CN1261882A - 速激肽受拮剂2-(r)-(1-(r)-(3,5-二(三氟甲基)苯基)乙氧基)-3-(s)-(4-氟)苯基-4-(3-(5-氧代-1h,4h-1,2,4-三唑)甲基吗啉的多晶型物 - Google Patents
速激肽受拮剂2-(r)-(1-(r)-(3,5-二(三氟甲基)苯基)乙氧基)-3-(s)-(4-氟)苯基-4-(3-(5-氧代-1h,4h-1,2,4-三唑)甲基吗啉的多晶型物 Download PDFInfo
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- CN1261882A CN1261882A CN98806703A CN98806703A CN1261882A CN 1261882 A CN1261882 A CN 1261882A CN 98806703 A CN98806703 A CN 98806703A CN 98806703 A CN98806703 A CN 98806703A CN 1261882 A CN1261882 A CN 1261882A
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- phenyl
- trifluoromethyl
- oxo
- methylmorpholine
- fluorine
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- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Abstract
Description
Claims (20)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5160097P | 1997-07-02 | 1997-07-02 | |
US60/051,600 | 1997-07-02 | ||
GB9800216.5 | 1998-01-07 | ||
GBGB9800216.5A GB9800216D0 (en) | 1998-01-07 | 1998-01-07 | Polymorphic form of a tachykinin receptor antagonist |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1261882A true CN1261882A (zh) | 2000-08-02 |
CN1106390C CN1106390C (zh) | 2003-04-23 |
Family
ID=26312895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN98806703A Expired - Lifetime CN1106390C (zh) | 1997-07-02 | 1998-07-01 | 速激肽受体拮抗剂2-(r)-(1-(r)-(3,5-二(三氟甲基)苯基)乙氧基)-3-(s)-(4-氟)苯基-4-(3-(5-氧代-1h,4h-1,2,4-三唑)甲基码啉的晶型 |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP0994867B1 (zh) |
JP (1) | JP2000513383A (zh) |
KR (1) | KR20010020593A (zh) |
CN (1) | CN1106390C (zh) |
AT (1) | ATE372991T1 (zh) |
AU (1) | AU735230B2 (zh) |
BG (1) | BG64703B1 (zh) |
CA (1) | CA2293836C (zh) |
CZ (1) | CZ295410B6 (zh) |
DE (1) | DE69838421D1 (zh) |
DZ (1) | DZ2551A1 (zh) |
EA (1) | EA002405B1 (zh) |
EE (1) | EE04152B1 (zh) |
HK (1) | HK1029345A1 (zh) |
HR (1) | HRP980370B1 (zh) |
HU (1) | HU228003B1 (zh) |
ID (1) | ID23191A (zh) |
IL (1) | IL133357A (zh) |
IS (1) | IS2617B (zh) |
NO (1) | NO316893B1 (zh) |
NZ (1) | NZ501589A (zh) |
PE (1) | PE86499A1 (zh) |
PL (1) | PL191496B1 (zh) |
SK (1) | SK285644B6 (zh) |
TR (1) | TR199903299T2 (zh) |
TW (1) | TW577887B (zh) |
WO (1) | WO1999001444A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104119325A (zh) * | 2014-07-15 | 2014-10-29 | 中山奕安泰医药科技有限公司 | 阿瑞吡坦多晶型物的制备方法 |
CN105837526A (zh) * | 2016-01-22 | 2016-08-10 | 浙江工业大学 | 一种阿瑞吡坦重要合成中间体(2s,3r)-4-苄基-3-(4-氟苯基)吗啉-2-醇的制备方法 |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1343901A (en) * | 1999-10-29 | 2001-05-14 | Merck & Co., Inc. | Polymorphic form of a tachykinin receptor antagonist |
GB0203061D0 (en) * | 2002-02-08 | 2002-03-27 | Novartis Ag | Organic compounds |
ES2299720T3 (es) * | 2002-05-31 | 2008-06-01 | Schering Corporation | Formas polimorfas de un inhibidor de xantina-fosfodiesterasa v. |
GB0417702D0 (en) * | 2004-08-09 | 2004-09-08 | Merck Sharp & Dohme | New uses |
WO2007039883A2 (en) | 2005-10-05 | 2007-04-12 | Ranbaxy Laboratories Limited | Process for preparation of aprepitant |
US9227958B2 (en) | 2006-02-03 | 2016-01-05 | Glenmark Pharmaceuticals Limited | Amorphous and crystalline forms of aprepitant and processes for the preparation thereof |
AR060353A1 (es) | 2006-04-05 | 2008-06-11 | Schering Corp | Sales de hidrocloruro de 8 - [( 1- (3,5 -bis- (trifluorometil) fenil) -etoxi) -metil] -8-fenil-1,7 -diaza- spiro [4.5] decan -2-ona. composiciones farmaceuticas |
WO2008026216A2 (en) * | 2006-08-28 | 2008-03-06 | Hetero Drugs Limited | Process for purification of aprepitant |
WO2008044102A1 (en) * | 2006-10-13 | 2008-04-17 | Glenmark Pharmaceuticals Limited | Polymorph form of aprepitant and process for the preparation thereof |
BRPI0807972A2 (pt) | 2007-01-24 | 2014-06-10 | Glaxo Group Ltd | Composições farmacêuticas compreendendo 3,5-diamino-6-(2,3-diclofenil)-l,2,4-triazina ou r(-)-2,4-diamino-5-(2,3-diclorofenil)-6-fluorometilpirim idina e uma nk1 |
KR20110008166A (ko) * | 2008-02-18 | 2011-01-26 | 라보라토리오스 델 드라. 에스테브.에스.에이. | 화학요법의 결과로 발생하는 신경병적 통증의 치료를 위한 시그마 수용체 리간드에 결합하는 화합물들의 용도 |
EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
CN103619823B (zh) | 2011-06-30 | 2016-01-20 | 东丽株式会社 | 甘氨酸衍生物的晶体及其药物用途 |
CN103030668B (zh) * | 2011-10-09 | 2016-06-15 | 江苏豪森药业集团有限公司 | 一种制备福沙匹坦二甲葡胺的方法 |
CZ304770B6 (cs) | 2012-03-13 | 2014-10-08 | Zentiva, K.S. | Způsob výroby 3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluormethyl)fenyl)ethoxy)-3-(4-fluorfenyl)morfolino)methyl)-1H-1,2,4-triazol-5(4H)-onu (Aprepitantu) v polymorfní formě II |
CN102850339B (zh) * | 2012-10-17 | 2014-10-15 | 上海博志研新药物技术有限公司 | 一种神经激肽(nk-1)受体拮抗剂晶型制备方法 |
CN103288813A (zh) * | 2013-06-04 | 2013-09-11 | 四川百利药业有限责任公司 | 一种阿瑞匹坦的制备方法 |
KR20160097366A (ko) | 2013-12-17 | 2016-08-17 | 라보라토리오스 델 드라. 에스테브.에스.에이. | 세로토닌-노르에피네프린 재흡수 억제제들(SNRIs) 및 시그마 리셉터 리간드들 조합 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL111960A (en) * | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
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1998
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- 1998-07-01 AT AT98933088T patent/ATE372991T1/de not_active IP Right Cessation
- 1998-07-01 EA EA199901114A patent/EA002405B1/ru not_active IP Right Cessation
- 1998-07-01 HR HR980370A patent/HRP980370B1/xx not_active IP Right Cessation
- 1998-07-01 CN CN98806703A patent/CN1106390C/zh not_active Expired - Lifetime
- 1998-07-01 WO PCT/US1998/013766 patent/WO1999001444A1/en active IP Right Grant
- 1998-07-01 TW TW087110655A patent/TW577887B/zh not_active IP Right Cessation
- 1998-07-01 NZ NZ501589A patent/NZ501589A/en not_active IP Right Cessation
- 1998-07-01 CZ CZ19994777A patent/CZ295410B6/cs not_active IP Right Cessation
- 1998-07-01 DZ DZ980161A patent/DZ2551A1/xx active
- 1998-07-01 CA CA002293836A patent/CA2293836C/en not_active Expired - Lifetime
- 1998-07-01 EE EEP199900603A patent/EE04152B1/xx unknown
- 1998-07-01 DE DE69838421T patent/DE69838421D1/de not_active Expired - Lifetime
- 1998-07-01 SK SK1872-99A patent/SK285644B6/sk not_active IP Right Cessation
- 1998-07-01 AU AU82833/98A patent/AU735230B2/en not_active Expired
- 1998-07-01 KR KR1019997012571A patent/KR20010020593A/ko active Search and Examination
- 1998-07-01 HU HU0004008A patent/HU228003B1/hu not_active IP Right Cessation
- 1998-07-01 JP JP11507368A patent/JP2000513383A/ja active Pending
- 1998-07-01 EP EP98933088A patent/EP0994867B1/en not_active Expired - Lifetime
- 1998-07-01 PL PL337579A patent/PL191496B1/pl unknown
- 1998-07-01 ID IDW991716A patent/ID23191A/id unknown
- 1998-07-02 PE PE1998000593A patent/PE86499A1/es not_active IP Right Cessation
-
1999
- 1999-12-10 IS IS5293A patent/IS2617B/is unknown
- 1999-12-14 BG BG104010A patent/BG64703B1/bg unknown
- 1999-12-29 NO NO19996549A patent/NO316893B1/no not_active IP Right Cessation
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2001
- 2001-01-09 HK HK01100223A patent/HK1029345A1/xx not_active IP Right Cessation
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104119325A (zh) * | 2014-07-15 | 2014-10-29 | 中山奕安泰医药科技有限公司 | 阿瑞吡坦多晶型物的制备方法 |
CN104119325B (zh) * | 2014-07-15 | 2017-03-22 | 中山奕安泰医药科技有限公司 | 阿瑞吡坦多晶型物的制备方法 |
CN105837526A (zh) * | 2016-01-22 | 2016-08-10 | 浙江工业大学 | 一种阿瑞吡坦重要合成中间体(2s,3r)-4-苄基-3-(4-氟苯基)吗啉-2-醇的制备方法 |
CN105837526B (zh) * | 2016-01-22 | 2018-02-27 | 浙江工业大学 | 一种阿瑞吡坦重要合成中间体(2s,3r)‑4‑苄基‑3‑(4‑氟苯基)吗啉‑2‑醇的制备方法 |
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