CN107715051A - A kind of Chinese medicine preparation for reducing blood lipid hypotensive - Google Patents
A kind of Chinese medicine preparation for reducing blood lipid hypotensive Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine preparation for reducing blood lipid hypotensive, including 10 ~ 16 parts of 12 ~ 20 parts of 15 ~ 23 parts of the red sage root, cassia seed, giant knotweed in parts by weight, 8 ~ 12 parts of ganoderma lucidum, 10 ~ 14 parts of oriental wormwood, 12 ~ 16 parts of hawthorn, 16 ~ 22 parts of Poria cocos, 15 ~ 23 parts of radix bupleuri, 12 ~ 16 parts of the tuber of multiflower knotweed, 14 ~ 18 parts of rhizoma alismatis, 10 ~ 16 parts of radix scutellariae, 14 ~ 20 parts of cordyceps sinensis, 12 ~ 16 parts of turmeric.The beneficial effects of the invention are as follows：The present invention is based on the understanding and principle of reatment to hyperlipidemic conditions mechanism, using directly oral method, has the effect for reducing serum levels of triglyceride and cholesterol and effectively preventing and treating cardiovascular and cerebrovascular disease, it is evident in efficacy, quality is easily controlled, and stability is good, has no adverse reaction substantially.
Description
Technical field
The present invention relates to the field of Chinese medicines, is a kind of Chinese medicine preparation for reducing blood lipid hypotensive specifically.
Background technology
The cardiovascular and cerebrovascular diseases such as coronary heart disease, myocardial infarction, headstroke are clinically common a kind of diseases, the incidence of disease and dead
The rate of dying is first of various diseases, has seriously endangered the life and health of the mankind.And hyperlipemia is atherosclerosis, coronary disease
Disease, headstroke, the inducement of myocardial infarction, therefore plasma cholesterol, triglyceride, low-density lipoprotein are reduced to preventing and treating above-mentioned disease
Disease is particularly significant.Myocardial infarction and coronary artery blood vessel and its microcirculatory vascular tension force are too high also relevant, and antiotasis is too high and blood
Triglyceride, cholesterol level are too high also relevant in slurry, it is now recognized that the above-mentioned and too strong close relation of activity of calcium channels, therefore it is anti-
It is particularly important with cholesterol and triglyceride in anticalcium and reduction blood plasma to control myocardial infarction.Clinic proves, reduces plasma cholesterol
And triglyceride levels, the danger of myocardial infarction can be reduced.
The lipid-lowering medicine clinically used at present is such as：Meglutol list acyl coenzyme A (HMG-CoA) reductase inhibitor, algae
Though the Western medicine such as sour double fat sodium, clofibrate, nicotinic acid, Cholestyramine have the effect of preferable, stronger toxic side effect is respectively provided with, it is uncomfortable
The prolonged application of patient Yu is to prevent and treat cardiovascular and cerebrovascular disease.
The content of the invention
It is an object of the invention to provide a kind of Small side effects, curative effect is fast, the reducing blood lipid hypotensive that is used for of significant effect
Chinese medicine preparation.
The present invention is achieved through the following technical solutions：A kind of Chinese medicine preparation for reducing blood lipid hypotensive, including with weight
15 ~ 23 parts of the red sage root of part meter, 12 ~ 20 parts of cassia seed, 10 ~ 16 parts of giant knotweed, 8 ~ 12 parts of ganoderma lucidum, 10 ~ 14 parts of oriental wormwood, hawthorn 12 ~ 16
Part, 16 ~ 22 parts of Poria cocos, 15 ~ 23 parts of radix bupleuri, 12 ~ 16 parts of the tuber of multiflower knotweed, 14 ~ 18 parts of rhizoma alismatis, 10 ~ 16 parts of radix scutellariae, cordyceps sinensis 14 ~ 20
Part, 12 ~ 16 parts of turmeric.
A kind of bulk drug pharmacology of Chinese medicine composition for reducing blood lipid hypotensive of the present invention：
The red sage root：Cold nature, bitter.Thoughts of returning home warp, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation dysmenorrhoea, relieving restlessness that clears away heart-fire.Belong to lower point of drug for invigorating blood circulation and eliminating stasis
The blood-activating and menstruation-regulating medicinal of class.
Cassia seed：Cold nature, it is bitter, sweet.Return liver warp, kidney channel, large intestine channel.Heat-clearing improving eyesight, relax bowel.Belong under antipyretic
The deficient heat clearing drug of classification.
Giant knotweed：Cold nature, mildly bitter flavor.Return liver warp, gallbladder channel, lung channel.It is expelling wind and removing dampness, blood stasis removing analgesic, relieving cough and reducing sputum.Belong to Li Shui
The damp-excreting anti-icteric medicinal classified under excreting dampness medicine.
Ganoderma lucidum：It is mild-natured, it is sweet.Thoughts of returning home warp, lung channel, Liver Channel, kidney channel.It is invigorating qi for tranquilization, relieving cough and asthma.Belong to qi-restoratives medicine subordinate point
The Qi-tonifying drug of class.
Oriental wormwood：It is bitter, pungent, it is slightly cold.Returns spleen, stomach, liver, gallbladder channel.Clearing heat and promoting diuresis；Removing jaundice.
Hawthorn：Slightly warm in nature, it is sour, sweet.Returns spleen warp, stomach, Liver Channel.Digestion-promoting spleen-invigorating, promoting the circulation of qi dispersing blood stasis.Belong to digestants.
Poria cocos：It is mild-natured, it is sweet, light.Thoughts of returning home warp, lung channel, the spleen channel, kidney channel.Clearing damp and promoting diuresis, invigorating the spleen calming heart.Belong to clearing damp and promoting diuresis
The edema-alleviating diuretic of medicine subordinate classification.
Radix bupleuri：Cold nature, bitter.Return liver warp, gallbladder channel, lung channel.With in inducing diaphoresis, soothing the liver, rising Yang.Belong to diaphoretic medicine subordinate classification
Cold-pungent and diaphoretic drugs.
The tuber of multiflower knotweed：It is warm-natured, it is bitter, sweet, puckery.Return liver warp, kidney channel, the heart channel of Hang-Shaoyin.Detoxify, the carbuncle that disappears, relax bowel.Belong to lower point of purgatives medicine
The laxative drug of class.
Rhizoma alismatis：It is cold in nature, it is sweet, light.Return kidney channel, bladder warp.Diuresis, clearing away damp-heat.The profit classified under category damp-clearing drug
Urinate stranguria-relieving medicinal.
Radix scutellariae：It is cold in nature, bitter.Return lung warp, gallbladder channel, the spleen channel, large intestine channel, small intestinl channel.Heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis,
It is antiabortive.Belong to the heat-clearing and damp-drying drug of antipyretic subordinate classification.
Cordyceps sinensis：It is mild-natured, it is sweet.Return lung warp, kidney channel.Invigorate the lung and the kidney, stop blooding, resolving sputum.Belong to qi-restoratives medicine subordinate classification
Yang-tonifying drug.
Turmeric：It is warm-natured, it is bitter, pungent.Returns spleen warp, Liver Channel.It is blood-breaking, inducing meastruation to relieve menalgia.Belong to drug for invigorating blood circulation and eliminating stasis subordinate classification
Blood-activating analgesic.
Including 16 parts of 12 parts of 15 parts of the red sage root, cassia seed, giant knotweed by weight, 12 parts of ganoderma lucidum, 14 parts of oriental wormwood, hawthorn 12
Part, 16 parts of Poria cocos, 15 parts of radix bupleuri, 16 parts of the tuber of multiflower knotweed, 14 parts of rhizoma alismatis, 10 parts of radix scutellariae, 14 parts of cordyceps sinensis, 12 parts of turmeric.
Including 10 parts of 18 parts of 18 parts of the red sage root, cassia seed, giant knotweed by weight, 9 parts of ganoderma lucidum, 10 parts of oriental wormwood, 16 parts of hawthorn,
22 parts of Poria cocos, 23 parts of radix bupleuri, 12 parts of the tuber of multiflower knotweed, 18 parts of rhizoma alismatis, 16 parts of radix scutellariae, 20 parts of cordyceps sinensis, 16 parts of turmeric.
Including 3 parts of 20 parts of 23 parts of the red sage root, cassia seed, giant knotweed by weight, 8 parts of ganoderma lucidum, 12 parts of oriental wormwood, 14 parts of hawthorn,
20 parts of Poria cocos, 18 parts of radix bupleuri, 14 parts of the tuber of multiflower knotweed, 16 parts of rhizoma alismatis, 13 parts of radix scutellariae, 17 parts of cordyceps sinensis, 16 parts of turmeric.
The described red sage root, cassia seed, giant knotweed, ganoderma lucidum, oriental wormwood, hawthorn, Poria cocos, radix bupleuri, the tuber of multiflower knotweed, rhizoma alismatis, radix scutellariae, worm summer in winter
Grass, turmeric decoct and taken.
The present invention compared with prior art, has advantages below and beneficial effect：
The present invention is based on the understanding and principle of reatment to hyperlipidemic conditions mechanism, and using directly oral method, having reduces
Serum levels of triglyceride and cholesterol and the effect for effectively preventing and treating cardiovascular and cerebrovascular disease, evident in efficacy, quality is easily controlled, stable
Property is good, has no adverse reaction substantially.
Embodiment
The present invention is described in further detail with reference to embodiment, but the implementation of the present invention is not limited to this.
Embodiment 1：
A kind of Chinese medicine preparation for reducing blood lipid hypotensive, including 12 ~ 20 parts of 15 ~ 23 parts of the red sage root, cassia seed in parts by weight,
10 ~ 16 parts of giant knotweed, 8 ~ 12 parts of ganoderma lucidum, 10 ~ 14 parts of oriental wormwood, 12 ~ 16 parts of hawthorn, 16 ~ 22 parts of Poria cocos, 15 ~ 23 parts of radix bupleuri, the tuber of multiflower knotweed 12
~ 16 parts, 14 ~ 18 parts of rhizoma alismatis, 10 ~ 16 parts of radix scutellariae, 14 ~ 20 parts of cordyceps sinensis, 12 ~ 16 parts of turmeric.
The red sage root that the present invention uses is drug for invigorating blood circulation and eliminating stasis, there is blood circulation promoting nourishes blood effect, has antiplatelet, anti-freezing, improves the heart
Brain blood supply, decompression, lipid-loweringing, anti-trioxypurine effect.Turmeric can declare the gas in logical blood, make gas row and blood is not stopped up stagnant, and have inducing meastruation to relieve menalgia
The effect of.
Turmeric can increase bile and be formed and be secreted, and make cholic acid and the cholesterol increase drained in excrement.Although turmeric promotes
The effect of choleresis is weaker, but more lasting.Turmeric can also increase fibrinous dissolving activity, there is antithrombotic work
With.Cassia seed has the function that to suppress serum cholesterol rise and atherosclerotic plaque formation.Its lowering blood pressure and blood fat,
Antibacterial and other effects is notable.
The tuber of multiflower knotweed contributes to the operating of fat containing compositions such as abundant lecithin, starch.Tuber of multiflower knotweed ester derivant containing anthracene, it can make
Enterocinesia strengthens and suppressed cholesterol absorption；The tuber of multiflower knotweed can also prevent cholesterol from being detained or penetrate into intrahepatic deposition, in serum
In endarterium, to slow down atherogenesis.
Giant knotweed contains anthraquinone analog compound and flavonoids Multiple components, can extract from its rhizome white with component for reducing blood fat
Veratryl alcohol glycosides etc., play the role of to reduce cholesterol and triglycerides.
Rhizoma alismatis is a kind of good medicine for removing dirty substance in blood in human body in liquid and tissue.Its suction by disturbing cholesterol
Receive, decompose and drain, that is, suppress the absorption of cholesterol and triglyceride in food, influence the metabolism of internal cholesterol, accelerate sweet
The hydrolysis of oily three fat suppresses synthesis of the liver to it, and plays the effect for reducing serum cholesterol, triglyceride.It is in addition, damp
Rush down still have necessarily resist myocardial ischemia, be depressured, hypoglycemic and anti-fatty liver etc. acts on.
The compositions such as baicalein that radix scutellariae contains, Chinese Huang glucoside member, baicalin have effect for reducing blood fat.
Radix bupleuri, which has, to be dredged gas, Xie Yu, dissipates effect of fire.Serum courage is can significantly decrease for hypercholesterolemiapatients patients to consolidate
Alcohol and triglyceride levels, saikosaponin saikoside suppresses the fat splitting in the fat storehouse of adrenaline and ATCH inductions, while suppresses pancreas
Island element promote lipid nucleus formation and reduce fat content in blood, saikosaponin saikoside also increases cholesterol and its metabolite from courage
Drain in juice and in excrement.
Cassia seed contains phytosterol and anthraquinones, has and suppresses serum cholesterol rise and atherosclerotic plaque
The effect that block is formed.Lowering blood pressure and blood fat, antibacterial and other effects are notable.
Ganoderma lucidum can reduce serum cholesterol, triacylglycerol and low-density lipoprotein, increasing high density lipoprotein.Meanwhile
WBV and plasma viscosity can also be reduced, improves hemorheology obstacle.The hepatoprotective effect of ganoderma lucidum can prevent or mitigate chemistry
Hepatic injury caused by synthesis regulation blood fat medicine.
Oriental wormwood herb contains volatile oil about 0.23%, and main component is nopinene, capillen, capillon etc. in oil, these compositions
High fat of blood can not only be reduced, can also allevating angina pectoris and improvement electrocardiogram.
Hawthorn has expansion blood vessel, reduces blood pressure, reduces cholesterol, increasing gastric juice and disappear containing the material such as crataegolic acid, tartaric acid
Change enzyme etc. to use.
The method of the present embodiment medicine preparation, including following steps：
Step S1：In parts by weight, 15 ~ 23 parts of the red sage root, 12 ~ 20 parts of cassia seed, 10 ~ 16 parts of giant knotweed, 8 ~ 12 parts of ganoderma lucidum, mattress are weighed
Old 10 ~ 14 parts, 12 ~ 16 parts of hawthorn, 16 ~ 22 parts of Poria cocos, 15 ~ 23 parts of radix bupleuri, 12 ~ 16 parts of the tuber of multiflower knotweed, 14 ~ 18 parts of rhizoma alismatis, radix scutellariae 10 ~
16 parts, 14 ~ 20 parts of cordyceps sinensis, 12 ~ 16 parts of turmeric；
Step S2：By above-mentioned whole Chinese medicine material medicines, to be soaked 30 minutes with clear water or pure water in advance, water consumption for immersion is 1 ~
1.2L；
Step S3：Chinese medicine material medicine after immersion and its liquid medicine of immersion are added in decocting container, capping decocts jointly
Two hours, dosing included following steps：
Step S301：First the red sage root, cassia seed, giant knotweed, ganoderma lucidum, oriental wormwood are added in decocting container and decocted 10 minutes with small fire；
Step S302：Hawthorn, Poria cocos, radix bupleuri, the tuber of multiflower knotweed, rhizoma alismatis are added in decocting container again and decocted 10 minutes with small fire；
Step S303：Radix scutellariae, cordyceps sinensis, turmeric are added in decocting container again；
Step S4：Decocting container herb liquid is seethed with excitement with high heat, reuse slow fire and boil 20 ~ 25 minutes, 2 need to be stirred when boiling medicine
~ 3 times；
Step S5：After the completion of decoction, decoction is filtered out, it is endo-medicine to obtain decoction.
Step S6：Second is carried out using 0.7 ~ 0.8L clear water or pure water repeat step S3 ~ S5 to decoct one hour；
Third time is carried out using 0.5 ~ 0.6L clear water or pure water repeat step S3 ~ S5 to decoct one hour.
Embodiment 2：
In the present embodiment, including 16 parts of 12 parts of 15 parts of the red sage root, cassia seed, giant knotweed by weight, 12 parts of ganoderma lucidum, 14 parts of oriental wormwood,
12 parts of hawthorn, 16 parts of Poria cocos, 15 parts of radix bupleuri, 16 parts of the tuber of multiflower knotweed, 14 parts of rhizoma alismatis, 10 parts of radix scutellariae, 14 parts of cordyceps sinensis, 12 parts of turmeric.
Embodiment 3：
In the present embodiment, including 10 parts of 18 parts of 18 parts of the red sage root, cassia seed, giant knotweed by weight, 9 parts of ganoderma lucidum, 10 parts of oriental wormwood, mountain
16 parts of short, bristly hair or beard, 22 parts of Poria cocos, 23 parts of radix bupleuri, 12 parts of the tuber of multiflower knotweed, 18 parts of rhizoma alismatis, 16 parts of radix scutellariae, 20 parts of cordyceps sinensis, 16 parts of turmeric.
Embodiment 4：
In the present embodiment, including 3 parts of 20 parts of 23 parts of the red sage root, cassia seed, giant knotweed by weight, 8 parts of ganoderma lucidum, 12 parts of oriental wormwood, mountain
14 parts of short, bristly hair or beard, 20 parts of Poria cocos, 18 parts of radix bupleuri, 14 parts of the tuber of multiflower knotweed, 16 parts of rhizoma alismatis, 13 parts of radix scutellariae, 17 parts of cordyceps sinensis, 16 parts of turmeric.
Toxicology test：
Acute toxicity test：
Experimental observation, because LD50 can not be measured, therefore the measure of maximum dosage-feeding is carried out.Chinese medicine compound prescription prepared by embodiment 1
Mixture is dissolved in sterile saline, is configured to solution gavage mouse, is as a result shown, is given birth to medicine maximum administration concentration 9.65
Medicine/ml, for maximum administered volume 50ml/kg in being administered twice in 24 hours to mouse stomach, mouse maximum dosage-feeding is 763.25g
Crude drug/kg, animal do not occur adverse reaction and death, each internal organs no abnormality seen of anatomic observation.
Long term toxicity test：
SD rats 80 are applied in this experiment, and Chinese medicine compound prescription mixture prepared by embodiment 1 is dissolved in sterile saline, configuration
Into solution gavage, if control group and 24g, 35g, 49g crude drug/kg dosage groups, continuous gavage is administered 12 weeks, observes in the present invention
Influence of the drug composition to animal indices.Result of the test shows that successive administration 12 weeks, Chinese medicine composition of the invention is to big
The body weight of mouse, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index etc. have no significant effect；Blood biochemical 12
Item index determining result, 12 weeks low dose group BiLi values of administration are higher than control group（P<0.05)；Low dose group, middle dose group TP values
Higher than control group（P<0.05), but within normal physiologic range, other indexs no significant difference compared with control group.Recover
Phase each administration group indices measured value and the more equal no significant difference of control group.Each internal organs gross examination of skeletal muscle no abnormality seen of each group.
The clinical statisticses data of various hyperlipemic patients is directed to using medicine of the present invention：
By the Clinical practice of 300 patients, wherein male patient 173, female patient 127, medication age object 30 ~ 60 years old.Its
It is middle minimum 30 years old, maximum 60 years old, average age 45 years old.
Lee, man, 54 years old.Dizzy alliteration blurring of vision, high pressure, high fat 4 years, the mmHg of blood pressure 180/110, sweet before medication
Three ester 4.8mmol/L of oil, after two months, blood pressure is steadily 135/85mmHg, blood fat 1.4mmol/L for medication, and dizzy alliteration is delayed
Solution is clear depending on thing.
Mr. Wang, male, 57 years old, the high fat of high pressure 6 years, before medication, blood pressure 190/100mmHg, triglycerides 5.3mmol/L, the heart
Angina, shortness of breath uncomfortable in chest, medication three months, blood pressure are down to 138/80mmHg, triglycerides 1.6mmol/L, while shortness of breath uncomfortable in chest,
Angina pectoris relative remission.
It is described above, be only presently preferred embodiments of the present invention, any formal limitation not done to the present invention, it is every according to
Any simply modification, the equivalent variations made according to the technical spirit of the present invention to above example, each fall within the protection of the present invention
Within the scope of.
Claims (5)
- A kind of 1. Chinese medicine preparation for reducing blood lipid hypotensive, it is characterised in that：Including 15 ~ 23 parts of the red sage root in parts by weight, 12 ~ 20 parts of cassia seed, 10 ~ 16 parts of giant knotweed, 8 ~ 12 parts of ganoderma lucidum, 10 ~ 14 parts of oriental wormwood, 12 ~ 16 parts of hawthorn, 16 ~ 22 parts of Poria cocos, radix bupleuri 15 ~ 23 parts, 12 ~ 16 parts of the tuber of multiflower knotweed, 14 ~ 18 parts of rhizoma alismatis, 10 ~ 16 parts of radix scutellariae, 14 ~ 20 parts of cordyceps sinensis, 12 ~ 16 parts of turmeric.
- A kind of 2. Chinese medicine preparation for reducing blood lipid hypotensive according to claim 1, it is characterised in that：Including with weight 16 parts of 12 parts of 15 parts of the red sage root, cassia seed, the giant knotweed of meter, 12 parts of ganoderma lucidum, 14 parts of oriental wormwood, 12 parts of hawthorn, 16 parts of Poria cocos, radix bupleuri 15 Part, 16 parts of the tuber of multiflower knotweed, 14 parts of rhizoma alismatis, 10 parts of radix scutellariae, 14 parts of cordyceps sinensis, 12 parts of turmeric.
- A kind of 3. Chinese medicine preparation for reducing blood lipid hypotensive according to claim 1, it is characterised in that：Including with weight 10 parts of 18 parts of 18 parts of the red sage root, cassia seed, the giant knotweed of meter, 9 parts of ganoderma lucidum, 10 parts of oriental wormwood, 16 parts of hawthorn, 22 parts of Poria cocos, 23 parts of radix bupleuri, 12 parts of the tuber of multiflower knotweed, 18 parts of rhizoma alismatis, 16 parts of radix scutellariae, 20 parts of cordyceps sinensis, 16 parts of turmeric.
- A kind of 4. Chinese medicine preparation for reducing blood lipid hypotensive according to claim 1, it is characterised in that：Including with weight 3 parts of 20 parts of 23 parts of the red sage root, cassia seed, the giant knotweed of meter, 8 parts of ganoderma lucidum, 12 parts of oriental wormwood, 14 parts of hawthorn, 20 parts of Poria cocos, 18 parts of radix bupleuri, 14 parts of the tuber of multiflower knotweed, 16 parts of rhizoma alismatis, 13 parts of radix scutellariae, 17 parts of cordyceps sinensis, 16 parts of turmeric.
- A kind of 5. Chinese medicine preparation for reducing blood lipid hypotensive according to claim 1, it is characterised in that：Described pellet Ginseng, cassia seed, giant knotweed, ganoderma lucidum, oriental wormwood, hawthorn, Poria cocos, radix bupleuri, the tuber of multiflower knotweed, rhizoma alismatis, radix scutellariae, cordyceps sinensis, turmeric decoct and taken.
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| CN201710755850.6A CN107715051A (en) | 2017-08-29 | 2017-08-29 | A kind of Chinese medicine preparation for reducing blood lipid hypotensive |
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| CN201710755850.6A CN107715051A (en) | 2017-08-29 | 2017-08-29 | A kind of Chinese medicine preparation for reducing blood lipid hypotensive |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042841A (en) * | 2014-06-30 | 2014-09-17 | 曹健 | Traditional Chinese medicine preparation for treating hyperlipidemia |
| CN106421474A (en) * | 2016-11-07 | 2017-02-22 | 成都泠汐尚品科技有限公司 | Formula for traditional Chinese medicines capable of lowering blood lipid |
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2017
- 2017-08-29 CN CN201710755850.6A patent/CN107715051A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042841A (en) * | 2014-06-30 | 2014-09-17 | 曹健 | Traditional Chinese medicine preparation for treating hyperlipidemia |
| CN106421474A (en) * | 2016-11-07 | 2017-02-22 | 成都泠汐尚品科技有限公司 | Formula for traditional Chinese medicines capable of lowering blood lipid |
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