CN1303430A - 具有改善的可制备性的FAPα特异性抗体 - Google Patents

具有改善的可制备性的FAPα特异性抗体 Download PDF

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Publication number
CN1303430A
CN1303430A CN99806582A CN99806582A CN1303430A CN 1303430 A CN1303430 A CN 1303430A CN 99806582 A CN99806582 A CN 99806582A CN 99806582 A CN99806582 A CN 99806582A CN 1303430 A CN1303430 A CN 1303430A
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Prior art keywords
antibody protein
antibody
seq
ser
val
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Pending
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CN99806582A
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Chinese (zh)
Inventor
约翰·E·帕克
皮拉尔·加林－切萨
尤维·班伯格
沃尔夫冈·J·雷蒂格
奥利维尔·莱杰
乔斯·塞尔丹哈
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Publication of CN1303430A publication Critical patent/CN1303430A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN99806582A 1998-04-30 1999-04-22 具有改善的可制备性的FAPα特异性抗体 Pending CN1303430A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107925A EP0953639A1 (en) 1998-04-30 1998-04-30 FAPalpha-specific antibody with improved producibility
EP98107925.4 1998-04-30

Publications (1)

Publication Number Publication Date
CN1303430A true CN1303430A (zh) 2001-07-11

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CN99806582A Pending CN1303430A (zh) 1998-04-30 1999-04-22 具有改善的可制备性的FAPα特异性抗体

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EP (2) EP0953639A1 (https=)
JP (1) JP4421779B2 (https=)
KR (1) KR100580936B1 (https=)
CN (1) CN1303430A (https=)
AR (1) AR016243A1 (https=)
AT (1) ATE356873T1 (https=)
AU (1) AU760305B2 (https=)
BG (1) BG65034B1 (https=)
BR (1) BR9910577A (https=)
CA (1) CA2327586C (https=)
CO (1) CO5050255A1 (https=)
DE (1) DE69935516T2 (https=)
EA (1) EA005401B1 (https=)
EE (1) EE200000642A (https=)
ES (1) ES2283114T3 (https=)
HU (1) HUP0101501A3 (https=)
ID (1) ID26555A (https=)
IL (1) IL138701A0 (https=)
NO (1) NO20005412L (https=)
NZ (1) NZ508456A (https=)
PL (1) PL358087A1 (https=)
SK (1) SK16192000A3 (https=)
TR (1) TR200003181T2 (https=)
UA (1) UA73276C2 (https=)
WO (1) WO1999057151A2 (https=)
YU (1) YU66300A (https=)
ZA (1) ZA200005506B (https=)

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CN101896818A (zh) * 2007-12-10 2010-11-24 霍夫曼-拉罗奇有限公司 作为癌症的标记物的Seprase
CN103154038A (zh) * 2010-08-13 2013-06-12 罗切格利卡特公司 抗成纤维细胞激活蛋白抗体及使用方法
CN103267852A (zh) * 2013-05-15 2013-08-28 中国医学科学院北京协和医院 成纤维激活蛋白α在制备胰腺癌预后试剂盒中的用途
CN105646710A (zh) * 2014-11-17 2016-06-08 四川科伦药物研究院有限公司 一种全人源化抗vegfr-2单克隆抗体及其制备方法
CN106536553A (zh) * 2014-03-26 2017-03-22 尤利乌斯·马克西米利安维尔茨堡大学 生长和分化因子15(gdf‑15)的单克隆抗体及其治疗癌性恶病质和癌症的用途
CN109053893A (zh) * 2018-08-15 2018-12-21 苏州智维安生物技术有限公司 一种抗d-二聚体单克隆抗体及其制备方法
CN110291401A (zh) * 2016-12-14 2019-09-27 普渡研究基金会 成纤维细胞活化蛋白(fap)-靶向成像和治疗
CN110526979A (zh) * 2018-05-25 2019-12-03 深圳宾德生物技术有限公司 靶向fap的单链抗体、嵌合抗原受体t细胞及其制备方法和应用
CN110526991A (zh) * 2018-05-25 2019-12-03 深圳宾德生物技术有限公司 靶向fap的嵌合抗原受体、嵌合抗原受体t细胞及其制备方法和应用
US10526413B2 (en) 2015-10-02 2020-01-07 Hoffmann-La Roche Inc. Bispecific antibodies specific for OX40
WO2021043206A1 (zh) * 2019-09-03 2021-03-11 百奥泰生物制药股份有限公司 一种抗tigit免疫抑制剂及应用
CN112972675A (zh) * 2018-09-07 2021-06-18 上海君实生物医药科技股份有限公司 抗pd-1抗体在治疗肿瘤中的用途
US11111312B2 (en) 2011-02-10 2021-09-07 Roche Glycart Ag Mutant interleukin-2 polypeptides
CN113512116A (zh) * 2020-04-10 2021-10-19 苏州普乐康医药科技有限公司 一种抗igf-1r抗体及其应用
WO2023125796A1 (en) * 2021-12-30 2023-07-06 Concept To Medicine Biotech Co., Ltd. Human antibodies against fap-alpha
CN116589566A (zh) * 2022-11-18 2023-08-15 昆明医科大学第一附属医院 一种HIV-1中和抗体的改造重组单克隆IgM抗体及其应用
WO2024027771A1 (zh) * 2022-08-03 2024-02-08 南京维立志博生物科技有限公司 靶向FAP和TGFβ的抗体融合蛋白及其用途
CN119265201A (zh) * 2024-08-23 2025-01-07 中国人民解放军海军军医大学第一附属医院 编码基因、蛋白、表达il-15的nkg2dl-fap双靶点car-nk细胞及其构建方法和用途
WO2025152756A1 (zh) * 2024-01-15 2025-07-24 迈威(上海)生物科技股份有限公司 重组抗fap抗体及其应用
WO2026007560A1 (zh) * 2024-07-02 2026-01-08 国睿(广州)生物科技有限公司 一种靶向成纤维活化蛋白α的纳米抗体及其应用

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CN101896818A (zh) * 2007-12-10 2010-11-24 霍夫曼-拉罗奇有限公司 作为癌症的标记物的Seprase
CN105884898B (zh) * 2010-08-13 2022-10-11 罗切格利卡特公司 抗成纤维细胞激活蛋白抗体及使用方法
CN103154038B (zh) * 2010-08-13 2016-05-11 罗切格利卡特公司 抗成纤维细胞激活蛋白抗体及使用方法
US10577429B2 (en) 2010-08-13 2020-03-03 Roche Glycart Ag Anti-FAP antibodies and methods of use
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CN103154038A (zh) * 2010-08-13 2013-06-12 罗切格利卡特公司 抗成纤维细胞激活蛋白抗体及使用方法
US10253110B2 (en) 2010-08-13 2019-04-09 Roche Glycart Ag Anti-FAP antibodies and methods of use
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