AR060353A1 - Sales de hidrocloruro de 8 - [( 1- (3,5 -bis- (trifluorometil) fenil) -etoxi) -metil] -8-fenil-1,7 -diaza- spiro [4.5] decan -2-ona. composiciones farmaceuticas - Google Patents
Sales de hidrocloruro de 8 - [( 1- (3,5 -bis- (trifluorometil) fenil) -etoxi) -metil] -8-fenil-1,7 -diaza- spiro [4.5] decan -2-ona. composiciones farmaceuticasInfo
- Publication number
- AR060353A1 AR060353A1 ARP070101438A ARP070101438A AR060353A1 AR 060353 A1 AR060353 A1 AR 060353A1 AR P070101438 A ARP070101438 A AR P070101438A AR P070101438 A ARP070101438 A AR P070101438A AR 060353 A1 AR060353 A1 AR 060353A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- decan
- bis
- pharmaceutical compositions
- trifluorometil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Composiciones farmacéuticas que la contienen. Reivindicacion 1: Una forma 1 cristalina de sal de clorhidrato monohidrato del compuesto (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diazaspiro[4.5]decan-2-ona de formula 1,que se caracteriza por el siguiente patron de difraccion de rayos X de polvos expresado en funcion del ángulo de difraccion (en 2 theta), el espaciado reticular ôdö (en ángstroms) y las intensidades relativas de los máximos (ôIRö): Ángulo de difraccion (2theta) Rl Espaciado reticular (L +- 0.04) 16,1 Mediana 5,49 18,4 Mediana 4,83 21,6 Fuerte 4,11 23,5 Mediana 3,78
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78928006P | 2006-04-05 | 2006-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR060353A1 true AR060353A1 (es) | 2008-06-11 |
Family
ID=38542035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070101438A AR060353A1 (es) | 2006-04-05 | 2007-04-04 | Sales de hidrocloruro de 8 - [( 1- (3,5 -bis- (trifluorometil) fenil) -etoxi) -metil] -8-fenil-1,7 -diaza- spiro [4.5] decan -2-ona. composiciones farmaceuticas |
Country Status (16)
Country | Link |
---|---|
US (5) | US8178550B2 (es) |
EP (4) | EP2004646B1 (es) |
JP (3) | JP5352446B2 (es) |
CN (2) | CN102276606B (es) |
AR (1) | AR060353A1 (es) |
CA (1) | CA2648604C (es) |
ES (1) | ES2584838T3 (es) |
HU (2) | HUE028908T2 (es) |
LT (1) | LTPA2017031I1 (es) |
MX (1) | MX2008012935A (es) |
PE (3) | PE20071220A1 (es) |
PL (1) | PL2004646T3 (es) |
PT (1) | PT2004646T (es) |
SG (2) | SG170838A1 (es) |
TW (1) | TWI363058B (es) |
WO (1) | WO2007117486A2 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20030762A1 (es) | 2001-12-18 | 2003-09-05 | Schering Corp | Compuestos heterociclicos como antagonistas nk1 |
ES2553805T3 (es) | 2006-04-05 | 2015-12-11 | Opko Health, Inc. | Formulaciones farmacéuticas que comprenden sales de (5S,8S)-8-[{(1R)-1-(3,5-bis-(trifluorometil)fenil]-etoxi}-metil]-8-fenil-1,7-diazaespiro[4.5]decan-2-ona y su utilización médica |
MX2008012935A (es) * | 2006-04-05 | 2008-10-15 | Schering Corp | Sales de clorhidrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etox i}-metil]-8-fenil-1,7-diaza-spiro[4,5]decan-2-ona y su procedmiento de preparacion. |
AR066191A1 (es) * | 2007-03-22 | 2009-08-05 | Schering Corp | Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona |
AR065802A1 (es) * | 2007-03-22 | 2009-07-01 | Schering Corp | Formulaciones de comprimidos que contienen sales de 8- [( 1- ( 3,5- bis- (trifluorometil) fenil) -etoxi ) - metil) -8- fenil -1, 7- diaza- spiro [ 4,5] decan -2- ona y comprimidos elaborados a partir de estas |
ES2552322T3 (es) | 2008-09-05 | 2015-11-27 | Opko Health, Inc. | Productos intermedios para la síntesis de compuestos de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4,5]decán-2-ona |
KR101834577B1 (ko) | 2009-08-14 | 2018-03-05 | 옵코 헬스, 인크. | 뉴로키닌-1 길항제의 정맥내 제형 |
CN105017251B (zh) * | 2015-06-30 | 2018-06-29 | 齐鲁制药有限公司 | 一种nk-1受体拮抗剂的制备方法及其中间体 |
FR3047665B1 (fr) | 2016-02-17 | 2020-12-11 | Pf Medicament | Celastrol et ses derives dans le traitement des tumeurs et pathologies pre-cancereuses cutanees |
CN106866669A (zh) * | 2017-04-19 | 2017-06-20 | 成都百特万合医药科技有限公司 | 一种合成罗拉吡坦中间体的方法 |
CN114144416A (zh) * | 2019-07-25 | 2022-03-04 | 英特维特国际股份有限公司 | Telmapitant或(5R,8S)-8-[[(1R)-1-[3,5-双(三氟甲基)苯基]乙氧基]甲基]-8-苯基-1,3,7-三氮杂螺[4.5]癸烷-2,4-二酮的晶型 |
KR20220165251A (ko) | 2020-04-03 | 2022-12-14 | 네르 쎄라퓨틱스 리미티드 | 패혈증, 패혈성 쇼크, 급성 호흡 곤란 증후군 (ards) 또는 다발성 기관 기능장애 증후군 (mods)으로부터 선택된 질환을 치료하기 위한 nk-1 수용체 길항제 |
US11872222B2 (en) | 2020-06-02 | 2024-01-16 | Nerre Therapeutics Limited | Uses |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08502510A (ja) | 1992-10-28 | 1996-03-19 | メルク シヤープ エンド ドーム リミテツド | タキキニン拮抗剤としてのアリールメチルオキシメチルピペリジン |
US5661162A (en) | 1992-12-14 | 1997-08-26 | Merck Sharp & Dohme Limited | 4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenylpiperdines as tachykinin receptor antagonists |
AU685212B2 (en) | 1994-01-13 | 1998-01-15 | Merck Sharp & Dohme Limited | Gem-disubstituted azacyclic tachykinin antagonists |
WO1997007804A1 (en) | 1995-08-28 | 1997-03-06 | Schering Corporation | Combination therapy for advanced cancer comprising temozolomide and cisplatin |
US5939098A (en) | 1996-09-19 | 1999-08-17 | Schering Corporation | Cancer treatment with temozolomide |
TW577887B (en) | 1997-07-02 | 2004-03-01 | Merck & Co Inc | Polymorphic form I of a tachykinin receptor antagonist |
HUP0303154A3 (en) | 2001-02-12 | 2009-08-28 | Teva Pharma | New crystal forms of oxcarbazepine and processes for their preparation |
PE20030762A1 (es) | 2001-12-18 | 2003-09-05 | Schering Corp | Compuestos heterociclicos como antagonistas nk1 |
US7534913B2 (en) | 2002-07-18 | 2009-05-19 | Teva Pharmaceutica Industries Ltd. | Crystalline form of nateglinide |
US7323459B2 (en) | 2002-12-24 | 2008-01-29 | Teva Pharmaceutical Industries Ltd. | Crystal forms, methods for their preparation and method for preparation of olanzapine |
GB0321256D0 (en) | 2003-09-11 | 2003-10-08 | Generics Uk Ltd | Novel crystalline compounds |
US20050153999A1 (en) * | 2003-12-22 | 2005-07-14 | Schering Corporation | Pharmaceutical compositions |
US7498438B2 (en) | 2004-04-07 | 2009-03-03 | Schering Corporation | Fused ring NK1 antagonists |
EP3269713A1 (en) | 2004-07-01 | 2018-01-17 | OPKO Health, Inc. | Piperidine derivatives as nk1 antagonists |
JP2008519584A (ja) | 2004-11-09 | 2008-06-12 | シェーリング コーポレイション | 患者のmgmtレベルに基づいて癌を処置するための、テモゾロミドの改良された投薬養生法 |
MX2008012935A (es) | 2006-04-05 | 2008-10-15 | Schering Corp | Sales de clorhidrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etox i}-metil]-8-fenil-1,7-diaza-spiro[4,5]decan-2-ona y su procedmiento de preparacion. |
ES2553805T3 (es) | 2006-04-05 | 2015-12-11 | Opko Health, Inc. | Formulaciones farmacéuticas que comprenden sales de (5S,8S)-8-[{(1R)-1-(3,5-bis-(trifluorometil)fenil]-etoxi}-metil]-8-fenil-1,7-diazaespiro[4.5]decan-2-ona y su utilización médica |
WO2007114922A2 (en) | 2006-04-05 | 2007-10-11 | Schering Corporation | Salts of 8-[{1-(3,5-bis-(trifluoromethyl) phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor |
EP2049504A4 (en) | 2006-08-07 | 2010-09-22 | Stiefel Laboratories | ANTIFUNGAL CRYSTALLINE COMPOUNDS |
AR066191A1 (es) * | 2007-03-22 | 2009-08-05 | Schering Corp | Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona |
AR065802A1 (es) | 2007-03-22 | 2009-07-01 | Schering Corp | Formulaciones de comprimidos que contienen sales de 8- [( 1- ( 3,5- bis- (trifluorometil) fenil) -etoxi ) - metil) -8- fenil -1, 7- diaza- spiro [ 4,5] decan -2- ona y comprimidos elaborados a partir de estas |
ES2552322T3 (es) | 2008-09-05 | 2015-11-27 | Opko Health, Inc. | Productos intermedios para la síntesis de compuestos de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4,5]decán-2-ona |
KR101834577B1 (ko) * | 2009-08-14 | 2018-03-05 | 옵코 헬스, 인크. | 뉴로키닌-1 길항제의 정맥내 제형 |
-
2007
- 2007-04-04 MX MX2008012935A patent/MX2008012935A/es active IP Right Grant
- 2007-04-04 CA CA2648604A patent/CA2648604C/en active Active
- 2007-04-04 PL PL07774640.2T patent/PL2004646T3/pl unknown
- 2007-04-04 PE PE2007000413A patent/PE20071220A1/es active IP Right Grant
- 2007-04-04 AR ARP070101438A patent/AR060353A1/es not_active Application Discontinuation
- 2007-04-04 TW TW096112166A patent/TWI363058B/zh not_active IP Right Cessation
- 2007-04-04 CN CN2011101619320A patent/CN102276606B/zh not_active Expired - Fee Related
- 2007-04-04 PE PE2011001795A patent/PE20120545A1/es active IP Right Grant
- 2007-04-04 PE PE2014000758A patent/PE20142329A1/es not_active Application Discontinuation
- 2007-04-04 US US11/732,548 patent/US8178550B2/en active Active
- 2007-04-04 JP JP2009504269A patent/JP5352446B2/ja not_active Expired - Fee Related
- 2007-04-04 EP EP07774640.2A patent/EP2004646B1/en not_active Revoked
- 2007-04-04 ES ES07774640.2T patent/ES2584838T3/es active Active
- 2007-04-04 HU HUE07774640A patent/HUE028908T2/en unknown
- 2007-04-04 PT PT77746402T patent/PT2004646T/pt unknown
- 2007-04-04 EP EP13179424.0A patent/EP2676957A1/en not_active Withdrawn
- 2007-04-04 CN CN200780015817.4A patent/CN101437821B/zh not_active Expired - Fee Related
- 2007-04-04 SG SG201102463-5A patent/SG170838A1/en unknown
- 2007-04-04 WO PCT/US2007/008344 patent/WO2007117486A2/en active Application Filing
- 2007-04-04 EP EP13179376.2A patent/EP2662373A1/en not_active Withdrawn
- 2007-04-04 EP EP13179415.8A patent/EP2662374A1/en not_active Withdrawn
- 2007-04-04 SG SG10201500027TA patent/SG10201500027TA/en unknown
-
2009
- 2009-11-06 US US12/614,108 patent/US8470842B2/en active Active
-
2012
- 2012-11-19 JP JP2012253653A patent/JP5856944B2/ja not_active Expired - Fee Related
-
2013
- 2013-06-21 US US13/923,859 patent/US20130281477A1/en not_active Abandoned
-
2014
- 2014-09-25 JP JP2014194788A patent/JP6122411B2/ja active Active
-
2015
- 2015-04-10 US US14/683,871 patent/US10196394B2/en active Active
-
2017
- 2017-10-16 HU HUS1700037C patent/HUS1700037I1/hu unknown
- 2017-10-16 LT LTPA2017031C patent/LTPA2017031I1/lt unknown
-
2019
- 2019-01-09 US US16/243,404 patent/US20190375751A1/en not_active Abandoned
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