CN1244578C - 取代的苯并呋喃－2－甲酰胺衍生物 - Google Patents
取代的苯并呋喃－2－甲酰胺衍生物 Download PDFInfo
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- CN1244578C CN1244578C CNB028058135A CN02805813A CN1244578C CN 1244578 C CN1244578 C CN 1244578C CN B028058135 A CNB028058135 A CN B028058135A CN 02805813 A CN02805813 A CN 02805813A CN 1244578 C CN1244578 C CN 1244578C
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- Prior art keywords
- butyl
- piperazine
- cyano
- indol
- carboxamides
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Classifications
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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Landscapes
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- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10112151A DE10112151A1 (de) | 2001-03-14 | 2001-03-14 | Substituierte Benzofuran-2-carbonsäureamide |
| DE10112151.2 | 2001-03-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1494543A CN1494543A (zh) | 2004-05-05 |
| CN1244578C true CN1244578C (zh) | 2006-03-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028058135A Expired - Fee Related CN1244578C (zh) | 2001-03-14 | 2002-02-27 | 取代的苯并呋喃－2－甲酰胺衍生物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7244846B2 (enExample) |
| EP (1) | EP1368346A1 (enExample) |
| JP (1) | JP4485743B2 (enExample) |
| KR (1) | KR20030080083A (enExample) |
| CN (1) | CN1244578C (enExample) |
| AR (1) | AR035782A1 (enExample) |
| BR (1) | BR0208040A (enExample) |
| CA (1) | CA2440726C (enExample) |
| CZ (1) | CZ20032712A3 (enExample) |
| DE (1) | DE10112151A1 (enExample) |
| EC (1) | ECSP034798A (enExample) |
| EE (1) | EE200300447A (enExample) |
| HU (1) | HUP0303449A3 (enExample) |
| IL (1) | IL157889A0 (enExample) |
| MX (1) | MXPA03008140A (enExample) |
| PL (1) | PL362844A1 (enExample) |
| RU (1) | RU2003129057A (enExample) |
| SK (1) | SK12492003A3 (enExample) |
| WO (1) | WO2002083666A1 (enExample) |
| ZA (1) | ZA200307966B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10259244A1 (de) * | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | N-(Indolethyl-)cycloamin-Verbindungen |
| DE10305739A1 (de) * | 2003-02-11 | 2004-08-19 | Merck Patent Gmbh | Benzofuranderivate |
| DE10306941A1 (de) | 2003-02-18 | 2004-08-26 | Merck Patent Gmbh | Benzofuranoxyethylamine |
| DE10326939A1 (de) * | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
| DE10326940A1 (de) * | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
| PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
| TW200626142A (en) | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
| DE102005019670A1 (de) * | 2005-04-26 | 2006-11-02 | Merck Patent Gmbh | Verfahren zur Herstellung von (5-(4-[4-(5-Cyano-3-indolyl)-butyl)-1-piperazinyl)-benzofuran-2-carboxamid |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| DE102006060597A1 (de) * | 2006-12-21 | 2008-06-26 | Merck Patent Gmbh | Verfahren zur Herstellung von Benzofuran-2-carboxamiden |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| AU2009225025A1 (en) * | 2008-03-14 | 2009-09-17 | Merck Patent Gmbh | Azaindole compounds for treatment of central nervous system disorders |
| EP2110374A1 (en) * | 2008-04-18 | 2009-10-21 | Merck Sante | Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators |
| WO2010102968A1 (en) | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
| EP2338873A1 (en) | 2009-12-22 | 2011-06-29 | Gmeiner, Peter | New aminotetraline derivatives |
| KR101361145B1 (ko) * | 2011-03-10 | 2014-02-12 | 한국화학연구원 | 신규한 벤조퓨란-2-카르복사미드 유도체 및 그의 ｍｃｈ 수용체-1 관련 질환에 대한 치료학적 용도 |
| CN103570698B (zh) * | 2012-08-01 | 2016-08-03 | 江苏恩华药业股份有限公司 | 用于制备维拉佐酮的化合物及其中间体和应用 |
| CN104337812B (zh) | 2013-07-29 | 2018-09-14 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其使用方法和用途 |
| WO2016192657A1 (en) | 2015-06-03 | 2016-12-08 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4333254A1 (de) | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
| DE19730989A1 (de) * | 1997-07-18 | 1999-01-21 | Merck Patent Gmbh | Piperazin-Derivate |
| TW518218B (en) * | 1999-05-27 | 2003-01-21 | Merck Patent Gmbh | Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders |
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2001
- 2001-03-14 DE DE10112151A patent/DE10112151A1/de not_active Withdrawn
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2002
- 2002-02-27 PL PL02362844A patent/PL362844A1/xx unknown
- 2002-02-27 KR KR10-2003-7011886A patent/KR20030080083A/ko not_active Withdrawn
- 2002-02-27 US US10/471,584 patent/US7244846B2/en not_active Expired - Fee Related
- 2002-02-27 CN CNB028058135A patent/CN1244578C/zh not_active Expired - Fee Related
- 2002-02-27 JP JP2002581421A patent/JP4485743B2/ja not_active Expired - Fee Related
- 2002-02-27 IL IL15788902A patent/IL157889A0/xx unknown
- 2002-02-27 CZ CZ20032712A patent/CZ20032712A3/cs unknown
- 2002-02-27 WO PCT/EP2002/002093 patent/WO2002083666A1/en not_active Ceased
- 2002-02-27 SK SK1249-2003A patent/SK12492003A3/sk not_active Application Discontinuation
- 2002-02-27 EP EP02729940A patent/EP1368346A1/en not_active Withdrawn
- 2002-02-27 EE EEP200300447A patent/EE200300447A/xx unknown
- 2002-02-27 CA CA2440726A patent/CA2440726C/en not_active Expired - Fee Related
- 2002-02-27 RU RU2003129057/04A patent/RU2003129057A/ru not_active Application Discontinuation
- 2002-02-27 HU HU0303449A patent/HUP0303449A3/hu unknown
- 2002-02-27 BR BR0208040-0A patent/BR0208040A/pt not_active IP Right Cessation
- 2002-02-27 MX MXPA03008140A patent/MXPA03008140A/es unknown
- 2002-03-13 AR ARP020100898A patent/AR035782A1/es not_active Application Discontinuation
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2003
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Also Published As
| Publication number | Publication date |
|---|---|
| CZ20032712A3 (cs) | 2004-01-14 |
| HUP0303449A3 (en) | 2005-02-28 |
| WO2002083666A1 (en) | 2002-10-24 |
| US7244846B2 (en) | 2007-07-17 |
| SK12492003A3 (sk) | 2004-03-02 |
| EP1368346A1 (en) | 2003-12-10 |
| RU2003129057A (ru) | 2005-04-10 |
| PL362844A1 (en) | 2004-11-02 |
| ZA200307966B (en) | 2005-01-13 |
| MXPA03008140A (es) | 2003-12-12 |
| US20050075269A1 (en) | 2005-04-07 |
| EE200300447A (et) | 2003-12-15 |
| IL157889A0 (en) | 2004-03-28 |
| CN1494543A (zh) | 2004-05-05 |
| DE10112151A1 (de) | 2002-09-19 |
| KR20030080083A (ko) | 2003-10-10 |
| CA2440726C (en) | 2011-05-17 |
| JP2004527536A (ja) | 2004-09-09 |
| BR0208040A (pt) | 2004-02-25 |
| CA2440726A1 (en) | 2002-10-24 |
| JP4485743B2 (ja) | 2010-06-23 |
| HUP0303449A2 (hu) | 2004-01-28 |
| ECSP034798A (es) | 2003-12-01 |
| AR035782A1 (es) | 2004-07-14 |
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