BRPI0209852B8 - método para a produção de biperideno, e, composto - Google Patents

método para a produção de biperideno, e, composto

Info

Publication number
BRPI0209852B8
BRPI0209852B8 BRPI0209852A BR0209852A BRPI0209852B8 BR PI0209852 B8 BRPI0209852 B8 BR PI0209852B8 BR PI0209852 A BRPI0209852 A BR PI0209852A BR 0209852 A BR0209852 A BR 0209852A BR PI0209852 B8 BRPI0209852 B8 BR PI0209852B8
Authority
BR
Brazil
Prior art keywords
biperiden
compost
production
propanone
hept
Prior art date
Application number
BRPI0209852A
Other languages
English (en)
Other versions
BR0209852A (pt
BRPI0209852B1 (pt
Inventor
Vilsmaier Elmar
Martin Weber Klaus
Thyes Marco
Grosse Markus
Klein Peter
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of BR0209852A publication Critical patent/BR0209852A/pt
Publication of BRPI0209852B1 publication Critical patent/BRPI0209852B1/pt
Publication of BRPI0209852B8 publication Critical patent/BRPI0209852B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"método para a produção de biperideno, e, composto". a invenção refere-se a um método para a produção de biperideno por reação de uma mistura exo/endo de 1- (biciclo [2.2.1.] hept-5-en-2-il) -3-piperidino- 1-propanona com um composto de fenil magnésio, em que a relação exo/endo de 1 -(biciclo [2.2. 1.] hept-5-en-2-il) -3-piperidino- 1 -propanona é pelo menos de 4,5 : 1.
BRPI0209852A 2001-05-18 2002-05-17 método para a produção de biperideno, e, composto BRPI0209852B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10124449A DE10124449A1 (de) 2001-05-18 2001-05-18 Verfahren zur Herstellung von Biperiden
PCT/EP2002/005500 WO2002094781A1 (de) 2001-05-18 2002-05-17 Verfahren zur herstellung von biperiden ii

Publications (3)

Publication Number Publication Date
BR0209852A BR0209852A (pt) 2007-01-02
BRPI0209852B1 BRPI0209852B1 (pt) 2016-08-02
BRPI0209852B8 true BRPI0209852B8 (pt) 2021-05-25

Family

ID=7685401

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0209852A BRPI0209852B8 (pt) 2001-05-18 2002-05-17 método para a produção de biperideno, e, composto

Country Status (14)

Country Link
US (1) US6835839B2 (pt)
EP (1) EP1389188B1 (pt)
JP (1) JP4451600B2 (pt)
KR (1) KR100896837B1 (pt)
CN (1) CN1247543C (pt)
AT (1) ATE331710T1 (pt)
BR (1) BRPI0209852B8 (pt)
CY (1) CY1105200T1 (pt)
DE (2) DE10124449A1 (pt)
DK (1) DK1389188T3 (pt)
ES (1) ES2268090T3 (pt)
IL (2) IL158933A0 (pt)
PT (1) PT1389188E (pt)
WO (1) WO2002094781A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10124449A1 (de) 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung von Biperiden
DE10124453A1 (de) * 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung von Biperiden
DE10124451A1 (de) * 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung von Biperiden
ATE307124T1 (de) * 2001-05-18 2005-11-15 Farmaceutico S I T Specialita Verfahren zur herstellung von biperiden i
DE102005030745B4 (de) 2005-06-29 2008-05-29 Schleifring Und Apparatebau Gmbh HF-Spulen für Kernspintomographen
CN106187948B (zh) * 2016-08-02 2019-02-22 安徽省逸欣铭医药科技有限公司 盐酸比哌立登制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1005067B (de) * 1953-03-14 1957-03-28 Knoll Ag Verfahren zur Herstellung von bicyclisch substituierten Aminopropanolen
US2789110A (en) 1953-03-14 1957-04-16 Knoll Ag Amino alcohols substituted by bicycloalkyl residues and a process of making same
JPH11189729A (ja) 1997-12-26 1999-07-13 Chemiprokasei Kaisha Ltd 色素兼紫外線安定剤およびそれを含む高分子組成物
DE10124449A1 (de) 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung von Biperiden

Also Published As

Publication number Publication date
JP2005515154A (ja) 2005-05-26
US20040152899A1 (en) 2004-08-05
ATE331710T1 (de) 2006-07-15
DK1389188T3 (da) 2006-10-30
CN1525958A (zh) 2004-09-01
DE10124449A1 (de) 2002-11-21
US6835839B2 (en) 2004-12-28
PT1389188E (pt) 2006-11-30
IL158933A0 (en) 2004-05-12
IL158933A (en) 2009-12-24
BR0209852A (pt) 2007-01-02
WO2002094781A1 (de) 2002-11-28
ES2268090T3 (es) 2007-03-16
BRPI0209852B1 (pt) 2016-08-02
JP4451600B2 (ja) 2010-04-14
CN1247543C (zh) 2006-03-29
KR100896837B1 (ko) 2009-05-12
KR20040007580A (ko) 2004-01-24
CY1105200T1 (el) 2010-03-03
EP1389188B1 (de) 2006-06-28
EP1389188A1 (de) 2004-02-18
DE50207388D1 (de) 2006-08-10

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 211/32, C07D 211/20, A61P 25/00

Ipc: C07D 211/32 (2011.01), C07D 211/20 (2011.01)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

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