CN1313145C - 青蒿素相关性内过氧化物与携带铁的蛋白质之间的共价缀合物及其使用方法 - Google Patents

青蒿素相关性内过氧化物与携带铁的蛋白质之间的共价缀合物及其使用方法 Download PDF

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Publication number
CN1313145C
CN1313145C CNB038167956A CN03816795A CN1313145C CN 1313145 C CN1313145 C CN 1313145C CN B038167956 A CNB038167956 A CN B038167956A CN 03816795 A CN03816795 A CN 03816795A CN 1313145 C CN1313145 C CN 1313145C
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China
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protein
covalent conjugates
endoperoxide
iron
artemisinin
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Expired - Fee Related
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CNB038167956A
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Chinese (zh)
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CN1668323A (zh
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H·C·莱
T·佐佐木
N·P·辛格
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University of Washington
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University of Washington
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
CNB038167956A 2002-06-06 2003-06-06 青蒿素相关性内过氧化物与携带铁的蛋白质之间的共价缀合物及其使用方法 Expired - Fee Related CN1313145C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38692802P 2002-06-06 2002-06-06
US60/386,928 2002-06-06

Publications (2)

Publication Number Publication Date
CN1668323A CN1668323A (zh) 2005-09-14
CN1313145C true CN1313145C (zh) 2007-05-02

Family

ID=29736235

Family Applications (3)

Application Number Title Priority Date Filing Date
CNA038167972A Pending CN1668293A (zh) 2002-06-06 2003-06-06 使用青蒿素样化合物预防或延缓癌症显现的方法
CNB038167956A Expired - Fee Related CN1313145C (zh) 2002-06-06 2003-06-06 青蒿素相关性内过氧化物与携带铁的蛋白质之间的共价缀合物及其使用方法
CN201010165713A Pending CN101843904A (zh) 2002-06-06 2003-06-06 使用青蒿素样化合物预防或延缓癌症显现的方法

Family Applications Before (1)

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CNA038167972A Pending CN1668293A (zh) 2002-06-06 2003-06-06 使用青蒿素样化合物预防或延缓癌症显现的方法

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Application Number Title Priority Date Filing Date
CN201010165713A Pending CN101843904A (zh) 2002-06-06 2003-06-06 使用青蒿素样化合物预防或延缓癌症显现的方法

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Country Link
US (2) US20040058981A1 (enExample)
EP (2) EP1553935A4 (enExample)
JP (2) JP2005529938A (enExample)
CN (3) CN1668293A (enExample)
AU (2) AU2003243418B2 (enExample)
BR (2) BR0311627A (enExample)
CA (2) CA2488347A1 (enExample)
NZ (2) NZ537114A (enExample)
RU (2) RU2004139090A (enExample)
WO (1) WO2003103588A2 (enExample)
ZA (1) ZA200500023B (enExample)

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CN103393672A (zh) 2003-02-12 2013-11-20 乔治敦大学 青蒿素在治疗致癌病毒诱导的肿瘤和治疗病毒感染中的应用
US8394365B2 (en) * 2003-09-17 2013-03-12 Nektar Therapeutics Multi-arm polymer prodrugs
KR20120073370A (ko) * 2003-09-17 2012-07-04 넥타르 테라퓨틱스 다분지형 고분자 전구약물
CN1255106C (zh) * 2003-09-26 2006-05-10 李国桥 复方青蒿素
US20050096369A1 (en) * 2003-11-04 2005-05-05 Hoang Ba X. Compositions and methods for treating cellular proliferation disorders
CA2546210A1 (en) * 2003-11-19 2005-06-02 Vecta Ltd. Methods and compositions for the treatment of helicobacter pylori-associated diseases using endoperoxide bridge-containing compounds
CN1311832C (zh) * 2005-01-12 2007-04-25 四川科伦药业股份有限公司 溴代二氢青蒿素的医药用途
US20060270863A1 (en) * 2005-05-27 2006-11-30 Amyris Biotechnologies Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors
NZ568049A (en) * 2005-10-20 2011-10-28 Epipharm Gmbh Treatment and prevention of benign pigmented moles (nevi) using artemisinine and the derivatives thereof
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US20070231300A1 (en) * 2006-03-28 2007-10-04 Washington, University Of Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents
WO2008046109A2 (en) * 2006-10-13 2008-04-17 University Of Washington Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer
MX2009005780A (es) * 2006-11-30 2009-06-10 Nektar Therapeutics Al Corp Metodo para preparar un conjugado de polimeros.
KR20090108082A (ko) * 2007-02-09 2009-10-14 엔존 파마슈티컬즈, 인코포레이티드 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법
SG172737A1 (en) * 2008-01-30 2011-07-28 Pieris Ag Muteins of tear lipocalin having affinity to human c-met receptor tyrosine kinaseand methods for obtaining the same
CN101323569B (zh) * 2008-07-24 2011-01-26 上海交通大学 倍半萜青蒿萜酯ae及其提取纯化方法
CN102159250B (zh) 2008-08-11 2014-08-06 尼克塔治疗公司 多臂的聚合烷酸酯偶联物
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
RS59607B1 (sr) 2008-09-23 2020-01-31 Nektar Therapeutics Metod metronomskog doziranja kamptotecinskih prolekova (npr. peg-irinotekan)
KR20110075029A (ko) * 2008-10-21 2011-07-05 엔즌 파마슈티칼스, 인코포레이티드 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료
GB2469791B (en) * 2009-04-23 2011-12-14 Londonpharma Ltd Transmucosal formulation of compounds providing dihydroartemesinin for use in the treatment of neoplastic disease
BRPI1014887A8 (pt) * 2009-04-23 2019-02-12 Londonpharma Ltd composição farmacêutica para uso no tratamento de neoplasias e uso de um composto provendo di-hidroartemesinina via dosagem sublingual, transmucosal, bucal ou nasal
JP5624735B2 (ja) 2009-07-22 2014-11-12 国立大学法人岡山大学 フィルター
CN102399142B (zh) * 2010-09-14 2014-09-24 华北制药集团新药研究开发有限责任公司 一类倍半萜酯化合物及其制备方法和用途
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
CN102727522B (zh) * 2011-04-08 2013-09-25 石雁羽 由溴代双氢青蒿素和Fe2+剂组成的复方双释胶囊制剂
CN103845360A (zh) * 2012-11-29 2014-06-11 昆明制药集团股份有限公司 含蒿甲醚的药物组合物、制剂及其用途
CN103405779B (zh) * 2013-07-18 2015-09-30 江苏省血吸虫病防治研究所 一种预防血吸虫感染长效青蒿琥酯药物及其制备方法
GB201800736D0 (en) 2018-01-17 2018-02-28 St Georges Hospital Medical School Combination therapy for treatment of leukemia
CN109908137B (zh) * 2019-03-11 2022-02-18 江苏省人民医院（南京医科大学第一附属医院） 青蒿素在杀伤乳腺癌干细胞的药物中的应用
CN114983999A (zh) * 2022-06-09 2022-09-02 四川大学 一种青蒿素及其衍生物的新用途、验证方法

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US5578637A (en) * 1995-05-03 1996-11-26 University Of Washington Methods of inhibition or killing cancer cells using an endoperoxide
US6214864B1 (en) * 1999-02-12 2001-04-10 Council Of Scientific And Industrial Research Formulation of dihydroartemisinin for the control of wide spectrum of malaria

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US6214864B1 (en) * 1999-02-12 2001-04-10 Council Of Scientific And Industrial Research Formulation of dihydroartemisinin for the control of wide spectrum of malaria

Also Published As

Publication number Publication date
RU2004139090A (ru) 2005-06-10
BR0311627A (pt) 2005-08-30
AU2003243418A1 (en) 2003-12-22
EP1531851A2 (en) 2005-05-25
WO2003103588A3 (en) 2004-04-15
RU2325156C2 (ru) 2008-05-27
EP1553935A2 (en) 2005-07-20
WO2003103588A2 (en) 2003-12-18
JP2005535606A (ja) 2005-11-24
EP1531851A4 (en) 2007-12-12
AU2003243418B2 (en) 2009-02-19
EP1531851B1 (en) 2011-12-14
CA2488347A1 (en) 2003-12-18
NZ537114A (en) 2007-02-23
CN101843904A (zh) 2010-09-29
NZ537113A (en) 2007-01-26
EP1553935A4 (en) 2010-07-07
BR0312685A (pt) 2005-09-06
CN1668323A (zh) 2005-09-14
US20040058981A1 (en) 2004-03-25
US20080119542A1 (en) 2008-05-22
ZA200500023B (en) 2005-10-20
JP4440768B2 (ja) 2010-03-24
JP2005529938A (ja) 2005-10-06
CA2488360A1 (en) 2003-12-18
CN1668293A (zh) 2005-09-14
RU2004139096A (ru) 2005-06-10
AU2003251405A1 (en) 2003-12-22

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