CN1300291A - 蛋白质酪氨酸磷酸酶(ptp酶)的调节物 - Google Patents
蛋白质酪氨酸磷酸酶(ptp酶)的调节物 Download PDFInfo
- Publication number
- CN1300291A CN1300291A CN99806016A CN99806016A CN1300291A CN 1300291 A CN1300291 A CN 1300291A CN 99806016 A CN99806016 A CN 99806016A CN 99806016 A CN99806016 A CN 99806016A CN 1300291 A CN1300291 A CN 1300291A
- Authority
- CN
- China
- Prior art keywords
- amino
- dihydro
- thieno
- oxalyl
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/18—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrodes Of Semiconductors (AREA)
- Enzymes And Modification Thereof (AREA)
- Bipolar Transistors (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Control Of El Displays (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK0344/1998 | 1998-03-12 | ||
| DK34498 | 1998-03-12 | ||
| DK0480/1998 | 1998-04-03 | ||
| DK48098 | 1998-04-03 | ||
| DKPA199800938 | 1998-07-15 | ||
| DKPA199800938 | 1998-07-15 | ||
| DKPA199801385 | 1998-10-28 | ||
| DKPA199801385 | 1998-10-28 | ||
| DKPA199801612 | 1998-12-07 | ||
| DKPA199801612 | 1998-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1300291A true CN1300291A (zh) | 2001-06-20 |
Family
ID=27512769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99806016A Pending CN1300291A (zh) | 1998-03-12 | 1999-03-11 | 蛋白质酪氨酸磷酸酶(ptp酶)的调节物 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1080095B1 (https=) |
| JP (1) | JP2002506072A (https=) |
| KR (1) | KR20010041814A (https=) |
| CN (1) | CN1300291A (https=) |
| AT (1) | ATE308546T1 (https=) |
| AU (1) | AU2713599A (https=) |
| BR (1) | BR9908726A (https=) |
| CA (1) | CA2323493A1 (https=) |
| DE (1) | DE69928100D1 (https=) |
| HU (1) | HUP0104984A3 (https=) |
| IL (1) | IL138319A0 (https=) |
| NO (1) | NO20004527L (https=) |
| PL (1) | PL342816A1 (https=) |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007036138A1 (en) * | 2005-09-27 | 2007-04-05 | Tianjin Hemay Bio-Tech Co. Ltd | 5H-THIENO [3,4-c] PYRROLE-4, 6-DIONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR |
| CN102382076A (zh) * | 2010-09-03 | 2012-03-21 | 中国医学科学院药物研究所 | 芳酮和芳酰胺类化合物及其制法和药物用途 |
| CN102838625A (zh) * | 2011-06-22 | 2012-12-26 | 中国科学院上海药物研究所 | 四氢吡啶并噻唑类化合物、其制备方法、包含该化合物的药物组合物及其用途 |
| CN104193761A (zh) * | 2009-12-04 | 2014-12-10 | 桑诺维恩药品公司 | 多环化合物及其使用方法 |
| CN104277051A (zh) * | 2005-09-15 | 2015-01-14 | 霍夫曼-拉罗奇有限公司 | 4-氨基-噻吩并[3,2-c]吡啶-7-羧酸衍生物 |
| CN104788425A (zh) * | 2015-03-12 | 2015-07-22 | 佛山市赛维斯医药科技有限公司 | 一类含烟酸酰胺和哌啶结构ptp1b抑制剂、制备方法及其用途 |
| CN104788424A (zh) * | 2015-03-12 | 2015-07-22 | 佛山市赛维斯医药科技有限公司 | 含烟酸酰胺和哌啶结构的ptp1b抑制剂、制备方法及其用途 |
| CN104829629A (zh) * | 2015-03-26 | 2015-08-12 | 天津药物研究院有限公司 | 含磺酰胺基的四氢噻吩并[2,3-c]吡啶衍生物、其制备方法和用途 |
| CN103641765B (zh) * | 2004-06-24 | 2016-08-17 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的调控剂 |
| CN106748999A (zh) * | 2015-03-12 | 2017-05-31 | 佛山市赛维斯医药科技有限公司 | 一类含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途 |
| CN106866523A (zh) * | 2015-03-12 | 2017-06-20 | 佛山市赛维斯医药科技有限公司 | 含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途 |
| US10196403B2 (en) | 2016-07-29 | 2019-02-05 | Sunovion Pharmaceuticals Inc. | Compounds and compositions and uses thereof |
| US10780074B2 (en) | 2017-08-02 | 2020-09-22 | Sunovion Pharmaceuticals Inc. | Compounds and uses thereof |
| US10815249B2 (en) | 2018-02-16 | 2020-10-27 | Sunovion Pharmaceuticals Inc. | Salts, crystal forms, and production methods thereof |
| US11077090B2 (en) | 2016-07-29 | 2021-08-03 | Sunovion Pharmaceuticals Inc. | Compounds and compositions and uses thereof |
| US11129807B2 (en) | 2017-02-16 | 2021-09-28 | Sunovion Pharmaceuticals Inc. | Methods of treating schizophrenia |
| US11136304B2 (en) | 2019-03-14 | 2021-10-05 | Sunovion Pharmaceuticals Inc. | Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
| US11738002B2 (en) | 2020-04-14 | 2023-08-29 | Sunovion Pharmaceuticals Inc. | Methods of treating neurological and psychiatric disorders |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4224566B2 (ja) | 2000-12-18 | 2009-02-18 | 株式会社医薬分子設計研究所 | 炎症性サイトカイン産生遊離抑制剤 |
| CN101103977A (zh) * | 2002-06-05 | 2008-01-16 | 株式会社医药分子设计研究所 | 糖尿病治疗药 |
| EP1512396A4 (en) * | 2002-06-05 | 2008-12-31 | Inst Med Molecular Design Inc | HEMMER AGAINST ACTIVATION OF AP-1 AND NFAT |
| EA009701B1 (ru) | 2002-06-06 | 2008-02-28 | Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. | Противоаллергические средства |
| CA2488363C (en) | 2002-06-06 | 2011-01-04 | Institute Of Medicinal Molecular Design, Inc. | O-substituted hydroxyaryl derivatives |
| DK1753512T3 (da) * | 2004-05-28 | 2008-11-17 | 4Sc Ag | Tetrahydropyridothiophener |
| CA2568718A1 (en) * | 2004-06-04 | 2005-12-15 | Altana Pharma Ag | Tetrahydropyridothiophenes for use in the treatment of cancer |
| CA2569623A1 (en) * | 2004-06-11 | 2005-12-22 | Altana Pharma Ag | Novel compounds and use of tetrahydropyridothiophenes |
| AU2006212224A1 (en) * | 2005-02-09 | 2006-08-17 | 4Sc Ag | Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer |
| AU2006212179A1 (en) * | 2005-02-11 | 2006-08-17 | 4Sc Ag | Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer |
| EP2948147B1 (en) * | 2013-01-28 | 2019-03-13 | H. Lundbeck A/S | N-substituted-5-substituted phthalamic acids as sortilin inhibitors |
| WO2020233645A1 (zh) | 2019-05-21 | 2020-11-26 | 浙江海正药业股份有限公司 | 大环类衍生物、及其制备方法和用途 |
| US11629130B2 (en) * | 2020-04-14 | 2023-04-18 | Purdue Research Foundation | Lymphoid-specific tyrosine phosphatase (LYP) inhibitors |
-
1999
- 1999-03-11 CA CA002323493A patent/CA2323493A1/en not_active Abandoned
- 1999-03-11 HU HU0104984A patent/HUP0104984A3/hu unknown
- 1999-03-11 EP EP99907332A patent/EP1080095B1/en not_active Expired - Lifetime
- 1999-03-11 DE DE69928100T patent/DE69928100D1/de not_active Expired - Lifetime
- 1999-03-11 BR BR9908726-0A patent/BR9908726A/pt not_active IP Right Cessation
- 1999-03-11 KR KR1020007010093A patent/KR20010041814A/ko not_active Withdrawn
- 1999-03-11 JP JP2000535645A patent/JP2002506072A/ja not_active Withdrawn
- 1999-03-11 IL IL13831999A patent/IL138319A0/xx unknown
- 1999-03-11 AT AT99907332T patent/ATE308546T1/de not_active IP Right Cessation
- 1999-03-11 PL PL99342816A patent/PL342816A1/xx not_active Application Discontinuation
- 1999-03-11 CN CN99806016A patent/CN1300291A/zh active Pending
- 1999-03-11 AU AU27135/99A patent/AU2713599A/en not_active Abandoned
-
2000
- 2000-09-11 NO NO20004527A patent/NO20004527L/no unknown
Cited By (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103641765B (zh) * | 2004-06-24 | 2016-08-17 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的调控剂 |
| CN104788328B (zh) * | 2004-06-24 | 2017-09-12 | 沃泰克斯药物股份有限公司 | Atp‑结合弹夹转运蛋白的调控剂 |
| CN104277051B (zh) * | 2005-09-15 | 2017-06-09 | 霍夫曼-拉罗奇有限公司 | 4‑氨基‑噻吩并[3,2‑c]吡啶‑7‑羧酸衍生物 |
| CN104277051A (zh) * | 2005-09-15 | 2015-01-14 | 霍夫曼-拉罗奇有限公司 | 4-氨基-噻吩并[3,2-c]吡啶-7-羧酸衍生物 |
| WO2007036138A1 (en) * | 2005-09-27 | 2007-04-05 | Tianjin Hemay Bio-Tech Co. Ltd | 5H-THIENO [3,4-c] PYRROLE-4, 6-DIONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR |
| US10894033B2 (en) | 2009-12-04 | 2021-01-19 | Sunovion Pharmaceuticals Inc. | Multicyclic compounds and methods of use thereof |
| CN106883246B (zh) * | 2009-12-04 | 2020-05-29 | 桑诺维恩药品公司 | 多环化合物及其使用方法 |
| US10085968B2 (en) | 2009-12-04 | 2018-10-02 | Sunovion Pharmaceuticals Inc. | Multicyclic compounds and methods of use thereof |
| CN104193761A (zh) * | 2009-12-04 | 2014-12-10 | 桑诺维恩药品公司 | 多环化合物及其使用方法 |
| CN104193761B (zh) * | 2009-12-04 | 2017-10-17 | 桑诺维恩药品公司 | 多环化合物及其使用方法 |
| CN106883246A (zh) * | 2009-12-04 | 2017-06-23 | 桑诺维恩药品公司 | 多环化合物及其使用方法 |
| CN102382076A (zh) * | 2010-09-03 | 2012-03-21 | 中国医学科学院药物研究所 | 芳酮和芳酰胺类化合物及其制法和药物用途 |
| CN102382076B (zh) * | 2010-09-03 | 2016-08-17 | 中国医学科学院药物研究所 | 芳酮和芳酰胺类化合物及其制法和药物用途 |
| CN102838625A (zh) * | 2011-06-22 | 2012-12-26 | 中国科学院上海药物研究所 | 四氢吡啶并噻唑类化合物、其制备方法、包含该化合物的药物组合物及其用途 |
| CN106866523A (zh) * | 2015-03-12 | 2017-06-20 | 佛山市赛维斯医药科技有限公司 | 含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途 |
| CN106748999A (zh) * | 2015-03-12 | 2017-05-31 | 佛山市赛维斯医药科技有限公司 | 一类含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途 |
| CN104788425A (zh) * | 2015-03-12 | 2015-07-22 | 佛山市赛维斯医药科技有限公司 | 一类含烟酸酰胺和哌啶结构ptp1b抑制剂、制备方法及其用途 |
| CN104788424A (zh) * | 2015-03-12 | 2015-07-22 | 佛山市赛维斯医药科技有限公司 | 含烟酸酰胺和哌啶结构的ptp1b抑制剂、制备方法及其用途 |
| CN104829629A (zh) * | 2015-03-26 | 2015-08-12 | 天津药物研究院有限公司 | 含磺酰胺基的四氢噻吩并[2,3-c]吡啶衍生物、其制备方法和用途 |
| US10196403B2 (en) | 2016-07-29 | 2019-02-05 | Sunovion Pharmaceuticals Inc. | Compounds and compositions and uses thereof |
| US11958862B2 (en) | 2016-07-29 | 2024-04-16 | Sumitomo Pharma America, Inc. | Compounds and compositions and uses thereof |
| US10927124B2 (en) | 2016-07-29 | 2021-02-23 | Sunovion Pharmaceuticals Inc. | Compounds and compositions and uses thereof |
| US11077090B2 (en) | 2016-07-29 | 2021-08-03 | Sunovion Pharmaceuticals Inc. | Compounds and compositions and uses thereof |
| US11129807B2 (en) | 2017-02-16 | 2021-09-28 | Sunovion Pharmaceuticals Inc. | Methods of treating schizophrenia |
| US10780074B2 (en) | 2017-08-02 | 2020-09-22 | Sunovion Pharmaceuticals Inc. | Compounds and uses thereof |
| US11491133B2 (en) | 2017-08-02 | 2022-11-08 | Sunovion Pharmaceuticals Inc. | Heteroaryl-isochroman compounds and uses thereof |
| US11440921B2 (en) | 2018-02-16 | 2022-09-13 | Sunovion Pharmaceuticals Inc. | Salts, crystal forms, and production methods thereof |
| US10815249B2 (en) | 2018-02-16 | 2020-10-27 | Sunovion Pharmaceuticals Inc. | Salts, crystal forms, and production methods thereof |
| US11987591B2 (en) | 2018-02-16 | 2024-05-21 | Sumitomo Pharma America, Inc. | Salts, crystal forms, and production methods thereof |
| US11136304B2 (en) | 2019-03-14 | 2021-10-05 | Sunovion Pharmaceuticals Inc. | Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
| US11738002B2 (en) | 2020-04-14 | 2023-08-29 | Sunovion Pharmaceuticals Inc. | Methods of treating neurological and psychiatric disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002506072A (ja) | 2002-02-26 |
| IL138319A0 (en) | 2001-10-31 |
| PL342816A1 (en) | 2001-07-02 |
| BR9908726A (pt) | 2000-11-21 |
| EP1080095A1 (en) | 2001-03-07 |
| KR20010041814A (ko) | 2001-05-25 |
| HUP0104984A2 (hu) | 2002-04-29 |
| EP1080095B1 (en) | 2005-11-02 |
| DE69928100D1 (de) | 2005-12-08 |
| HUP0104984A3 (en) | 2003-07-28 |
| NO20004527D0 (no) | 2000-09-11 |
| ATE308546T1 (de) | 2005-11-15 |
| CA2323493A1 (en) | 1999-09-16 |
| AU2713599A (en) | 1999-09-27 |
| NO20004527L (no) | 2000-11-07 |
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