PE20142329A1 - Sales de hidrocloruro de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diazaspiro[4.5]decan-2-ona - Google Patents

Sales de hidrocloruro de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diazaspiro[4.5]decan-2-ona

Info

Publication number
PE20142329A1
PE20142329A1 PE2014000758A PE2014000758A PE20142329A1 PE 20142329 A1 PE20142329 A1 PE 20142329A1 PE 2014000758 A PE2014000758 A PE 2014000758A PE 2014000758 A PE2014000758 A PE 2014000758A PE 20142329 A1 PE20142329 A1 PE 20142329A1
Authority
PE
Peru
Prior art keywords
phenyl
etoxy
diazaspiro
decan
ona
Prior art date
Application number
PE2014000758A
Other languages
English (en)
Inventor
Neng-Yang Shih
Sunil Paliwal
Frank Guenter
Ingrid Mergelsberg
Mengwei Hu
Original Assignee
Opko Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38542035&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20142329(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Opko Health Inc filed Critical Opko Health Inc
Publication of PE20142329A1 publication Critical patent/PE20142329A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REFERIDA A UNA FORMA (I) CRISTALINA ANHIDRA DE LA SAL DE HIDROCLORURO DE (5S,8S)-8-[{(1R)-1-(3,5-BIS-(TRIFLUOROMETIL)FENIL)-ETOXI}-METIL]-8-FENIL-1,7-DIAZASPIRO[4.5]DECAN-2-ONA (FORMULA I) QUE PRESENTA UN PATRON DE DIFRACCION DE POLVO DE RAYOS X QUE TIENE PICOS PRESENTES EN LOS ANGULOS DE DIFRACCION EN 2 THETA DE: 12,9 (S), 15,4 (S), 17,3 (S), 20,2 (S). TAMBIEN ESTA REFERIDA LAS FORMAS CRISTALINAS (II), (III) Y (IV) DE LA SAL TOSILATO DE (5S,8S)-8-[{(1R)-1-(3,5-BIS-(TRIFLUOROMETIL)FENIL)-ETOXI}-METIL]-8-FENIL-1,7-DIAZASPIRO[4.5]DECAN-2-ONA
PE2014000758A 2006-04-05 2007-04-04 Sales de hidrocloruro de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diazaspiro[4.5]decan-2-ona PE20142329A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78928006P 2006-04-05 2006-04-05

Publications (1)

Publication Number Publication Date
PE20142329A1 true PE20142329A1 (es) 2015-01-30

Family

ID=38542035

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2014000758A PE20142329A1 (es) 2006-04-05 2007-04-04 Sales de hidrocloruro de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diazaspiro[4.5]decan-2-ona
PE2007000413A PE20071220A1 (es) 2006-04-05 2007-04-04 Sales de hidrocloruro de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decan-2-ona y su proceso de preparacion
PE2011001795A PE20120545A1 (es) 2006-04-05 2007-04-04 Composicion farmaceutica que comprende la forma i cristalina de la sal clorhidrato monohidrato de (5s,8s)-8-[{(1r)-1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diazaspiro[4,5]decan-2-ona

Family Applications After (2)

Application Number Title Priority Date Filing Date
PE2007000413A PE20071220A1 (es) 2006-04-05 2007-04-04 Sales de hidrocloruro de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decan-2-ona y su proceso de preparacion
PE2011001795A PE20120545A1 (es) 2006-04-05 2007-04-04 Composicion farmaceutica que comprende la forma i cristalina de la sal clorhidrato monohidrato de (5s,8s)-8-[{(1r)-1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diazaspiro[4,5]decan-2-ona

Country Status (16)

Country Link
US (5) US8178550B2 (es)
EP (4) EP2004646B1 (es)
JP (3) JP5352446B2 (es)
CN (2) CN101437821B (es)
AR (1) AR060353A1 (es)
CA (1) CA2648604C (es)
ES (1) ES2584838T3 (es)
HU (2) HUE028908T2 (es)
LT (1) LTPA2017031I1 (es)
MX (1) MX2008012935A (es)
PE (3) PE20142329A1 (es)
PL (1) PL2004646T3 (es)
PT (1) PT2004646T (es)
SG (2) SG170838A1 (es)
TW (1) TWI363058B (es)
WO (1) WO2007117486A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20030762A1 (es) 2001-12-18 2003-09-05 Schering Corp Compuestos heterociclicos como antagonistas nk1
PT2004646T (pt) * 2006-04-05 2016-07-14 Opko Health Inc Sais cloridrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)- etoxi} -metil]-8-fenil-1,7-diazaespiro[4.5]decan-2-ona e processo para a sua preparação
EP2004148B1 (en) 2006-04-05 2015-07-15 OPKO Health, Inc. Pharmaceutical formulations comprising salts of (5S,8S)-8-[{(1 R)-1-(3,5-Bis-trifluoromethyl)phenyl]- ethoxy}-methyl]-8-phenyl-1 ,7-diazaspiro[4.5]decan-2-one and their medical use
PE20081891A1 (es) 2007-03-22 2008-12-27 Opko Health Inc Formulaciones de comprimidos que contienen sales de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-spiro[4.5]decan-2-ona y comprimidos elaborados a partir de estas
AR066191A1 (es) * 2007-03-22 2009-08-05 Schering Corp Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona
CN104496988B (zh) * 2008-09-05 2017-04-12 欧科生医股份有限公司 用于合成8‑[{1‑(3,5‑双‑(三氟甲基)苯基)‑乙氧基}‑甲基]‑8‑苯基‑1,7‑二氮杂‑螺[4.5]癸‑2‑酮化合物的方法和中间体
EP2464230B1 (en) * 2009-08-14 2016-10-05 OPKO Health, Inc. Intravenous formulations of rolapitant
CN105017251B (zh) * 2015-06-30 2018-06-29 齐鲁制药有限公司 一种nk-1受体拮抗剂的制备方法及其中间体
FR3047665B1 (fr) 2016-02-17 2020-12-11 Pf Medicament Celastrol et ses derives dans le traitement des tumeurs et pathologies pre-cancereuses cutanees
CN106866669A (zh) * 2017-04-19 2017-06-20 成都百特万合医药科技有限公司 一种合成罗拉吡坦中间体的方法
CN114144416A (zh) * 2019-07-25 2022-03-04 英特维特国际股份有限公司 Telmapitant或(5R,8S)-8-[[(1R)-1-[3,5-双(三氟甲基)苯基]乙氧基]甲基]-8-苯基-1,3,7-三氮杂螺[4.5]癸烷-2,4-二酮的晶型
US20230190740A1 (en) 2020-04-03 2023-06-22 Nerre Therapeutics Limited An nk-1 receptor antagonist for treating a disease selecting from sepsis, septic shock, acute respiratory distress syndrome (ards) or multiple organ dysfunction syndrome (mods)
AU2021285503A1 (en) 2020-06-02 2022-12-08 Nerre Therapeutics Limited Neurokinin (NK)-1 receptor antagonists for use in the treatment of pulmonary fibrosis conditions promoted by mechanical injury to the lungs

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2141174T3 (es) 1992-10-28 2000-03-16 Merck Sharp & Dohme 4-arilmetiloximetil piperidinas como antagonistas de taquiquinina.
CA2150951A1 (en) 1992-12-14 1994-06-23 Angus Murray Macleod 4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenylpiperidines as tachykinin receptor antagonists
EP0739336B1 (en) 1994-01-13 1998-08-26 MERCK SHARP & DOHME LTD. Gem-disubstituted azacyclic tachykinin antagonists
EP0858341B1 (en) 1995-08-28 2001-10-24 Schering Corporation Combination therapy for advanced cancer comprising temozolomide and cisplatin
US5939098A (en) 1996-09-19 1999-08-17 Schering Corporation Cancer treatment with temozolomide
TR199903299T2 (xx) 1997-07-02 2000-07-21 Merck & Co., Inc. Ta�ikinin resept�r antagonisti 2-(R)-(1-(R)- (3,5-Bis(triflorometil) Fenil)Etoksi-3-(S)- (4-Floro)Fenil-4- (3-5(-okso-1H,4H-1,2,4-Triazolo) metilmorfolin'in polimorfik formu.
CA2437402A1 (en) 2001-02-12 2002-08-22 Teva Pharmaceutical Industries, Ltd. New crystal forms of oxcarbazepine and processes for their preparation
PE20030762A1 (es) 2001-12-18 2003-09-05 Schering Corp Compuestos heterociclicos como antagonistas nk1
US7534913B2 (en) 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
EP1575962A1 (en) 2002-12-24 2005-09-21 Teva Pharmaceutical Industries Limited Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
AU2004308935A1 (en) * 2003-12-22 2005-07-14 Schering Corporation Pharmaceutical compositions
US7498438B2 (en) 2004-04-07 2009-03-03 Schering Corporation Fused ring NK1 antagonists
SG187416A1 (en) 2004-07-01 2013-02-28 Opko Health Inc Piperidine derivatives as nk1 antagonists
JP2008519584A (ja) 2004-11-09 2008-06-12 シェーリング コーポレイション 患者のｍｇｍｔレベルに基づいて癌を処置するための、テモゾロミドの改良された投薬養生法
EP2004148B1 (en) * 2006-04-05 2015-07-15 OPKO Health, Inc. Pharmaceutical formulations comprising salts of (5S,8S)-8-[{(1 R)-1-(3,5-Bis-trifluoromethyl)phenyl]- ethoxy}-methyl]-8-phenyl-1 ,7-diazaspiro[4.5]decan-2-one and their medical use
PT2004646T (pt) 2006-04-05 2016-07-14 Opko Health Inc Sais cloridrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)- etoxi} -metil]-8-fenil-1,7-diazaespiro[4.5]decan-2-ona e processo para a sua preparação
CL2007000947A1 (es) 2006-04-05 2008-01-25 Schering Corp Formas cristalinas de las sales de esilato, oxalato, mesilato y maleato de 8-[[1-(3,5-bis-(trifluorometil)fenil)-etoxi]-metil]-8-fenil-1,7-diaza-espiro[4.5]decan-2-ona; composicion farmaceutica; y uso en la preparacion de un medicamento par el tratamiento y/o prevencion de emesis y/o nausea.
ES2652670T3 (es) 2006-08-07 2018-02-05 Palau Pharma, S.A. Compuestos antifúngicos cristalinos
PE20081891A1 (es) 2007-03-22 2008-12-27 Opko Health Inc Formulaciones de comprimidos que contienen sales de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-spiro[4.5]decan-2-ona y comprimidos elaborados a partir de estas
AR066191A1 (es) * 2007-03-22 2009-08-05 Schering Corp Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona
CN104496988B (zh) 2008-09-05 2017-04-12 欧科生医股份有限公司 用于合成8‑[{1‑(3,5‑双‑(三氟甲基)苯基)‑乙氧基}‑甲基]‑8‑苯基‑1,7‑二氮杂‑螺[4.5]癸‑2‑酮化合物的方法和中间体
EP2464230B1 (en) * 2009-08-14 2016-10-05 OPKO Health, Inc. Intravenous formulations of rolapitant

Also Published As

Publication number Publication date
MX2008012935A (es) 2008-10-15
HUE028908T2 (en) 2017-01-30
EP2676957A1 (en) 2013-12-25
CN102276606A (zh) 2011-12-14
US20150210693A1 (en) 2015-07-30
PT2004646T (pt) 2016-07-14
US20070244142A1 (en) 2007-10-18
JP2009532472A (ja) 2009-09-10
CN101437821A (zh) 2009-05-20
LTPA2017031I1 (lt) 2017-11-10
EP2004646A2 (en) 2008-12-24
JP2014240437A (ja) 2014-12-25
HUS1700037I1 (hu) 2017-11-28
SG10201500027TA (en) 2015-02-27
CA2648604A1 (en) 2007-10-18
EP2662373A1 (en) 2013-11-13
CA2648604C (en) 2016-05-24
PE20071220A1 (es) 2007-12-14
JP2013032404A (ja) 2013-02-14
EP2662374A1 (en) 2013-11-13
WO2007117486A2 (en) 2007-10-18
US8178550B2 (en) 2012-05-15
WO2007117486A3 (en) 2008-02-14
SG170838A1 (en) 2011-05-30
US20100048601A1 (en) 2010-02-25
CN102276606B (zh) 2013-06-12
TW200815439A (en) 2008-04-01
JP5352446B2 (ja) 2013-11-27
JP6122411B2 (ja) 2017-04-26
PE20120545A1 (es) 2012-05-21
EP2004646B1 (en) 2016-06-08
TWI363058B (en) 2012-05-01
US20130281477A1 (en) 2013-10-24
US8470842B2 (en) 2013-06-25
ES2584838T3 (es) 2016-09-29
CN101437821B (zh) 2014-06-04
JP5856944B2 (ja) 2016-02-10
AR060353A1 (es) 2008-06-11
US20190375751A1 (en) 2019-12-12
PL2004646T3 (pl) 2016-12-30
US10196394B2 (en) 2019-02-05

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