CN1251041A - 精细调节的protegrin - Google Patents

精细调节的protegrin Download PDF

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Publication number
CN1251041A
CN1251041A CN96199632A CN96199632A CN1251041A CN 1251041 A CN1251041 A CN 1251041A CN 96199632 A CN96199632 A CN 96199632A CN 96199632 A CN96199632 A CN 96199632A CN 1251041 A CN1251041 A CN 1251041A
Authority
CN
China
Prior art keywords
seq
amino acid
exist
peptide
cha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96199632A
Other languages
English (en)
Chinese (zh)
Inventor
张正
顾志良
陈颉
D·A·斯泰恩堡
R·I·勒雷尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CALIFORNIA SENATE
Ardea Biociences Inc
Original Assignee
CALIFORNIA SENATE
IntraBiotics Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CALIFORNIA SENATE, IntraBiotics Pharmaceuticals Inc filed Critical CALIFORNIA SENATE
Publication of CN1251041A publication Critical patent/CN1251041A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Dentistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paints Or Removers (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN96199632A 1995-11-22 1996-11-22 精细调节的protegrin Pending CN1251041A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US56234695A 1995-11-22 1995-11-22
US08/562,346 1995-11-22
US64981196A 1996-05-17 1996-05-17
US08/649,811 1996-05-17
US69092196A 1996-08-01 1996-08-01
US08/690,921 1996-08-01
US08/752,852 US5994306A (en) 1995-11-22 1996-11-21 Fine-tuned protegrins
US08/752,852 1996-11-21

Publications (1)

Publication Number Publication Date
CN1251041A true CN1251041A (zh) 2000-04-19

Family

ID=27415886

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96199632A Pending CN1251041A (zh) 1995-11-22 1996-11-22 精细调节的protegrin

Country Status (12)

Country Link
US (1) US5994306A (https=)
EP (1) EP0862448A4 (https=)
JP (1) JP2001520639A (https=)
KR (1) KR19990071546A (https=)
CN (1) CN1251041A (https=)
AU (1) AU720467B2 (https=)
BR (1) BR9611565A (https=)
CZ (1) CZ159198A3 (https=)
HU (1) HUP0104431A2 (https=)
NO (2) NO982310L (https=)
PL (1) PL336763A1 (https=)
WO (2) WO1997018827A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103623391A (zh) * 2013-10-10 2014-03-12 中山大学 抗菌肽Protegrin-1在防治猪蓝耳病中的应用
CN103936827A (zh) * 2014-04-22 2014-07-23 福州大学 一种韭菜籽抗菌三肽及其制备方法与应用
CN105175509A (zh) * 2015-10-19 2015-12-23 河南科技学院 一种抗菌肽xyz-1及其应用
CN113975373A (zh) * 2021-11-18 2022-01-28 宁波市眼科医院 眼用制剂

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US6159936A (en) * 1993-07-20 2000-12-12 The Regents Of The University Of California Compositions and methods for treating and preventing microbial and viral infections
US6653442B1 (en) 1993-07-20 2003-11-25 Intrabiotics Pharmaceuticals, Inc. Protegrins
USRE38828E1 (en) * 1995-07-06 2005-10-11 Intrabiotics Pharmaceuticals, Inc. Parevins and tachytegrins
US6307016B1 (en) * 1995-07-06 2001-10-23 Intrabiotics Pharmaceuticals, Inc. Parevins and tachytegrins
FR2767323B1 (fr) * 1997-08-12 2001-01-05 Synt Em Peptides lineaires derives de peptides antibiotiques, leur preparation et leur utilisation pour vectoriser des substances actives
US6043220A (en) * 1997-12-03 2000-03-28 Intrabiotics Pharmaceuticals, Inc. Threonine-containing protegrins
KR100314721B1 (ko) * 1998-01-22 2001-11-23 김일웅 생물학적 활성이 있는 신규한 펩타이드
DE69933785T2 (de) * 1998-03-12 2007-10-04 Georgetown University Peptide enthaltend eine cholesterin-erkennungssequenz und deren verwendungen
US7223727B2 (en) 1998-04-09 2007-05-29 Serono Genetics Institute S.A. GSSP4 polynucleotides and polypeptides and uses thereof
EP0974360A3 (en) * 1998-06-26 2000-03-29 N.V. Nutricia Pharmaceutical preparations for use in combatting or preventing surface infections caused by microorganisms
CA2332127A1 (en) * 1998-06-26 2000-01-06 N.V. Nutricia Pharmaceutical preparations for use in combatting or preventing surface infections caused by microorganisms
DE69903732T2 (de) * 1998-07-02 2003-07-03 Stichting Skeletal Tissue Engineering Group Amsterdam, Amsterdam Knochenzement mit antimikrobiellen peptiden
AU5006499A (en) * 1998-07-23 2000-02-14 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the treatment or prevention of pulmonary infections
US6335318B1 (en) 1999-05-10 2002-01-01 The Regents Of The University Of California Antimicrobial theta defensins and methods of using same
JP2003516150A (ja) 1999-12-08 2003-05-13 ジェンセット 潜在性分泌タンパク質をコードする全長ヒトｃＤＮＡ
CA2391356A1 (en) * 1999-12-21 2001-06-28 Innogenetics N.V. Peptides designed for the diagnosis and treatment of rheumatoid arthritis
BR0001870B1 (pt) * 2000-05-29 2014-02-25 Peptídeo, processo de obtenção de peptídeo, formulação compreendendo peptídeo, método de prevenção de crescimento de parasitas, fungos e bactérias, método para inativar a endotoxina de bactérias gram-negativas
GB0031425D0 (en) * 2000-12-22 2001-02-07 Amoebics Ltd Antibacterial treatments
KR100738362B1 (ko) * 2001-03-19 2007-07-12 재단법인서울대학교산학협력재단 신규한 디아민디티올 유도체 및 그의 방사성 레늄 또는방사성 테크네슘 착체； 그리고, 그의 방사성 레늄 착체와리피오돌을 포함하는 간암 치료용 조성물 및 그의 제조용키트
US20040235745A1 (en) * 2001-06-22 2004-11-25 Deber Charles M Antimicrobial Peptides
US7033991B2 (en) * 2001-07-16 2006-04-25 Board Of Supervisors Of Louisiana State University And Agriculture And Mechanical College Inhibiting furin with polybasic peptides
WO2003062266A2 (en) * 2002-01-22 2003-07-31 Intrabiotics Pharmaceuticals, Inc. Hybrid synthetic method for antimicrobial peptides
CA2482995C (en) 2002-04-22 2013-01-29 Dow Global Technologies Inc. Low-cost production of peptides
US7119070B2 (en) * 2002-04-30 2006-10-10 The Regents Of The University Of California Antimicrobial theta defensins, analogs thereof, and methods of use
AU2003246644A1 (en) * 2002-07-08 2004-01-23 Genova, Ltd. Secreted peptides
US20080255052A1 (en) * 2004-12-23 2008-10-16 The Regents Of The University Of California Immunologic regulation by theta defensins
US7875620B2 (en) * 2005-06-30 2011-01-25 Piper Medical, Inc. Methods of treating microbial infections
CA2661634C (en) 2006-09-06 2017-03-28 The Regents Of The University Of California Selectively targeted antimicrobial peptides and the use thereof
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
CN102088991A (zh) 2008-05-13 2011-06-08 堪萨斯大学 金属提取肽标签和相关方法
TWI394578B (zh) * 2009-01-09 2013-05-01 Academia Sinica 抗菌蛋白之新用途
US20100202983A1 (en) * 2009-02-09 2010-08-12 Jernberg Gary R Selectively targeted antimicrobials for the treatment of periodontal disease
DK2709619T3 (en) 2011-05-16 2018-01-15 Cellceutix Corp RELATIONSHIPS FOR USING THE TREATMENT OF MUCOSITIS
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
WO2014052438A1 (en) 2012-09-25 2014-04-03 Regents Of The University Of Minnesota Methods for making and using antimicrobial peptides
RU2016117275A (ru) 2013-11-01 2017-12-04 Сфериум Биомед С.Л. Тельца включения для трансдермальной доставки терапевтических и косметических средств
CN108524911B (zh) * 2018-02-27 2022-03-08 成都山信药业有限公司 Protegrin-1抗菌肽衍生物在制备抗口腔致病菌药物中的用途
JP7755994B2 (ja) * 2018-10-19 2025-10-17 リップタイド バイオサイエンス インコーポレイテッド 抗菌性ペプチド及びその使用方法
WO2020139852A1 (en) 2018-12-28 2020-07-02 General Probiotics, Inc. Combinations of engineered antimicrobial probiotics for treatment of gastrointestinal tract pathogens
KR20210151945A (ko) 2019-04-12 2021-12-14 립타이드 바이오사이언스, 인코포레이티드 대식세포 활성을 조정하기 위한 방법
WO2021248008A1 (en) 2020-06-05 2021-12-09 Innovation Pharmaceuticals Inc. Arylamide compounds for treatment and prevention of viral infections

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103623391A (zh) * 2013-10-10 2014-03-12 中山大学 抗菌肽Protegrin-1在防治猪蓝耳病中的应用
CN103936827A (zh) * 2014-04-22 2014-07-23 福州大学 一种韭菜籽抗菌三肽及其制备方法与应用
CN105175509A (zh) * 2015-10-19 2015-12-23 河南科技学院 一种抗菌肽xyz-1及其应用
CN113975373A (zh) * 2021-11-18 2022-01-28 宁波市眼科医院 眼用制剂

Also Published As

Publication number Publication date
HUP0104431A2 (hu) 2002-03-28
US5994306A (en) 1999-11-30
AU720467B2 (en) 2000-06-01
JP2001520639A (ja) 2001-10-30
AU7739496A (en) 1997-06-11
NO982311L (no) 1998-07-22
PL336763A1 (en) 2000-07-17
EP0862448A1 (en) 1998-09-09
NO982310D0 (no) 1998-05-20
CZ159198A3 (cs) 1998-10-14
BR9611565A (pt) 1999-12-28
NO982311D0 (no) 1998-05-20
WO1997018827A1 (en) 1997-05-29
KR19990071546A (ko) 1999-09-27
EP0862448A4 (en) 1999-03-31
NO982310L (no) 1998-07-22
WO1997018826A1 (en) 1997-05-29

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