CN100438898C - Orally taken medicine for treating climacteric xerophthalmia and its prepn - Google Patents
Orally taken medicine for treating climacteric xerophthalmia and its prepn Download PDFInfo
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- CN100438898C CN100438898C CNB2005100476216A CN200510047621A CN100438898C CN 100438898 C CN100438898 C CN 100438898C CN B2005100476216 A CNB2005100476216 A CN B2005100476216A CN 200510047621 A CN200510047621 A CN 200510047621A CN 100438898 C CN100438898 C CN 100438898C
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Abstract
The present invention relates to orally taken medicine for treating climacteric xerophthalmia, of which the composing prescriptions are composed of raw materials of the following weight ratios: 10 to 15 of ophiopogon root, 3 to 6 of licorice root, 8 to 12 of phellodendron bark, 8 to 12 of anemarrhenae, 8 to 12 of curculigo rhizome, 8 to 12 of Epimedium, 6 to 10 of sun-dried ginseng, 6 to 10 of pinellia tuber, 8 to 12 of angelica root, and 8 to 12 of morinda root. The present invention is physic liquor obtained from decocting the raw materials. The method for preparing the medicine is as follows: a, medicinal materials are taken for a soak, raw materials of the various medicinal materials are taken according to the weight ratios in the prescriptions, the various medicinal materials are put in a herb decocting clay pot, water is added to the herb decocting clay pot to immerse the medicinal materials for a soak of 25 minutes to 35 minutes; b, physic liquor is decocted and concentrated, the well soaked raw materials are heated and decocted for 40 minutes on slow fire, the decocted physic liquor is taken out, water of which the weight is 7 to 11 times of the total weight of the raw material is added to residual dregs of decoction to heat and to decocte for 30 minutes on slow fire, the physic liquor decocted twice is combined after the physic liquor is disposed of dregs of decoction to obtain the present invention. The present invention has the advantages of high curative effect and little side effect, and raw materials of the medicinal materials are simple and easy to obtain.
Description
One, technical field:
The invention belongs to a kind of medicament and preparation method for the treatment of oculopathy of making, especially relate to kind of oral drugs that treatment climacteric eyes are dry and its preparation method.
Two, background technology:
Xerophthalmia is meant because the tear film that causes unusually of the matter of tear or amount is unstable and the eye surface damage, thereby causes a class disease of ophthalmic uncomfortable symptom.The patient has asthenopia, foreign body sensation, eyelid is heavy, dry and astringent, the eye burning sensation of eye, ophthalmic pruritus is come the ophthalmology outpatient service when photophobia, symptom such as furious and is examined, as be diagnosed as xerophthalmia just should be at etiological treatment.
During tradition western medical treatment xerophthalmia, think more and cause by exopathogenic factor, treatment is also in addition because main, so only adopt the treatment means of doctor trained in Western medicine, effect and bad, thus in western medical treatment, use theory of Chinese medical science carry out in, the doctor trained in Western medicine combined treatment, theory of Chinese medical science thinks that the cause of disease of xerophthalmia is relevant with exopathogenic factor to a certain extent, but the cause of disease of xerophthalmia is relevant with endogenous cause of ill to a great extent.
The traditional Chinese medical science is thought the kidney generating marrow and dominating bone, main water, and main reproduction, and the function of moist internal organs is arranged.The woman seventy-seven, the kidney qi degradation, and menses will cut off, and will be Kidney-Yin deficient, deficiency of kidney yin is disturbed on the asthenic fire, and the yang-energy diminuendo can not be given birth to the moon, YIN-fluid being insufficient then down can not enriching yin and nourishing kidney, and then Liver and kidney loses and supports, and soreness of the waist and knees occurs, dizziness and tinnitus, dysphoria with feverish sensation in the chest palms and soles, the menopause syndrome of insomnia forgetfulness etc., on can not lung moistening support order, dryness of the mouth and throat is then arranged, do with eye simultaneously, puckery, fatigue, ophthalmic pruritus is disturbed on the asthenic fire, then burns the red eye symptom that waits of color.
At present, mainly adopt Western medicine at the direct drop of eye to the treatment of xerophthalmia symptom, do not adopt oral drugs, morbific endogenous cause of ill is regulated, particularly relating to the dry eye patients that climacteric causes does not more have suitable medicine to treat.
Three, summary of the invention:
1, goal of the invention: the invention provides a kind of oral drugs and preparation method for the treatment of the climacteric xerophthalmia, its objective is when solving the xerophthalmia that traditional treatment climacteric causes, do not have suitable medicine that endogenous cause of ill is regulated the problem that aspects such as reaching therapeutic effect exists.
2, technical scheme: the present invention is achieved through the following technical solutions:
A kind of oral drugs for the treatment of the climacteric xerophthalmia is characterized in that: the prescription of this medicine mainly is made up of the raw material of following weight ratio:
Radix Ophiopogonis 10～15: Radix Glycyrrhizae 3～6: Cortex Phellodendri 8～12: the Rhizoma Anemarrhenae 8～12: Rhizoma Curculiginis 8～12: Herba Epimedii 8～12: Radix Ginseng 6～10: the Rhizoma Pinelliae 6～10: Radix Angelicae Sinensis 8～12: crust halberd 8～12; The medicinal liquid of gained promptly after decocting with water.
Above-mentioned gained medicinal liquid is added starch, dextrin, correctives, mix the back and granulate promptly.
A kind of preparation method for the treatment of the oral drugs of climacteric xerophthalmia is characterized in that: the preparation method of this medicine is as follows:
A, the material of getting it filled, immersion: get various medicinal raw materials by the weight ratio of the described prescription of claim 1, various medical materials are put into decocting medicine pot, add water logging and cross medical material, soaked 25～35 minutes;
B, decoction, concentrated medicament: soaked raw material was decocted 10 minutes with slow fire heating, get the liquid of boiling medicine, after in the residue medicinal residues, adding the heating of hydrology fire and decocting 30 minutes, will fry in shallow oil for twice to such an extent that medicinal liquid merges promptly after discarding medicinal residues.
The medicinal liquid that merges the back gained among the above-mentioned steps b is concentrated into the blue or green cream of dark brown, and it is an amount of to add starch, dextrin, correctives then, mixes the back and granulates, and dry back packing promptly.
The starch weight that adds is to make 0.5 times of the blue or green cream weight of dark brown; The weight that adds dextrin be make the blue or green cream weight of dark brown 0.1-0.15 doubly, the correctives of adding is an aspartame, the weight of correctives be make the blue or green cream weight of dark brown 0.02-0.05 doubly.
3, advantage and effect: by the enforcement of technical solution of the present invention, in the time of can solving the xerophthalmia that traditional western medical treatment climacteric causes well, treat because of main beyond many, therapeutic effect is bad, and do not have on the market oral, with the problem of the Chinese patent medicine of interior because main treatment xerophthalmus of climacteric period.Advantage of the present invention is as follows: medicine of the present invention plays the effect of supplementing QI and nourishing YIN, tonifying both YIN and YANG, Chong and Ren Meridians regulating, is applicable to dizziness and tinnitus, soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, dry mouth and throat, the dried order of eye is puckery, menopause syndrome such as insomnia forgetfulness dashes and appoints void to decline, and infrequent menstruation is gradually exhausted, do with eye simultaneously, puckery, fatigue, ophthalmic pruritus, burn the red eye symptom that waits of color.The Chinese medicine that makes through preparation method of the present invention has taking convenience, respectively the distinguish the flavor of drug effect of medical material of maximum performance, and curative effect height, side effect be little, be easy to preserve, and medicinal raw material is simple and easy to.
Four, the specific embodiment:
The present invention is a kind of oral drugs for the treatment of the climacteric xerophthalmia, and it can make decoction and dissolved granule.This drug main will be made up of starch, dextrin, correctives and Chinese prescription, and wherein Chinese prescription is made up of by following weight each medicinal raw material: Radix Ophiopogonis 10～15g: Radix Glycyrrhizae 3～6g: Cortex Phellodendri 8～12g: the Rhizoma Anemarrhenae 8～12g: Rhizoma Curculiginis 8～12g: Herba Epimedii 8～12g: Radix Ginseng 6～10g: the Rhizoma Pinelliae 6～10g: Radix Angelicae Sinensis 8～12g: crust halberd 8～12g; Medical material in the above-mentioned prescription is put into decocting medicine pot, add water 1000ml medical material was all soaked, soaked 30 minutes, the active ingredient of the medicine of respectively distinguishing the flavor of is entered in the water; The slow fire heating decocted 40 minutes, got the liquid of boiling medicine, and the residue medicinal residues add water 800ml, and the slow fire heating decocted 30 minutes, and each active ingredient in the medical material is all extracted in the medicinal liquid like this.To fry in shallow oil for twice to such an extent that medicinal liquid merges after discarding medicinal residues, the gained medicinal liquid can use as decoction.Also can concentrated medicament to the blue or green cream of dark brown, the blue or green cream weight of gained is 10g, the weight that adds starch 5g, adding dextrin in the blue or green cream of the dark brown that concentrates gained is that 1～1.5g, correctives are aspartame, it adds weight is 0.2～0.5g, mix the back and granulate, dry back packing promptly gets dissolved granule of the present invention.
Embodiment 1:
The present invention treats the oral drugs of climacteric xerophthalmia, and the prescription of this medicine mainly is made up of the raw material of following weight: Radix Ophiopogonis 10g: Radix Glycyrrhizae 3g: Cortex Phellodendri 8g: Rhizoma Anemarrhenae 8g: Rhizoma Curculiginis 8g: Herba Epimedii 8g: Radix Ginseng 6g: Rhizoma Pinelliae 6g: Radix Angelicae Sinensis 8g: crust halberd 8g.
The preparation method of medicine of the present invention is undertaken by following step:
A, the material of getting it filled, immersion: the medical material in the above-mentioned prescription is put into decocting medicine pot, add water 900ml, soaked 25 minutes;
B, boil medicine, concentrate: soaked medical material heat on slow fire with above-mentioned decocting medicine pot decocted 40 minutes, get the liquid of boiling medicine, add water 800ml in the residue medicinal residues, slow fire heated decoction after 30 minutes, with frying in shallow oil for twice to such an extent that medicinal liquid merges after discarding medicinal residues, promptly got decoction of the present invention.Also can concentrated medicament to the blue or green cream of dark brown, the blue or green cream weight of gained is 10g; Add starch 5g in the blue or green cream of the dark brown of gained, add dextrin 1g, add aspartame 0.02g, dry back packing promptly gets finished particle electuary of the present invention.
Embodiment 2:
The present invention treats the oral drugs and the preparation method of climacteric xerophthalmia, and the prescription of this medicine mainly is made up of the raw material of following weight: Radix Ophiopogonis 15g: Radix Glycyrrhizae 6g: Cortex Phellodendri 12g: Rhizoma Anemarrhenae 12g: Rhizoma Curculiginis 12g: Herba Epimedii 12g: Radix Ginseng 10g: Rhizoma Pinelliae 10g: Radix Angelicae Sinensis 12g: crust halberd 12g.
The preparation method of medicine of the present invention is undertaken by following step:
A, the material of getting it filled, immersion: the medical material in the above-mentioned prescription is put into decocting medicine pot, add water 1100ml, soaked 35 minutes;
B, boil medicine, concentrate: soaked medical material heat decoction 40 minutes with above-mentioned decocting medicine pot on slow fire, get the liquid of boiling medicine, remain medicinal residues and add water 800ml, the slow fire heating decocted 30 minutes, to fry in shallow oil for twice to such an extent that medicinal liquid merges after discarding medicinal residues, concentrated medicament be to the blue or green cream of dark brown, and the blue or green cream weight of gained is 12g;
Add starch 6g in the blue or green cream of the dark brown of above-mentioned steps b gained, add dextrin 12g, add aspartame 0.6g, dry back packing promptly gets finished particle electuary of the present invention.
Embodiment 3:
The present invention treats the oral drugs and the preparation method of climacteric xerophthalmia, and the prescription of this medicine mainly is made up of the raw material of following weight: Radix Ophiopogonis 12g: Radix Glycyrrhizae 5g: Cortex Phellodendri 10g: Rhizoma Anemarrhenae 10g: Rhizoma Curculiginis 10g: Herba Epimedii 10g: Radix Ginseng 8g: Rhizoma Pinelliae 8g: Radix Angelicae Sinensis 10g: crust halberd 10g.
The preparation method of medicine of the present invention is undertaken by following step:
A, the material of getting it filled, immersion: the medical material in the above-mentioned prescription is put into decocting medicine pot, add water 1000ml, soaked 30 minutes;
B, boil medicine, concentrate: soaked medical material heat decoction 40 minutes with above-mentioned decocting medicine pot on slow fire, get the liquid of boiling medicine, remain medicinal residues and add water 800ml, the slow fire heating decocted 30 minutes, to fry in shallow oil for twice to such an extent that medicinal liquid merges after discarding medicinal residues, concentrated medicament be to the blue or green cream of dark brown, and the blue or green cream weight of gained is 10g;
Add starch 5g in the blue or green cream of the dark brown of above-mentioned steps b gained, add dextrin 1.4g, add aspartame 0.04g, dry back packing promptly gets finished particle electuary of the present invention.
Toxicity summary before clinical:
(1), acute toxicity test
1, once irritate stomach in maximum volume for mice, the medicine of Cmax treatment xerophthalmia, dosage is 231.5g/kg, and toxic reaction does not appear in mice, and none example is dead.
2, give the LD50 and the 95% credible 13.6～12g/kg that is limited to of the medicine of mice once abdominal cavity injection treatment xerophthalmia, toxic reaction does not appear in mice, and none example is dead.
(2), long term toxicity test
This test objective is to estimate the medicine for the treatment of xerophthalmia to rat oral gavage 100g/kg, 40g/kg, 2.00g/kg, six months toxic reaction of successive administration.The experimental session rat does not have death.All Non Apparent Abnormality performances such as the general state of animal, outward appearance sign, behavioral activity, feces character, the hematuria routine, every indexs such as blood biochemical and liver, renal function are all no abnormal through repeatedly checking, main organs index administration group and blank group compare, no significant difference.Each organizes diet, the body weight dynamic change of rat does not have significant difference.Test shows that the following dosage of 100g/kg does not have the cumulative toxicity reaction, is the safe dose scope.
Adopt the clinical drug treatment situation of the treatment xerophthalmia that prescription of the present invention and preparation method make as follows:
Implement case one: name: Kang Yafen; Sex: woman; Age: 41; Prescription on individual diagnosis card number: 133982; Diagnosis: through " DR-1 type xerophthalmia tester " (Japanese KOWA Co., Ltd. make) testing and diagnosing is the severe xerophthalmia.
Use medicine; The decoction that the present invention makes;
Usage and dosage: boiled water is taken after mixing it with water, one time 1 bag, 3 times on the one, take after 30 days check continuously.Be slight xerophthalmia through " DR-1 type xerophthalmia tester " test, effect is obvious.
Implement case two: name: Bao Guizhen; Sex: woman; Age: 67; Prescription on individual diagnosis card number: 176103; Diagnosis: through " DR-1 type xerophthalmia tester " testing and diagnosing is the severe xerophthalmia.
Use medicine; The dissolved granule that the present invention makes;
Usage and dosage: boiled water is taken after mixing it with water, one time 1 bag, 2 times on the one, take after 40 days check continuously.Be slight xerophthalmia through " DR-1 type xerophthalmia tester " test, effect is obvious.
Implement case three: name: Li Na; Sex: woman; Age: 32; Prescription on individual diagnosis card number: 128688; Diagnosis: through " DR-1 type xerophthalmia tester " testing and diagnosing is the moderate xerophthalmia.
Use medicine; The dissolved granule that the present invention makes;
Usage and dosage: boiled water is taken after mixing it with water, one time 1 bag, 2 times on the one, take after 30 days check continuously.Be normal value through " DR-1 type xerophthalmia tester " test, effect is recovery from illness.
The treatment conclusion: what formula ophthalmologic hospital of ShenYang, Liaoning Province city has been used for the climacteric dry eye patients with prescription of the present invention since in July, 1998.About 2000 multidigit patients accept the treatment of prescription of the present invention and eye drop.Judge according to Ministry of Public Health pharmaceutical effectiveness index, wherein entirely more more than 90%; Produce effects is more than 70%, and is effective more than 30%, and invalid is zero, and through clinical practice in the past few years, we think that prescription of the present invention to treatment climacteric xerophthalmia patient, has comparatively satisfied curative effect.
Claims (5)
1, a kind of oral drugs for the treatment of the climacteric xerophthalmia, it is characterized in that: the prescription of this medicine mainly is made up of the raw material of following weight ratio:
Radix Ophiopogonis 10～15: Radix Glycyrrhizae 3～6: Cortex Phellodendri 8～12: the Rhizoma Anemarrhenae 8～12: Rhizoma Curculiginis 8～12: Herba Epimedii 8～12: Radix Ginseng 6～10: the Rhizoma Pinelliae 6～10: Radix Angelicae Sinensis 8～12: crust halberd 8～12; The medicinal liquid of gained promptly after decocting with water.
2, according to a kind of oral drugs for the treatment of the climacteric xerophthalmia described in the claim 1, it is characterized in that: gained medicinal liquid in the claim 1 is added starch, dextrin, correctives, mix the back and granulate promptly.
3, a kind of preparation method for the treatment of the oral drugs of climacteric xerophthalmia, it is characterized in that: the preparation method of this medicine is as follows:
A, the material of getting it filled, immersion: get various medicinal raw materials by the weight ratio of the described prescription of claim 1, various medical materials are put into decocting medicine pot, add water logging and cross medical material, soaked 25～35 minutes;
B, decoction, concentrated medicament: soaked raw material was decocted 40 minutes with slow fire heating, get the liquid of boiling medicine, after in the residue medicinal residues, adding the heating of hydrology fire and decocting 30 minutes, will fry in shallow oil for twice to such an extent that medicinal liquid merges promptly after discarding medicinal residues.
4, according to a kind of preparation method for the treatment of the oral drugs of climacteric xerophthalmia described in the claim 3, it is characterized in that: the medicinal liquid that merges the back gained among the claim 3 step b is concentrated into the blue or green cream of dark brown, it is an amount of to add starch, dextrin, correctives then, mix the back and granulate, dry back packing promptly.
5, according to a kind of preparation method for the treatment of the oral drugs of climacteric xerophthalmia described in the claim 4, it is characterized in that: the starch weight of adding is to make 0.5 times of the blue or green cream weight of dark brown; The weight that adds dextrin be make the blue or green cream weight of dark brown 0.1-0.15 doubly, the correctives of adding is an aspartame, the weight of correctives be make the blue or green cream weight of dark brown 0.02-0.05 doubly.
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| CNB2005100476216A CN100438898C (en) | 2005-11-03 | 2005-11-03 | Orally taken medicine for treating climacteric xerophthalmia and its prepn |
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| CNB2005100476216A CN100438898C (en) | 2005-11-03 | 2005-11-03 | Orally taken medicine for treating climacteric xerophthalmia and its prepn |
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| CN100438898C true CN100438898C (en) | 2008-12-03 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105125848A (en) * | 2015-09-25 | 2015-12-09 | 刘海强 | Traditional Chinese medicine for treating dry eye syndromes |
| WO2019054491A1 (en) * | 2017-09-14 | 2019-03-21 | 協同乳業株式会社 | Food/drink item or preparation for improving tear secretion performance/tear stability |
| CN109771557A (en) * | 2017-11-15 | 2019-05-21 | 广西西林县农本生物科技有限公司 | A kind of Chinese medicine composition for treating female climacteric syndrome |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1335177A (en) * | 2001-08-15 | 2002-02-13 | 沙鹏程 | Yang-strengthening and kidney-invigorating medicine and is prepn |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1335177A (en) * | 2001-08-15 | 2002-02-13 | 沙鹏程 | Yang-strengthening and kidney-invigorating medicine and is prepn |
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Effective date of registration: 20170531 Address after: 110034, 128 North Main Street, Yuhong District, Shenyang, Liaoning, the Yellow River Patentee after: Ho ho Eye Hospital of Shenyang Ltd. Address before: 110034 No. 128 North Main Street, Shenyang, Liaoning, the Yellow River Patentee before: He Wei |