CN1296703C - 鉴定蛋白质的方法、装置和系统 - Google Patents
鉴定蛋白质的方法、装置和系统 Download PDFInfo
- Publication number
- CN1296703C CN1296703C CNB008032874A CN00803287A CN1296703C CN 1296703 C CN1296703 C CN 1296703C CN B008032874 A CNB008032874 A CN B008032874A CN 00803287 A CN00803287 A CN 00803287A CN 1296703 C CN1296703 C CN 1296703C
- Authority
- CN
- China
- Prior art keywords
- concentration
- washing agent
- agent
- polypeptide
- dissociating buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44747—Composition of gel or of carrier mixture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24314999A | 1999-02-02 | 1999-02-02 | |
| US09/243,149 | 1999-02-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1339104A CN1339104A (zh) | 2002-03-06 |
| CN1296703C true CN1296703C (zh) | 2007-01-24 |
Family
ID=22917535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB008032874A Expired - Lifetime CN1296703C (zh) | 1999-02-02 | 2000-02-02 | 鉴定蛋白质的方法、装置和系统 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6475364B1 (enExample) |
| EP (2) | EP2278320B1 (enExample) |
| JP (1) | JP4515640B2 (enExample) |
| CN (1) | CN1296703C (enExample) |
| AU (1) | AU758309B2 (enExample) |
| CA (1) | CA2358683A1 (enExample) |
| MX (1) | MXPA01007804A (enExample) |
| WO (1) | WO2000046594A1 (enExample) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| US20050027111A1 (en) * | 1999-02-02 | 2005-02-03 | Caliper Life Sciences, Inc. | Methods, devices and systems for characterizing proteins |
| EP2278320B1 (en) * | 1999-02-02 | 2018-07-18 | Caliper Life Sciences, Inc. | Methods and devices for characterizing proteins |
| US6749814B1 (en) | 1999-03-03 | 2004-06-15 | Symyx Technologies, Inc. | Chemical processing microsystems comprising parallel flow microreactors and methods for using same |
| US7485454B1 (en) * | 2000-03-10 | 2009-02-03 | Bioprocessors Corp. | Microreactor |
| US6635487B1 (en) * | 2000-05-17 | 2003-10-21 | Caliper Technologies Corp. | Fluorescence standard for use in microfluidic instruments |
| AU2001280951B2 (en) | 2000-08-02 | 2006-03-02 | Caliper Life Sciences, Inc. | High throughput separations based analysis systems |
| WO2002028531A1 (en) * | 2000-10-06 | 2002-04-11 | Protasis Corporation | Fluid separation conduit cartridge with encryption capability |
| US20090118139A1 (en) | 2000-11-07 | 2009-05-07 | Caliper Life Sciences, Inc. | Microfluidic method and system for enzyme inhibition activity screening |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US20040132166A1 (en) * | 2001-04-10 | 2004-07-08 | Bioprocessors Corp. | Determination and/or control of reactor environmental conditions |
| US20050032204A1 (en) * | 2001-04-10 | 2005-02-10 | Bioprocessors Corp. | Microreactor architecture and methods |
| US20040058437A1 (en) * | 2001-04-10 | 2004-03-25 | Rodgers Seth T. | Materials and reactor systems having humidity and gas control |
| US20040058407A1 (en) * | 2001-04-10 | 2004-03-25 | Miller Scott E. | Reactor systems having a light-interacting component |
| US7723123B1 (en) | 2001-06-05 | 2010-05-25 | Caliper Life Sciences, Inc. | Western blot by incorporating an affinity purification zone |
| WO2003054517A2 (en) * | 2001-12-19 | 2003-07-03 | Biogen Idec Ma Inc. | Methods for detecting half-antibodies using chip-based gel electrophoresis |
| CA2480200A1 (en) * | 2002-04-02 | 2003-10-16 | Caliper Life Sciences, Inc. | Methods and apparatus for separation and isolation of components from a biological sample |
| US20050026134A1 (en) * | 2002-04-10 | 2005-02-03 | Bioprocessors Corp. | Systems and methods for control of pH and other reactor environment conditions |
| US20050106714A1 (en) * | 2002-06-05 | 2005-05-19 | Zarur Andrey J. | Rotatable reactor systems and methods |
| GB0217481D0 (en) * | 2002-07-29 | 2002-09-04 | Pa Consulting Services | Method of separation a mixture of chemical compounds and support for performing separation |
| US7452507B2 (en) * | 2002-08-02 | 2008-11-18 | Sandia Corporation | Portable apparatus for separating sample and detecting target analytes |
| AU2003287029A1 (en) * | 2002-10-08 | 2004-05-04 | University Of Virginia Patent Foundation | Methods and systems for multiplexing ir-mediated heating on a microchip |
| US7132787B2 (en) * | 2002-11-20 | 2006-11-07 | The Regents Of The University Of California | Multilayer polymer-quantum dot light emitting diodes and methods of making and using thereof |
| WO2005033687A1 (en) * | 2003-01-17 | 2005-04-14 | University Of Virginia Patent Foundation | Method for microchip and capillary detection of proteins in the sub-ug/ml range |
| US20050014134A1 (en) * | 2003-03-06 | 2005-01-20 | West Jason Andrew Appleton | Viral identification by generation and detection of protein signatures |
| US7820030B2 (en) | 2003-04-16 | 2010-10-26 | Handylab, Inc. | System and method for electrochemical detection of biological compounds |
| JP4320210B2 (ja) * | 2003-05-01 | 2009-08-26 | 株式会社日立ハイテクノロジーズ | 電気泳動装置 |
| US20050026273A1 (en) * | 2003-06-05 | 2005-02-03 | Zarur Andrey J. | Reactor with memory component |
| EP2407243B1 (en) | 2003-07-31 | 2020-04-22 | Handylab, Inc. | Multilayered microfluidic device |
| US7311476B2 (en) | 2003-10-30 | 2007-12-25 | Cytonome, Inc. | Multilayer hydrodynamic sheath flow structure |
| US20050095602A1 (en) * | 2003-11-04 | 2005-05-05 | West Jason A. | Microfluidic integrated microarrays for biological detection |
| US20070275481A1 (en) * | 2003-11-24 | 2007-11-29 | Biogen Idec Ma Inc. | Methods For Detecting Half-Antibodies Using Chip Based Gel Electophoresis |
| US8592219B2 (en) * | 2005-01-17 | 2013-11-26 | Gyros Patent Ab | Protecting agent |
| ES2553097T3 (es) | 2004-05-03 | 2015-12-04 | Handylab, Inc. | Procesamiento de muestras que contienen polinucleótidos |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| EP1765487A1 (en) * | 2004-06-07 | 2007-03-28 | Bioprocessors Corporation | Reactor mixing |
| EP1761331A2 (en) * | 2004-06-07 | 2007-03-14 | Bioprocessors Corporation | Control of reactor environmental conditions |
| JP2008501365A (ja) * | 2004-06-07 | 2008-01-24 | バイオプロセッサーズ コーポレイション | 反応器における剪断力の生成 |
| US20070036690A1 (en) * | 2004-06-07 | 2007-02-15 | Bioprocessors Corp. | Inlet channel volume in a reactor |
| US20080038760A1 (en) * | 2004-06-08 | 2008-02-14 | Method For Decting Anti-Transglutaminase Antibodies | Method for Detecting Anti-Transglutaminase Antibodies |
| US7935479B2 (en) | 2004-07-19 | 2011-05-03 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| US7846676B2 (en) * | 2004-07-19 | 2010-12-07 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| EP1533612B1 (en) * | 2004-07-30 | 2007-04-11 | Agilent Technologies, Inc. | Electrophoresis gel matrix containing DMSO |
| CN102759466A (zh) * | 2004-09-15 | 2012-10-31 | 英特基因有限公司 | 微流体装置 |
| US7524672B2 (en) * | 2004-09-22 | 2009-04-28 | Sandia Corporation | Microfluidic microarray systems and methods thereof |
| US7592139B2 (en) | 2004-09-24 | 2009-09-22 | Sandia National Laboratories | High temperature flow-through device for rapid solubilization and analysis |
| CN100348978C (zh) * | 2005-01-20 | 2007-11-14 | 上海交通大学 | 基于聚二甲基硅氧烷的微型生物试剂分析检测芯片 |
| EP1586893A1 (en) * | 2005-02-16 | 2005-10-19 | Agilent Technologies Inc | Microfluidic device with fluid sample shape adaptation |
| CN1307418C (zh) * | 2005-04-22 | 2007-03-28 | 江汉大学 | 基于盐溶蛋白图谱技术的豇豆品种分析鉴定方法 |
| US20070111327A1 (en) * | 2005-05-05 | 2007-05-17 | Jay Gregory D | Methods of detecting lubricin |
| WO2007035864A2 (en) | 2005-09-20 | 2007-03-29 | Cell Biosciences, Inc. | Electrophoresis standards, methods and kits |
| CN1319848C (zh) * | 2005-09-22 | 2007-06-06 | 上海交通大学 | 阵列式多腔压电驱动微混合器 |
| US20070199821A1 (en) * | 2005-10-05 | 2007-08-30 | Chow Andrea W | Automated two-dimensional gel electrophoresis |
| EP1991876B1 (en) * | 2006-02-10 | 2010-11-10 | Agilent Technologies, Inc. | Protein analysis using a polymethine marker dye |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
| EP2018558A2 (en) * | 2006-05-09 | 2009-01-28 | Schering Corporation | Development of a novel assay for mgmt (methyl guanine transferase) |
| US20080017512A1 (en) * | 2006-07-24 | 2008-01-24 | Bordunov Andrei V | Coatings for capillaries capable of capturing analytes |
| US8216056B2 (en) * | 2007-02-13 | 2012-07-10 | Cfph, Llc | Card picks for progressive prize |
| EP2091647A2 (en) | 2006-11-14 | 2009-08-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US20080227209A1 (en) * | 2007-03-14 | 2008-09-18 | David Xing-Fei Deng | Methods, Kits And Devices For Analysis Of Lipoprotein(a) |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US20090136385A1 (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
| USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
| ES2648798T3 (es) | 2007-07-13 | 2018-01-08 | Handylab, Inc. | Materiales de captura de polinucleótidos y métodos de utilización de los mismos |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US8016260B2 (en) * | 2007-07-19 | 2011-09-13 | Formulatrix, Inc. | Metering assembly and method of dispensing fluid |
| US10107782B2 (en) | 2008-01-25 | 2018-10-23 | ProteinSimple | Method to perform limited two dimensional separation of proteins and other biologicals |
| USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| US8100293B2 (en) * | 2009-01-23 | 2012-01-24 | Formulatrix, Inc. | Microfluidic dispensing assembly |
| US8974651B2 (en) | 2010-04-17 | 2015-03-10 | C.C. Imex | Illuminator for visualization of fluorophores |
| US10481069B2 (en) * | 2011-01-03 | 2019-11-19 | Cytonome/St, Llc | Method and apparatus for monitoring and optimizing microfluidic particle sorting |
| JP6088487B2 (ja) | 2011-04-15 | 2017-03-01 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 走査リアルタイムマイクロ流体熱サイクラーと同期熱サイクリング及び走査光学検出の方法 |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| AU2012315595B2 (en) | 2011-09-30 | 2015-10-22 | Becton, Dickinson And Company | Unitized reagent strip |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| KR20130086743A (ko) * | 2012-01-26 | 2013-08-05 | 삼성전자주식회사 | 미세유동장치 및 그 제어방법 |
| JP6262152B2 (ja) | 2012-02-03 | 2018-01-17 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 分子診断試験の分布及び試験間のコンパチビリティ判断のための外部ファイル |
| EP2839276B1 (en) | 2012-04-19 | 2018-06-27 | ProteinSimple | Dual wavelength isoelectric focusing for determining drug load in antibody drug conjugates |
| EP4220124A1 (en) | 2013-03-14 | 2023-08-02 | Cytonome/ST, LLC | Hydrodynamic focusing apparatus and methods |
| EP2999538B1 (en) * | 2013-05-23 | 2021-04-21 | Tecan Trading AG | Digital microfluidics system with swappable pcb`s |
| US9766206B2 (en) | 2013-09-27 | 2017-09-19 | ProteinSimple | Apparatus, systems, and methods for capillary electrophoresis |
| US9835587B2 (en) | 2014-04-01 | 2017-12-05 | C.C. Imex | Electrophoresis running tank assembly |
| US10031104B2 (en) * | 2014-06-13 | 2018-07-24 | Yes Way Intellectual Holdings, Llc | Mobile micro-lab for chemical analysis of fluids |
| US9264370B1 (en) * | 2015-02-10 | 2016-02-16 | Centripetal Networks, Inc. | Correlating packets in communications networks |
| JP6451433B2 (ja) * | 2015-03-19 | 2019-01-16 | 株式会社島津製作所 | キャピラリ電気泳動装置 |
| CN105466993A (zh) * | 2015-09-14 | 2016-04-06 | 青岛爱迪生物科技有限公司 | 一种快速蛋白电泳缓冲液 |
| CN105241856B (zh) * | 2015-09-29 | 2018-04-20 | 窦晓鸣 | 毛细管聚合物电泳分析检测miRNA的系统及方法 |
| CN105241855B (zh) * | 2015-09-29 | 2018-04-20 | 窦晓鸣 | 微通道电泳定量分析装置及方法 |
| EP4301494A4 (en) | 2021-03-04 | 2025-01-22 | ProteinSimple | SHELL CHANNEL FORMATION BETWEEN CAPILLARIES FOR HIGH-THROUGHPUT CAPILLARY ELECTROPHORESIS |
| CN113466459B (zh) * | 2021-09-02 | 2021-11-19 | 信纳克(北京)生化标志物检测医学研究有限责任公司 | 靶向治疗后b细胞肿瘤的检测试剂及治疗靶标与相关应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996004547A1 (en) * | 1994-08-01 | 1996-02-15 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis |
| CN1185836A (zh) * | 1996-02-29 | 1998-06-24 | 生物辐射实验室股份有限公司 | 用含氨基酸的缓冲液通过毛细管电泳分离蛋白质的方法 |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4077845A (en) | 1977-04-20 | 1978-03-07 | Miles Laboratories, Inc. | Disposable inoculation device and process of using same |
| US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
| US4390403A (en) | 1981-07-24 | 1983-06-28 | Batchelder J Samuel | Method and apparatus for dielectrophoretic manipulation of chemical species |
| US5171534A (en) | 1984-01-16 | 1992-12-15 | California Institute Of Technology | Automated DNA sequencing technique |
| US5140161A (en) | 1985-08-05 | 1992-08-18 | Biotrack | Capillary flow device |
| US5164598A (en) | 1985-08-05 | 1992-11-17 | Biotrack | Capillary flow device |
| US4963498A (en) | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
| US5144139A (en) | 1985-08-05 | 1992-09-01 | Biotrack, Inc. | Capillary flow device |
| US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
| US5089111A (en) | 1989-01-27 | 1992-02-18 | Bio-Rad Laboratories, Inc. | Electrophoretic sieving in gel-free media with dissolved polymers |
| US5096554A (en) | 1989-08-07 | 1992-03-17 | Applied Biosystems, Inc. | Nucleic acid fractionation by counter-migration capillary electrophoresis |
| US5181999A (en) | 1989-11-06 | 1993-01-26 | Applied Biosystems, Inc. | Capillary electrophoresis method with polymer tube coating |
| US5015350A (en) | 1989-11-06 | 1991-05-14 | Applied Biosystems, Inc. | Flow-rate-controlled surface-charge coating for capillary electrophoresis |
| US5264101A (en) | 1989-11-06 | 1993-11-23 | Applied Biosystems, Inc. | Capillary electrophoresis molecular weight separation of biomolecules using a polymer-containing solution |
| US5126022A (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
| US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
| JP2833115B2 (ja) * | 1990-03-09 | 1998-12-09 | 株式会社島津製作所 | タンパク質分析法 |
| US5332481A (en) | 1991-01-29 | 1994-07-26 | Beckman Instruments, Inc. | Capillary electrophoresis using replaceable gels |
| US5126021A (en) | 1991-07-17 | 1992-06-30 | Applied Biosystems Inc. | Low-viscosity polymer solution for capillary electrophoresis |
| US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
| US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
| US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| US5759369A (en) * | 1992-09-24 | 1998-06-02 | The Perkin-Elmer Corporation | Viscous electrophoresis polymer medium and method |
| US5885432A (en) * | 1992-11-05 | 1999-03-23 | Soane Biosciences | Un-crosslinked polymeric media for electrophoresis |
| US5374527A (en) | 1993-01-21 | 1994-12-20 | Applied Biosystems, Inc. | High resolution DNA sequencing method using low viscosity medium |
| JPH06265447A (ja) * | 1993-03-16 | 1994-09-22 | Hitachi Ltd | 微量反応装置およびこれを使用する微量成分測定装置 |
| EP0653631B1 (de) | 1993-11-11 | 2003-05-14 | Aclara BioSciences, Inc. | Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen |
| AU1254295A (en) | 1993-12-17 | 1995-07-03 | Perkin-Elmer Corporation, The | Uncharged polymers for separation of biomolecules by capillary electrophoresis |
| EP0665430B1 (en) | 1994-01-28 | 1998-04-15 | Hewlett-Packard GmbH | Capillary made of plastics material for use in capillary electrophoresis and process for its production |
| JP3415682B2 (ja) * | 1994-08-10 | 2003-06-09 | 株式会社日立製作所 | キャピラリー電気泳動・質量分析計 |
| US5500071A (en) | 1994-10-19 | 1996-03-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
| US5571410A (en) | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
| US5603351A (en) | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device |
| US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| US5560811A (en) | 1995-03-21 | 1996-10-01 | Seurat Analytical Systems Incorporated | Capillary electrophoresis apparatus and method |
| US5616502A (en) * | 1995-05-19 | 1997-04-01 | Molecular Probes, Inc. | Non-specific protein staining using merocyanine dyes |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US5753094A (en) * | 1995-09-20 | 1998-05-19 | Beckman Instruments, Inc. | Borate storage buffer and sample diluent |
| US5716825A (en) | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
| US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
| US6399023B1 (en) | 1996-04-16 | 2002-06-04 | Caliper Technologies Corp. | Analytical system and method |
| US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| US5779868A (en) | 1996-06-28 | 1998-07-14 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
| US6547942B1 (en) | 1996-06-28 | 2003-04-15 | Caliper Technologies Corp. | Electropipettor and compensation means for electrophoretic bias |
| US5800690A (en) | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
| US5699157A (en) | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel |
| US5964995A (en) | 1997-04-04 | 1999-10-12 | Caliper Technologies Corp. | Methods and systems for enhanced fluid transport |
| JP2001521622A (ja) * | 1997-04-04 | 2001-11-06 | カリパー テクノロジーズ コーポレイション | 閉ループ生化学分析器 |
| CN1105914C (zh) * | 1997-04-25 | 2003-04-16 | 卡钳技术有限公司 | 改进了通道几何结构的微型流体装置 |
| US5976336A (en) | 1997-04-25 | 1999-11-02 | Caliper Technologies Corp. | Microfluidic devices incorporating improved channel geometries |
| US5869004A (en) | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
| US5882465A (en) | 1997-06-18 | 1999-03-16 | Caliper Technologies Corp. | Method of manufacturing microfluidic devices |
| US5959291A (en) | 1997-06-27 | 1999-09-28 | Caliper Technologies Corporation | Method and apparatus for measuring low power signals |
| US6001231A (en) | 1997-07-15 | 1999-12-14 | Caliper Technologies Corp. | Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems |
| US5876675A (en) | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems |
| US5989402A (en) | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems |
| US5965410A (en) | 1997-09-02 | 1999-10-12 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
| US6012902A (en) | 1997-09-25 | 2000-01-11 | Caliper Technologies Corp. | Micropump |
| US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
| US5958694A (en) | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems |
| US5948227A (en) | 1997-12-17 | 1999-09-07 | Caliper Technologies Corp. | Methods and systems for performing electrophoretic molecular separations |
| EP1046032A4 (en) * | 1998-05-18 | 2002-05-29 | Univ Washington | LIQUID ANALYSIS CARTRIDGE |
| US6103199A (en) * | 1998-09-15 | 2000-08-15 | Aclara Biosciences, Inc. | Capillary electroflow apparatus and method |
| US6498497B1 (en) * | 1998-10-14 | 2002-12-24 | Caliper Technologies Corp. | Microfluidic controller and detector system with self-calibration |
| US6062261A (en) * | 1998-12-16 | 2000-05-16 | Lockheed Martin Energy Research Corporation | MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs |
| EP2278320B1 (en) * | 1999-02-02 | 2018-07-18 | Caliper Life Sciences, Inc. | Methods and devices for characterizing proteins |
| US6524456B1 (en) * | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
| AU2003243137A1 (en) | 2002-03-22 | 2003-10-08 | Georgia Tech Research Corporation | Floating-gate analog circuit |
-
2000
- 2000-02-02 EP EP10009493.7A patent/EP2278320B1/en not_active Expired - Lifetime
- 2000-02-02 JP JP2000597626A patent/JP4515640B2/ja not_active Expired - Lifetime
- 2000-02-02 CN CNB008032874A patent/CN1296703C/zh not_active Expired - Lifetime
- 2000-02-02 WO PCT/US2000/002680 patent/WO2000046594A1/en not_active Ceased
- 2000-02-02 EP EP00914483A patent/EP1159605B1/en not_active Expired - Lifetime
- 2000-02-02 CA CA002358683A patent/CA2358683A1/en not_active Abandoned
- 2000-02-02 MX MXPA01007804A patent/MXPA01007804A/es unknown
- 2000-02-02 US US09/496,849 patent/US6475364B1/en not_active Expired - Lifetime
- 2000-02-02 AU AU35869/00A patent/AU758309B2/en not_active Ceased
-
2002
- 2002-09-03 US US10/233,760 patent/US20030015429A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996004547A1 (en) * | 1994-08-01 | 1996-02-15 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis |
| US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
| CN1185836A (zh) * | 1996-02-29 | 1998-06-24 | 生物辐射实验室股份有限公司 | 用含氨基酸的缓冲液通过毛细管电泳分离蛋白质的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU758309B2 (en) | 2003-03-20 |
| WO2000046594A9 (en) | 2001-11-15 |
| US6475364B1 (en) | 2002-11-05 |
| JP4515640B2 (ja) | 2010-08-04 |
| EP1159605B1 (en) | 2012-07-11 |
| JP2002536639A (ja) | 2002-10-29 |
| EP2278320B1 (en) | 2018-07-18 |
| CA2358683A1 (en) | 2000-08-10 |
| EP2278320A1 (en) | 2011-01-26 |
| AU3586900A (en) | 2000-08-25 |
| EP1159605A4 (en) | 2006-09-20 |
| US20030015429A1 (en) | 2003-01-23 |
| EP1159605A1 (en) | 2001-12-05 |
| WO2000046594A1 (en) | 2000-08-10 |
| MXPA01007804A (es) | 2003-06-09 |
| CN1339104A (zh) | 2002-03-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1296703C (zh) | 鉴定蛋白质的方法、装置和系统 | |
| CN1228841A (zh) | 电吸移管和电泳偏离补偿装置 | |
| JPH0593708A (ja) | ゲル収容毛管カラム、毛管に満たされるゲルの形成方法、試料の分離方法および毛管電気泳動機構 | |
| US20140110260A1 (en) | Isotachophoresis of blood-derived samples | |
| EP1920255B1 (en) | Complex formation method and separation method | |
| Tan et al. | Integrated on-line system for DNA sequencing by capillary electrophoresis: From template to called bases | |
| Zabzdyr et al. | New approaches to single-cell analysis by capillary electrophoresis | |
| CN1910450A (zh) | 表征蛋白质的方法、装置和系统 | |
| US6878254B2 (en) | Size separation of analytes using monomeric surfactants | |
| Miki et al. | Immunoassay for human serum albumin using capillary electrophoresis–semiconductor laser-induced fluorometry | |
| Tsukagoshi et al. | Improvement of a capillary electrophoresis-chemiluminescence detection system for using a polyacrylamide-coated capillary | |
| US20240192164A1 (en) | Method for enhancing signals associated with electrophoretically separated analytes using post-electrophoresis treatment | |
| CN1322004C (zh) | 一种蛋白质分离分析用微流控芯片及分离分析方法 | |
| Liu et al. | Assay of IgG purity and heterogeneity using high-resolution sodium dodecyl sulfate capillary gel electrophoresis | |
| Weiss et al. | Chip electrophoresis of gelatin‐based nanoparticles | |
| Wehr | Capillary electrophoresis in the biopharmaceutical industry: Part I | |
| Tsukagoshi et al. | Analysis of a biopolymer by capillary electrophoresis with a chemiluminescence detector using a polymer solution as the separation medium | |
| Ma et al. | A rapid performance assessment method for microfluidic chips | |
| WO2025133647A1 (en) | Method for non-covalent in-migratio fluorophore labeling of sds-proteins using counter-current electromigration in sds-cge | |
| Hu et al. | Capillary electrophoresis of peptides and proteins | |
| Freitag | Capillary Gel Electrophoresis | |
| Kostel | Capillary electrophoresis of proteins and peptides | |
| Tsukagoshi et al. | Application of capillary electrophoresis with sensitive detection to analysis for saccharide molecules | |
| Gump | Analysis of proteins and peptides using microcolumn analytical methods | |
| Swerdlow | A Capillary Instrument for High Speed DNA-Based Tumor Diagnosis. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20070124 |
|
| CX01 | Expiry of patent term |