KR100580936B1 - 개선된 생산성을 갖는 ＦＡＰα-특이적 항체 - Google Patents

개선된 생산성을 갖는 ＦＡＰα-특이적 항체 Download PDF

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Publication number
KR100580936B1
KR100580936B1 KR1020007011585A KR20007011585A KR100580936B1 KR 100580936 B1 KR100580936 B1 KR 100580936B1 KR 1020007011585 A KR1020007011585 A KR 1020007011585A KR 20007011585 A KR20007011585 A KR 20007011585A KR 100580936 B1 KR100580936 B1 KR 100580936B1
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ser
val
antibody protein
thr
gly
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KR20010042826A (ko
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파크존에드워드
가린-체사필라
밤버거우웨
레티크볼프강제이.
레거올리비에르
살단하조세
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베링거 인겔하임 인터내셔날 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020007011585A 1998-04-30 1999-04-22 개선된 생산성을 갖는 ＦＡＰα-특이적 항체 Expired - Fee Related KR100580936B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107925A EP0953639A1 (en) 1998-04-30 1998-04-30 FAPalpha-specific antibody with improved producibility
EP98107925.4 1998-04-30

Publications (2)

Publication Number Publication Date
KR20010042826A KR20010042826A (ko) 2001-05-25
KR100580936B1 true KR100580936B1 (ko) 2006-05-17

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KR1020007011585A Expired - Fee Related KR100580936B1 (ko) 1998-04-30 1999-04-22 개선된 생산성을 갖는 ＦＡＰα-특이적 항체

Country Status (27)

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EP (2) EP0953639A1 (https=)
JP (1) JP4421779B2 (https=)
KR (1) KR100580936B1 (https=)
CN (1) CN1303430A (https=)
AR (1) AR016243A1 (https=)
AT (1) ATE356873T1 (https=)
AU (1) AU760305B2 (https=)
BG (1) BG65034B1 (https=)
BR (1) BR9910577A (https=)
CA (1) CA2327586C (https=)
CO (1) CO5050255A1 (https=)
DE (1) DE69935516T2 (https=)
EA (1) EA005401B1 (https=)
EE (1) EE200000642A (https=)
ES (1) ES2283114T3 (https=)
HU (1) HUP0101501A3 (https=)
ID (1) ID26555A (https=)
IL (1) IL138701A0 (https=)
NO (1) NO20005412L (https=)
NZ (1) NZ508456A (https=)
PL (1) PL358087A1 (https=)
SK (1) SK16192000A3 (https=)
TR (1) TR200003181T2 (https=)
UA (1) UA73276C2 (https=)
WO (1) WO1999057151A2 (https=)
YU (1) YU66300A (https=)
ZA (1) ZA200005506B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220020227A (ko) * 2020-08-11 2022-02-18 주식회사 카나프테라퓨틱스 Il-12 및 항-fap 항체를 포함하는 융합단백질 및 이의 용도

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KR20220020227A (ko) * 2020-08-11 2022-02-18 주식회사 카나프테라퓨틱스 Il-12 및 항-fap 항체를 포함하는 융합단백질 및 이의 용도
KR102799318B1 (ko) * 2020-08-11 2025-04-23 주식회사 카나프테라퓨틱스 Il-12 및 항-fap 항체를 포함하는 융합단백질 및 이의 용도

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DE69935516T2 (de) 2008-01-31
EA005401B1 (ru) 2005-02-24
KR20010042826A (ko) 2001-05-25
EA200001023A1 (ru) 2001-06-25
CA2327586A1 (en) 1999-11-11
ES2283114T3 (es) 2007-10-16
UA73276C2 (en) 2005-07-15
EE200000642A (et) 2002-04-15
YU66300A (sh) 2004-03-12
CN1303430A (zh) 2001-07-11
ID26555A (id) 2001-01-18
JP4421779B2 (ja) 2010-02-24
CA2327586C (en) 2013-02-26
EP0953639A1 (en) 1999-11-03
PL358087A1 (en) 2004-08-09
AR016243A1 (es) 2001-06-20
NO20005412L (no) 2000-12-06
BG65034B1 (bg) 2006-12-29
DE69935516D1 (de) 2007-04-26
AU4032299A (en) 1999-11-23
WO1999057151A2 (en) 1999-11-11
TR200003181T2 (tr) 2001-04-20
BR9910577A (pt) 2001-09-11
EP1098979B1 (en) 2007-03-14
JP2002513556A (ja) 2002-05-14
EP1098979A2 (en) 2001-05-16
CO5050255A1 (es) 2001-06-27
IL138701A0 (en) 2001-10-31
HUP0101501A2 (hu) 2001-08-28
BG104828A (en) 2001-09-28
AU760305B2 (en) 2003-05-15
NO20005412D0 (no) 2000-10-27
WO1999057151A3 (en) 2000-03-16
ZA200005506B (en) 2002-05-14
HUP0101501A3 (en) 2004-01-28
NZ508456A (en) 2004-03-26
ATE356873T1 (de) 2007-04-15
SK16192000A3 (sk) 2001-04-09

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