CN1245520C - 使用精细颗粒生产生物材料的探针列阵的方法 - Google Patents

使用精细颗粒生产生物材料的探针列阵的方法 Download PDF

Info

Publication number
CN1245520C
CN1245520C CN 00806177 CN00806177A CN1245520C CN 1245520 C CN1245520 C CN 1245520C CN 00806177 CN00806177 CN 00806177 CN 00806177 A CN00806177 A CN 00806177A CN 1245520 C CN1245520 C CN 1245520C
Authority
CN
China
Prior art keywords
probe
beads
bead
array
probes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN 00806177
Other languages
English (en)
Chinese (zh)
Other versions
CN1347329A (zh
Inventor
神原英记
三桥将人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi Chengdu Research And Development Co ltd
Hitachi Ltd
Resonac Corp
Original Assignee
Hitachi Chengdu Research And Development Co ltd
Hitachi Chemical Co Ltd
Hitachi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Chengdu Research And Development Co ltd, Hitachi Chemical Co Ltd, Hitachi Ltd filed Critical Hitachi Chengdu Research And Development Co ltd
Publication of CN1347329A publication Critical patent/CN1347329A/zh
Application granted granted Critical
Publication of CN1245520C publication Critical patent/CN1245520C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00468—Beads by manipulation of individual beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN 00806177 1999-04-12 2000-04-11 使用精细颗粒生产生物材料的探针列阵的方法 Expired - Fee Related CN1245520C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12886199P 1999-04-12 1999-04-12
US60/128,861 1999-04-12

Publications (2)

Publication Number Publication Date
CN1347329A CN1347329A (zh) 2002-05-01
CN1245520C true CN1245520C (zh) 2006-03-15

Family

ID=22437355

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 00806177 Expired - Fee Related CN1245520C (zh) 1999-04-12 2000-04-11 使用精细颗粒生产生物材料的探针列阵的方法

Country Status (3)

Country Link
JP (1) JP3746658B2 (enExample)
CN (1) CN1245520C (enExample)
WO (1) WO2000061198A1 (enExample)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001004628A (ja) * 1999-06-18 2001-01-12 Kanagawa Acad Of Sci & Technol 免疫分析装置と免疫分析方法
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US6267884B1 (en) * 2000-01-04 2001-07-31 Waters Investments Limited Capillary columns employing monodispersed particles
US20030153006A1 (en) * 2000-05-22 2003-08-14 Masao Washizu Novel method for forming polymer pattern
JP2002186480A (ja) * 2000-12-22 2002-07-02 Hitachi Software Eng Co Ltd ビーズ
US20050014286A1 (en) 2002-03-15 2005-01-20 Motohiro Furuki Bio-assay substrate, bio-assay apparatus, and reading apparatus
JP3593525B2 (ja) 2002-04-19 2004-11-24 株式会社日立製作所 微粒子アレー作製方法およびその装置
CN101078718A (zh) * 2002-05-08 2007-11-28 松下电器产业株式会社 含生物分子珠粒的管和使用它的分析装置
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7164533B2 (en) * 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
AU2003267192A1 (en) * 2002-09-12 2004-04-30 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
AU2003270655A1 (en) * 2002-09-12 2004-04-30 Cyvera Corporation Assay stick comprising coded microbeads
EP1540591A1 (en) 2002-09-12 2005-06-15 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
WO2004061085A2 (en) 2002-12-30 2004-07-22 The Regents Of The University Of California Methods and apparatus for pathogen detection and analysis
JP4180964B2 (ja) * 2003-04-18 2008-11-12 日立ソフトウエアエンジニアリング株式会社 ビーズ配列構造物、その製造方法、及びキャピラリビーズアレイのビーズ配列方法
JP3711988B2 (ja) * 2003-05-12 2005-11-02 株式会社日立製作所 微粒子アレー分析システム、微粒子アレーキットおよび化学分析方法
JP4049713B2 (ja) 2003-06-27 2008-02-20 株式会社日立製作所 ビーズアレイチップ作製装置及び作製方法
SE0301945D0 (sv) * 2003-06-30 2003-06-30 Gyros Ab Confidence determination
JP2005046121A (ja) * 2003-07-31 2005-02-24 Japan Science & Technology Agency オンチップバイオアッセイ方法及びキット
AT414047B (de) * 2003-09-16 2006-08-15 Upper Austrian Res Gmbh Anordnung zur bindung von molekülen
JP2005114576A (ja) * 2003-10-08 2005-04-28 Hitachi Software Eng Co Ltd 両親媒性分子固定化ビーズ、その製造方法、及びキャピラリビーズアレイのビーズ配列方法
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7799553B2 (en) * 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
JP4427411B2 (ja) 2004-07-28 2010-03-10 日立ソフトウエアエンジニアリング株式会社 ビーズ配列装置及びビーズ配列方法
JP2006058195A (ja) 2004-08-23 2006-03-02 Alps Electric Co Ltd 検査用プレート、および前記検査用プレートを用いた検査方法
JP4279754B2 (ja) * 2004-09-13 2009-06-17 アルプス電気株式会社 プレート及び前記プレートを用いた検査方法
CN102759466A (zh) 2004-09-15 2012-10-31 英特基因有限公司 微流体装置
JP4263154B2 (ja) * 2004-09-30 2009-05-13 日立ソフトウエアエンジニアリング株式会社 機能性微粒子アレイ及びその使用方法
WO2006038643A1 (ja) 2004-10-06 2006-04-13 Universal Bio Research Co., Ltd. 反応容器、および反応制御装置
WO2006055735A2 (en) 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
EP1869615B1 (en) 2004-11-16 2010-03-03 Illumina, Inc. Methods and apparatus for reading coded microbeads
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
EP1821106B1 (en) * 2004-12-10 2018-02-14 Universal Bio Research Co., Ltd. Biomaterial immobilization carrier enclosing tip and method of treating therefor
TWI416107B (zh) 2004-12-10 2013-11-21 Universal Bio Research Co Ltd 封入生物材料固定用區域之滴尖、生物材料固定用區域處理裝置及其方法
JP4936901B2 (ja) 2005-01-07 2012-05-23 ユニバーサル・バイオ・リサーチ株式会社 担体封入チップ、担体処理装置、および担体処理方法
USD601712S1 (en) 2005-01-07 2009-10-06 Universal Bio Research Co., Ltd. Carrier enclosing tip
JP4520359B2 (ja) * 2005-05-13 2010-08-04 日立ソフトウエアエンジニアリング株式会社 粒子捕捉装置、並びに粒子配列方法及び粒子配列装置
AU2006246598B2 (en) * 2005-05-20 2010-04-01 Hitachi Chemical Company, Ltd. Method of analyzing biochemical
JP4520361B2 (ja) * 2005-05-25 2010-08-04 日立ソフトウエアエンジニアリング株式会社 プローブビーズの品質検査方法
KR101354764B1 (ko) 2005-09-05 2014-01-22 유니바사루 바이오 리사치 가부시키가이샤 각종 물질 유지체, 각종 물질 유지체 처리장치, 및 그처리방법
JP4711125B2 (ja) * 2005-09-27 2011-06-29 横河電機株式会社 バイオチップ、バイオチップ読み取り装置、およびバイオチップ読み取り方法
US8029744B2 (en) 2005-11-16 2011-10-04 Hitachi, Ltd. Method of liquid droplet formation and transport apparatus therefor and particle manipulating apparatus
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
WO2008030631A2 (en) 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Microfluidic devices
JP2007248318A (ja) * 2006-03-17 2007-09-27 Hokkaido Univ バイオセンサーアレイ
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
JP5531374B2 (ja) * 2006-03-23 2014-06-25 日立化成株式会社 マイクロ流体デバイス及びその製造方法
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
JP4721958B2 (ja) * 2006-06-09 2011-07-13 株式会社日立ソリューションズ ビーズチッププレート
JP5122091B2 (ja) 2006-06-13 2013-01-16 ユニバーサル・バイオ・リサーチ株式会社 担体封入変形容器、担体封入変形容器処理装置、および担体封入変形容器処理方法
USD561347S1 (en) 2006-09-13 2008-02-05 Universal Bio Research Co., Ltd. Pipette with particulate carriers therein
USD561906S1 (en) 2006-09-13 2008-02-12 Universal Bio Research Co., Ltd. Pipette with particulate carriers therein
USD569989S1 (en) 2006-09-13 2008-05-27 Universal Bio Research Co., Ltd. Pipette with particulate carriers therein
USD560815S1 (en) 2006-09-13 2008-01-29 Universal Bio Research Co., Ltd. Pipette with particulate carriers therein
USD565192S1 (en) 2006-09-13 2008-03-25 Universal Bio Research Co., Ltd. Pipette with particulate carriers therein
EP2067035A2 (en) 2006-09-15 2009-06-10 Haemonetics Corporation Surface mapping by optical manipulation of particles in relation to a functionalized surface
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
WO2008055915A2 (en) * 2006-11-06 2008-05-15 Clondiag Gmbh Device and process for assays using binding members
US8454906B2 (en) 2007-07-24 2013-06-04 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions
WO2009108260A2 (en) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
KR101656846B1 (ko) * 2008-12-23 2016-09-12 미카티스 엔브이 생물학적 분석들을 수행하기 위한 분석 장치 및 방법
EP2384429A1 (en) 2008-12-31 2011-11-09 Integenx Inc. Instrument with microfluidic chip
EP2438154A1 (en) 2009-06-02 2012-04-11 Integenx Inc. Fluidic devices with diaphragm valves
AU2010256429B2 (en) 2009-06-05 2015-09-17 Integenx Inc. Universal sample preparation system and use in an integrated analysis system
JP2010284101A (ja) * 2009-06-11 2010-12-24 Hitachi High-Technologies Corp 反応容器，並列処理装置、及びシーケンサ
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
EP2606154B1 (en) 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
EP2606242B1 (en) 2010-08-20 2026-04-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
EP2484447A1 (en) * 2011-02-07 2012-08-08 Biocartis SA Improved encoded microcarriers, assay system using them and method for performing an assay
JP5899908B2 (ja) * 2011-12-26 2016-04-06 株式会社Ｊｖｃケンウッド 試料分析用ディスク
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
JP5354621B2 (ja) * 2011-12-27 2013-11-27 一般財団法人生産技術研究奨励会 マイクロビーズの配列方法及びその配列装置
JP2013150567A (ja) * 2012-01-25 2013-08-08 Hitachi High-Technologies Corp 核酸分析用反応デバイス、及び核酸分析装置
US10288606B2 (en) 2012-10-22 2019-05-14 Universal Bio Research Co., Ltd. Analysis method and analysis kit for simultaneously detecting or quantitating multiple types of target substances
CN105873681B (zh) 2013-11-18 2019-10-11 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
WO2016065073A1 (en) 2014-10-22 2016-04-28 Integenx Inc. Systems and methods for sample preparation, processing and analysis
US20200290038A1 (en) 2016-10-12 2020-09-17 Mycartis N.V. Prefilled cartridge

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3563140B2 (ja) * 1995-01-19 2004-09-08 株式会社日立製作所 キャピラリーアレイ電気泳動装置
JP3467995B2 (ja) * 1996-11-28 2003-11-17 株式会社日立製作所 キャピラリー電気泳動装置
EP1003759A2 (en) * 1997-08-13 2000-05-31 Cepheid Microstructures for the manipulation of fluid samples
ATE506449T1 (de) * 1997-12-22 2011-05-15 Hitachi Chemical Co Ltd Direkte rt-pcr auf oligonukleotid-immobilisierten pcr-mikroplatten

Also Published As

Publication number Publication date
JP2000346842A (ja) 2000-12-15
JP3746658B2 (ja) 2006-02-15
WO2000061198A1 (en) 2000-10-19
CN1347329A (zh) 2002-05-01

Similar Documents

Publication Publication Date Title
CN1347329A (zh) 使用精细颗粒生产生物材料的探针列阵的方法
US7670992B2 (en) Method of producing probe arrays for biological materials using fine particles
US9260744B2 (en) Various-substance holder, various-substance holder treating apparatus, and various-substance holder treating method
AU734126C (en) Analytical biochemistry system with robotically carried bioarray
US9476814B2 (en) Carrier-enclosed transformable container, carrier-enclosed transformable container processing apparatus, and carrier-enclosed transformable container processing method
US8999726B2 (en) Microfluidic interface for highly parallel addressing of sensing arrays
US20030138969A1 (en) Closed substrate platforms suitable for analysis of biomolecules
WO2004074818A2 (en) Assay apparatus and method using microfluidic arrays
WO2001062377A2 (en) Microarray fabrication techniques and apparatus
JP2007530039A (ja) 透明フィルタ付キャピラリー
AU5316599A (en) Sensor arrays for the measurement and identification of multiple analytes in solutions
WO2007057989A1 (ja) 液滴生成搬送方法及び装置、並びに粒子操作装置
JP2004536694A (ja) 標的−受容体との結合を促進および強化する方法、およびそのための装置
JP2003232791A (ja) プローブ固相化反応アレイ
JP4262512B2 (ja) プローブ固相化反応アレイ
CN101886126B (zh) 一种用于生物芯片分析的毛细管探针阵列的制备方法
JP5552134B2 (ja) 担体封入変形容器、担体封入変形容器処理装置、および担体封入変形容器処理方法
JP2003247990A (ja) 生化学的検査用の検査基板とこれに用いる微小基板

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060315

Termination date: 20170411

CF01 Termination of patent right due to non-payment of annual fee