CN1245161C - 调制离子通道机能活动的方法 - Google Patents
调制离子通道机能活动的方法 Download PDFInfo
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- CN1245161C CN1245161C CNB998120197A CN99812019A CN1245161C CN 1245161 C CN1245161 C CN 1245161C CN B998120197 A CNB998120197 A CN B998120197A CN 99812019 A CN99812019 A CN 99812019A CN 1245161 C CN1245161 C CN 1245161C
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- RINCXYDBBGOEEQ-UHFFFAOYSA-N succinic anhydride Chemical class O=C1CCC(=O)O1 RINCXYDBBGOEEQ-UHFFFAOYSA-N 0.000 description 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 108700026222 vpu Genes Proteins 0.000 description 1
- 101150090490 vpu gene Proteins 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (21)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPP6464 | 1998-10-12 | ||
AUPP6464A AUPP646498A0 (en) | 1998-10-12 | 1998-10-12 | A method of modulating ion channel functional activity |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1323212A CN1323212A (zh) | 2001-11-21 |
CN1245161C true CN1245161C (zh) | 2006-03-15 |
Family
ID=3810686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB998120197A Expired - Fee Related CN1245161C (zh) | 1998-10-12 | 1999-10-12 | 调制离子通道机能活动的方法 |
Country Status (8)
Country | Link |
---|---|
US (2) | US7179803B1 (zh) |
EP (1) | EP1121128B1 (zh) |
JP (1) | JP4624562B2 (zh) |
CN (1) | CN1245161C (zh) |
AU (1) | AUPP646498A0 (zh) |
CA (1) | CA2345896C (zh) |
NZ (1) | NZ510437A (zh) |
WO (1) | WO2000021538A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10210206A1 (de) * | 2002-03-01 | 2003-09-04 | Florian Lang | Fertilitätsreduzierung bei Vertebraten |
AU2003903251A0 (en) * | 2003-06-26 | 2003-07-10 | Biotron Limited | Antiviral compounds and methods |
JP5030587B2 (ja) | 2003-06-26 | 2012-09-19 | バイオトロン・リミテッド | 抗ウイルスアシルグアニジン化合物および方法 |
US20060275812A1 (en) * | 2005-06-01 | 2006-12-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Assay for agonists and antagonists of ion channels and for regulators of genetic expression |
CN112156753A (zh) * | 2020-09-23 | 2021-01-01 | 中国石油大学(华东) | 石墨烯气凝胶及其制备方法和应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
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US4085211A (en) * | 1975-12-15 | 1978-04-18 | Merck & Co., Inc. | Pyrazinecarboxamides and processes for preparing same |
WO1990009792A1 (en) * | 1989-03-03 | 1990-09-07 | The General Hospital Corporation | Topical application of amiloride or analogues thereof for treatment of inflammation |
US5506231A (en) * | 1989-03-31 | 1996-04-09 | The Children's Medical Center Corporation | Treatment of aids dementia, myelopathy and blindness |
US5215991A (en) * | 1990-01-26 | 1993-06-01 | Allergan, Inc. | Combination of selective alpha-adrenergic agonists and Na+ /H+ ex |
JPH0725768A (ja) | 1993-07-09 | 1995-01-27 | Mitsubishi Chem Corp | 血管内膜肥厚抑制剤 |
EP0937460A3 (en) * | 1994-04-12 | 2000-04-05 | Adolor Corporation | Use of an antidiarrheal for the manufacture of a medicament for the treatment of inflammatory conditions |
AUPO258196A0 (en) * | 1996-09-27 | 1996-10-17 | Australian National University, The | Method for determining ion channel activity of a substance |
-
1998
- 1998-10-12 AU AUPP6464A patent/AUPP646498A0/en not_active Abandoned
-
1999
- 1999-10-12 CN CNB998120197A patent/CN1245161C/zh not_active Expired - Fee Related
- 1999-10-12 US US09/807,277 patent/US7179803B1/en not_active Expired - Lifetime
- 1999-10-12 EP EP99970324.2A patent/EP1121128B1/en not_active Expired - Lifetime
- 1999-10-12 JP JP2000575514A patent/JP4624562B2/ja not_active Expired - Fee Related
- 1999-10-12 CA CA002345896A patent/CA2345896C/en not_active Expired - Fee Related
- 1999-10-12 NZ NZ510437A patent/NZ510437A/en not_active IP Right Cessation
- 1999-10-12 WO PCT/AU1999/000872 patent/WO2000021538A1/en active IP Right Grant
-
2006
- 2006-12-14 US US11/638,416 patent/US20070112013A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2000021538A1 (en) | 2000-04-20 |
JP2002527397A (ja) | 2002-08-27 |
EP1121128A4 (en) | 2004-10-27 |
US20070112013A1 (en) | 2007-05-17 |
US7179803B1 (en) | 2007-02-20 |
JP4624562B2 (ja) | 2011-02-02 |
CA2345896C (en) | 2009-03-24 |
CN1323212A (zh) | 2001-11-21 |
EP1121128A1 (en) | 2001-08-08 |
CA2345896A1 (en) | 2000-04-20 |
AUPP646498A0 (en) | 1998-11-05 |
NZ510437A (en) | 2005-01-28 |
EP1121128B1 (en) | 2013-04-17 |
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