CN1288153C - 2－氨基－4－吡啶基甲基－二氢噻唑衍生物作为诱导型no－合酶抑制剂的用途 - Google Patents

2－氨基－4－吡啶基甲基－二氢噻唑衍生物作为诱导型no－合酶抑制剂的用途 Download PDF

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Publication number
CN1288153C
CN1288153C CNB028246934A CN02824693A CN1288153C CN 1288153 C CN1288153 C CN 1288153C CN B028246934 A CNB028246934 A CN B028246934A CN 02824693 A CN02824693 A CN 02824693A CN 1288153 C CN1288153 C CN 1288153C
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compound
formula
alkyl
acceptable salt
preparation
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Chinese (zh)
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CN1602311A (zh
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E·巴克
A·比戈
J-C·卡里
S·米尼亚尼
B·罗南
M·塔巴尔
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Aventis Pharma SA
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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CNB028246934A 2001-11-09 2002-11-07 2－氨基－4－吡啶基甲基－二氢噻唑衍生物作为诱导型no－合酶抑制剂的用途 Expired - Fee Related CN1288153C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR01/14508 2001-11-09
FR0114508A FR2832150B1 (fr) 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-pyridylmethyl-thiazoline comme inhibiteurs de no-synthase inductible
US35297802P 2002-01-30 2002-01-30
US60/352,978 2002-01-30

Publications (2)

Publication Number Publication Date
CN1602311A CN1602311A (zh) 2005-03-30
CN1288153C true CN1288153C (zh) 2006-12-06

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CNB028246934A Expired - Fee Related CN1288153C (zh) 2001-11-09 2002-11-07 2－氨基－4－吡啶基甲基－二氢噻唑衍生物作为诱导型no－合酶抑制剂的用途

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US (1) US6762196B2 (enExample)
EP (1) EP1450750B1 (enExample)
JP (1) JP4342309B2 (enExample)
CN (1) CN1288153C (enExample)
AT (1) ATE446295T1 (enExample)
BR (1) BR0206368A (enExample)
CA (1) CA2465877C (enExample)
CY (1) CY1110284T1 (enExample)
DE (1) DE60234117D1 (enExample)
DK (1) DK1450750T3 (enExample)
ES (1) ES2335090T3 (enExample)
HR (1) HRP20040402A2 (enExample)
HU (1) HUP0402033A2 (enExample)
IL (2) IL161843A0 (enExample)
MA (1) MA27143A1 (enExample)
MX (1) MXPA04004213A (enExample)
NO (1) NO20033131L (enExample)
PL (1) PL370267A1 (enExample)
PT (1) PT1450750E (enExample)
RU (1) RU2004117531A (enExample)
SI (1) SI1450750T1 (enExample)
WO (1) WO2003039446A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10240735A1 (de) * 2002-08-29 2004-03-18 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verwendung von Modulatoren der NO-Signalkaskade und pharmazeutische Zusammensetzung
RU2416603C9 (ru) * 2005-10-25 2012-06-20 Сионоги Энд Ко., Лтд. Производные аминодигидротиазина
WO2008133273A1 (ja) 2007-04-24 2008-11-06 Shionogi & Co., Ltd. アルツハイマー症治療用医薬組成物
TW200902526A (en) 2007-04-24 2009-01-16 Shionogi & Amp Co Ltd Aminodihydrothiazin derivative substituted with a cyclic group
AU2009258496B8 (en) 2008-06-13 2014-06-26 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity
US8703785B2 (en) 2008-10-22 2014-04-22 Shionogi & Co., Ltd. 2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity
KR20120104570A (ko) 2009-12-11 2012-09-21 시오노기세야쿠 가부시키가이샤 옥사진 유도체
US9018219B2 (en) 2010-10-29 2015-04-28 Shionogi & Co., Ltd. Fused aminodihydropyrimidine derivative
EP2634186A4 (en) 2010-10-29 2014-03-26 Shionogi & Co naphthyridine
EP2703399A4 (en) 2011-04-26 2014-10-15 Shionogi & Co OXAZINE DERIVATIVE AND BACE-1 HEMMER THEREOF
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5533094A (en) * 1992-11-27 1994-06-22 Wellcome Foundation Limited, The Enzyme inhibitors
CA2173468A1 (en) * 1993-10-21 1995-04-27 Donald W. Hansen, Jr. Amidino derivatives useful as nitric oxide synthase inhibitors
WO1996014842A1 (en) * 1994-11-15 1996-05-23 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
FR2810037B1 (fr) * 2000-06-09 2004-04-23 Aventis Pharma Sa Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible

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Publication number Publication date
CA2465877C (fr) 2009-12-29
WO2003039446A2 (fr) 2003-05-15
BR0206368A (pt) 2004-02-10
PL370267A1 (en) 2005-05-16
HRP20040402A2 (en) 2004-10-31
NO20033131D0 (no) 2003-07-08
CN1602311A (zh) 2005-03-30
EP1450750B1 (fr) 2009-10-21
CY1110284T1 (el) 2015-01-14
PT1450750E (pt) 2010-01-18
JP4342309B2 (ja) 2009-10-14
RU2004117531A (ru) 2005-04-10
NO20033131L (no) 2003-08-27
IL161843A (en) 2011-08-31
ES2335090T3 (es) 2010-03-22
US6762196B2 (en) 2004-07-13
MXPA04004213A (es) 2004-07-08
DK1450750T3 (da) 2010-03-08
JP2005517634A (ja) 2005-06-16
IL161843A0 (en) 2005-11-20
DE60234117D1 (de) 2009-12-03
HUP0402033A2 (hu) 2005-02-28
ATE446295T1 (de) 2009-11-15
US20030153605A1 (en) 2003-08-14
SI1450750T1 (sl) 2010-02-26
CA2465877A1 (fr) 2003-05-15
MA27143A1 (fr) 2005-01-03
WO2003039446A3 (fr) 2003-11-27
EP1450750A2 (fr) 2004-09-01

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