CN102552608A - Medicine composition used for treating fracture and bone injury, preparation method thereof, and purpose thereof - Google Patents
Medicine composition used for treating fracture and bone injury, preparation method thereof, and purpose thereof Download PDFInfo
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Abstract
The invention provides a medicine composition used for treating fracture and bone injury. The medicine is a preparation prepared from medicine materials of, by weight: 6-12 parts of dragon's blood, 15-30 parts of salvia miltiorrhiza, 20-40 parts of myrrh, 30-40 parts of frankincense, 4-8 parts of redroot gromwell, dipsacus asper, 4-8 parts of cibotium barometz, lumbricus, 6-12 parts of psoralea corylifolia, 4-8 parts of Chinese taxillus herb, 2-4 parts of common achyranthes, 6-12 parts of drynaria, 1-2 parts of musk, 9-15 parts of yanhusuo tuber, and 4-10 parts of borneol. The invention also provides a preparation method and a purpose of the medicine composition. As a result of clinical experiments, with the medicine composition, local blood circulation can be substantially improved; symptoms such as fracture local pain, pressing pain, and swelling can be relieved; bony callus growth can be promoted; and fracture healing can be accelerated.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of treating fracture, bone injury and preparation method thereof, belong to drug world.
Background technology
Fracture, bone injury are that the integrity or the seriality of bone is interrupted or destroys, and are a kind of common frequently-occurring disease in clinical.Because traffic accident, the unexpected and irresistible natural disaster of building take place, and the primary disease sickness rate is risen gradually, the local congestive edema of the human body that causes after the fracture, pain, deformity; Moving obstacle etc.; Had a strong impact on people's healthy living, and perform a surgical operation or manual reduction treating after, increase tissue injury again to some extent; Trouble limb congestive edema is increased the weight of, and the pain increased.How accelerating union of bone fracture is one of common key subjects of paying close attention to of present medical circle.
Chinese traditional treatment fracture, the existing thousands of years history of bone injury have accumulated rich experiences, manifest day by day in the advantage aspect the promotion union of fracture.Chinese medicine thinks that traumatic injury causes limb fracture, after the wound the long-pending stasis of blood must be arranged, blood stasis vapour lock, sluggishness or stagnation of blood circulation; Meridians are stopped up stagnant, and are capable not smooth through fate, and saying of " as if rolling over due to wound; blood influencing meridian network, the road that blood is capable must not being declared logical, and the stasis of blood is long-pending does not loose, then for swelling, being bitterly " through flow of QI being obstructed then bitterly, therefore arranged in " Prescriptions for Universal Relief, folding are hindered door "; Clear old scholar's tongued bell " cave heaven difficult to understand purport traumatic injury skin ulcer " also have " the traumatic injury skin ulcer, all blood stasis and do not loose also, the blood stasis of blood of not living then can not be gone, the stasis of blood is not gone then to roll over and can not be continued " opinion.This shows, fracture and fracture surgery, all because of hemorrhage, long-pending not the loosing of the stasis of blood causes meridians to be obstructed; QI and blood is obstructed, and the limbs stasis of blood, swollen, is bitterly just arranged, and therefore should give blood circulation promoting and blood stasis dispelling, promoting of the circulation of QI and removing the obstruction in the collaterals in the treatment; Make the stasis of blood new life that dispels, the capable ruton of gas, then the stasis of blood, swollen, pain can be removed, and fracture can continue.The traditional Chinese medical science thinks that union of fracture is the process of a kind of " stasis of blood goes, newborn, bone and ", thinks the kidney generating marrow and dominating bone, and the healing of fracture depends on kidney essense and supplements nutrition; The kidney essense abundance then heals smoothly; Deficiency of kidney-essence is then fractured and is difficult to for continuous, and secondly blood stasis is the main pathological product after the fracture, and whether the going or staying of blood stasis directly has influence on the healing of fracture; The stasis of blood is gone then newborn, and the stasis of blood does not go then newly not give birth to, bone does not connect.Therefore delayed union of fracture or disunion and the blood stasis of suffering from a deficiency of the kidney are in close relations, the many purposes that promote union of fracture that reach through the kidney invigorating, blood stasis dispelling of Chinese medicine fracture.
The Chinese medicine fracture mainly contains manual correction at present, and folder is tied up fixing, and Chinese medicine is inside and outside to be controlled, acupuncture and moxibustion treatment, and means such as functional exercise differ from one another.External therapy of Chinese herb can be divided into ointment, plaster, put on the skin and wipe a type medicated wine, Chinese medicine fumigation and washing, fomentation etc., just in the Chinese medicine fracture, occupies one seat since ancient times.Use the healing record that external used medicine promotes fracture as in ancient books such as Shennong's Herbal, " 52 Bingfang ", " Liu Juanzi Guiyi Fang, Liu Juanzi ", just having.Modern a large amount of experiment or clinical research data confirm to use the effect that external therapy of Chinese herb has accelerating union of bone fracture; Dampen JIEGU GAO (containing Eupolyphaga Seu Steleophaga, Herba sambuci chinensis, Gypsum Fibrosum, Matrii Sulfas Exsiccatus, Pyritum, Herba Taraxaci, Radix Et Rhizoma Rhei, Radix Dipsaci, Rhizoma Curcumae Longae, Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Drynariae, Myrrha, Borneolum Syntheticum etc.) treatment traumatic fracture 555 examples with self-control on an equal basis like old generation; Compare with matched group 114 examples, the clinical healing time average is 12.76 days (P＜0.01) in advance.Chen Juan adopts homemade traditional Chinese drug and stiff patient's 1050 examples of the fumigating bed fumigation treatment fracture posterior joint of constant temperature, obtains effect preferably.Yang Liyong self-control JIEGU GAO (Radix Et Rhizoma Rhei, Semen Sinapis, Pericarpium Citri Reticulatae, Radix Rehmanniae, Cortex Phellodendri, the Radix Linderae, Sanguis Draxonis, each 15g of catechu; Semen Momordicae, Rhizoma Pinelliae Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Arisaematis, Radix Scutellariae, Radix Paeoniae Rubra, each 20g of Rhizoma Cyperi; The Radix Aucklandiae, Olibanum, Semen Persicae, Herba Artemisiae Anomalae, Fructus Gardeniae, each 25g of Radix Angelicae Sinensis; Rhizoma Drynariae, Semen Melo, Pyritum, each 30g of Eupolyphaga Seu Steleophaga grind into powder with vinegar furnishing pasty state) treatment fracture 569 examples, compare with identical routine number matched group; The healing time of treatment group as a result average out to 26.75 days, matched group are 34.85 days (P＜0.01).It is clinical that employings such as Pan Cheng Huan are applied to orthopaedics from plan " JIEGU GAO "; 500 routine patients are imposed external application; No matter the General Symptoms of fracture patient still be a local symptom or fracture dysfunction afterwards, complete and the limb function after the stable fracture not, all obtained satisfactory effect.Zhai Xianbin etc. use the patient behind " Mount Taishan JIEGU GAO " treatment 156 routine fracture operations treatments and the non-operative treatment; Through the comparative analysis to curative effect, the result shows that treatment group total effective rate is 97.4%, and matched group is 91.0%; Two groups relatively; Difference has statistical significance (P＜0.01), and the treatment group is superior to matched group, and this shows that " Mount Taishan JIEGU GAO " has the effect of tangible promotion union of fracture.
External therapy of Chinese herb is promoting have drug absorption to distribute soon aspect the union of fracture; Drug effect directly, rapidly; It is little influenced by individual variation, produces the little characteristics of untoward reaction, and the advantage of strengthening injury muscle contraction, promotion fracture site close proximity, strengthening union of fracture biomechanics effect is arranged.But research is very few on its mechanism of action at present, and extract drugs method and form of administration are more backward mostly, as also being traditional leaded plaster (black plaster) a lot, causes patient skin allergy easily.In order to inherit and develop Chinese medicine in the advantage aspect the treatment fracture, under Chinese medical theory instructs, use science and technology now, it is rationally advanced to develop a kind of dosage form, and the external bone injury class preparation of determined curative effect has very important significance.
Summary of the invention
The object of the present invention is to provide a kind of have cooling blood and relieving pain, blood circulation promoting and blood stasis dispelling and symplectic bone granulation promoting effect, be used to fracture, the pharmaceutical composition of each stage treatment of bone injury.Another object of the present invention has provided this preparation of drug combination method.
The invention provides a kind of pharmaceutical composition, it is the preparation that is prepared from following materials of weight proportions medicine:
Sanguis Draxonis 6-12 part, Radix Salviae Miltiorrhizae 15-30 part, Myrrha 20-40 part, Olibanum 30-40 part, Radix Arnebiae (Radix Lithospermi) 4-8 part, Radix Dipsaci, Rhizoma Cibotii 4-8 part, Pheretima, Fructus Psoraleae 6-12 part, Herba Taxilli 4-8 part, Radix Achyranthis Bidentatae 2-4 part, Rhizoma Drynariae 6-12 part, Moschus 1-2 part, Rhizoma Corydalis 9-15 part, Borneolum Syntheticum 4-10 part.
Further, it is the preparation that is prepared from following materials of weight proportions medicine:
9 parts of Sanguis Draxonis, 20 parts of Radix Salviae Miltiorrhizaes, 30 parts of Myrrhas, 35 parts of Olibanums, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 6 parts of Radix Dipsacis, 6 parts of Rhizoma Cibotiis, 9 parts of Pheretimas, 9 parts of Fructus Psoraleaes, 6 parts of Herba Taxillis, 3 parts of Radix Achyranthis Bidentataes, 9 parts of Rhizoma Drynariae, 1.5 parts in Moschus, 12 parts of Rhizoma Corydalis, 7 parts of Borneolum Syntheticums.
Wherein, it is the powder with part or all of crude drug, or the water of part material medicine or extractive with organic solvent be active component, adds the preparation that medicine adjuvant commonly used is prepared from.
Further, described preparation is an external preparation.
Wherein, said preparation is ointment, rubber-emplastrum, black plaster, cataplasma, patch, membrane, paste, gel, powder, medicated wine, tincture etc.
The present invention also provides the method for preparing of aforementioned pharmaceutical compositions: it comprises the steps:
(1) weighting raw materials by weight ratio;
(2) with after the crude drug pulverizing, mixing adds that adjuvant commonly used is prepared into preparation.
The present invention also provides another method for preparing of this pharmaceutical composition, and it comprises the steps:
(1) weighting raw materials by weight ratio;
(2) Sanguis Draxonis, Moschus, Borneolum Syntheticum are pulverized, subsequent use; After residue medical material water or organic solvent etc. extracted in will writing out a prescription, gained water or extractive with organic solvent mixed with Sanguis Draxonis, Moschus, Borneolum Syntheticum medicated powder, added medicine adjuvant commonly used or complementary composition and were prepared into preparation pharmaceutically commonly used.Wherein, the said organic solvent of step (2) comprises ethanol, Chinese liquor, vegetable oil.
The present invention also provides the purposes of described pharmaceutical composition in the external used medicine of preparation treatment fracture or bone injury.
Medicine material medicine of the present invention is a principal agent with Sanguis Draxonis, Radix Salviae Miltiorrhizae, Olibanum, Myrrha, gets its blood circulation promoting and blood stasis dispelling, the merit of granulation promoting pain relieving; Because of " the blood stasis of blood of not living is not then gone, the stasis of blood do not go then bone does not connect ", be aided with promoting flow of QI and blood, dispelling wind and removing obstruction in the collateral such as Rhizoma Corydalis, Radix Arnebiae (Radix Lithospermi), Pheretima.Liver governing tendons, kidney governing bones, assistant are repaired and callus formation to promote muscles and bones with the medicine of invigorating the liver and kidney such as Fructus Psoraleae, Herba Taxilli, Radix Achyranthis Bidentatae, Radix Dipsaci, Rhizoma Cibotii, Rhizoma Drynariae; Use Moschus, Borneolum Syntheticum to be messenger drug, removing obstruction in the collateral to relieve pain.At the medicine compatibility, play the merit of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, symplectic bone granulation promoting altogether.Modern clinical proof, pharmaceutical composition of the present invention significantly improves local blood circulation, alleviates symptoms such as fracture local pain, tenderness, swelling, promotes growth of spur, accelerating union of bone fracture.
The specific embodiment
Embodiment 1 preparation of drug combination of the present invention (cataplasma)
Medicine is formed:
Sanguis Draxonis 9g Radix Salviae Miltiorrhizae 20g Myrrha 30g Olibanum 35g Radix Arnebiae (Radix Lithospermi) 6g
Radix Dipsaci 6g Rhizoma Cibotii 6g Pheretima 9g Fructus Psoraleae 9g Herba Taxilli 6g
Radix Achyranthis Bidentatae 3g Rhizoma Drynariae 9g Moschus 1.5g Rhizoma Corydalis 12g Borneolum Syntheticum 7g
Adjuvant is formed:
Sodium polyacrylate NP-700120g dihydroxyaluminum aminoacetate 6g EDTA-2Na 1.5g
Glycerol 500g 30 POVIDONE K 30 BP/USP-90 50g tartaric acid 2.5g micropowder silica gel 50g
Azone 10g gelatin 30g distilled water 130g
Sanguis Draxonis, Moschus, Borneolum Syntheticum powder are broken into fine powder.Get all the other 12 flavor medical materials in the prescription such as Myrrha, be ground into coarse powder, add 6 times of amount 70% alcohol reflux, reclaim ethanol and dry, be ground into fine powder, with crude drug fine powder mix homogeneously such as above-mentioned Sanguis Draxonis,, subsequent use as drug moiety.
Get dihydroxyaluminum aminoacetate, EDTA-2Na, 30 POVIDONE K 30 BP/USP-90, azone, Tween-80 and add in the glycerol, fully behind the mixing, slowly add sodium polyacrylate NP-70, stir, subsequent use; Tartaric acid, gelatin slowly add in the glycerin liquid after dissolving with purified water, after stirring, slowly add micropowder silica gel again, stir 30 minutes, and be as substrate, subsequent use.
Under continuous condition of stirring, slowly medicine is added in the substrate, stir, take out mastic, coating, covering adherent layer, section makes 100, promptly gets.
Embodiment 2 preparation of drug combination of the present invention (black plaster agent)
Medicine is formed with embodiment 1.
Adjuvant is formed:
Oleum Sesami 700g Plumbum preparatium 200g
Sanguis Draxonis, Moschus, Borneolum Syntheticum powder are broken into fine powder, subsequent use.Get Oleum Sesami to pot, be heated to 220 ℃～250 ℃, earlier with fried Huangs such as Radix Salviae Miltiorrhizae, Radix Dipsaci, Rhizoma Cibotii, Pheretima, Fructus Psoraleae, Radix Achyranthis Bidentatae, Rhizoma Corydalis, Rhizoma Drynariae; Drop into Radix Arnebiae (Radix Lithospermi), Herba Taxilli again, fried to surperficial dark brown, inner sallow for spending; Pull medicinal residues out, after adding Myrrha, the Olibanum fusion, refining is to dripping into pearl; Plumbum preparatium is added in the oil, stir, be brewed into cream.In plaster impouring cold water, wooden stick stirs, and makes to become band. and pinch pressure repeatedly, process bulk, immerse in the water; Change water every day 1 time, about 2 weeks, make fire-toxin go to the greatest extent after, be heated to fusion, add Sanguis Draxonis, Moschus, Borneolum Syntheticum; Mix homogeneously is shared in mounting on the backing material, processes 100, promptly gets.
Embodiment 3 preparation of drug combination of the present invention (rubber-emplastrum)
Medicine is formed with embodiment 1.
Adjuvant is formed:
Raw rubber 550g Colophonium 100g lanoline 50g vaseline 150g
Zinc oxide 50g
The drug moiety method for making is with embodiment 1.
Get raw rubber, behind the colloidal sol, add Colophonium, lanoline, vaseline, zinc oxide etc. successively and stir, add the said medicine fine powder, continue to stir into even cream slurry,, evenly be applied on the canequim, reclaim solvent with No. 7 sievings, the lid lining, cutting, packing promptly gets.
Embodiment 4 preparation of drug combination of the present invention (oil ointment)
Medicine is formed with embodiment 1.
Adjuvant is formed:
Vaseline 180g lanoline 20g
The drug moiety method for making is with embodiment 1.After heating and melting is bathed in water intaking, add the said medicine fine powder, stir, put coldly, promptly get.
Embodiment 5 preparation of drug combination of the present invention (membrane)
Medicine is formed with embodiment 1.
Adjuvant is formed:
The about 40ml of PVA (17-88) 400g Tween-80 15ml glycerol
Distilled water 2000ml
The drug moiety method for making is with embodiment 1.Get the PVA (17-88) that handles well, add distilled water, heating in water bath makes it to dissolve into glue, supplies moisture content, and is subsequent use.With the said medicine fine powder, glycerol adding, Tween-80 grinds evenly, slowly the PVA glue is added, and grinds well, leave standstill the glue bubble after, film, the stand is even, dries in the air after half-dried, puts 60 ℃ of oven dry, sterilization, packing promptly gets.
Embodiment 6 preparation of drug combination of the present invention (powder)
Sanguis Draxonis 8g Radix Salviae Miltiorrhizae 15g Myrrha 30g Olibanum 40g Radix Arnebiae (Radix Lithospermi) 7g
Radix Dipsaci 5g Rhizoma Cibotii 9g Pheretima 12g Fructus Psoraleae 6g Herba Taxilli 5g
Radix Achyranthis Bidentatae 2g Rhizoma Drynariae 10g Moschus 1g Rhizoma Corydalis 10g Borneolum Syntheticum 5g
Get above-mentioned medical material, be ground into fine powder, promptly get powder.
Embodiment 7 preparation of drug combination of the present invention (powder)
Sanguis Draxonis 12g Radix Salviae Miltiorrhizae 25g Myrrha 35g Olibanum 30g Radix Arnebiae (Radix Lithospermi) 4g
Radix Dipsaci 4g Rhizoma Cibotii 6g Pheretima 6g Fructus Psoraleae 10g Herba Taxilli 8g
Radix Achyranthis Bidentatae 4g Rhizoma Drynariae 6g Moschus 2g Rhizoma Corydalis 15g Borneolum Syntheticum 9g
Press the preparation of embodiment 1 drug moiety, promptly get.
Embodiment 8 preparation of drug combination of the present invention (powder)
Prescription is with embodiment 7.
Method for making: Sanguis Draxonis, Myrrha, Olibanum, Moschus, Borneolum Syntheticum etc. are ground into fine powder, subsequent use.Get medical materials such as residue Radix Salviae Miltiorrhizae, be ground into coarse powder, add 6 times of amount 80% alcohol reflux 2 times, each 30 minutes, filter, decompression filtrate recycling ethanol also concentrates, and is subsequent use.Medicinal residues add 8 times of water gaging persons of frying in shallow oil 2 times again, each 1 hour, filter.Fine powders such as Sanguis Draxonis are added in the percolate, stir and make dissolving, filter, after filtrating concentrates, add the alcohol extraction concentrated solution, mix homogeneously, drying is ground into fine powder, adds crude drug fine powders such as Sanguis Draxonis again, and mix homogeneously promptly gets.
Embodiment 9 preparation of drug combination of the present invention (medicated wine)
Sanguis Draxonis 8g Radix Salviae Miltiorrhizae 20g Myrrha 30g Olibanum 30g Radix Arnebiae (Radix Lithospermi) 7g
Radix Dipsaci 6g Rhizoma Cibotii 6g Pheretima 10g Fructus Psoraleae 8g Herba Taxilli 8g
Radix Achyranthis Bidentatae 4g Rhizoma Drynariae 10g Moschus 1g Rhizoma Corydalis 10g Borneolum Syntheticum 5g
With pulverizing such as Sanguis Draxonis, Moschus, Borneolum Syntheticums, subsequent use.Get all the other medical materials such as residue Radix Salviae Miltiorrhizae, be ground into coarse powder, add 6 times of amounts, 60 degree Chinese liquor percolation, get percolate, subsequent use.Fine powders such as Sanguis Draxonis are added in the percolate, stir and make dissolving, filter, filtrating is settled to 500ml with 60 degree, promptly gets.Put on the skin in the affected part with before getting in right amount.
Embodiment 10 preparation of drug combination of the present invention (tincture)
Prescription is with embodiment 9.
Method for making and embodiment 9 are basic identical, change 60% ethanol but will extract solvent into by Chinese liquor.
Below through concrete Test Example beneficial effect of the present invention is described.
The clinical research of Test Example 1 medicine composite for curing fracture of the present invention
1. clinical data
1.1 the case choice criteria had direct or indirect trauma history with interior extremity fracture patient in fresh 3 days, General Symptoms is uncomplicated simple closed fracture; Local symptom is pain, tenderness, local swelling.After the X line is taken the photograph sheet and is made a definite diagnosis, clear and definite classification of fracture, displacement mode, localized variation such as fracture end form.
1.2 the case data meets 184 routine cases of case choice criteria, all comes from the red Chinese medicine orthopedics department of Zhongshan city state.Wherein 92 examples are organized in treatment, male 54 examples, women 38 examples, 7～58 years old age, average 32.8 years old, chi fracture of radial shaft 18 examples wherein, fracture of shaft of tibia 24 examples, humeral shaft fracture 26 examples, fracture of shaft of femur 24 examples.Matched group 92 examples, male 52 examples, women 40 examples, 10～61 years old age, average 34.1 years old, chi fracture of radial shaft 22 examples wherein, fracture of shaft of tibia 20 examples, humeral shaft fracture 23 examples, fracture of shaft of femur 27 examples.
2. medication preparation
With Sanguis Draxonis 9g, Moschus 1.5g, Borneolum Syntheticum 7g, Myrrha 30g, Olibanum 35g, be ground into fine powder.Get the 300ml vegetable oil to pot, be heated to 220 ℃～250 ℃, earlier with fried Huangs such as Radix Salviae Miltiorrhizae 20g, Radix Dipsaci 6g, Rhizoma Cibotii 6g, Pheretima 9g, Fructus Psoraleae 89g, Radix Achyranthis Bidentatae 6g, Rhizoma Drynariae 9g, Rhizoma Corydalis 12g; Drop into Radix Arnebiae (Radix Lithospermi) 6g, Herba Taxilli 6g again, fried to surperficial dark brown, inner sallow for spending; Pull medicinal residues out; After adding Sanguis Draxonis, Myrrha, Olibanum fusion, add white beeswax 150g again, be brewed into cream.In plaster impouring cold water, wooden stick stirs, and makes to become band. and pinch pressure repeatedly, process bulk, immerse in the water; Change water every day 1 time, about 2 weeks, make fire-toxin go to the greatest extent after, be heated to fusion; Add Moschus, Borneolum Syntheticum, mix homogeneously is shared in mounting on the backing material by every 10g standard, promptly gets.
3. Therapeutic Method
After treatment group patient all adopts manual reduction, plaster is spread out with the roasting heat of alcohol burner, when temperature is moderate, be affixed on the bone injury place of the back that resets, conventional fixing with clamping plate or Gypsum Fibrosum then, changed 1 time in 7 days, 4 times is 1 course of treatment.Skin allergy, local red and swollen heat pain forbidding are prohibited the pungent cold and cool article of clothes during the medication.
After the matched group patient all adopts manual reduction, conventional fixing with clamping plate or Gypsum Fibrosum, need not any medicine, prohibit the pungent cold and cool article of clothes during the treatment.
4. observation of curative effect
After treating 2 courses of treatment, by following index observing union of fracture situation.
Clinicing symptom observation: mainly observe local pain after the medication, tenderness, swelling and improve situation.Adopt the degrees of symptoms scoring method.6 minutes: sharp ache, stiff, violent tenderness, severe swelling, dermatoglyph disappears; 4 minutes: pain was obvious, can be movable slightly, and obvious tenderness, moderate swelling, dermatoglyph significant change; 2 minutes: pain is arranged slightly, but do not influence activity, mild tenderness, mild swelling, dermatoglyph slightly changes; 0 minute: no pain or pain disappeared, no tenderness, no swelling.DPS software is adopted in data statistics; Data represent that with
difference adopts the T check.The result sees shown in the table 1.
Clinical efficacy evaluation: by People's Republic of China's Chinese medicine industry standard.Clinical healing: fracture end does not have tenderness, no longitudinal axis percussion pain, no abnormal activity and bony crepitus, and x line sheet shows that fracture line is fuzzy, and fracture end has successive callus formation.Produce effects: the broken ends of fractured bone does not have obvious tenderness or axial percussion pain, and no abnormal activity has the part callus to pass through.Effectively: the broken ends of fractured bone does not have obvious tenderness or axial percussion pain, and the callus index increases to some extent.Invalid: do not have obviously improvement before symptom and the treatment, x line sheet shows that fracture still is in the slow concrescence state.The gained data are used χ
2Check, the result sees shown in the table 2.
Compare before and after the table 1 liang group symptom integral
*P＜0.05，
**P＜0.01
Table 2 liang group curative effect relatively
*P＜0.05，
**P＜0.01
The result shows; After 2 courses of treatment, treatment group fracture pain, tenderness, swelling doing well,improving, fracture healing rate and effective percentage all are significantly higher than matched group, explain that pharmaceutical composition of the present invention significantly improves local blood circulation; Alleviate symptoms such as fracture local pain, tenderness, swelling; Promote growth of spur, accelerating union of bone fracture is worthy to be popularized.
Claims (9)
1. treat the fracture or the pharmaceutical composition of bone injury for one kind, it is characterized in that: it is the preparation that is prepared from following materials of weight proportions medicine:
Sanguis Draxonis 6-12 part, Radix Salviae Miltiorrhizae 15-30 part, Myrrha 20-40 part, Olibanum 30-40 part, Radix Arnebiae (Radix Lithospermi) 4-8 part, Radix Dipsaci, Rhizoma Cibotii 4-8 part, Pheretima, Fructus Psoraleae 6-12 part, Herba Taxilli 4-8 part, Radix Achyranthis Bidentatae 2-4 part, Rhizoma Drynariae 6-12 part, Moschus 1-2 part, Rhizoma Corydalis 9-15 part, Borneolum Syntheticum 4-10 part.
2. pharmaceutical composition according to claim 1 is characterized in that: it is the preparation that is prepared from following materials of weight proportions medicine:
9 parts of Sanguis Draxonis, 20 parts of Radix Salviae Miltiorrhizaes, 30 parts of Myrrhas, 35 parts of Olibanums, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 6 parts of Radix Dipsacis, 6 parts of Rhizoma Cibotiis, 9 parts of Pheretimas, 9 parts of Fructus Psoraleaes, 6 parts of Herba Taxillis, 3 parts of Radix Achyranthis Bidentataes, 9 parts of Rhizoma Drynariae, 1.5 parts in Moschus, 12 parts of Rhizoma Corydalis, 7 parts of Borneolum Syntheticums.
3. pharmaceutical composition according to claim 1 and 2; It is characterized in that: it is the powder with whole crude drug; Or Sanguis Draxonis, Moschus, the powder of Borneolum Syntheticum and the water or the extractive with organic solvent of all the other crude drug be mixed into active component, adds the preparation that adjuvant pharmaceutically commonly used or complementary composition are prepared from.
4. pharmaceutical composition according to claim 3 is characterized in that: described preparation is an external preparation.
5. pharmaceutical composition according to claim 4 is characterized in that: described preparation is ointment, rubber-emplastrum, black plaster, cataplasma, patch, membrane, paste, gel, powder, medicated wine or tincture.
6. method for preparing any described pharmaceutical composition of claim 1-4, it comprises the steps:
(1) weighting raw materials by weight ratio;
(2) with after the crude drug pulverizing, mixing adds that adjuvant commonly used is prepared into preparation.
7. method for preparing any described pharmaceutical composition of claim 1-4, it comprises the steps:
(1) weighting raw materials by weight ratio;
(2) Sanguis Draxonis, Moschus, Borneolum Syntheticum are pulverized, subsequent use; After residue medical material water or organic solvent etc. extracted in will writing out a prescription, gained water or extractive with organic solvent mixed with Sanguis Draxonis, Moschus, Borneolum Syntheticum medicated powder, added medicine adjuvant commonly used or complementary composition and were prepared into preparation pharmaceutically commonly used.
8. preparation of drug combination method according to claim 7 is characterized in that: the said organic solvent of step (2) comprises ethanol, Chinese liquor, vegetable oil.
9. the purposes of any described pharmaceutical composition of claim 1-5 in the external used medicine of preparation treatment fracture or bone injury.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919836A (en) * | 2014-04-02 | 2014-07-16 | 周云飞 | Traditional Chinese medicine for promoting fracture healing |
| CN103919837A (en) * | 2014-04-02 | 2014-07-16 | 周云飞 | Traditional Chinese medicine with hemostatic effect |
| CN104706624A (en) * | 2015-03-10 | 2015-06-17 | 北京化工大学 | Drug-loading pressure-sensitive adhesive patch using plant oil containing traditional Chinese medicines as plasticizer and preparation method of patch |
| CN110507709A (en) * | 2019-07-24 | 2019-11-29 | 李自明 | A kind of Chinese medicine preparation of the activating microcirculation and removing stasis medicinal of transdermal flux |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1395957A (en) * | 2002-09-03 | 2003-02-12 | 夏元鹏 | Plaster for setting up bone, dispersing stasis and analgesia and its preparing process |
| CN1586547A (en) * | 2004-07-15 | 2005-03-02 | 李敬忍 | Medicine for treating bone wound |
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2012
- 2012-02-08 CN CN 201210027818 patent/CN102552608B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1395957A (en) * | 2002-09-03 | 2003-02-12 | 夏元鹏 | Plaster for setting up bone, dispersing stasis and analgesia and its preparing process |
| CN1586547A (en) * | 2004-07-15 | 2005-03-02 | 李敬忍 | Medicine for treating bone wound |
Non-Patent Citations (1)
| Title |
|---|
| 翟献斌 等: "泰山接骨膏治疗骨折的临床研究", 《中医正骨》, vol. 19, no. 4, 30 April 2007 (2007-04-30), pages 11 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919836A (en) * | 2014-04-02 | 2014-07-16 | 周云飞 | Traditional Chinese medicine for promoting fracture healing |
| CN103919837A (en) * | 2014-04-02 | 2014-07-16 | 周云飞 | Traditional Chinese medicine with hemostatic effect |
| CN104706624A (en) * | 2015-03-10 | 2015-06-17 | 北京化工大学 | Drug-loading pressure-sensitive adhesive patch using plant oil containing traditional Chinese medicines as plasticizer and preparation method of patch |
| CN104706624B (en) * | 2015-03-10 | 2017-11-28 | 北京化工大学 | It is a kind of using the vegetable oil containing Chinese medicine as pressure-sensitive adhesive of load medicine of plasticizer and preparation method thereof |
| CN110507709A (en) * | 2019-07-24 | 2019-11-29 | 李自明 | A kind of Chinese medicine preparation of the activating microcirculation and removing stasis medicinal of transdermal flux |
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| Publication number | Publication date |
|---|---|
| CN102552608B (en) | 2013-06-12 |
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