG C of heating of water adding 10 times amount (V/W) are concentrated into original volume 1/5, and filter to get filtrate A;
Take Herba Artemisiae Annuae, Herba Leonuri in proportion, add 10% EtOH Sonicate (500W, 80kHz) and extract 1h, filter, filtrate is placed in 60 DEG C After volatilizing solvent, it is mixed in filtrate A and prepares potion.Take at twice, every day potion.
For proving that the present invention has a good curative effect, clinical data and to enumerate model case as follows:
Clinical observation
1, clinical data: selected from outpatient service and inpatient totally 78 example, the wherein early cervical carcinoma in June, 2011 in JIUYUE, 2012 26 examples.Age is 48-64 year, average 56.4 years old.
2, diagnostic criteria: with the diagnosis of cervical cancer mark in " China's common cancer diagnosis and treatment specification " that China's Ministry of Public Health is compiled Standard is foundation.Clinical stages, all belongs to II phase, III phase, IV phase.Meet standard and the visitor of " China's common cancer diagnosis and treatment specification " See efficacy assessment standard, use WHO standard to evaluate.
3, Therapeutic Method: take medicine of the present invention, sooner or later take at twice.It within 1 month, it is 1 course for the treatment of.
4, efficacy assessment standard: according to Ministry of Public Health " China's common cancer diagnosis and treatment specification " cervical cancer efficacy evaluation mark Standard, with before patient treatment with treatment after B super or CT compares, alleviate (PR), stable with complete incidence graph (CR), part (SD), progress (PD) carries out efficacy evaluation.
5, therapeutic outcome: complete incidence graph 62 example, part is alleviated 7 examples, is stablized 9 examples, is in progress 0 example.Effective percentage (CR+PR) is 88.5%, coefficient of stabilization (CR+PR+SD) is 100%.(tumor all disappears to have 20 examples to cure the most in early days in 26 example early cervical carcinomas Lose, follow up a case by regular visits to 1 year not recur).
In sum, the present invention, for treating the medicine of cervical cancer, through clinical trial, shows that it can effectively suppress cervical cancer Development, improves patients symptomatic, sign, and without obvious toxic-side effects.
Case one:
Zhu, man, 49 years old.This patient's hemorrhage of cervix, is diagnosed as cervical cancer in early days through examination in hospital.?
In western medical treatment and chemotherapy process, nausea and vomiting, inappetence, stop treatment.Through taking Drug therapy one of the present invention After the individual course for the treatment of, there is not bleeding in cervix uteri, and vaginal secretions is normal, after the course for the treatment of of continuing to take medicine, and transference cure, extensive Multiple normal.
Case two:
Mrs Zhao, 38 years old., there is haemorrhagia sub coitu symptom in patient's lower abdominal pain the most often, and recent leucorrhea is many and has abnormal flavour.Go doctor It is cervical cancer that institute makes a definite diagnosis on inspection, and after taking two courses for the treatment of of Drug therapy of the present invention, bleeding substantially eliminates, hypogastralgia Alleviating, leucorrhea is normal, and after two courses for the treatment of of continuing to take medicine, rehabilitation is fully recovered.
Case three:
Solemn so-and-so, female, 48 years old, people from Xi'an.Patient, because of abnormal vaginal bleeding more than a year, has 3 by certain examination in hospital cervix uteri Individual scleroma, contact bleeding.Being diagnosed as the cervical cancer second phase, after five courses for the treatment of of row radiotherapy, aggravation, vaginal hemorrhage amount is many, weak Few gas Mental fatigue, lower abdominal distention pain.Taking two courses for the treatment of of treatment by Chinese herbs of the present invention, symptom takes a turn for the better, and sensation of oppression over the chest with shortness of breath alleviates, and lower abdomen pain subtracts Gently, food of receiving increases, and two is the most normal.Top plus-minus two courses for the treatment of of following the service, symptom disappears substantially.

Claims (2)

1. the Chinese medicine treating cervical cancer, it is characterised in that be made up of the crude drug of following parts by weight: Herba Sarcandrae 30 parts, open country Flos Chrysanthemi 60 parts, Herba Artemisiae Annuae 90 parts, Radix Sophorae Flavescentis 30 parts, Fructus Akebiae 60 parts, Herba clerodendranthi spicati 30 parts, Herba Patriniae 60 parts, Herba Agrimoniae 60 parts, Agkistrodon SHECAO 60 parts, Herba Leonuri 30 parts, Radix Scutellariae 15 parts.
A kind of Chinese medicine treating cervical cancer the most according to claim 1, it is characterised in that comprise the following steps:
1) proportioning as described in claim 1 weigh Herba Sarcandrae, Flos Chrysanthemi Indici, Radix Sophorae Flavescentis, Fructus Akebiae, Herba clerodendranthi spicati, Herba Patriniae, Herba Agrimoniae, Herba Hedyotidis Diffusae, Radix Scutellariae, the 100 DEG C of heating of water adding 10 times amount are concentrated into original volume 1/5, and filter to get filtrate A;
2) proportioning as described in claim 1 takes Herba Artemisiae Annuae and Herba Leonuri, adds 10% ethanol solution and is placed in power 500W, frequency 80kHz Ultrasonic container in extract 1h, filter, filtrate is placed in 60 DEG C volatilize solvent after, be mixed in filtrate A prepare.
CN201610889602.6A 2016-10-12 2016-10-12 Traditional Chinese medicine for treating cervical cancer Pending CN106309749A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110507734A (en) * 2019-09-21 2019-11-29 王冶 A kind of Chinese medicine composition of auxiliary treatment of cervical carcinoma and preparation method thereof
CN112426500A (en) * 2020-08-15 2021-03-02 仲崇允 Traditional Chinese medicine composition for treating cervical cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1287839A (en) * 2000-09-07 2001-03-21 周春熙 Compound injection for treating cancer and prepn. method therefor
CN1265808C (en) * 2003-05-29 2006-07-26 广东省一七七医院 Combination of medication for anti herpes virus and its application
CN1954870A (en) * 2005-10-26 2007-05-02 黄振华 Medical composite prepared by sarcandra and oldenlandia
CN102671129A (en) * 2012-05-21 2012-09-19 唐武 Traditional Chinese medicine compound for treating cervical cancer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1287839A (en) * 2000-09-07 2001-03-21 周春熙 Compound injection for treating cancer and prepn. method therefor
CN1265808C (en) * 2003-05-29 2006-07-26 广东省一七七医院 Combination of medication for anti herpes virus and its application
CN1954870A (en) * 2005-10-26 2007-05-02 黄振华 Medical composite prepared by sarcandra and oldenlandia
CN102671129A (en) * 2012-05-21 2012-09-19 唐武 Traditional Chinese medicine compound for treating cervical cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
孙长岗 等: "《中西医结合肿瘤学(第一版)》", 31 December 2015, 科学技术文献出版社 *
肖国土 等: "《中医秘方全书(第一版)》", 30 June 2012, 湖南科技出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110507734A (en) * 2019-09-21 2019-11-29 王冶 A kind of Chinese medicine composition of auxiliary treatment of cervical carcinoma and preparation method thereof
CN112426500A (en) * 2020-08-15 2021-03-02 仲崇允 Traditional Chinese medicine composition for treating cervical cancer

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Application publication date: 20170111