CN1317034C - 核酸佐剂 - Google Patents

核酸佐剂 Download PDF

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Publication number
CN1317034C
CN1317034C CNB018195709A CN01819570A CN1317034C CN 1317034 C CN1317034 C CN 1317034C CN B018195709 A CNB018195709 A CN B018195709A CN 01819570 A CN01819570 A CN 01819570A CN 1317034 C CN1317034 C CN 1317034C
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CN
China
Prior art keywords
composition
nucleic acid
subunit
dna
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018195709A
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English (en)
Chinese (zh)
Other versions
CN1537013A (zh
Inventor
约尔·R·海恩斯
约书亚·E·阿林顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Powderject Vaccines Inc
Original Assignee
Powderject Vaccines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Powderject Vaccines Inc filed Critical Powderject Vaccines Inc
Publication of CN1537013A publication Critical patent/CN1537013A/zh
Application granted granted Critical
Publication of CN1317034C publication Critical patent/CN1317034C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB018195709A 2000-11-27 2001-11-26 核酸佐剂 Expired - Fee Related CN1317034C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72431500A 2000-11-27 2000-11-27
US09/724,315 2000-11-27

Publications (2)

Publication Number Publication Date
CN1537013A CN1537013A (zh) 2004-10-13
CN1317034C true CN1317034C (zh) 2007-05-23

Family

ID=24909936

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018195709A Expired - Fee Related CN1317034C (zh) 2000-11-27 2001-11-26 核酸佐剂

Country Status (16)

Country Link
EP (1) EP1379273B1 (enExample)
JP (1) JP4221289B2 (enExample)
KR (1) KR20040045391A (enExample)
CN (1) CN1317034C (enExample)
AT (1) ATE442858T1 (enExample)
AU (1) AU2001297988B2 (enExample)
BR (1) BR0115646A (enExample)
CA (1) CA2429708A1 (enExample)
DE (1) DE60139959D1 (enExample)
DK (1) DK1379273T3 (enExample)
ES (1) ES2332261T3 (enExample)
IL (2) IL156041A0 (enExample)
MX (1) MXPA03004638A (enExample)
NZ (1) NZ526175A (enExample)
PT (1) PT1379273E (enExample)
WO (1) WO2003004055A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101225395B1 (ko) 2003-10-10 2013-01-28 파우더젝트 백신, 인코포레이티드 핵산 구조물
BRPI0507579A (pt) 2004-02-11 2007-07-03 Angeletti P Ist Richerche Bio molécula de ácido nucleico, vetor, célula hospedeira, processo para expressar uma proteìna de fusão cea em uma célula hospedeira recombinante, proteìna de fusão cea purificada, método de prevenção ou tratamento de cáncer, plasmìdeo de vacina, e, método de tratamento de um mamìfero sofrendo de ou predisposto a um cáncer associados com cea
GB0507997D0 (en) * 2005-02-01 2005-05-25 Powderject Vaccines Inc Nucleic acid constructs
US8389686B2 (en) 2008-05-07 2013-03-05 Osaka University Noncovalent collagen crosslinking agent
US11246915B2 (en) 2010-09-15 2022-02-15 Applied Molecular Transport Inc. Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
CA2848656C (en) 2010-09-15 2017-10-10 Randall J. Mrsny Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences
CN103060253A (zh) * 2013-01-24 2013-04-24 麻丽丹 霍乱弧菌ctxAB基因的质粒克隆菌株以及制备方法和应用
DK3139965T3 (da) 2014-05-07 2021-11-22 Applied Molecular Transport Inc Fusionsmolekyler afledt af cholix-toksin til oral indgivelse af biologisk aktive stoffer
EP4082558B1 (en) 2018-03-08 2023-08-23 Applied Molecular Transport Inc. Toxin-derived delivery constructs for oral delivery
KR20210110294A (ko) 2018-11-07 2021-09-07 어플라이드 몰레큘라 트랜스포트 인크. 통과세포외배출용 전달 구조체 및 관련 방법
BR112022002962A2 (pt) 2019-08-16 2022-07-05 Applied Molecular Transport Inc Composições, formulações e produção e purificação de interleucina

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980898A (en) * 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6056960A (en) * 1995-06-07 2000-05-02 Kaslow; Harvey R. Compositions exhibiting ADP-ribosyltransferase activity and methods for the preparation and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
TW404844B (en) 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
GB9416663D0 (en) 1994-08-17 1994-10-12 Oxford Bioscience Limited Particle delivery
AU3703895A (en) 1994-10-24 1996-05-15 Oxford Biosciences Limited Particle delivery
GB9426379D0 (en) 1994-12-23 1995-03-01 Oxford Biosciences Ltd Particle delivery
GB9612629D0 (en) 1996-06-17 1996-08-21 Oxford Biosciences Ltd Method for providing dense particle compositions for use in transdermal particle delivery

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6056960A (en) * 1995-06-07 2000-05-02 Kaslow; Harvey R. Compositions exhibiting ADP-ribosyltransferase activity and methods for the preparation and use thereof
US5980898A (en) * 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Transcutaneous immunization with bacterial ADP-ribosylatingexotoxins as antigens and adjuvants GLENN G M,INFECTION AND IMMUNITY,Vol.67 No.3 1999 *
Transcutaneous immunization with bacterialADP-ribosylating exotoxins,subunits,and unrelated adjuvants SCHARTON.KERSTEN T,INFECTION AND IMMUNITY,Vol.68 No.9 2000 *

Also Published As

Publication number Publication date
KR20040045391A (ko) 2004-06-01
EP1379273B1 (en) 2009-09-16
DE60139959D1 (de) 2009-10-29
CN1537013A (zh) 2004-10-13
BR0115646A (pt) 2005-12-13
MXPA03004638A (es) 2004-04-20
ES2332261T3 (es) 2010-02-01
WO2003004055A3 (en) 2003-11-20
JP2004536107A (ja) 2004-12-02
IL156041A0 (en) 2003-12-23
CA2429708A1 (en) 2003-01-16
ATE442858T1 (de) 2009-10-15
JP4221289B2 (ja) 2009-02-12
AU2001297988B2 (en) 2006-10-26
PT1379273E (pt) 2009-11-27
EP1379273A2 (en) 2004-01-14
NZ526175A (en) 2006-01-27
IL156041A (en) 2010-05-17
WO2003004055A2 (en) 2003-01-16
DK1379273T3 (da) 2009-11-09

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C06 Publication
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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070523

Termination date: 20111126