CN1330301C - L－肉碱、乙酰l－肉碱和丙酰l－肉碱在制备治疗精子减少精子活力不足畸形精子的联合药物中的应用 - Google Patents

L－肉碱、乙酰l－肉碱和丙酰l－肉碱在制备治疗精子减少精子活力不足畸形精子的联合药物中的应用 Download PDF

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Publication number
CN1330301C
CN1330301C CNB038050935A CN03805093A CN1330301C CN 1330301 C CN1330301 C CN 1330301C CN B038050935 A CNB038050935 A CN B038050935A CN 03805093 A CN03805093 A CN 03805093A CN 1330301 C CN1330301 C CN 1330301C
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CN
China
Prior art keywords
carnitine
acetyl
purposes
propionyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB038050935A
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English (en)
Chinese (zh)
Other versions
CN1638754A (zh
Inventor
G·卡瓦里尼
G·比亚乔蒂
A·科沃里奇
F·萨德利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alpha Sigma Co ltd
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
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Publication of CN1638754A publication Critical patent/CN1638754A/zh
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Publication of CN1330301C publication Critical patent/CN1330301C/zh
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Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNB038050935A 2002-04-09 2003-04-08 L－肉碱、乙酰l－肉碱和丙酰l－肉碱在制备治疗精子减少精子活力不足畸形精子的联合药物中的应用 Expired - Lifetime CN1330301C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2002A000194 2002-04-09
IT2002RM000194A ITRM20020194A1 (it) 2002-04-09 2002-04-09 Composizione utile per aumentare la concentrazione e la motilita' degli spermatozoi e migliorarne la morfologia nell'uomo.

Publications (2)

Publication Number Publication Date
CN1638754A CN1638754A (zh) 2005-07-13
CN1330301C true CN1330301C (zh) 2007-08-08

Family

ID=11456235

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038050935A Expired - Lifetime CN1330301C (zh) 2002-04-09 2003-04-08 L－肉碱、乙酰l－肉碱和丙酰l－肉碱在制备治疗精子减少精子活力不足畸形精子的联合药物中的应用

Country Status (19)

Country Link
US (2) US20050107470A1 (enExample)
EP (1) EP1492521B1 (enExample)
JP (1) JP4663987B2 (enExample)
KR (1) KR20040098005A (enExample)
CN (1) CN1330301C (enExample)
AT (1) ATE476974T1 (enExample)
AU (1) AU2003224443B2 (enExample)
BR (1) BR0309055A (enExample)
CA (1) CA2478674C (enExample)
CY (1) CY1111273T1 (enExample)
DE (1) DE60333742D1 (enExample)
DK (1) DK1492521T3 (enExample)
ES (1) ES2350338T3 (enExample)
IT (1) ITRM20020194A1 (enExample)
MX (1) MXPA04009763A (enExample)
PL (1) PL214859B1 (enExample)
PT (1) PT1492521E (enExample)
SI (1) SI1492521T1 (enExample)
WO (1) WO2003084526A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109999042A (zh) * 2019-05-16 2019-07-12 北京华睿鼎信科技有限公司 包含脱氢表雄酮或其硫酸酯、左卡尼汀、乙酰左卡尼汀或它们的可药用盐的组合物及其应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776913B2 (en) 2002-12-13 2010-08-17 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Carnitines for treating or preventing disorders caused by andropause
EP2429299B1 (en) 2009-05-01 2016-06-01 Celloxess Llc Treating male infertility secondary to sperm oxidative stress
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
CN108041588A (zh) * 2017-12-08 2018-05-18 冯纪敏 一种含有海藻糖的组合物及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0539336A1 (en) * 1991-10-21 1993-04-28 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Use of L-carnitine or of acyl L-carnitine for the treatment of idiopathic oligoasthenospermias
CN1284871A (zh) * 1997-12-01 2001-02-21 希格马托保健科学股份公司 增加人类精子的浓度和运动性的组合物及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291127B1 (it) * 1997-04-01 1998-12-29 Sigma Tau Ind Farmaceuti Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica
IT1295408B1 (it) * 1997-10-03 1999-05-12 Sigma Tau Ind Farmaceuti Associazione di l-carnitina e alcanoil l-carnitine per il trattamento dell'alcoolismo
GB9721746D0 (en) 1997-10-15 1997-12-10 Panos Therapeutics Limited Compositions
ITRM20010029A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali metallici di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per
ITRM20020055A1 (it) 2002-02-04 2003-08-04 Aldo Fassi Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0539336A1 (en) * 1991-10-21 1993-04-28 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Use of L-carnitine or of acyl L-carnitine for the treatment of idiopathic oligoasthenospermias
CN1284871A (zh) * 1997-12-01 2001-02-21 希格马托保健科学股份公司 增加人类精子的浓度和运动性的组合物及方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109999042A (zh) * 2019-05-16 2019-07-12 北京华睿鼎信科技有限公司 包含脱氢表雄酮或其硫酸酯、左卡尼汀、乙酰左卡尼汀或它们的可药用盐的组合物及其应用
CN109999042B (zh) * 2019-05-16 2021-05-18 北京华睿鼎信科技有限公司 包含脱氢表雄酮或其硫酸酯、左卡尼汀、乙酰左卡尼汀或它们的可药用盐的组合物及其应用

Also Published As

Publication number Publication date
ES2350338T3 (es) 2011-01-21
PT1492521E (pt) 2010-11-11
ITRM20020194A0 (it) 2002-04-09
AU2003224443B2 (en) 2008-09-11
PL214859B1 (pl) 2013-09-30
KR20040098005A (ko) 2004-11-18
CN1638754A (zh) 2005-07-13
JP2006505499A (ja) 2006-02-16
ITRM20020194A1 (it) 2003-10-09
BR0309055A (pt) 2005-02-22
CA2478674A1 (en) 2003-10-16
SI1492521T1 (sl) 2010-12-31
US20050107470A1 (en) 2005-05-19
HK1078460A1 (en) 2006-03-17
EP1492521A1 (en) 2005-01-05
CA2478674C (en) 2010-10-19
WO2003084526A1 (en) 2003-10-16
AU2003224443A1 (en) 2003-10-20
DK1492521T3 (da) 2010-11-22
US20090012169A1 (en) 2009-01-08
US8415392B2 (en) 2013-04-09
JP4663987B2 (ja) 2011-04-06
DE60333742D1 (de) 2010-09-23
EP1492521B1 (en) 2010-08-11
PL372924A1 (en) 2005-08-08
MXPA04009763A (es) 2004-12-13
CY1111273T1 (el) 2015-08-05
ATE476974T1 (de) 2010-08-15

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Granted publication date: 20070808