CN1304011C - 保护性寡聚脱氧核糖核苷酸的制药用途 - Google Patents

保护性寡聚脱氧核糖核苷酸的制药用途 Download PDF

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Publication number
CN1304011C
CN1304011C CNB038125013A CN03812501A CN1304011C CN 1304011 C CN1304011 C CN 1304011C CN B038125013 A CNB038125013 A CN B038125013A CN 03812501 A CN03812501 A CN 03812501A CN 1304011 C CN1304011 C CN 1304011C
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CN
China
Prior art keywords
cell
defibrotide
purposes
ara
immunosuppressant
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Expired - Fee Related
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CNB038125013A
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English (en)
Chinese (zh)
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CN1655801A (zh
Inventor
甘特·艾斯内
恩斯特·霍勒
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Universitaet Regensburg
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Universitaet Regensburg
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Publication of CN1655801A publication Critical patent/CN1655801A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
CNB038125013A 2002-05-31 2003-06-02 保护性寡聚脱氧核糖核苷酸的制药用途 Expired - Fee Related CN1304011C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38411402P 2002-05-31 2002-05-31
US60/384,114 2002-05-31
US38743802P 2002-06-11 2002-06-11
US60/387,438 2002-06-11

Publications (2)

Publication Number Publication Date
CN1655801A CN1655801A (zh) 2005-08-17
CN1304011C true CN1304011C (zh) 2007-03-14

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ID=29715309

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038125013A Expired - Fee Related CN1304011C (zh) 2002-05-31 2003-06-02 保护性寡聚脱氧核糖核苷酸的制药用途

Country Status (16)

Country Link
EP (1) EP1509235A1 (ja)
JP (1) JP2005527636A (ja)
CN (1) CN1304011C (ja)
AU (1) AU2003238189A1 (ja)
CA (1) CA2487171A1 (ja)
EA (1) EA008213B1 (ja)
HR (1) HRP20041213A2 (ja)
IL (1) IL165353A0 (ja)
IS (1) IS7548A (ja)
MX (1) MXPA04011941A (ja)
NO (1) NO20045655L (ja)
NZ (1) NZ536864A (ja)
PL (1) PL374402A1 (ja)
RS (1) RS102504A (ja)
UA (1) UA83628C2 (ja)
WO (1) WO2003101468A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031714A1 (it) * 2003-09-05 2005-03-06 Gentium Spa Formazioni ad azione antitumorale.
JP6069209B2 (ja) * 2010-11-12 2017-02-01 ジェンティウム ソシエタ ア レスポンサビリタ リミタータ 移植片対宿主病(gvhd)の予防および/または治療に使用するためのデフィブロタイド
CN104619857A (zh) 2012-06-22 2015-05-13 真蒂奥姆有限公司 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法
EP3026122A1 (en) * 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998048843A1 (en) * 1997-04-28 1998-11-05 Arsinur Burcoglu Method of treating hiv infection and related secondary infections thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998048843A1 (en) * 1997-04-28 1998-11-05 Arsinur Burcoglu Method of treating hiv infection and related secondary infections thereof

Also Published As

Publication number Publication date
NO20045655L (no) 2004-12-27
UA83628C2 (ru) 2008-08-11
JP2005527636A (ja) 2005-09-15
HRP20041213A2 (en) 2006-04-30
EA200401448A1 (ru) 2005-06-30
WO2003101468A1 (en) 2003-12-11
MXPA04011941A (es) 2005-07-26
EA008213B1 (ru) 2007-04-27
CA2487171A1 (en) 2003-12-11
PL374402A1 (en) 2005-10-17
IS7548A (is) 2004-11-24
EP1509235A1 (en) 2005-03-02
RS102504A (en) 2006-12-15
NZ536864A (en) 2008-08-29
IL165353A0 (en) 2006-01-15
CN1655801A (zh) 2005-08-17
AU2003238189A1 (en) 2003-12-19

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Granted publication date: 20070314

Termination date: 20100602