CN1181850C

CN1181850C - Chinese medicinal preparation for treating cadiovascular and cerebrovascular diseases

Info

Publication number: CN1181850C
Application number: CNB021094942A
Authority: CN
Inventors: 王亚东
Original assignee: Individual
Current assignee: Individual
Priority date: 2002-04-16
Filing date: 2002-04-16
Publication date: 2004-12-29
Anticipated expiration: 2022-04-16
Also published as: CN1451402A

Abstract

The present invention relates to a traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases, particularly to a medicine composition for treating cardiovascular and cerebrovascular diseases. The medicine composition is prepared from 50 to 200% of astragalus root, 10 to 150% of red sage root, 10 to 60% of notoginseng, 10 to 50% of saffron, 10 to 70% of earthworm, 5 to 20% of scorpion, 20 to 70% of red peony root, 1 to 80% of pueraria root, 10 to 80% of Chuanxiong rhizome, 2 to 90% of cyathula root, 10 to 30% of deglued antler, 10 to 50% of prepared fleece flower root, 10 to 80% of eucommia bark, 2 to 80% of concha haliotidis, 10 to 80% of puncturevine caltrop fruit, 10 to 20% of artificial bezoar, 2 to 15% of artificial musk and 2 to 20% of borneol. The present invention has the advantages that experiments indicate that the medicinal preparation can obviously increase myocardial flow, cerebral blood flow, cardiac index, heartbeat index and cardiac output; the medicinal preparation has the functions of lowering heart rate, reducing cerebrovascular resistance, obviously lowering the extent of myocardial ischemia, narrowing the range of myocardial ischemia, narrowing the range of myocardial infarction, obviously inhibiting external thrombosis and platelet aggregation, and lowering blood viscosity.

Description

A kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease

Technical field:

The invention belongs to Chinese patent drug technique field, relate to a kind of pharmaceutical composition for the treatment of cardiovascular and cerebrovascular disease.

Background technology:

Modern study proves that apoplexy is equivalent to the cerebrovascular of doctor trained in Western medicine, because high incidence, high relapse rate, the high disability rate of cerebrovascular have all brought huge financial burden for society and family, is having a strong impact on the middle-aged and elderly people life quality.

Obstruction of qi in the chest and cardialgia in the theory of Chinese medical science is the heart disease of the coronary atherosclerosis of doctor trained in Western medicine, and a large amount of clinical cases think that coronary heart disease belongs to QI and blood stasis of blood person and accounts for more than 70%, and the heart substantially at kidney, is mainly involved, the double spleen that relates at the heart in sick position.

At present, the medicine that much suits in clinical diagnosis and treatment is arranged,, different therapeutic effect is all arranged, but curative effect is all not ideal enough as HUOLUO WAN, FUFANG DANSHEN PIAN, SHANHAI PILL, XINNAOKANG etc.

Summary of the invention:

Technical problem to be solved by this invention is:

A kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease that a kind of therapeutic effect is good, production cost is low is provided.

Prescription of the present invention is as follows:

It is made by following materials of weight proportions: the Radix Astragali 50---and 200; Radix Salviae Miltiorrhizae 10---150; Radix Notoginseng 10---60; Stigma Croci 10---50; Pheretima 10---70; Scorpio 5---20; Radix Paeoniae Rubra 20---70; Radix Puerariae 1---80; Rhizoma Chuanxiong (parch) 10---80; Radix Cyathulae 2---90; Cornu Cervi Degelatinatum 10---30; Radix Polygoni Multiflori Preparata 10---50; the Cortex Eucommiae (salt stir-fry) 10---80; Concha Haliotidis 2---80; Fructus Tribuli (parch) 10---80; the artificial Calculus Bovis 10---and 20; the artificial Moschus 2---and 15; Borneolum Syntheticum 2---20.

The invention has the beneficial effects as follows:

1, recording maximum tolerated dose by acute toxicity test is 36g/kg, is equivalent to 414 times of clinical consumption, proves that this medicine is safe and reliable when clinical use.

2, show by the long-term clinical test results of animal, this medicine is to animal food-intake, hair growth, breath cycle, defecate etc. do not have obviously influence, every physiochemical indice, organ coefficient and biochemical measurement index are compared no significant difference with matched group, do not find toxicity target cell organ, illustrate that this medical instrument has higher safety, the safe dose of this medicine is 5.22g/kg/d, is equivalent to 60 times of clinical consumption.

3, pass through the big hemodynamics of normal open chest anesthetized, myocardial oxygen consumption and cerebral blood flow, test shows that this medicine can obviously increase myocardial flow, cerebral blood flow, cardiac index, heartbeat exponential sum heart output.Reduce heart rate, hat brain resistance, cerebral vascular resistance, total peripheral resistance reduces myocardial oxygen consumption and oxygen uptake rate.Heart output, heartbeat index increase direct reflection cardiac pumping function and improve, and may reduce with external resistance, and the peripheral blood vessel expansion is relevant.Point out this medicine can improve the cardio-cerebrovascular function, adjust heart blood supply, oxygen supply balance, to control cardiovascular and cerebrovascular disease such as coronary heart disease, myocardial ischemia, common apoplexy such as cerebral ischemia, coronary heart disease are significant.

Show by test that 4, this medicine can obviously reduce degree of myocardial ischemia (S-ST), reduce myocardial ischemia scope (N-ST), dwindle myocardial infarct size (MIS) the experimental myocardial infarction dog.

5, the result of the test by auxiliary pharmacodynamics shows that this medicine can obviously suppress in the rat body, outer thrombosis, and anticoagulant reduces blood viscosity, and blood fat reducing improves anti-anoxia ability.

The specific embodiment:

Embodiment 1: Radix Astragali 100g, Radix Salviae Miltiorrhizae 20g, Radix Notoginseng 40g, Stigma Croci 10g, Pheretima 50g, Scorpio 10g, Radix Paeoniae Rubra 20g, Radix Puerariae 15g, Rhizoma Chuanxiong (parch) 60g, Radix Cyathulae 60g, Cornu Cervi Degelatinatum 10g, Radix Polygoni Multiflori Preparata 15g, the Cortex Eucommiae (salt stir-fry) 10g, Concha Haliotidis 60g, Fructus Tribuli (parch) 30g, artificial Calculus Bovis 15g, artificial Moschus 5g, Borneolum Syntheticum 10g.

Reparation technology is as follows:

Get the Radix Astragali 1/3rd amounts and Stigma Croci, Radix Notoginseng, Rhizoma Chuanxiong, Cornu Cervi Degelatinatum, Concha Haliotidis pulverizing and be ground into fine powder, Radix Salviae Miltiorrhizae added alcohol reflux 2 hours, filter, filtrate concentrates at decompression recycling ethanol below 80 ℃, extractum is in oven dry below 80 ℃, pulverize standby, the medicinal residues and the residue Radix Astragali and other flavour of a drug decocting three times, time was followed successively by 2:2:1 hour, merged decoction liquor and filtered, and filtrate is concentrated into the thick paste of relative density 1.30 (50 ℃), the fine powder that adds Six-element medicines such as the above-mentioned Radix Astragali, mixing, drying and crushing, sieving for standby.Get Pheretima, Scorpio is ground into fine powder, gets artificial Calculus Bovis, artificial Moschus and Borneolum Syntheticum porphyrize and above-mentioned fine powder mixing again, packing.

Embodiment 2: Radix Astragali 60g, Radix Salviae Miltiorrhizae 80g, Radix Notoginseng 60g, Stigma Croci 40g, Pheretima 30g, Scorpio 5g, Radix Paeoniae Rubra 40g, Radix Puerariae 80g, Rhizoma Chuanxiong (parch) 40g, Radix Cyathulae 40g, Cornu Cervi Degelatinatum 20g, Radix Polygoni Multiflori Preparata 40g, the Cortex Eucommiae (salt stir-fry) 50g, Concha Haliotidis 40g, Fructus Tribuli (parch) 70g, artificial Calculus Bovis 20g, artificial Moschus 10g, Borneolum Syntheticum 20g.

Reparation technology is identical with embodiment 1.

Embodiment 3: Radix Astragali 120g, Radix Salviae Miltiorrhizae 100g, Radix Notoginseng 80g, Stigma Croci 25g, Pheretima 20g, Scorpio 15g, Radix Paeoniae Rubra 60g, Radix Puerariae 70G, Rhizoma Chuanxiong (parch) 70g, Radix Cyathulae 80g, Cornu Cervi Degelatinatum 25g, Radix Polygoni Multiflori Preparata 40g, the Cortex Eucommiae (salt stir-fry) 60g, Concha Haliotidis 50g, Fructus Tribuli (parch) 60g, artificial Calculus Bovis 10g, artificial Moschus 3g, Borneolum Syntheticum 15g.

Reparation technology is identical with embodiment 1.

Claims

1, a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease is characterized in that it is made by following materials of weight proportions:

Radix Astragali 50--200, Radix Salviae Miltiorrhizae 10--150, Radix Notoginseng 10--60,

Stigma Croci 10--50, Pheretima 10--70, Scorpio 5--20,

Radix Paeoniae Rubra 20--70, Radix Puerariae 1--80, Rhizoma Chuanxiong (parch) 10--

80 Radix Cyathulae 2--90, Cornu Cervi Degelatinatum 10--30, Radix Polygoni Multiflori Preparata 10--50,

The Cortex Eucommiae (salt stir-fry) 10--80, Concha Haliotidis 2--80, Fructus Tribuli (parch) 10--80,

Artificial Calculus Bovis 10--20, artificial Moschus 2--15, Borneolum Syntheticum 2--20.