DK1379273T3 - Nukleinsyreadjuvanser - Google Patents
NukleinsyreadjuvanserInfo
- Publication number
- DK1379273T3 DK1379273T3 DK01274277T DK01274277T DK1379273T3 DK 1379273 T3 DK1379273 T3 DK 1379273T3 DK 01274277 T DK01274277 T DK 01274277T DK 01274277 T DK01274277 T DK 01274277T DK 1379273 T3 DK1379273 T3 DK 1379273T3
- Authority
- DK
- Denmark
- Prior art keywords
- nucleic acid
- molecules
- truncated
- acid adjuvants
- coding region
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 6
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 239000002671 adjuvant Substances 0.000 title 1
- 108091026890 Coding region Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000002095 exotoxin Substances 0.000 abstract 1
- 231100000776 exotoxin Toxicity 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72431500A | 2000-11-27 | 2000-11-27 | |
| PCT/US2001/043151 WO2003004055A2 (en) | 2000-11-27 | 2001-11-26 | Nucleic acid adjuvants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1379273T3 true DK1379273T3 (da) | 2009-11-09 |
Family
ID=24909936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01274277T DK1379273T3 (da) | 2000-11-27 | 2001-11-26 | Nukleinsyreadjuvanser |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1379273B1 (enExample) |
| JP (1) | JP4221289B2 (enExample) |
| KR (1) | KR20040045391A (enExample) |
| CN (1) | CN1317034C (enExample) |
| AT (1) | ATE442858T1 (enExample) |
| AU (1) | AU2001297988B2 (enExample) |
| BR (1) | BR0115646A (enExample) |
| CA (1) | CA2429708A1 (enExample) |
| DE (1) | DE60139959D1 (enExample) |
| DK (1) | DK1379273T3 (enExample) |
| ES (1) | ES2332261T3 (enExample) |
| IL (2) | IL156041A0 (enExample) |
| MX (1) | MXPA03004638A (enExample) |
| NZ (1) | NZ526175A (enExample) |
| PT (1) | PT1379273E (enExample) |
| WO (1) | WO2003004055A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101225395B1 (ko) | 2003-10-10 | 2013-01-28 | 파우더젝트 백신, 인코포레이티드 | 핵산 구조물 |
| BRPI0507579A (pt) | 2004-02-11 | 2007-07-03 | Angeletti P Ist Richerche Bio | molécula de ácido nucleico, vetor, célula hospedeira, processo para expressar uma proteìna de fusão cea em uma célula hospedeira recombinante, proteìna de fusão cea purificada, método de prevenção ou tratamento de cáncer, plasmìdeo de vacina, e, método de tratamento de um mamìfero sofrendo de ou predisposto a um cáncer associados com cea |
| GB0507997D0 (en) * | 2005-02-01 | 2005-05-25 | Powderject Vaccines Inc | Nucleic acid constructs |
| US8389686B2 (en) | 2008-05-07 | 2013-03-05 | Osaka University | Noncovalent collagen crosslinking agent |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| CA2848656C (en) | 2010-09-15 | 2017-10-10 | Randall J. Mrsny | Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences |
| CN103060253A (zh) * | 2013-01-24 | 2013-04-24 | 麻丽丹 | 霍乱弧菌ctxAB基因的质粒克隆菌株以及制备方法和应用 |
| DK3139965T3 (da) | 2014-05-07 | 2021-11-22 | Applied Molecular Transport Inc | Fusionsmolekyler afledt af cholix-toksin til oral indgivelse af biologisk aktive stoffer |
| EP4082558B1 (en) | 2018-03-08 | 2023-08-23 | Applied Molecular Transport Inc. | Toxin-derived delivery constructs for oral delivery |
| KR20210110294A (ko) | 2018-11-07 | 2021-09-07 | 어플라이드 몰레큘라 트랜스포트 인크. | 통과세포외배출용 전달 구조체 및 관련 방법 |
| BR112022002962A2 (pt) | 2019-08-16 | 2022-07-05 | Applied Molecular Transport Inc | Composições, formulações e produção e purificação de interleucina |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| TW404844B (en) | 1993-04-08 | 2000-09-11 | Oxford Biosciences Ltd | Needleless syringe |
| GB9416663D0 (en) | 1994-08-17 | 1994-10-12 | Oxford Bioscience Limited | Particle delivery |
| AU3703895A (en) | 1994-10-24 | 1996-05-15 | Oxford Biosciences Limited | Particle delivery |
| GB9426379D0 (en) | 1994-12-23 | 1995-03-01 | Oxford Biosciences Ltd | Particle delivery |
| US6056960A (en) * | 1995-06-07 | 2000-05-02 | Kaslow; Harvey R. | Compositions exhibiting ADP-ribosyltransferase activity and methods for the preparation and use thereof |
| GB9612629D0 (en) | 1996-06-17 | 1996-08-21 | Oxford Biosciences Ltd | Method for providing dense particle compositions for use in transdermal particle delivery |
| US5980898A (en) * | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
-
2001
- 2001-11-26 ES ES01274277T patent/ES2332261T3/es not_active Expired - Lifetime
- 2001-11-26 AT AT01274277T patent/ATE442858T1/de active
- 2001-11-26 CA CA002429708A patent/CA2429708A1/en not_active Abandoned
- 2001-11-26 NZ NZ526175A patent/NZ526175A/en unknown
- 2001-11-26 JP JP2003510065A patent/JP4221289B2/ja not_active Expired - Fee Related
- 2001-11-26 AU AU2001297988A patent/AU2001297988B2/en not_active Ceased
- 2001-11-26 EP EP01274277A patent/EP1379273B1/en not_active Expired - Lifetime
- 2001-11-26 IL IL15604101A patent/IL156041A0/xx unknown
- 2001-11-26 WO PCT/US2001/043151 patent/WO2003004055A2/en not_active Ceased
- 2001-11-26 KR KR10-2003-7007121A patent/KR20040045391A/ko not_active Ceased
- 2001-11-26 DK DK01274277T patent/DK1379273T3/da active
- 2001-11-26 BR BR0115646-2A patent/BR0115646A/pt not_active Application Discontinuation
- 2001-11-26 PT PT01274277T patent/PT1379273E/pt unknown
- 2001-11-26 CN CNB018195709A patent/CN1317034C/zh not_active Expired - Fee Related
- 2001-11-26 DE DE60139959T patent/DE60139959D1/de not_active Expired - Lifetime
- 2001-11-26 MX MXPA03004638A patent/MXPA03004638A/es active IP Right Grant
-
2003
- 2003-05-21 IL IL156041A patent/IL156041A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040045391A (ko) | 2004-06-01 |
| EP1379273B1 (en) | 2009-09-16 |
| DE60139959D1 (de) | 2009-10-29 |
| CN1537013A (zh) | 2004-10-13 |
| BR0115646A (pt) | 2005-12-13 |
| MXPA03004638A (es) | 2004-04-20 |
| ES2332261T3 (es) | 2010-02-01 |
| WO2003004055A3 (en) | 2003-11-20 |
| JP2004536107A (ja) | 2004-12-02 |
| CN1317034C (zh) | 2007-05-23 |
| IL156041A0 (en) | 2003-12-23 |
| CA2429708A1 (en) | 2003-01-16 |
| ATE442858T1 (de) | 2009-10-15 |
| JP4221289B2 (ja) | 2009-02-12 |
| AU2001297988B2 (en) | 2006-10-26 |
| PT1379273E (pt) | 2009-11-27 |
| EP1379273A2 (en) | 2004-01-14 |
| NZ526175A (en) | 2006-01-27 |
| IL156041A (en) | 2010-05-17 |
| WO2003004055A2 (en) | 2003-01-16 |
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