CN1245976C - 羟丙甲基纤维素胶囊形式的药物制剂 - Google Patents

羟丙甲基纤维素胶囊形式的药物制剂 Download PDF

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Publication number
CN1245976C
CN1245976C CNB008021422A CN00802142A CN1245976C CN 1245976 C CN1245976 C CN 1245976C CN B008021422 A CNB008021422 A CN B008021422A CN 00802142 A CN00802142 A CN 00802142A CN 1245976 C CN1245976 C CN 1245976C
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CN
China
Prior art keywords
preparation
capsule
cpt
sgf
semisolid matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008021422A
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English (en)
Chinese (zh)
Other versions
CN1327387A (zh
Inventor
P·西瓦罗里
L·马格蒂
A·马蒂尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Publication of CN1327387A publication Critical patent/CN1327387A/zh
Application granted granted Critical
Publication of CN1245976C publication Critical patent/CN1245976C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB008021422A 1999-08-10 2000-07-11 羟丙甲基纤维素胶囊形式的药物制剂 Expired - Fee Related CN1245976C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9918885.6A GB9918885D0 (en) 1999-08-10 1999-08-10 Pharmaceutical formulations in hydroxypropymethycellulose capsules
GB9918885.6 1999-08-10

Publications (2)

Publication Number Publication Date
CN1327387A CN1327387A (zh) 2001-12-19
CN1245976C true CN1245976C (zh) 2006-03-22

Family

ID=10858930

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008021422A Expired - Fee Related CN1245976C (zh) 1999-08-10 2000-07-11 羟丙甲基纤维素胶囊形式的药物制剂

Country Status (18)

Country Link
US (1) US6569452B1 (no)
EP (1) EP1126851B1 (no)
CN (1) CN1245976C (no)
AR (1) AR025060A1 (no)
AT (1) ATE262905T1 (no)
AU (1) AU6158200A (no)
CA (1) CA2354039C (no)
CO (1) CO5200854A1 (no)
CZ (1) CZ293749B6 (no)
DE (1) DE60009442D1 (no)
EA (1) EA200100568A1 (no)
GB (1) GB9918885D0 (no)
HK (1) HK1040930B (no)
HU (1) HUP0104476A3 (no)
IL (2) IL143502A0 (no)
NO (1) NO319712B1 (no)
PE (1) PE20010407A1 (no)
WO (1) WO2001010443A1 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9925127D0 (en) * 1999-10-22 1999-12-22 Pharmacia & Upjohn Spa Oral formulations for anti-tumor compounds
CN1316970C (zh) * 2002-11-14 2007-05-23 武汉华中科大纳米药业有限公司 一种羟喜树碱固体分散物及其制剂
JP2005183361A (ja) * 2003-10-03 2005-07-07 Ngk Insulators Ltd 電子放出素子、電子放出装置、ディスプレイ及び光源
US20050208146A1 (en) * 2003-10-30 2005-09-22 Pfizer Inc Novel dosage and administration method for oral camptosar
GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
WO2007033522A1 (fr) * 2005-09-21 2007-03-29 Shenzhen Tys R & D Co., Ltd. Formulation de gélule contenant de la moxifloxacine et son procédé de préparation
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
US20100008998A1 (en) * 2006-09-26 2010-01-14 Samyang Corporation Submicron nanoparticle of poorly water soluble camptothecin derivatives and process for preparation thereof
JP2014517046A (ja) * 2011-06-24 2014-07-17 アセンダ ファーマ インコーポレイテッド エステルプロドラッグの吸収を改善するための方法及び改善された医薬組成物
CN103110605A (zh) * 2011-11-17 2013-05-22 天士力制药集团股份有限公司 一种热熔胶囊制剂及其制备方法
KR102537085B1 (ko) * 2014-01-17 2023-05-25 옹코랄 파르마 에이피에스 암의 치료를 위한 이리노테칸의 고형 경구 투여형
CN105287427B (zh) * 2015-10-20 2017-04-19 沈阳红旗制药有限公司 一种利福平半固体胶囊及其制备方法
KR102066402B1 (ko) * 2017-12-22 2020-01-15 대화제약 주식회사 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678516A (en) * 1984-10-09 1987-07-07 The Dow Chemical Company Sustained release dosage form based on highly plasticized cellulose ether gels
US5597829A (en) 1994-05-09 1997-01-28 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin and methods for uses thereof
EP0758237B1 (en) 1994-04-28 2003-08-27 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin or 7-ethyl camptothecin in dimethylisosorbide or dimethylacetamide
US5756123A (en) * 1994-12-01 1998-05-26 Japan Elanco Co., Ltd. Capsule shell
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
CN1088584C (zh) 1996-08-02 2002-08-07 久光制药株式会社 口服制剂用胶囊及口服胶囊制剂
AR013261A1 (es) 1997-08-01 2000-12-13 Smithkline Beecham Corp Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina

Also Published As

Publication number Publication date
NO20013205L (no) 2001-06-26
CN1327387A (zh) 2001-12-19
HUP0104476A3 (en) 2004-05-28
CA2354039C (en) 2008-09-23
HK1040930B (zh) 2006-10-27
NO20013205D0 (no) 2001-06-26
HUP0104476A2 (hu) 2002-03-28
DE60009442D1 (de) 2004-05-06
EP1126851B1 (en) 2004-03-31
EA200100568A1 (ru) 2001-10-22
AR025060A1 (es) 2002-11-06
CA2354039A1 (en) 2001-02-15
CZ293749B6 (cs) 2004-07-14
GB9918885D0 (en) 1999-10-13
NO319712B1 (no) 2005-09-05
WO2001010443A1 (en) 2001-02-15
US6569452B1 (en) 2003-05-27
EP1126851A1 (en) 2001-08-29
PE20010407A1 (es) 2001-03-28
IL143502A0 (en) 2002-04-21
CZ20012089A3 (cs) 2001-10-17
HK1040930A1 (en) 2002-06-28
ATE262905T1 (de) 2004-04-15
AU6158200A (en) 2001-03-05
CO5200854A1 (es) 2002-09-27
IL143502A (en) 2006-12-10

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060322

Termination date: 20090711