CN1362138A - Nano influenza treating decoction and its preparation - Google Patents
Nano influenza treating decoction and its preparation Download PDFInfo
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- CN1362138A CN1362138A CN 01100191 CN01100191A CN1362138A CN 1362138 A CN1362138 A CN 1362138A CN 01100191 CN01100191 CN 01100191 CN 01100191 A CN01100191 A CN 01100191A CN 1362138 A CN1362138 A CN 1362138A
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Abstract
The present invention discloses a nano Liugancha preparation medicine. It is made up by using 10 Chinese medicinal materials of nano phragmites, nano atractylodes, nano pueraria, nano patchouli, nano magnolia bark and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grains ize is less than 100 nm. Said medicine is high in biological utilization rate and obfious in therapeutic effect.
Description
The present invention relates to the nano influenza treating decoction of a kind of heat clearing away of driving away summer heat, the removing dampness of inducing sweat, the invention still further relates to the method for this medication preparation.
Influenza tea is a kind of classical Chinese patent medicine, mainly contains the heat clearing away of driving away summer heat, effect such as the removing dampness of inducing sweat, and is used for summer-heat cold, fever with chills, and the headache body is tired, inappetence, vomiting and nausea uncomfortable in chest, white and greasy fur.But traditional influenza tea absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano influenza treating decoction of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano influenza treating decoction.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Phragmitis 280-720 part nanometer Rhizoma Atractylodis 84-216 part nanometer Radix Puerariae 140-360 part
Nanometer Herba Pogostemonis 56-144 part nanometer Cortex Magnoliae Officinalis 112-288 part nanometer Talcum 280-720 part
Nanometer Seem Lablab Album 112-288 part nanometer Semen Arecae 140-360 part nanometer Herba Moslae 112-288 part
Nanometer Rhizoma Et Radix Notopterygii 84-216 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Phragmitis 400-600 part nanometer Rhizoma Atractylodis 120-180 part nanometer Radix Puerariae 200-300 part
Nanometer Herba Pogostemonis 80-120 part nanometer Cortex Magnoliae Officinalis 160-240 part nanometer Talcum 400-600 part
Nanometer Seem Lablab Album 160-240 part nanometer Semen Arecae 200-300 part nanometer Herba Moslae 160-240 part
Nanometer Rhizoma Et Radix Notopterygii 120-180 part
The optimum weight proportioning of medicine of the present invention is:
250 parts of 150 parts of nanometer Radix Puerariaes of 500 parts of nanometer Rhizoma Atractylodis of nanometer Rhizoma Phragmitis
500 parts in 200 parts of nanometer Talcums of 100 parts of nanometer Cortex Magnoliae Officinalis of nanometer Herba Pogostemonis
200 parts of 250 parts of nanometer Herba Moslaes of 200 portions of nanometer Semen Arecaes of nanometer Seem Lablab Album
150 parts of nanometer Rhizoma Et Radix Notopterygiis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa surging,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa surging,, get influenza tea formulation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano influenza treating decoction is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common influenza tea formulation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: the bioavailability height, and solid preparation of the present invention disintegrate rapidly, solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup of nano influenza treating decoction etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for summer-heat cold, fever with chills, and the headache body is tired, inappetence, vomiting and nausea uncomfortable in chest, treatment of conditions such as white and greasy fur, clinical efficacy significantly is better than traditional influenza tea.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
250 parts of 150 parts of nanometer Radix Puerariaes of 500 parts of nanometer Rhizoma Atractylodis of nanometer Rhizoma Phragmitis
500 parts in 200 parts of nanometer Talcums of 100 parts of nanometer Cortex Magnoliae Officinalis of nanometer Herba Pogostemonis
200 parts of 250 parts of nanometer Herba Moslaes of 200 portions of nanometer Semen Arecaes of nanometer Seem Lablab Album
150 parts of nanometer Rhizoma Et Radix Notopterygiis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
250 parts of 150 parts of nanometer Radix Puerariaes of 500 parts of nanometer Rhizoma Atractylodis of nanometer Rhizoma Phragmitis
500 parts in 200 parts of nanometer Talcums of 100 parts of nanometer Cortex Magnoliae Officinalis of nanometer Herba Pogostemonis
200 parts of 250 parts of nanometer Herba Moslaes of 200 portions of nanometer Semen Arecaes of nanometer Seem Lablab Album
150 parts of nanometer Rhizoma Et Radix Notopterygiis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer influenza powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
250 parts of 150 parts of nanometer Radix Puerariaes of 500 parts of nanometer Rhizoma Atractylodis of nanometer Rhizoma Phragmitis
500 parts in 200 parts of nanometer Talcums of 100 parts of nanometer Cortex Magnoliae Officinalis of nanometer Herba Pogostemonis
200 parts of 250 parts of nanometer Herba Moslaes of 200 portions of nanometer Semen Arecaes of nanometer Seem Lablab Album
150 parts of nanometer Rhizoma Et Radix Notopterygiis
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer influenza membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest, cervical region.
Claims (6)
1, a kind of nano influenza treating decoction is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Phragmitis 280-720 part nanometer Rhizoma Atractylodis 84-216 part nanometer Radix Puerariae 140-360 part
Nanometer Herba Pogostemonis 56-144 part nanometer Cortex Magnoliae Officinalis 112-288 part nanometer Talcum 280-720 part
Nanometer Seem Lablab Album 112-288 part nanometer Semen Arecae 140-360 part nanometer Herba Moslae 112-288 part
Nanometer Rhizoma Et Radix Notopterygii 84-216 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa surging, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano influenza treating decoction according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Phragmitis 400-600 part nanometer Rhizoma Atractylodis 120-180 part nanometer Radix Puerariae 200-300 part
Nanometer Herba Pogostemonis 80-120 part nanometer Cortex Magnoliae Officinalis 160-240 part nanometer Talcum 400-600 part
Nanometer Seem Lablab Album 160-240 part nanometer Semen Arecae 200-300 part nanometer Herba Moslae 160-240 part
Nanometer Rhizoma Et Radix Notopterygii 120-180 part
3, nano influenza treating decoction according to claim 1, wherein the weight proportion of each nano raw material is:
250 parts of 150 parts of nanometer Radix Puerariaes of 500 parts of nanometer Rhizoma Atractylodis of nanometer Rhizoma Phragmitis
500 parts in 200 parts of nanometer Talcums of 100 parts of nanometer Cortex Magnoliae Officinalis of nanometer Herba Pogostemonis
200 parts of 250 parts of nanometer Herba Moslaes of 200 portions of nanometer Semen Arecaes of nanometer Seem Lablab Album
150 parts of nanometer Rhizoma Et Radix Notopterygiis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano influenza treating decoctions.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano influenza treating decoctions; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa surging, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100191 CN1362138A (en) | 2001-01-04 | 2001-01-04 | Nano influenza treating decoction and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100191 CN1362138A (en) | 2001-01-04 | 2001-01-04 | Nano influenza treating decoction and its preparation |
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| CN1362138A true CN1362138A (en) | 2002-08-07 |
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| CN 01100191 Pending CN1362138A (en) | 2001-01-04 | 2001-01-04 | Nano influenza treating decoction and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100339101C (en) * | 2003-07-07 | 2007-09-26 | 天津天士力制药股份有限公司 | Preparation and usage of |
-
2001
- 2001-01-04 CN CN 01100191 patent/CN1362138A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100339101C (en) * | 2003-07-07 | 2007-09-26 | 天津天士力制药股份有限公司 | Preparation and usage of |
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