CN1245520C - 使用精细颗粒生产生物材料的探针列阵的方法 - Google Patents
使用精细颗粒生产生物材料的探针列阵的方法 Download PDFInfo
- Publication number
- CN1245520C CN1245520C CN 00806177 CN00806177A CN1245520C CN 1245520 C CN1245520 C CN 1245520C CN 00806177 CN00806177 CN 00806177 CN 00806177 A CN00806177 A CN 00806177A CN 1245520 C CN1245520 C CN 1245520C
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- China
- Prior art keywords
- probe
- pearl
- hole
- solid articles
- array
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
- B01J2219/00468—Beads by manipulation of individual beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12886199P | 1999-04-12 | 1999-04-12 | |
US60/128,861 | 1999-04-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1347329A CN1347329A (zh) | 2002-05-01 |
CN1245520C true CN1245520C (zh) | 2006-03-15 |
Family
ID=22437355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 00806177 Expired - Fee Related CN1245520C (zh) | 1999-04-12 | 2000-04-11 | 使用精细颗粒生产生物材料的探针列阵的方法 |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP3746658B2 (ja) |
CN (1) | CN1245520C (ja) |
WO (1) | WO2000061198A1 (ja) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2001004628A (ja) * | 1999-06-18 | 2001-01-12 | Kanagawa Acad Of Sci & Technol | 免疫分析装置と免疫分析方法 |
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
US6267884B1 (en) * | 2000-01-04 | 2001-07-31 | Waters Investments Limited | Capillary columns employing monodispersed particles |
WO2001090225A1 (fr) * | 2000-05-22 | 2001-11-29 | Kabushiki Kaisya Advance | Nouveau procede de preparation de composition polymere |
JP2002186480A (ja) * | 2000-12-22 | 2002-07-02 | Hitachi Software Eng Co Ltd | ビーズ |
KR100994306B1 (ko) * | 2002-03-15 | 2010-11-12 | 소니 주식회사 | 바이오 어세이용 기판, 바이오 어세이 방법, 바이오 어세이 장치 및 기판 기록 정보의 판독 장치 |
JP3593525B2 (ja) | 2002-04-19 | 2004-11-24 | 株式会社日立製作所 | 微粒子アレー作製方法およびその装置 |
KR100991052B1 (ko) | 2002-05-08 | 2010-10-29 | 파나소닉 주식회사 | 생체분자 기판 및 그것을 이용한 검사 및 진단의 방법 및장치 |
US7164533B2 (en) * | 2003-01-22 | 2007-01-16 | Cyvera Corporation | Hybrid random bead/chip based microarray |
AU2003270655A1 (en) * | 2002-09-12 | 2004-04-30 | Cyvera Corporation | Assay stick comprising coded microbeads |
EP1575707A1 (en) * | 2002-09-12 | 2005-09-21 | Cyvera Corporation | Method and apparatus for aligning elongated microbeads in order to interrogate the same |
KR20050088476A (ko) | 2002-12-30 | 2005-09-06 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 병원균 검출과 분석을 위한 방법과 기구 |
JP4180964B2 (ja) | 2003-04-18 | 2008-11-12 | 日立ソフトウエアエンジニアリング株式会社 | ビーズ配列構造物、その製造方法、及びキャピラリビーズアレイのビーズ配列方法 |
JP3711988B2 (ja) * | 2003-05-12 | 2005-11-02 | 株式会社日立製作所 | 微粒子アレー分析システム、微粒子アレーキットおよび化学分析方法 |
JP4049713B2 (ja) | 2003-06-27 | 2008-02-20 | 株式会社日立製作所 | ビーズアレイチップ作製装置及び作製方法 |
SE0301945D0 (sv) * | 2003-06-30 | 2003-06-30 | Gyros Ab | Confidence determination |
JP2005046121A (ja) * | 2003-07-31 | 2005-02-24 | Japan Science & Technology Agency | オンチップバイオアッセイ方法及びキット |
AT414047B (de) * | 2003-09-16 | 2006-08-15 | Upper Austrian Res Gmbh | Anordnung zur bindung von molekülen |
JP2005114576A (ja) * | 2003-10-08 | 2005-04-28 | Hitachi Software Eng Co Ltd | 両親媒性分子固定化ビーズ、その製造方法、及びキャピラリビーズアレイのビーズ配列方法 |
US7799553B2 (en) * | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
JP4427411B2 (ja) * | 2004-07-28 | 2010-03-10 | 日立ソフトウエアエンジニアリング株式会社 | ビーズ配列装置及びビーズ配列方法 |
JP2006058195A (ja) | 2004-08-23 | 2006-03-02 | Alps Electric Co Ltd | 検査用プレート、および前記検査用プレートを用いた検査方法 |
JP4279754B2 (ja) * | 2004-09-13 | 2009-06-17 | アルプス電気株式会社 | プレート及び前記プレートを用いた検査方法 |
US20070248958A1 (en) | 2004-09-15 | 2007-10-25 | Microchip Biotechnologies, Inc. | Microfluidic devices |
JP4263154B2 (ja) * | 2004-09-30 | 2009-05-13 | 日立ソフトウエアエンジニアリング株式会社 | 機能性微粒子アレイ及びその使用方法 |
US8445265B2 (en) | 2004-10-06 | 2013-05-21 | Universal Bio Research Co., Ltd. | Reaction vessel and reaction controller |
DE602005019791D1 (de) | 2004-11-16 | 2010-04-15 | Illumina Inc | Verfahren und vorrichtung zum lesen von kodierten mikrokugeln |
KR101339544B1 (ko) | 2004-12-10 | 2013-12-10 | 유니바사루 바이오 리사치 가부시키가이샤 | 생체물질 고정담체 봉입 칩, 생체물질 고정담체 처리장치및 그 처리방법 |
US8133454B2 (en) | 2004-12-10 | 2012-03-13 | Universal Bio Research Co., Ltd. | Biological material fixed region enclosing tip, biological material fixed region treatment apparatus, and treatment method thereof |
EP1835020A4 (en) | 2005-01-07 | 2011-06-15 | Universal Bio Research Co Ltd | VEHICLE PLATE WITH VEHICLE, APPARATUS AND METHOD FOR PROCESSING THE VEHICLE |
JP4520359B2 (ja) | 2005-05-13 | 2010-08-04 | 日立ソフトウエアエンジニアリング株式会社 | 粒子捕捉装置、並びに粒子配列方法及び粒子配列装置 |
US8178305B2 (en) | 2005-05-20 | 2012-05-15 | Hitachi Chemical Company, Ltd. | Method of analyzing biochemical |
JP4520361B2 (ja) * | 2005-05-25 | 2010-08-04 | 日立ソフトウエアエンジニアリング株式会社 | プローブビーズの品質検査方法 |
US9260744B2 (en) | 2005-09-05 | 2016-02-16 | Universal Bio Research Co., Ltd. | Various-substance holder, various-substance holder treating apparatus, and various-substance holder treating method |
JP4711125B2 (ja) | 2005-09-27 | 2011-06-29 | 横河電機株式会社 | バイオチップ、バイオチップ読み取り装置、およびバイオチップ読み取り方法 |
CN101310169B (zh) * | 2005-11-16 | 2011-06-08 | 株式会社日立制作所 | 液滴生成运送方法和装置以及粒子操作装置 |
CA2641271A1 (en) | 2006-02-03 | 2008-03-13 | Microchip Biotechnologies, Inc. | Microfluidic devices |
JP2007248318A (ja) * | 2006-03-17 | 2007-09-27 | Hokkaido Univ | バイオセンサーアレイ |
US7766033B2 (en) | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
JP5531374B2 (ja) * | 2006-03-23 | 2014-06-25 | 日立化成株式会社 | マイクロ流体デバイス及びその製造方法 |
US7830575B2 (en) | 2006-04-10 | 2010-11-09 | Illumina, Inc. | Optical scanner with improved scan time |
JP4721958B2 (ja) * | 2006-06-09 | 2011-07-13 | 株式会社日立ソリューションズ | ビーズチッププレート |
JP5122091B2 (ja) | 2006-06-13 | 2013-01-16 | ユニバーサル・バイオ・リサーチ株式会社 | 担体封入変形容器、担体封入変形容器処理装置、および担体封入変形容器処理方法 |
EP2067035A2 (en) | 2006-09-15 | 2009-06-10 | Haemonetics Corporation | Surface mapping by optical manipulation of particles in relation to a functionalized surface |
WO2008052138A2 (en) | 2006-10-25 | 2008-05-02 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated dna analysis system using same |
CA2668639C (en) * | 2006-11-06 | 2017-06-27 | Clondiag Gmbh | Assays |
WO2009015296A1 (en) | 2007-07-24 | 2009-01-29 | The Regents Of The University Of California | Microfabricated dropley generator |
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US9040463B2 (en) | 2008-12-23 | 2015-05-26 | Mycartis Nv | Assay device and method for performing biological assays |
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KR20150074057A (ko) | 2012-10-22 | 2015-07-01 | 유니바사루 바이오 리사치 가부시키가이샤 | 복수 종의 목적 물질을 동시에 검출 또는 정량하기 위한 분석 방법 및 분석 키트 |
WO2015073999A1 (en) | 2013-11-18 | 2015-05-21 | Integenx Inc. | Cartridges and instruments for sample analysis |
US10208332B2 (en) | 2014-05-21 | 2019-02-19 | Integenx Inc. | Fluidic cartridge with valve mechanism |
CN113092563B (zh) | 2014-10-22 | 2024-06-07 | 尹特根埃克斯有限公司 | 用于样品制备、处理和分析的系统和方法 |
EP3512633A1 (en) | 2016-10-12 | 2019-07-24 | MyCartis N.V. | Prefilled cartridge |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3563140B2 (ja) * | 1995-01-19 | 2004-09-08 | 株式会社日立製作所 | キャピラリーアレイ電気泳動装置 |
JP3467995B2 (ja) * | 1996-11-28 | 2003-11-17 | 株式会社日立製作所 | キャピラリー電気泳動装置 |
AU745989B2 (en) * | 1997-08-13 | 2002-04-11 | Cepheid | Microstructures for the manipulation of fluid samples |
EP1865074B1 (en) * | 1997-12-22 | 2011-04-20 | Hitachi Chemical Co., Ltd. | Direct RT-PCR on oligonucleotide-immobilized PCR microplates |
-
2000
- 2000-04-11 JP JP2000109503A patent/JP3746658B2/ja not_active Expired - Lifetime
- 2000-04-11 CN CN 00806177 patent/CN1245520C/zh not_active Expired - Fee Related
- 2000-04-11 WO PCT/US2000/009685 patent/WO2000061198A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2000061198A1 (en) | 2000-10-19 |
CN1347329A (zh) | 2002-05-01 |
JP2000346842A (ja) | 2000-12-15 |
JP3746658B2 (ja) | 2006-02-15 |
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Granted publication date: 20060315 Termination date: 20170411 |