CN1326562C - Il－18抑制剂制造治疗和/或预防心脏病的药物的应用 - Google Patents

Il－18抑制剂制造治疗和/或预防心脏病的药物的应用 Download PDF

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Publication number
CN1326562C
CN1326562C CNB02807503XA CN02807503A CN1326562C CN 1326562 C CN1326562 C CN 1326562C CN B02807503X A CNB02807503X A CN B02807503XA CN 02807503 A CN02807503 A CN 02807503A CN 1326562 C CN1326562 C CN 1326562C
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heart disease
ischemia
myocardial
tnf
human
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Chinese (zh)
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CN1499982A (zh
Inventor
C·迪纳洛
B·波梅兰茨
L·列兹尼科夫
A·哈肯
Y·奇韦提克
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Merck Serono SA
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Applied Research Systems ARS Holding NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNB02807503XA 2001-01-29 2002-01-28 Il－18抑制剂制造治疗和/或预防心脏病的药物的应用 Expired - Lifetime CN1326562C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01101959 2001-01-29
EP01101959.3 2001-01-29

Publications (2)

Publication Number Publication Date
CN1499982A CN1499982A (zh) 2004-05-26
CN1326562C true CN1326562C (zh) 2007-07-18

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ID=8176323

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CNB02807503XA Expired - Lifetime CN1326562C (zh) 2001-01-29 2002-01-28 Il－18抑制剂制造治疗和/或预防心脏病的药物的应用

Country Status (31)

Country Link
US (1) US20040234523A1 (cg-RX-API-DMAC10.html)
EP (1) EP1355668B1 (cg-RX-API-DMAC10.html)
JP (2) JP4860897B2 (cg-RX-API-DMAC10.html)
KR (1) KR100857376B1 (cg-RX-API-DMAC10.html)
CN (1) CN1326562C (cg-RX-API-DMAC10.html)
AR (1) AR032422A1 (cg-RX-API-DMAC10.html)
AT (1) ATE380558T1 (cg-RX-API-DMAC10.html)
BG (1) BG66483B1 (cg-RX-API-DMAC10.html)
BR (1) BR0206819A (cg-RX-API-DMAC10.html)
CA (1) CA2435466C (cg-RX-API-DMAC10.html)
CY (1) CY1107203T1 (cg-RX-API-DMAC10.html)
CZ (1) CZ305653B6 (cg-RX-API-DMAC10.html)
DE (1) DE60224004T2 (cg-RX-API-DMAC10.html)
DK (1) DK1355668T3 (cg-RX-API-DMAC10.html)
EA (2) EA006767B1 (cg-RX-API-DMAC10.html)
EE (1) EE05534B1 (cg-RX-API-DMAC10.html)
ES (1) ES2295332T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20030609A2 (cg-RX-API-DMAC10.html)
HU (1) HU229164B1 (cg-RX-API-DMAC10.html)
IL (2) IL157024A0 (cg-RX-API-DMAC10.html)
ME (1) ME00549B (cg-RX-API-DMAC10.html)
MX (1) MXPA03006776A (cg-RX-API-DMAC10.html)
NO (1) NO331083B1 (cg-RX-API-DMAC10.html)
PL (1) PL213568B1 (cg-RX-API-DMAC10.html)
PT (1) PT1355668E (cg-RX-API-DMAC10.html)
RS (1) RS51125B (cg-RX-API-DMAC10.html)
SI (1) SI1355668T1 (cg-RX-API-DMAC10.html)
SK (1) SK287620B6 (cg-RX-API-DMAC10.html)
UA (1) UA80676C2 (cg-RX-API-DMAC10.html)
WO (1) WO2002060479A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200305439B (cg-RX-API-DMAC10.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK12942002A3 (sk) 2000-02-10 2003-05-02 Abbott Laboratories Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia
AU2002211744B8 (en) 2000-10-11 2008-03-20 Viron Therapeutics, Inc. Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
AU2004238524B2 (en) 2003-05-13 2011-06-23 Merck Serono Sa Active variants of the IL-18 binding protein and medical uses thereof
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
JP4961559B2 (ja) * 2004-03-11 2012-06-27 友昭 星野 インターロイキン１８阻害剤を有効成分とする疾患の予防又は治療剤
CA2609060C (en) 2005-06-03 2014-07-15 Urs Weber Production of recombinant il-18 binding protein
PT1891088E (pt) 2005-06-10 2011-12-19 Ares Trading Sa Processo para a purificação da proteína de ligação il-18
TW200927060A (en) 2007-11-05 2009-07-01 Kci Licensing Inc Identification of tissue for debridement
US9376489B2 (en) 2012-09-07 2016-06-28 Novartis Ag IL-18 binding molecules
WO2015032932A1 (en) * 2013-09-05 2015-03-12 Ab2 Bio Sa Il-18 binding protein (il-18bp) in inflammatory diseases
CN107660150B (zh) * 2015-03-05 2023-10-24 Ab2生物股份有限公司 Il-18结合蛋白(il-18bp)和抗体在炎性疾病中
US11091795B2 (en) 2016-07-11 2021-08-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1267307A (zh) * 1997-08-14 2000-09-20 耶达研究发展有限公司 白细胞介素－18结合蛋白质及其制备和用途
WO2001003719A2 (en) * 1999-07-09 2001-01-18 Amgen Inc. Combination therapy for conditions leading to bone loss

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US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5605690A (en) * 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
NZ322197A (en) * 1995-11-21 1999-02-25 Yamanouchi Pharma Co Ltd Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
ATE310528T1 (de) * 1996-09-12 2005-12-15 Idun Pharmaceuticals Inc Hemmung der apoptose unter verwendung von inhibitoren der interleukin-1 beta converting enzym (ice)/ced-3 familie
JP4094066B2 (ja) * 1996-12-06 2008-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド インターロイキン−１β変換酵素のインヒビター
SK122199A3 (en) * 1997-03-18 2000-12-11 Basf Ag Methods and compositions for modulating responsiveness to corticosteroids
DE19743687C1 (de) * 1997-10-06 1998-11-26 Henkel Kgaa Detergensgemische und deren Verwendung
AU4961499A (en) * 1998-06-26 2000-01-17 Eli Lilly And Company 5-HT1f agonists
CA2340579A1 (en) * 1998-09-01 2000-03-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin 18-binding protein
EP1022027A1 (en) * 1999-01-22 2000-07-26 Applied Research Systems ARS Holding N.V. Tumor necrosis factor antagonists and their use in endometriosis
EP1165490B1 (en) * 1999-03-16 2006-08-16 Cytovia, Inc. Substituted 2-aminobenzamide caspase inhibitors and the use thereof
CA2369619A1 (en) * 1999-04-09 2000-10-19 Cytovia, Inc. Caspase inhibitors and the use thereof
SK12942002A3 (sk) * 2000-02-10 2003-05-02 Abbott Laboratories Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia
CA2407895C (en) * 2000-05-05 2012-12-18 Applied Research Systems Ars Holding N.V. Use of il-18 inhibitors for the treatment and/or prevention of atherosclerosis
WO2002032374A2 (en) * 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN1267307A (zh) * 1997-08-14 2000-09-20 耶达研究发展有限公司 白细胞介素－18结合蛋白质及其制备和用途
WO2001003719A2 (en) * 1999-07-09 2001-01-18 Amgen Inc. Combination therapy for conditions leading to bone loss

Also Published As

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JP2009102354A (ja) 2009-05-14
YU57803A (sh) 2006-05-25
DE60224004T2 (de) 2009-07-23
PT1355668E (pt) 2008-01-04
NO331083B1 (no) 2011-10-03
EE05534B1 (et) 2012-04-16
AR032422A1 (es) 2003-11-05
DE60224004D1 (de) 2008-01-24
EA200501549A1 (ru) 2006-04-28
JP4860897B2 (ja) 2012-01-25
ZA200305439B (en) 2004-07-15
EE200300328A (et) 2003-10-15
HUP0303306A3 (en) 2005-12-28
EA006767B1 (ru) 2006-04-28
EA010180B1 (ru) 2008-06-30
CZ305653B6 (cs) 2016-01-27
HK1062810A1 (en) 2004-11-26
WO2002060479A1 (en) 2002-08-08
IL157024A (en) 2014-02-27
PL366802A1 (en) 2005-02-07
ME00549B (me) 2011-10-10
BG108128A (bg) 2004-11-30
BG66483B1 (bg) 2015-03-31
JP2004522748A (ja) 2004-07-29
CN1499982A (zh) 2004-05-26
CA2435466A1 (en) 2002-08-08
BR0206819A (pt) 2004-02-03
NO20033228L (no) 2003-09-26
HRP20030609A2 (en) 2005-06-30
HU229164B1 (en) 2013-09-30
EA200300844A1 (ru) 2003-12-25
CY1107203T1 (el) 2012-11-21
EP1355668B1 (en) 2007-12-12
HUP0303306A2 (hu) 2004-01-28
PL213568B1 (pl) 2013-03-29
MXPA03006776A (es) 2003-10-24
ES2295332T3 (es) 2008-04-16
NO20033228D0 (no) 2003-07-16
EP1355668A1 (en) 2003-10-29
RS51125B (sr) 2010-10-31
UA80676C2 (en) 2007-10-25
ATE380558T1 (de) 2007-12-15
SK10892003A3 (sk) 2004-02-03
CA2435466C (en) 2012-04-03
DK1355668T3 (da) 2008-05-05
KR100857376B1 (ko) 2008-09-05
SI1355668T1 (sl) 2008-06-30
IL157024A0 (en) 2004-02-08
CZ20032335A3 (en) 2004-07-14
US20040234523A1 (en) 2004-11-25
KR20030070143A (ko) 2003-08-27
SK287620B6 (sk) 2011-04-05

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