JP4663987B2 - 精子減少・無力・奇形症の治療のためのｌ−カルニチン、アセチルｌ−カルニチンおよびプロピオニルｌ−カルニチンの併用 - Google Patents

精子減少・無力・奇形症の治療のためのｌ−カルニチン、アセチルｌ−カルニチンおよびプロピオニルｌ−カルニチンの併用 Download PDF

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Publication number
JP4663987B2
JP4663987B2 JP2003581766A JP2003581766A JP4663987B2 JP 4663987 B2 JP4663987 B2 JP 4663987B2 JP 2003581766 A JP2003581766 A JP 2003581766A JP 2003581766 A JP2003581766 A JP 2003581766A JP 4663987 B2 JP4663987 B2 JP 4663987B2
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Japan
Prior art keywords
carnitine
salt
acid
acetyl
propionyl
Prior art date
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JP2003581766A
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English (en)
Japanese (ja)
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JP2006505499A (ja
JP2006505499A5 (enExample
Inventor
ジョルジョ・カヴァッリーニ
ジュリオ・ビアジョッティ
アレアルド・コヴェレック
フランチェスカ・サルデッリ
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2003581766A 2002-04-09 2003-04-08 精子減少・無力・奇形症の治療のためのｌ−カルニチン、アセチルｌ−カルニチンおよびプロピオニルｌ−カルニチンの併用 Expired - Lifetime JP4663987B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002RM000194A ITRM20020194A1 (it) 2002-04-09 2002-04-09 Composizione utile per aumentare la concentrazione e la motilita' degli spermatozoi e migliorarne la morfologia nell'uomo.
PCT/IT2003/000214 WO2003084526A1 (en) 2002-04-09 2003-04-08 Combined use of l-carnitine, acetyl l-carnitine and propionyl l-carnitine for the treatment of oligoasthenoteratospermia

Publications (3)

Publication Number Publication Date
JP2006505499A JP2006505499A (ja) 2006-02-16
JP2006505499A5 JP2006505499A5 (enExample) 2006-07-06
JP4663987B2 true JP4663987B2 (ja) 2011-04-06

Family

ID=11456235

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003581766A Expired - Lifetime JP4663987B2 (ja) 2002-04-09 2003-04-08 精子減少・無力・奇形症の治療のためのｌ−カルニチン、アセチルｌ−カルニチンおよびプロピオニルｌ−カルニチンの併用

Country Status (19)

Country Link
US (2) US20050107470A1 (enExample)
EP (1) EP1492521B1 (enExample)
JP (1) JP4663987B2 (enExample)
KR (1) KR20040098005A (enExample)
CN (1) CN1330301C (enExample)
AT (1) ATE476974T1 (enExample)
AU (1) AU2003224443B2 (enExample)
BR (1) BR0309055A (enExample)
CA (1) CA2478674C (enExample)
CY (1) CY1111273T1 (enExample)
DE (1) DE60333742D1 (enExample)
DK (1) DK1492521T3 (enExample)
ES (1) ES2350338T3 (enExample)
IT (1) ITRM20020194A1 (enExample)
MX (1) MXPA04009763A (enExample)
PL (1) PL214859B1 (enExample)
PT (1) PT1492521E (enExample)
SI (1) SI1492521T1 (enExample)
WO (1) WO2003084526A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776913B2 (en) 2002-12-13 2010-08-17 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Carnitines for treating or preventing disorders caused by andropause
EP2429299B1 (en) 2009-05-01 2016-06-01 Celloxess Llc Treating male infertility secondary to sperm oxidative stress
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
CN108041588A (zh) * 2017-12-08 2018-05-18 冯纪敏 一种含有海藻糖的组合物及其应用
CN109999042B (zh) * 2019-05-16 2021-05-18 北京华睿鼎信科技有限公司 包含脱氢表雄酮或其硫酸酯、左卡尼汀、乙酰左卡尼汀或它们的可药用盐的组合物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1249462B (it) * 1991-10-21 1995-02-23 Sigma Tau Ind Farmaceuti Impiego di l-carnitina e acil l-carnitine nel trattamento delle oligoastenospermie idiopatiche.
IT1291127B1 (it) * 1997-04-01 1998-12-29 Sigma Tau Ind Farmaceuti Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica
IT1295408B1 (it) * 1997-10-03 1999-05-12 Sigma Tau Ind Farmaceuti Associazione di l-carnitina e alcanoil l-carnitine per il trattamento dell'alcoolismo
GB9721746D0 (en) 1997-10-15 1997-12-10 Panos Therapeutics Limited Compositions
US6090848A (en) * 1997-12-01 2000-07-18 Sigma-Tau Healthscience S.P.A. Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
ITRM20010029A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali metallici di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per
ITRM20020055A1 (it) 2002-02-04 2003-08-04 Aldo Fassi Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti

Also Published As

Publication number Publication date
ES2350338T3 (es) 2011-01-21
PT1492521E (pt) 2010-11-11
ITRM20020194A0 (it) 2002-04-09
AU2003224443B2 (en) 2008-09-11
PL214859B1 (pl) 2013-09-30
KR20040098005A (ko) 2004-11-18
CN1638754A (zh) 2005-07-13
JP2006505499A (ja) 2006-02-16
ITRM20020194A1 (it) 2003-10-09
CN1330301C (zh) 2007-08-08
BR0309055A (pt) 2005-02-22
CA2478674A1 (en) 2003-10-16
SI1492521T1 (sl) 2010-12-31
US20050107470A1 (en) 2005-05-19
HK1078460A1 (en) 2006-03-17
EP1492521A1 (en) 2005-01-05
CA2478674C (en) 2010-10-19
WO2003084526A1 (en) 2003-10-16
AU2003224443A1 (en) 2003-10-20
DK1492521T3 (da) 2010-11-22
US20090012169A1 (en) 2009-01-08
US8415392B2 (en) 2013-04-09
DE60333742D1 (de) 2010-09-23
EP1492521B1 (en) 2010-08-11
PL372924A1 (en) 2005-08-08
MXPA04009763A (es) 2004-12-13
CY1111273T1 (el) 2015-08-05
ATE476974T1 (de) 2010-08-15

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US6090848A (en) Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
US8415392B2 (en) Combined use of L-carnitine, acetyle L-carnitine and propionyl L-carnitine for the treatment of oligoasthenoteratospermia
US6235784B1 (en) Medicament and therapeutical method for treating idiopathic asthenozoospermia
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