CN1771955A - 一种复方镇咳祛痰药物的软胶囊组合物 - Google Patents
一种复方镇咳祛痰药物的软胶囊组合物 Download PDFInfo
- Publication number
- CN1771955A CN1771955A CN 200510095247 CN200510095247A CN1771955A CN 1771955 A CN1771955 A CN 1771955A CN 200510095247 CN200510095247 CN 200510095247 CN 200510095247 A CN200510095247 A CN 200510095247A CN 1771955 A CN1771955 A CN 1771955A
- Authority
- CN
- China
- Prior art keywords
- soft capsule
- guaifenesin
- medicine
- capsule
- dextromethorphan hydrobromide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 38
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 150000001875 compounds Chemical class 0.000 title claims abstract description 10
- 206010011224 Cough Diseases 0.000 title abstract description 10
- 206010062717 Increased upper airway secretion Diseases 0.000 title abstract description 6
- 208000026435 phlegm Diseases 0.000 title abstract description 6
- 239000000203 mixture Substances 0.000 title description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 56
- 229960003782 dextromethorphan hydrobromide Drugs 0.000 claims abstract description 24
- YQSHYGCCYVPRDI-UHFFFAOYSA-N (4-propan-2-ylphenyl)methanamine Chemical compound CC(C)C1=CC=C(CN)C=C1 YQSHYGCCYVPRDI-UHFFFAOYSA-N 0.000 claims abstract description 22
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229960002146 guaifenesin Drugs 0.000 claims abstract description 22
- 238000002360 preparation method Methods 0.000 claims abstract description 22
- 235000011187 glycerol Nutrition 0.000 claims abstract description 19
- 239000004094 surface-active agent Substances 0.000 claims abstract description 13
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 10
- 229920000053 polysorbate 80 Polymers 0.000 claims description 10
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 9
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- 239000007963 capsule composition Substances 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 3
- -1 dextromethorphan hydrobromides Chemical class 0.000 claims description 3
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 3
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 3
- 229940113124 polysorbate 60 Drugs 0.000 claims description 3
- 229960001985 dextromethorphan Drugs 0.000 claims 1
- 239000002609 medium Substances 0.000 description 14
- 239000000470 constituent Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000006187 pill Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 229960004126 codeine Drugs 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003679 aging effect Effects 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 210000001767 medulla oblongata Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Abstract
Description
处方1 | 处方2 | 处方3 | 处方4 | 处方5 | ||
药液由的各成分重 | 愈创木酚甘油醚 | 1 | 1 | 1 | 1 | 1 |
氢溴酸右美沙芬 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | |
PEG400 | 2 | 6 | 1 | 2 | 2 | |
甘油 | 0.1 | 0.1 | 0.1 | 0.02 | 1.5 | |
吐温80 | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 | |
试验结果 | 经加速试验180天后药丸未发生明显变化,崩解时限正常 | 经加速试验30天后药丸出现瘪丸 | 药物析出,流动性差,不适合制备软胶囊 | 经加速试验30天后,药丸变硬,崩解超出时限 | 经加速试验30天后,药丸变软,出现漏油 |
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100952477A CN1315475C (zh) | 2005-11-04 | 2005-11-04 | 一种复方镇咳祛痰药物的软胶囊组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100952477A CN1315475C (zh) | 2005-11-04 | 2005-11-04 | 一种复方镇咳祛痰药物的软胶囊组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1771955A true CN1771955A (zh) | 2006-05-17 |
CN1315475C CN1315475C (zh) | 2007-05-16 |
Family
ID=36759208
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005100952477A Expired - Fee Related CN1315475C (zh) | 2005-11-04 | 2005-11-04 | 一种复方镇咳祛痰药物的软胶囊组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1315475C (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101254249B (zh) * | 2008-03-20 | 2011-01-12 | 张辉 | 一种治疗咳嗽痰多症的中西药复方制剂及其生产方法 |
CN102038684A (zh) * | 2009-10-16 | 2011-05-04 | 北京润德康医药技术有限公司 | 用于镇咳化痰的药物组合物 |
CN111374982A (zh) * | 2020-02-27 | 2020-07-07 | 佛山手心制药有限公司 | 一种祛痰平喘的药物组合物及其应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1224382C (zh) * | 2003-01-20 | 2005-10-26 | 黑龙江省医药工业研究所 | 一种止咳祛痰药的制造方法 |
-
2005
- 2005-11-04 CN CNB2005100952477A patent/CN1315475C/zh not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101254249B (zh) * | 2008-03-20 | 2011-01-12 | 张辉 | 一种治疗咳嗽痰多症的中西药复方制剂及其生产方法 |
CN102038684A (zh) * | 2009-10-16 | 2011-05-04 | 北京润德康医药技术有限公司 | 用于镇咳化痰的药物组合物 |
CN111374982A (zh) * | 2020-02-27 | 2020-07-07 | 佛山手心制药有限公司 | 一种祛痰平喘的药物组合物及其应用 |
Also Published As
Publication number | Publication date |
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CN1315475C (zh) | 2007-05-16 |
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