CN1433305A - 从发酵肉汤中回收抑素化合物的方法 - Google Patents

从发酵肉汤中回收抑素化合物的方法 Download PDF

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Publication number
CN1433305A
CN1433305A CN00818725A CN00818725A CN1433305A CN 1433305 A CN1433305 A CN 1433305A CN 00818725 A CN00818725 A CN 00818725A CN 00818725 A CN00818725 A CN 00818725A CN 1433305 A CN1433305 A CN 1433305A
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CN
China
Prior art keywords
compound
salt
organic
solution
pravastatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00818725A
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English (en)
Chinese (zh)
Inventor
V·科里
L·迪克
I·福加斯
C·斯扎搏
E·A·纳格伊内
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22609918&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1433305(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of CN1433305A publication Critical patent/CN1433305A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Manufacturing & Machinery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN00818725A 1999-11-30 2000-11-28 从发酵肉汤中回收抑素化合物的方法 Pending CN1433305A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16805699P 1999-11-30 1999-11-30
US60/168,056 1999-11-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2005100739122A Division CN1754872A (zh) 1999-11-30 2000-11-28 从发酵肉汤中回收抑素化合物的方法

Publications (1)

Publication Number Publication Date
CN1433305A true CN1433305A (zh) 2003-07-30

Family

ID=22609918

Family Applications (2)

Application Number Title Priority Date Filing Date
CN00818725A Pending CN1433305A (zh) 1999-11-30 2000-11-28 从发酵肉汤中回收抑素化合物的方法
CNA2005100739122A Pending CN1754872A (zh) 1999-11-30 2000-11-28 从发酵肉汤中回收抑素化合物的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2005100739122A Pending CN1754872A (zh) 1999-11-30 2000-11-28 从发酵肉汤中回收抑素化合物的方法

Country Status (22)

Country Link
US (3) US6444452B1 (https=)
EP (1) EP1265604B1 (https=)
JP (5) JP3881240B2 (https=)
KR (1) KR20030026920A (https=)
CN (2) CN1433305A (https=)
AT (2) ATE342717T1 (https=)
AU (1) AU1804601A (https=)
CA (1) CA2393057C (https=)
CY (1) CY1105925T1 (https=)
DE (3) DE04010770T1 (https=)
DK (1) DK1265604T3 (https=)
ES (2) ES2239937T1 (https=)
HR (1) HRP20020454A2 (https=)
HU (1) HUP0204012A3 (https=)
MX (1) MXPA02005283A (https=)
PL (1) PL364918A1 (https=)
PT (1) PT1265604E (https=)
RU (1) RU2002114072A (https=)
SK (1) SK7342002A3 (https=)
WO (1) WO2001039768A1 (https=)
YU (1) YU39102A (https=)
ZA (1) ZA200203912B (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141602B2 (en) * 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
JP3881240B2 (ja) * 1999-11-30 2007-02-14 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 醗酵ブロスからスタチン化合物を回収するための方法
SK8312002A3 (en) * 1999-12-14 2003-05-02 Biogal Gyogyszergyar Novel forms of pravastatin sodium
CN1468098A (zh) * 2000-10-05 2004-01-14 �ݰ¸Ƕ�ҩ�����޹�˾ 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
JP2002121172A (ja) * 2000-10-16 2002-04-23 Sankyo Co Ltd プラバスタチン又はその薬理上許容される塩の精製方法
DE10119718A1 (de) * 2001-04-21 2002-10-31 Boehringer Ingelheim Pharma Verfahren zur kontinuierlichen Herstellung inhalierfähiger Arzneistoffe, Vorrichtung zur Durchführung des Verfahrens und nach diesem Verfahren hergestellter Arzneistoff
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1477471A1 (en) * 2003-05-14 2004-11-17 Chunghwa Chemical Synthesis & Biotech Co., Ltd. Process for purifying pravastin sodium from a fermentation broth
CA2546377A1 (en) * 2003-11-24 2005-06-09 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying pravastatin
RU2317991C1 (ru) * 2003-12-05 2008-02-27 Байокон Лимитид Способ выделения и очистки макролидов
WO2006046130A2 (en) * 2004-10-29 2006-05-04 Ranbaxy Laboratories Limited Process for the preparation of pravastatin
TW200640854A (en) * 2005-02-09 2006-12-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Methods of making pravastatin sodium
JP4813841B2 (ja) * 2005-07-25 2011-11-09 キユーピー株式会社 プラバスタチンナトリウムの製造方法
DE102006028817A1 (de) * 2006-06-21 2007-12-27 Evonik Degussa Gmbh Aufarbeitung von Reaktionslösungen aus Ganzzell-Biotransformationen
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
US20110130450A1 (en) * 2008-04-02 2011-06-02 Aad Johannes Bouman Pravastatin extraction
IN2009MU00380A (https=) * 2009-02-18 2010-04-02
CN102993145B (zh) * 2011-09-19 2015-06-03 北大方正集团有限公司 一种提取纯化洛伐他汀的方法

Family Cites Families (24)

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Publication number Priority date Publication date Assignee Title
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
DE3682557D1 (de) * 1985-09-13 1992-01-02 Sankyo Co Hydroxy-ml-236b-derivate, deren herstellung und anwendung.
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4857522A (en) * 1988-03-21 1989-08-15 E. R. Squibb & Sons, Inc. Derivatives of pravastatin for inhibiting cholesterol biosynthesis
US5180589A (en) * 1988-03-31 1993-01-19 E. R. Squibb & Sons, Inc. Pravastatin pharmaceuatical compositions having good stability
US5099035A (en) * 1989-02-27 1992-03-24 E. R. Squibb & Sons, Inc. Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5140012A (en) * 1990-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Method for preventing onset of restenosis after angioplasty employing pravastatin
US5202029A (en) 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
US5157025A (en) * 1991-04-01 1992-10-20 E. R. Squibb & Sons, Inc. Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
SI9300303A (en) 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5616595A (en) 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
US5942423A (en) 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
US5883109A (en) * 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
WO1998037220A1 (en) * 1997-02-20 1998-08-27 Dsm N.V. Nitrogen feed in statin fermentation
AU9264598A (en) 1997-08-22 1999-03-16 Gist-Brocades B.V. Statin production by fermentation
SI9800046A (sl) * 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
SK10932001A3 (sk) * 1999-02-03 2002-06-04 Institute For Drug Research Ltd. Mikrobiálny spôsob výroby pravastatínu
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
JP3881240B2 (ja) * 1999-11-30 2007-02-14 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 醗酵ブロスからスタチン化合物を回収するための方法
CN1468098A (zh) * 2000-10-05 2004-01-14 �ݰ¸Ƕ�ҩ�����޹�˾ 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物

Also Published As

Publication number Publication date
JP2003515334A (ja) 2003-05-07
DE60037687D1 (de) 2008-02-14
AU1804601A (en) 2001-06-12
WO2001039768A1 (en) 2001-06-07
DK1265604T3 (da) 2007-02-05
JP3881240B2 (ja) 2007-02-14
ATE382344T1 (de) 2008-01-15
ATE342717T1 (de) 2006-11-15
EP1265604B1 (en) 2006-10-18
US20020187531A1 (en) 2002-12-12
DE60031447T2 (de) 2007-08-30
ES2239937T1 (es) 2005-10-16
MXPA02005283A (es) 2003-10-06
PT1265604E (pt) 2006-12-29
EP1265604A4 (en) 2004-06-16
JP2008109948A (ja) 2008-05-15
EP1265604A1 (en) 2002-12-18
PL364918A1 (en) 2004-12-27
HUP0204012A2 (hu) 2003-03-28
DE60031447D1 (de) 2006-11-30
JP2006273861A (ja) 2006-10-12
US6444452B1 (en) 2002-09-03
CA2393057A1 (en) 2001-06-07
KR20030026920A (ko) 2003-04-03
HUP0204012A3 (en) 2003-12-29
ZA200203912B (en) 2003-08-21
JP4343987B2 (ja) 2009-10-14
CA2393057C (en) 2008-01-29
HRP20020454A2 (en) 2005-10-31
CN1754872A (zh) 2006-04-05
RU2002114072A (ru) 2004-07-20
DE04010770T1 (de) 2005-10-20
YU39102A (sh) 2006-01-16
SK7342002A3 (en) 2004-03-02
JP2004350687A (ja) 2004-12-16
JP2006055174A (ja) 2006-03-02
ES2273737T3 (es) 2007-05-16
US6689590B2 (en) 2004-02-10
US20040115781A1 (en) 2004-06-17
CY1105925T1 (el) 2011-04-06

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication