CN1250572C - 能选择性检测朊病毒PrPsc同型异构体的抗体 - Google Patents

能选择性检测朊病毒PrPsc同型异构体的抗体 Download PDF

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Publication number
CN1250572C
CN1250572C CNB01809936XA CN01809936A CN1250572C CN 1250572 C CN1250572 C CN 1250572C CN B01809936X A CNB01809936X A CN B01809936XA CN 01809936 A CN01809936 A CN 01809936A CN 1250572 C CN1250572 C CN 1250572C
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CN
China
Prior art keywords
tyr
gln
antibody
glu
prp
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Expired - Fee Related
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CNB01809936XA
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English (en)
Chinese (zh)
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CN1441811A (zh
Inventor
弗拉德卡·丘林－塞尔贝克
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Blood Transfusion Centre of Slovenia
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Blood Transfusion Centre of Slovenia
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Publication of CN1441811A publication Critical patent/CN1441811A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CNB01809936XA 2000-05-23 2001-05-15 能选择性检测朊病毒PrPsc同型异构体的抗体 Expired - Fee Related CN1250572C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00111108.7 2000-05-23
EP00111108A EP1158003B2 (en) 2000-05-23 2000-05-23 Antibodies capable to selectively detect prion PrP Sc isoforms

Publications (2)

Publication Number Publication Date
CN1441811A CN1441811A (zh) 2003-09-10
CN1250572C true CN1250572C (zh) 2006-04-12

Family

ID=8168816

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB01809936XA Expired - Fee Related CN1250572C (zh) 2000-05-23 2001-05-15 能选择性检测朊病毒PrPsc同型异构体的抗体

Country Status (14)

Country Link
EP (1) EP1158003B2 (https=)
JP (1) JP5042430B2 (https=)
KR (1) KR100829447B1 (https=)
CN (1) CN1250572C (https=)
AR (1) AR029098A1 (https=)
AT (1) ATE312848T1 (https=)
AU (2) AU2001284355B2 (https=)
CA (1) CA2407905C (https=)
DE (1) DE60024787T3 (https=)
DK (1) DK1158003T4 (https=)
ES (1) ES2253156T5 (https=)
HU (1) HU229454B1 (https=)
PL (1) PL208292B1 (https=)
WO (1) WO2001090191A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003059386A2 (en) * 2002-01-18 2003-07-24 Cytos Biotechnology Ag Prion protein carrier-conjugates
EP1596199A1 (en) * 2004-05-14 2005-11-16 Prionics AG Method for the detection of disease-related prion
JP4246777B1 (ja) * 2007-11-20 2009-04-02 森永乳業株式会社 異常型プリオン蛋白質結合剤および異常型プリオン蛋白質の検出方法
EP2135880A1 (en) * 2008-06-17 2009-12-23 Heinrich-Heine-Universität Düsseldorf Anti-prion protein antibody fragment
AU2009301580B2 (en) 2008-10-06 2015-11-26 The University Of British Columbia Methods and systems for predicting misfolded protein epitopes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ246059A (en) * 1991-12-03 1995-08-28 Proteus Molecular Design Synthetic polypeptides with at least one antigenic site of a prion protein, methods of their use and manufacture, antibodies thereto, compositions and kits
DE852011T1 (de) * 1995-09-14 2001-10-11 Scripps Res Inst La Jolla Für natives prp-sc spezifische antikörper
EP0861900A1 (en) † 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunological detection of prions
DE19741607A1 (de) * 1997-09-20 1999-03-25 Prionics Ag Synthetische Polypeptide zur Diagnose und Therapie von Prionerkrankungen

Also Published As

Publication number Publication date
ES2253156T5 (es) 2013-04-30
DE60024787T3 (de) 2013-06-06
CN1441811A (zh) 2003-09-10
AU8435501A (en) 2001-12-03
AU2001284355B2 (en) 2005-11-10
PL208292B1 (pl) 2011-04-29
EP1158003B2 (en) 2012-12-26
EP1158003A1 (en) 2001-11-28
HUP0302413A2 (hu) 2003-10-28
HU229454B1 (en) 2013-12-30
WO2001090191A3 (en) 2002-06-20
ATE312848T1 (de) 2005-12-15
EP1158003B1 (en) 2005-12-14
PL360139A1 (en) 2004-09-06
WO2001090191A2 (en) 2001-11-29
ES2253156T3 (es) 2006-06-01
JP2003534000A (ja) 2003-11-18
DK1158003T4 (da) 2013-04-08
KR20030014234A (ko) 2003-02-15
KR100829447B1 (ko) 2008-05-15
CA2407905A1 (en) 2001-11-29
DK1158003T3 (da) 2006-05-01
JP5042430B2 (ja) 2012-10-03
DE60024787T2 (de) 2006-09-07
CA2407905C (en) 2012-08-14
AR029098A1 (es) 2003-06-04
DE60024787D1 (de) 2006-01-19

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Granted publication date: 20060412

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CF01 Termination of patent right due to non-payment of annual fee