CN1266105C - 4－苯丁酸的合成 - Google Patents

4－苯丁酸的合成 Download PDF

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Publication number
CN1266105C
CN1266105C CNB028102649A CN02810264A CN1266105C CN 1266105 C CN1266105 C CN 1266105C CN B028102649 A CNB028102649 A CN B028102649A CN 02810264 A CN02810264 A CN 02810264A CN 1266105 C CN1266105 C CN 1266105C
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China
Prior art keywords
formula
compound
catalyzer
benzene
mixture
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Expired - Fee Related
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CNB028102649A
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English (en)
Chinese (zh)
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CN1511133A (zh
Inventor
斯坦尼斯劳R·伯辛斯基
L·穆西亚尔
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
CNB028102649A 2001-05-21 2002-05-02 4－苯丁酸的合成 Expired - Fee Related CN1266105C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/862,074 US6372938B1 (en) 2001-05-21 2001-05-21 Synthesis of 4-phenylbutyric acid
US09/862,074 2001-05-21

Publications (2)

Publication Number Publication Date
CN1511133A CN1511133A (zh) 2004-07-07
CN1266105C true CN1266105C (zh) 2006-07-26

Family

ID=25337569

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028102649A Expired - Fee Related CN1266105C (zh) 2001-05-21 2002-05-02 4－苯丁酸的合成

Country Status (12)

Country Link
US (1) US6372938B1 (https=)
EP (1) EP1404638B1 (https=)
JP (1) JP4338401B2 (https=)
KR (1) KR100905139B1 (https=)
CN (1) CN1266105C (https=)
AT (1) ATE517857T1 (https=)
CA (1) CA2447803C (https=)
HU (1) HU229996B1 (https=)
IL (2) IL158914A0 (https=)
PL (1) PL201802B1 (https=)
RU (1) RU2297998C2 (https=)
WO (1) WO2002094756A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1291015A1 (en) * 2001-09-10 2003-03-12 Lunamed AG Dosage forms having prolonged active ingredient release
CN1659126A (zh) * 2002-06-03 2005-08-24 昭和电工株式会社 通过弗瑞德－克来福特反应制备芳族化合物的方法
CA2582255A1 (en) * 2004-08-30 2006-08-08 Lunamed, Inc. 4-phenylbutyric acid controlled-release formulations for therapeutic use
US20070004805A1 (en) * 2005-07-01 2007-01-04 Navinta Llc Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
JP5163986B2 (ja) * 2005-09-23 2013-03-13 エスケー バイオファーマスティカルズ カンパニー リミテッド フェニル酪酸ナトリウムを使用する、薬物依存症又はアルコール依存症或いは躁うつ病の予防又は治療のための医薬組成物
JP2013523795A (ja) * 2010-04-06 2013-06-17 バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー 植物のストレス耐性を増強させるための４−フェニル酪酸及び／又はその塩の使用
KR101374241B1 (ko) * 2010-11-17 2014-03-14 전북대학교병원 페닐부틸산（４－ｐｈｅｎｙｌｂｕｔｙｒｉｃ ａｃｉｄ）또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는, 천식 치료용 약학적 조성물
EP2599477A1 (en) 2011-11-30 2013-06-05 Lunamed AG 4-Phenylbutyric acid sustained release formulation
FR2993141B1 (fr) 2012-07-11 2014-11-28 Inst Rech Developpement Ird Utilisation de l'acide 4-phenylbutyrique pour ameliorer la tolerance des plantes aux bioagresseurs
CN103304402B (zh) * 2013-05-24 2015-04-22 苏州诚和医药化学有限公司 一种制备4-苯-1-丁酸的方法
CN103304403B (zh) * 2013-05-24 2015-04-22 苏州诚和医药化学有限公司 一种4-苯-1-丁酸的合成方法
US9914692B2 (en) * 2016-05-25 2018-03-13 Horizon Therapeutics, Llc Procedure for the preparation of 4-phenyl butyrate and uses thereof
CN106117045A (zh) * 2016-06-22 2016-11-16 北京阳光诺和药物研究有限公司 一种苯基丁酸的纯化方法
CN108530290A (zh) * 2018-06-04 2018-09-14 福州华博立乐新材料科技有限公司 一种4-苯基-1-丁酸的合成方法
CN110317132B (zh) * 2019-07-26 2021-09-10 南京工业大学 一种苯丁酸钠的制备方法
FR3110336B1 (fr) 2020-05-20 2022-12-23 Inst Des Sciences Et Industries Du Vivant Et De Lenvir Utilisation de l’Acide 4-phénylbutyrique et/ou de l’Acide 3-phénylbutyrique et/ou de l’Acide 2-phénylbutyrique pour la Prévention et le Traitement des Maladies Cryptogamiques
WO2024200617A1 (en) * 2023-03-28 2024-10-03 Dipharma Francis S.R.L. Process and intermediates for preparing a drug for the treatment of urea cycle disorders
IT202300019125A1 (it) * 2023-09-18 2025-03-18 Dipharma Francis Srl Metodo di purificazione di un farmaco usato per il trattamento di disturbi del ciclo dell’urea

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037376A (en) 1991-10-21 2000-03-14 The United States Of America As Represented By The Department Of Health And Human Services Methods for therapy of cancer

Also Published As

Publication number Publication date
HU229996B1 (hu) 2015-04-28
ATE517857T1 (de) 2011-08-15
IL158914A (en) 2010-04-29
KR20040025679A (ko) 2004-03-24
WO2002094756A1 (en) 2002-11-28
EP1404638A1 (en) 2004-04-07
PL364646A1 (en) 2004-12-13
HUP0400053A2 (hu) 2004-04-28
JP2004527577A (ja) 2004-09-09
RU2297998C2 (ru) 2007-04-27
PL201802B1 (pl) 2009-05-29
US6372938B1 (en) 2002-04-16
CA2447803A1 (en) 2002-11-28
CN1511133A (zh) 2004-07-07
HK1065996A1 (en) 2005-03-11
RU2003136765A (ru) 2005-04-10
JP4338401B2 (ja) 2009-10-07
HUP0400053A3 (en) 2006-01-30
CA2447803C (en) 2009-04-07
EP1404638B1 (en) 2011-07-27
IL158914A0 (en) 2004-05-12
KR100905139B1 (ko) 2009-06-29

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