CN1247543C - 比哌立登的制备方法ⅱ - Google Patents

比哌立登的制备方法ⅱ Download PDF

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Publication number
CN1247543C
CN1247543C CNB028137507A CN02813750A CN1247543C CN 1247543 C CN1247543 C CN 1247543C CN B028137507 A CNB028137507 A CN B028137507A CN 02813750 A CN02813750 A CN 02813750A CN 1247543 C CN1247543 C CN 1247543C
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CN
China
Prior art keywords
external form
dicyclo
heptan
alkene
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB028137507A
Other languages
English (en)
Chinese (zh)
Other versions
CN1525958A (zh
Inventor
P·克莱恩
M·赛伊斯
M·格罗斯
K·M·韦伯
E·维尔斯迈尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Ltd
Original Assignee
Abort & Co KG GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abort & Co KG GmbH filed Critical Abort & Co KG GmbH
Publication of CN1525958A publication Critical patent/CN1525958A/zh
Application granted granted Critical
Publication of CN1247543C publication Critical patent/CN1247543C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
CNB028137507A 2001-05-18 2002-05-17 比哌立登的制备方法ⅱ Expired - Lifetime CN1247543C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10124449A DE10124449A1 (de) 2001-05-18 2001-05-18 Verfahren zur Herstellung von Biperiden
DE10124449.5 2001-05-18

Publications (2)

Publication Number Publication Date
CN1525958A CN1525958A (zh) 2004-09-01
CN1247543C true CN1247543C (zh) 2006-03-29

Family

ID=7685401

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028137507A Expired - Lifetime CN1247543C (zh) 2001-05-18 2002-05-17 比哌立登的制备方法ⅱ

Country Status (14)

Country Link
US (1) US6835839B2 (el)
EP (1) EP1389188B1 (el)
JP (1) JP4451600B2 (el)
KR (1) KR100896837B1 (el)
CN (1) CN1247543C (el)
AT (1) ATE331710T1 (el)
BR (1) BRPI0209852B8 (el)
CY (1) CY1105200T1 (el)
DE (2) DE10124449A1 (el)
DK (1) DK1389188T3 (el)
ES (1) ES2268090T3 (el)
IL (2) IL158933A0 (el)
PT (1) PT1389188E (el)
WO (1) WO2002094781A1 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10124449A1 (de) 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung von Biperiden
EP1389193B1 (de) * 2001-05-18 2005-10-19 LABORATORIO FARMACEUTICO S.I.T. SPECIALITA' IGIENICO TERAPEUTICHE S.r.l. Verfahren zur herstellung von biperiden i
DE10124451A1 (de) * 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung von Biperiden
DE10124453A1 (de) * 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung von Biperiden
DE102005030745B4 (de) 2005-06-29 2008-05-29 Schleifring Und Apparatebau Gmbh HF-Spulen für Kernspintomographen
CN106187948B (zh) * 2016-08-02 2019-02-22 安徽省逸欣铭医药科技有限公司 盐酸比哌立登制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1005067B (de) 1953-03-14 1957-03-28 Knoll Ag Verfahren zur Herstellung von bicyclisch substituierten Aminopropanolen
US2789110A (en) * 1953-03-14 1957-04-16 Knoll Ag Amino alcohols substituted by bicycloalkyl residues and a process of making same
JPH11189729A (ja) 1997-12-26 1999-07-13 Chemiprokasei Kaisha Ltd 色素兼紫外線安定剤およびそれを含む高分子組成物
DE10124449A1 (de) 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung von Biperiden

Also Published As

Publication number Publication date
BR0209852A (pt) 2007-01-02
US20040152899A1 (en) 2004-08-05
CY1105200T1 (el) 2010-03-03
BRPI0209852B8 (pt) 2021-05-25
ES2268090T3 (es) 2007-03-16
ATE331710T1 (de) 2006-07-15
EP1389188A1 (de) 2004-02-18
CN1525958A (zh) 2004-09-01
IL158933A0 (en) 2004-05-12
DE10124449A1 (de) 2002-11-21
DE50207388D1 (de) 2006-08-10
JP4451600B2 (ja) 2010-04-14
WO2002094781A1 (de) 2002-11-28
BRPI0209852B1 (pt) 2016-08-02
KR100896837B1 (ko) 2009-05-12
US6835839B2 (en) 2004-12-28
DK1389188T3 (da) 2006-10-30
PT1389188E (pt) 2006-11-30
IL158933A (en) 2009-12-24
JP2005515154A (ja) 2005-05-26
EP1389188B1 (de) 2006-06-28
KR20040007580A (ko) 2004-01-24

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20201228

Address after: Wiesbaden

Patentee after: Abbott Ltd.

Address before: Wiesbaden

Patentee before: Abbott & Co.,Ltd.

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20060329