CN1288153C - 2－氨基－4－吡啶基甲基－二氢噻唑衍生物作为诱导型no－合酶抑制剂的用途 - Google Patents

2－氨基－4－吡啶基甲基－二氢噻唑衍生物作为诱导型no－合酶抑制剂的用途 Download PDF

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Publication number
CN1288153C
CN1288153C CNB028246934A CN02824693A CN1288153C CN 1288153 C CN1288153 C CN 1288153C CN B028246934 A CNB028246934 A CN B028246934A CN 02824693 A CN02824693 A CN 02824693A CN 1288153 C CN1288153 C CN 1288153C
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compound
formula
alkyl
acceptable salt
preparation
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Chinese (zh)
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CN1602311A (zh
Inventor
E·巴克
A·比戈
J-C·卡里
S·米尼亚尼
B·罗南
M·塔巴尔
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Aventis Pharma SA
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Aventis Pharma SA
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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CNB028246934A 2001-11-09 2002-11-07 2－氨基－4－吡啶基甲基－二氢噻唑衍生物作为诱导型no－合酶抑制剂的用途 Expired - Fee Related CN1288153C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0114508A FR2832150B1 (fr) 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-pyridylmethyl-thiazoline comme inhibiteurs de no-synthase inductible
FR01/14508 2001-11-09
US35297802P 2002-01-30 2002-01-30
US60/352,978 2002-01-30

Publications (2)

Publication Number Publication Date
CN1602311A CN1602311A (zh) 2005-03-30
CN1288153C true CN1288153C (zh) 2006-12-06

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CNB028246934A Expired - Fee Related CN1288153C (zh) 2001-11-09 2002-11-07 2－氨基－4－吡啶基甲基－二氢噻唑衍生物作为诱导型no－合酶抑制剂的用途

Country Status (22)

Country Link
US (1) US6762196B2 (enExample)
EP (1) EP1450750B1 (enExample)
JP (1) JP4342309B2 (enExample)
CN (1) CN1288153C (enExample)
AT (1) ATE446295T1 (enExample)
BR (1) BR0206368A (enExample)
CA (1) CA2465877C (enExample)
CY (1) CY1110284T1 (enExample)
DE (1) DE60234117D1 (enExample)
DK (1) DK1450750T3 (enExample)
ES (1) ES2335090T3 (enExample)
HR (1) HRP20040402A2 (enExample)
HU (1) HUP0402033A2 (enExample)
IL (2) IL161843A0 (enExample)
MA (1) MA27143A1 (enExample)
MX (1) MXPA04004213A (enExample)
NO (1) NO20033131L (enExample)
PL (1) PL370267A1 (enExample)
PT (1) PT1450750E (enExample)
RU (1) RU2004117531A (enExample)
SI (1) SI1450750T1 (enExample)
WO (1) WO2003039446A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10240735A1 (de) * 2002-08-29 2004-03-18 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verwendung von Modulatoren der NO-Signalkaskade und pharmazeutische Zusammensetzung
ES2537898T3 (es) 2005-10-25 2015-06-15 Shionogi & Co., Ltd. Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1
AU2008245082B8 (en) 2007-04-24 2012-09-13 Shionogi & Co., Ltd. Aminodihydrothiazine derivatives substituted with a cyclic group
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
US8637504B2 (en) 2008-06-13 2014-01-28 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
WO2010047372A1 (ja) 2008-10-22 2010-04-29 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２－アミノピリミジン－４－オンおよび２－アミノピリジン誘導体
RU2012129168A (ru) 2009-12-11 2014-01-20 Сионоги Энд Ко. Лтд. Производные оксазина
US9018219B2 (en) 2010-10-29 2015-04-28 Shionogi & Co., Ltd. Fused aminodihydropyrimidine derivative
CA2816285A1 (en) 2010-10-29 2012-05-03 Shionogi & Co., Ltd. Naphthyridine derivative
WO2012147763A1 (ja) 2011-04-26 2012-11-01 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107771A0 (en) * 1992-11-27 1994-02-27 Wellcome Found Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation
AU688811B2 (en) * 1993-10-21 1998-03-19 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
WO1996014842A1 (en) * 1994-11-15 1996-05-23 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
FR2810037B1 (fr) * 2000-06-09 2004-04-23 Aventis Pharma Sa Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible

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PL370267A1 (en) 2005-05-16
CA2465877C (fr) 2009-12-29
WO2003039446A3 (fr) 2003-11-27
MXPA04004213A (es) 2004-07-08
SI1450750T1 (sl) 2010-02-26
CA2465877A1 (fr) 2003-05-15
IL161843A (en) 2011-08-31
CN1602311A (zh) 2005-03-30
NO20033131L (no) 2003-08-27
ES2335090T3 (es) 2010-03-22
HUP0402033A2 (hu) 2005-02-28
BR0206368A (pt) 2004-02-10
EP1450750B1 (fr) 2009-10-21
WO2003039446A2 (fr) 2003-05-15
ATE446295T1 (de) 2009-11-15
CY1110284T1 (el) 2015-01-14
US20030153605A1 (en) 2003-08-14
NO20033131D0 (no) 2003-07-08
US6762196B2 (en) 2004-07-13
HRP20040402A2 (en) 2004-10-31
PT1450750E (pt) 2010-01-18
JP2005517634A (ja) 2005-06-16
EP1450750A2 (fr) 2004-09-01
DK1450750T3 (da) 2010-03-08
JP4342309B2 (ja) 2009-10-14
DE60234117D1 (de) 2009-12-03
MA27143A1 (fr) 2005-01-03
IL161843A0 (en) 2005-11-20
RU2004117531A (ru) 2005-04-10

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