CN106983825A - It is a kind of to be used to treat Chinese medicine composition of cerebral thrombus and its preparation method and application - Google Patents
It is a kind of to be used to treat Chinese medicine composition of cerebral thrombus and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for being used to treat cerebral thrombus and its preparation method and application.Said composition is main as made by the bulk drug of following parts by weight：55 80 parts of spina date seed, 35 60 parts of the seed of Oriental arborvitae, 25 40 parts of sealwort, 18 33 parts of radix glycyrrhizae, 15 24 parts of dried orange peel, 12 18 parts of red medicine, 10 15 parts of Plant Soot, 10 15 parts of Chinese herbaceous peony, 8 15 parts of donkey-hide gelatin.The Chinese medicine composition preparation method for being used to treat cerebral thrombus of the present invention is simple and convenient, and cost is low.Compared with the chemotherapeutic agent of Current therapeutic cerebral thrombus, adverse reaction and side effect are significantly reduced.Chinese medicine composition effect of the present invention is comprehensive, medication effect more preferably, due to add a certain proportion of red medicine and Plant Soot mixed with other Chinese medicine materials after the pharmaceutical composition for preparing can effectively treat patient cerebral thrombus and recurrence rate is low, synergy can significantly be effectively improved the symptom of cerebral thrombus.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and its preparation for being used to treat cerebral thrombus
Methods and applications.
Background technology
Cerebral thrombus is a kind of common cranial vascular disease, its mainly due to supply brain artery because of atherosclerosis etc.
Itself lesion makes luminal stenosis, occlusion, or forms thrombus on the basis of narrow, causes the interruption of brain topical acute blood flow, ischemic
Anoxic and soften necrosis, there is corresponding neurological symptom.The morbidity crowd of cerebral thrombus is mainly the person in middle and old age of more than 45 years old
People, wherein male are slightly more than women.Clinical manifestation after cerebral thrombus morbidity is mainly facial paralysis, glossolalia, numbness in hands and feet,
Severe patient hemiplegia, it can't take care of oneself.Patient once fall ill, fatal rate and suffer from sequelae probability it is very high.
Doctor trained in Western medicine thinks that the origin cause of formation of cerebral thrombus is endothelial cell damage, and the change of the change of blood fluidised form and blood in itself makes
Blood condense in the blood vessel or blood in some compositions occur the phenomenons of viscous collection.The Western medicine of existing treatment cerebral thrombus is main with molten
Bolt, dilute blood, prevent based on encephaledema, although these medicines can play a part for the treatment of to a certain extent, all deposit
In course for the treatment of length, slowly effect and the low problem of cure rate.
The traditional Chinese medical science thinks, the main cause of cerebral thrombus morbidity is patient's deficiency of qi and blood usually, the heart, liver, the dirty imbalance of yin and yang of kidney three,
QI-blood circulation is obstructed, and skin tendon and vessel is lost to be caused in moistening foster.Differential diagnosis in tcm thinks extreme hyperactivity of the liver-yang, obstruction of collateral caused by windphlegm, phlegm-heat accumulation, the deficiency of vital energy
Blood stasis, wind formation from yin deficiency, wind fire, which cover key, convulsive seizure due to phlegm-fire and close key, phlegm wet and cover key, vigour, decays for main reason.
The medicament categories for the treatment of cerebral thrombus are various at present, and curative effect is different.So the medicine for the treatment of cerebral thrombus should possess QI invigorating
The effect of promoting blood circulation, thrombolytic collaterals-activating, be the guarantee of curative effect.
The content of the invention
Goal of the invention：The problem of existing for prior art, the present invention provides a kind of Chinese medicine group for being used to treat cerebral thrombus
Compound.The pharmaceutical composition can effectively treat cerebral thrombus, and recurrence rate is low, have no side effect.
The present invention also provides the preparation method and application that this kind is used to treat the Chinese medicine composition of cerebral thrombus.
Technical scheme：It is to achieve these goals, a kind of as described herein to be used to treat the Chinese medicine composition of cerebral thrombus,
Mainly as made by the bulk drug of following parts by weight：55-80 parts of spina date seed, 35-60 parts of the seed of Oriental arborvitae, 25-40 parts of sealwort, radix glycyrrhizae
18-33 parts, 15-24 parts of dried orange peel, red medicine 12-18 parts, 10-15 parts of Plant Soot, 10-15 parts of Chinese herbaceous peony, 8-15 parts of donkey-hide gelatin.
Preferably, the described Chinese medicine composition for being used to treat cerebral thrombus, mainly by the bulk drug institute of following parts by weight
It is made：65-75 parts of spina date seed, 45-50 parts of the seed of Oriental arborvitae, 30-35 parts of sealwort, 25-30 parts of radix glycyrrhizae, 20-22 parts of dried orange peel, red medicine 15-
18 parts, 12-15 parts of Plant Soot, 10-12 parts of Chinese herbaceous peony, 12-15 parts of donkey-hide gelatin.
The preparation method of the present invention for being used to treat the Chinese medicine composition of cerebral thrombus, comprises the following steps：
(1) do not have powder with water logging after weighing spina date seed, the seed of Oriental arborvitae, sealwort, radix glycyrrhizae, dried orange peel mixing in proportion, with being cooked by slow fire
Boil, collecting decoction filtering obtains filtrate A；
(2) the filtrate A alcohol refluxs for adding 5-8 times of volume are extracted, merges extract solution, reclaimed ethanol to without alcohol taste, obtain
Extract solution B；
(3) red medicine, Plant Soot, Chinese herbaceous peony, donkey-hide gelatin are soaked, boiled, filter the second that backward filtrate adds 6-8 times of volume
Alcohol reflux is extracted, and is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.25~1.27 lotion when being condensed into 70 DEG C, is produced.
Wherein, step (1) is described with being cooked by slow fire 3-4 times, each 30-40min.
Preferably, step (2) and the ethanol that step (3) described ethanol is volume fraction 60-70%.
Application of the Chinese medicine composition of the present invention for being used to treat cerebral thrombus in treatment cerebral thrombus medicine is prepared.
Preferably, the medicine includes decoction, oral liquid, tablet, capsule or granule.
Beneficial effect：Compared with prior art, the Chinese medicine composition preparation method letter for being used to treat cerebral thrombus of the invention
Just, cost is low for folk prescription.Compared with the chemotherapeutic agent of Current therapeutic cerebral thrombus, Chinese medicine composition of the present invention is natural pure Chinese medicine
Preparation, adverse reaction and side effect are significantly reduced, and particularly it does not produce any destruction for intestinal mucosa.In the present invention
Drug composition effect is comprehensive, and medication effect is more preferably, a certain proportion of red due to adding in pharmaceutical composition of the invention
The pharmaceutical composition that medicine and Plant Soot are prepared after being mixed with other Chinese medicine materials can effectively treat the cerebral thrombus of patient and
Recurrence rate is low, synergy can significantly significantly improve the symptom of cerebral thrombus.
Embodiment
The present invention is further described with reference to embodiment.
Embodiment 1
Component：
55 parts of spina date seed, 60 parts of the seed of Oriental arborvitae, 40 parts of sealwort, 18 parts of radix glycyrrhizae, 24 parts of dried orange peel, 12 parts of red medicine, 10 parts of Plant Soot,
10 parts of Chinese herbaceous peony, 8 parts of donkey-hide gelatin.
Preparation method：
(1) do not have powder with water logging after weighing spina date seed, the seed of Oriental arborvitae, sealwort, radix glycyrrhizae, dried orange peel mixing in proportion, with being cooked by slow fire
Boil 3 times, each 30min, collecting decoction filtering obtains filtrate A；
(2) the filtrate A alcohol refluxs of volume fraction 60% for adding 5 times of volumes are extracted 2 times, each 2h merges extract solution,
Ethanol is reclaimed to without alcohol taste, extract solution B is obtained；
(3) red medicine, Plant Soot, Chinese herbaceous peony, donkey-hide gelatin are soaked, boiled, filter the volume that backward filtrate adds 6 times of volumes
The alcohol reflux of fraction 60% is extracted 2 times, each 2h, is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.25 lotion when being condensed into 70 DEG C, is produced.
Decoction is made according to conventional formulation method in lotion.
Embodiment 2
Component：
80 parts of spina date seed, 35 parts of the seed of Oriental arborvitae, 40 parts of sealwort, 33 parts of radix glycyrrhizae, 15 parts of dried orange peel, 18 parts of red medicine, 15 parts of Plant Soot,
15 parts of Chinese herbaceous peony, 15 parts of donkey-hide gelatin.
Preparation method：
(1) do not have powder with water logging after weighing spina date seed, the seed of Oriental arborvitae, sealwort, radix glycyrrhizae, dried orange peel mixing in proportion, with being cooked by slow fire
Boil 4 times, each 40min, collecting decoction filtering obtains filtrate A；
(2) the filtrate A alcohol refluxs of volume fraction 70% for adding 8 times of volumes are extracted 3 times, each 1h merges extract solution,
Ethanol is reclaimed to without alcohol taste, extract solution B is obtained；
(3) red medicine, Plant Soot, Chinese herbaceous peony, donkey-hide gelatin are soaked, boiled, filter the volume that backward filtrate adds 8 times of volumes
The alcohol reflux of fraction 70% is extracted 3 times, each 1h, is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.27 lotion when being condensed into 70 DEG C, is produced.
Oral agents are made according to conventional formulation method in lotion.
Embodiment 3
Component：
70 parts of spina date seed, 48 parts of the seed of Oriental arborvitae, 35 parts of sealwort, 25 parts of radix glycyrrhizae, 20 parts of dried orange peel, 15 parts of red medicine, 12 parts of Plant Soot,
12 parts of Chinese herbaceous peony, 12 parts of donkey-hide gelatin.
Preparation method：
(1) do not have powder with water logging after weighing spina date seed, the seed of Oriental arborvitae, sealwort, radix glycyrrhizae, dried orange peel mixing in proportion, with being cooked by slow fire
Boil 3 times, each 35min, collecting decoction filtering obtains filtrate A；
(2) the filtrate A alcohol refluxs of volume fraction 70% for adding 6 times of volumes are extracted 3 times, each 1.5h merges and extracted
Liquid, reclaims ethanol to without alcohol taste, obtains extract solution B；
(3) red medicine, Plant Soot, Chinese herbaceous peony, donkey-hide gelatin are soaked, boiled, filter the volume that backward filtrate adds 7 times of volumes
The alcohol reflux of fraction 70% is extracted 3 times, each 1h, is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.26 lotion when being condensed into 70 DEG C, is produced.
Tablet is made according to conventional formulation method in lotion.
Embodiment 4
Component：
65 parts of spina date seed, 45 parts of the seed of Oriental arborvitae, 30 parts of sealwort, 25 parts of radix glycyrrhizae, 20 parts of dried orange peel, 15 parts of red medicine, 12 parts of Plant Soot,
10 parts of Chinese herbaceous peony, 12 parts of donkey-hide gelatin.
Preparation method：
(1) do not have powder with water logging after weighing spina date seed, the seed of Oriental arborvitae, sealwort, radix glycyrrhizae, dried orange peel mixing in proportion, with being cooked by slow fire
Boil 4 times, each 40min, collecting decoction filtering obtains filtrate A；
(2) the filtrate A alcohol refluxs of volume fraction 70% for adding 8 times of volumes are extracted 2 times, each 2h merges extract solution,
Ethanol is reclaimed to without alcohol taste, extract solution B is obtained；
(3) red medicine, Plant Soot, Chinese herbaceous peony, donkey-hide gelatin are soaked, boiled, filter the volume that backward filtrate adds 8 times of volumes
The alcohol reflux of fraction 70% is extracted 3 times, each 2h, is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.25 lotion when being condensed into 70 DEG C, is produced.
Granule is made according to conventional formulation method in lotion.
Embodiment 5
75 parts of spina date seed, 50 parts of the seed of Oriental arborvitae, 35 parts of sealwort, 30 parts of radix glycyrrhizae, 22 parts of dried orange peel, 18 parts of red medicine, 15 parts of Plant Soot,
12 parts of Chinese herbaceous peony, 15 parts of donkey-hide gelatin.
Preparation method：
(1) do not have powder with water logging after weighing spina date seed, the seed of Oriental arborvitae, sealwort, radix glycyrrhizae, dried orange peel mixing in proportion, with being cooked by slow fire
Boil 3 times, each 30min, collecting decoction filtering obtains filtrate A；
(2) the filtrate A alcohol refluxs of volume fraction 60% for adding 5 times of volumes are extracted 2 times, each 1h merges extract solution,
Ethanol is reclaimed to without alcohol taste, extract solution B is obtained；
(3) red medicine, Plant Soot, Chinese herbaceous peony, donkey-hide gelatin are soaked, boiled, filter the volume that backward filtrate adds 8 times of volumes
The alcohol reflux of fraction 60% is extracted 2 times, each 1h, is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.27 lotion when being condensed into 70 DEG C, is produced.
Capsule is made according to conventional formulation method in lotion.
Test example 1
Toxicological experiment
40 SD rats, are grouped at random by body weight, every group 10, institute prepared by the oral embodiment 1-5 of above-mentioned rat
Chinese medicine composition is obtained, consumption is that one day consumption carries out acute toxicity test, and dosage is 1.0g/, is not as a result occurred any
Toxic reaction, to observation post administration 7 days, as a result all rats perfected, and its activity, diet, hair, excreta are no abnormal, not
See toxic reaction.To place's post mortem, its main organs observation Non Apparent Abnormality.
Test example 2
1st, general information
200 cerebral thrombus patients, man 100, female 100.Stochastic averagina is divided into five groups, respectively control group 1, control group
2nd, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, each group sex, age, course of disease etc. are statistically analyzed, no significant difference
Meaning (P>O.05), with comparativity.
2nd, treatment method
Control group 1 gives FUFANG XUESHUANTONG JIAONANG (commercially available), is used by package insert, orally, 3, one
Day 3 times.
Control group 2 give it is identical with the prescription and preparation method of embodiment 3, difference with do not have in prescription red medicine and
The preparation of Chinese medicine composition obtained by Plant Soot, consumption is conventional one day consumption, and once a dose sooner or later, and it 15 days is a treatment to take
Journey.
3 groups of 1 group of embodiment, 2 groups of embodiment and embodiment give the embodiment of the present invention 1, embodiment 2 and embodiment 3 respectively
Gained Chinese medicine composition, consumption is conventional one day consumption, and once a dose sooner or later, and it 15 days is a course for the treatment of to take.
3rd, diagnostic criteria
Recovery clinical improvement rate >=5%, effective clinical improvement rate >=52%, effective clinical improvement rate >=41%, invalid face
Bed improvement rate >=2%.
4th, treatment results
Ten courses for the treatment of are treated as stated above, investigate the total effective rate (%) that each group is treated eventually, and be discontinued after half a year
Recurrence rate (%), the results are shown in Table 1.
The each group patient clinical of table 1 treats total effective rate and recurrence rate investigates result
From the result of upper table 1, compared with the existing medicine of control group 1, the embodiment of the present invention 1,2 and 3 gained Chinese medicines
Composition, the therapeutic effect for cerebral thrombus is more preferable, it was demonstrated that it can effectively treat cerebral thrombus；Simultaneously compared with control group 2
Effective cure rate of the present invention is also higher, and the ratio of recovery from illness is high, illustrates that red medicine and Plant Soot inside serve key effect；
And in terms of recurrence rate, the recurrence rate after traditional Chinese medicine composition for treating of the present invention is only up to 5%, well below control group 1 and 2,
Prove that Chinese medicine composition of the present invention can significantly reduce the recurrence rate of cerebral thrombus.And over the course for the treatment of, each treatment group is without pair
Reaction occurs.
Claims (7)
1. a kind of Chinese medicine composition for being used to treat cerebral thrombus, it is characterised in that main made by the bulk drug of following parts by weight
Into：55-80 parts of spina date seed, 35-60 parts of the seed of Oriental arborvitae, 25-40 parts of sealwort, 18-33 parts of radix glycyrrhizae, 15-24 parts of dried orange peel, red medicine 12-18
Part, 10-15 parts of Plant Soot, 10-15 parts of Chinese herbaceous peony, 8-15 parts of donkey-hide gelatin.
2. the Chinese medicine composition according to claim 1 for being used to treat cerebral thrombus, it is characterised in that mainly by following weight
Made by the bulk drug of part：65-75 parts of spina date seed, 45-50 parts of the seed of Oriental arborvitae, 30-35 parts of sealwort, 25-30 parts of radix glycyrrhizae, dried orange peel 20-
22 parts, red medicine 15-18 parts, 12-15 parts of Plant Soot, 10-12 parts of Chinese herbaceous peony, 12-15 parts of donkey-hide gelatin.
3. being used for described in claim any one of 1-2 treats the preparation method of the Chinese medicine composition of cerebral thrombus, it is characterised in that
Comprise the following steps：
(1) do not have powder with water logging after weighing spina date seed, the seed of Oriental arborvitae, sealwort, radix glycyrrhizae, dried orange peel mixing in proportion, with being cooked by slow fire, close
And decocting liquid is filtered, and obtains filtrate A；
(2) the filtrate A alcohol refluxs for adding 5-8 times of volume are extracted, merges extract solution, reclaimed ethanol to without alcohol taste, must extract
Liquid B；
(3) red medicine, Plant Soot, Chinese herbaceous peony, donkey-hide gelatin are soaked, boiled, filter the ethanol time that backward filtrate adds 6-8 times of volume
Stream is extracted, and is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.25~1.27 lotion when being condensed into 70 DEG C, is produced.
4. preparation method according to claim 3, it is characterised in that step (1) is described with being cooked by slow fire 3-4 times, every time
30-40min。
5. preparation method according to claim 3, it is characterised in that step (2) and step (3) described ethanol are volume integral
Number 60-70% ethanol.
6. being used for described in claim any one of 1-2 treats the Chinese medicine composition of cerebral thrombus in treatment cerebral thrombus medicine is prepared
Application.
7. application according to claim 6, it is characterised in that the medicine includes decoction, oral liquid, tablet, capsule
Or granule.
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| CN201710388100.XA CN106983825A (en) | 2017-05-27 | 2017-05-27 | It is a kind of to be used to treat Chinese medicine composition of cerebral thrombus and its preparation method and application |
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| CN201710388100.XA Pending CN106983825A (en) | 2017-05-27 | 2017-05-27 | It is a kind of to be used to treat Chinese medicine composition of cerebral thrombus and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108542942A (en) * | 2018-05-24 | 2018-09-18 | 江苏苏南药业实业有限公司 | It is a kind of to be used to treat Chinese medicine composition of stiff neck and its preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150904A (en) * | 1995-11-21 | 1997-06-04 | 陕西省中医药研究院 | Kenading muscle and anti-paralysis tablet |
| CN101254256A (en) * | 2007-10-15 | 2008-09-03 | 李志伟 | Clearing blood nourishing heart powder |
-
2017
- 2017-05-27 CN CN201710388100.XA patent/CN106983825A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150904A (en) * | 1995-11-21 | 1997-06-04 | 陕西省中医药研究院 | Kenading muscle and anti-paralysis tablet |
| CN101254256A (en) * | 2007-10-15 | 2008-09-03 | 李志伟 | Clearing blood nourishing heart powder |
Non-Patent Citations (2)
| Title |
|---|
| 徐士骏等: "《徐士骏、张秀英中医验方》", 28 February 2009, 远方出版社 * |
| 王莉等: ""温胆汤加味配合常规治疗脑梗塞60"例", 《光明中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108542942A (en) * | 2018-05-24 | 2018-09-18 | 江苏苏南药业实业有限公司 | It is a kind of to be used to treat Chinese medicine composition of stiff neck and its preparation method and application |
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Application publication date: 20170728 |