CN1308332C - 芳基醚的制备方法 - Google Patents

芳基醚的制备方法 Download PDF

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Publication number
CN1308332C
CN1308332C CNB998153028A CN99815302A CN1308332C CN 1308332 C CN1308332 C CN 1308332C CN B998153028 A CNB998153028 A CN B998153028A CN 99815302 A CN99815302 A CN 99815302A CN 1308332 C CN1308332 C CN 1308332C
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China
Prior art keywords
general formula
reaction
compound
alkyl
carried out
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Expired - Fee Related
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CNB998153028A
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English (en)
Chinese (zh)
Other versions
CN1332719A (zh
Inventor
K·E·赫尼伽
S·E·曼茨尼
K·D·麦斯托
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Pharmacia and Upjohn Co
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Pharmacia and Upjohn Co
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Publication of CN1332719A publication Critical patent/CN1332719A/zh
Application granted granted Critical
Publication of CN1308332C publication Critical patent/CN1308332C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB998153028A 1998-12-29 1999-12-23 芳基醚的制备方法 Expired - Fee Related CN1308332C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11409298P 1998-12-29 1998-12-29
US60/114,092 1998-12-29

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CNB2004100323697A Division CN1249038C (zh) 1998-12-29 1999-12-23 芳基醚的制备方法
CNB2004100869263A Division CN100340552C (zh) 1998-12-29 1999-12-23 芳基醚的制备方法

Publications (2)

Publication Number Publication Date
CN1332719A CN1332719A (zh) 2002-01-23
CN1308332C true CN1308332C (zh) 2007-04-04

Family

ID=22353332

Family Applications (3)

Application Number Title Priority Date Filing Date
CNB2004100323697A Expired - Fee Related CN1249038C (zh) 1998-12-29 1999-12-23 芳基醚的制备方法
CNB2004100869263A Expired - Fee Related CN100340552C (zh) 1998-12-29 1999-12-23 芳基醚的制备方法
CNB998153028A Expired - Fee Related CN1308332C (zh) 1998-12-29 1999-12-23 芳基醚的制备方法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CNB2004100323697A Expired - Fee Related CN1249038C (zh) 1998-12-29 1999-12-23 芳基醚的制备方法
CNB2004100869263A Expired - Fee Related CN100340552C (zh) 1998-12-29 1999-12-23 芳基醚的制备方法

Country Status (24)

Country Link
US (1) US6376711B1 (enExample)
EP (2) EP1308443B1 (enExample)
JP (1) JP2002533430A (enExample)
KR (2) KR100616386B1 (enExample)
CN (3) CN1249038C (enExample)
AT (2) ATE260238T1 (enExample)
AU (1) AU764492B2 (enExample)
BR (1) BR9916615A (enExample)
CA (1) CA2349619A1 (enExample)
CO (1) CO5140125A1 (enExample)
DE (2) DE69940833D1 (enExample)
DK (1) DK1140788T3 (enExample)
ES (1) ES2214060T3 (enExample)
HK (1) HK1041688B (enExample)
HU (1) HUP0202144A3 (enExample)
IL (2) IL161840A0 (enExample)
NZ (1) NZ511452A (enExample)
PE (1) PE20001366A1 (enExample)
PT (1) PT1140788E (enExample)
SI (1) SI1140788T1 (enExample)
TR (1) TR200101885T2 (enExample)
TW (1) TWI238155B (enExample)
WO (1) WO2000039072A1 (enExample)
ZA (1) ZA200103532B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796069B3 (fr) 1999-07-09 2001-08-24 Sanofi Synthelabo Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes
AR030284A1 (es) * 2000-06-08 2003-08-20 Merck & Co Inc Proceso para la sintesis de (2r, 2-alfa-r,3a) -2-[1-(3,5-bis(trifluorometil) fenil) etoxi]-3-(4-fluorofenil)-1,4-oxazina; dicho compuesto y sus formas polimorficas
BRPI0507917A (pt) * 2004-02-20 2007-07-10 Pharmacia & Upjohn Co Llc método para preparação de éteres de arila
WO2005082869A1 (en) * 2004-02-20 2005-09-09 Pharmacia & Upjohn Company Llc Method for the preparation of aryl ethers
WO2005095435A1 (ja) * 2004-03-31 2005-10-13 Kuraray Co., Ltd. プレグナン誘導体の製造方法
GB0409744D0 (en) * 2004-04-30 2004-06-09 Pfizer Ltd Novel compounds
EA200601798A1 (ru) 2004-04-30 2007-04-27 Уорнер-Ламберт Компани Ллс Замещенные соединения морфолина для лечения расстройств центральной нервной системы
SI2076508T1 (sl) 2006-10-18 2011-04-29 Pfizer Prod Inc Spojine biaril eter sečnine
US20100069389A1 (en) * 2008-09-06 2010-03-18 Bionevia Pharmaceuticals, Inc. Novel forms of reboxetine
CN103804316A (zh) * 2012-11-13 2014-05-21 天津药物研究院 一种（2RS,3RS）-6-[a-（2-乙氧基苯氧基）苄基]吗啉-3-酮（Ⅰ）的制备方法
CN104557936A (zh) * 2015-01-15 2015-04-29 河南科技学院 一种新型手性非环嘌呤核苷类似物的合成方法
US20190381056A1 (en) 2018-06-17 2019-12-19 Axsome Therapeutics, Inc. Compositions for delivery of reboxetine
US20200147093A1 (en) 2018-10-15 2020-05-14 Axsome Therapeutics, Inc. Use of esreboxetine to treat nervous system disorders such as fibromyalgia
US11020402B2 (en) 2018-10-15 2021-06-01 Axsome Therapeutics, Inc. Use of reboxetine to treat narcolepsy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391735A (en) * 1984-08-02 1995-02-21 Farmitalia Carlo Erba S.P.A. Process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785185A (en) * 1952-08-07 1957-03-12 Union Carbide & Carbon Corp Process for making oxirane compounds from olefins and aldehyde monoperacylates
GB1053972A (enExample) * 1962-08-30 1967-01-04
IL56369A (en) * 1978-01-20 1984-05-31 Erba Farmitalia Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391735A (en) * 1984-08-02 1995-02-21 Farmitalia Carlo Erba S.P.A. Process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane

Also Published As

Publication number Publication date
EP1140788A1 (en) 2001-10-10
ATE430144T1 (de) 2009-05-15
CA2349619A1 (en) 2000-07-06
ZA200103532B (en) 2002-08-02
ES2214060T3 (es) 2004-09-01
CN1332719A (zh) 2002-01-23
TR200101885T2 (tr) 2002-01-21
DE69915110D1 (de) 2004-04-01
DK1140788T3 (da) 2004-06-07
ATE260238T1 (de) 2004-03-15
SI1140788T1 (en) 2004-08-31
IL144012A (en) 2005-11-20
CN1636988A (zh) 2005-07-13
DE69915110T2 (de) 2004-08-26
HK1078572A1 (zh) 2006-03-17
EP1308443A2 (en) 2003-05-07
HUP0202144A2 (hu) 2002-11-28
EP1308443B1 (en) 2009-04-29
EP1140788B1 (en) 2004-02-25
US6376711B1 (en) 2002-04-23
EP1308443A3 (en) 2003-10-01
JP2002533430A (ja) 2002-10-08
HK1041688A1 (en) 2002-07-19
IL161840A0 (en) 2005-11-20
AU2381900A (en) 2000-07-31
PE20001366A1 (es) 2000-11-19
KR20060090310A (ko) 2006-08-10
PT1140788E (pt) 2004-07-30
HK1041688B (zh) 2007-12-07
KR20010099999A (ko) 2001-11-09
NZ511452A (en) 2002-11-26
BR9916615A (pt) 2001-10-23
HUP0202144A3 (en) 2003-10-28
TWI238155B (en) 2005-08-21
CN100340552C (zh) 2007-10-03
CO5140125A1 (es) 2002-03-22
CN1532194A (zh) 2004-09-29
CN1249038C (zh) 2006-04-05
AU764492B2 (en) 2003-08-21
IL144012A0 (en) 2002-04-21
KR100616386B1 (ko) 2006-08-28
KR100616029B1 (ko) 2006-08-28
WO2000039072A1 (en) 2000-07-06
HK1066004A1 (en) 2005-03-11
DE69940833D1 (de) 2009-06-10

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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Granted publication date: 20070404

Termination date: 20100125