CN1237905A - 应用Sibutramine类似物预防糖尿病的发展 - Google Patents

应用Sibutramine类似物预防糖尿病的发展 Download PDF

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Publication number
CN1237905A
CN1237905A CN97199787A CN97199787A CN1237905A CN 1237905 A CN1237905 A CN 1237905A CN 97199787 A CN97199787 A CN 97199787A CN 97199787 A CN97199787 A CN 97199787A CN 1237905 A CN1237905 A CN 1237905A
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CN
China
Prior art keywords
insulin
formula
chemical compound
patient
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97199787A
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English (en)
Chinese (zh)
Inventor
C·J·拜莱
R·B·琼斯
H·C·杰克逊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll GmbH filed Critical Knoll GmbH
Publication of CN1237905A publication Critical patent/CN1237905A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electrotherapy Devices (AREA)
CN97199787A 1996-09-21 1997-09-15 应用Sibutramine类似物预防糖尿病的发展 Pending CN1237905A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9619757.9 1996-09-21
GBGB9619757.9A GB9619757D0 (en) 1996-09-21 1996-09-21 Chemical process

Publications (1)

Publication Number Publication Date
CN1237905A true CN1237905A (zh) 1999-12-08

Family

ID=10800326

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97199787A Pending CN1237905A (zh) 1996-09-21 1997-09-15 应用Sibutramine类似物预防糖尿病的发展

Country Status (26)

Country Link
US (3) US6174925B1 (enExample)
EP (1) EP0927028A1 (enExample)
JP (1) JP2001503737A (enExample)
KR (1) KR20000048501A (enExample)
CN (1) CN1237905A (enExample)
AU (1) AU724488B2 (enExample)
BG (1) BG64473B1 (enExample)
BR (1) BR9711517A (enExample)
CA (1) CA2266401C (enExample)
CZ (1) CZ93699A3 (enExample)
GB (1) GB9619757D0 (enExample)
HR (1) HRP970505A2 (enExample)
HU (1) HUP9904026A3 (enExample)
ID (1) ID18320A (enExample)
IL (1) IL128850A (enExample)
MY (1) MY116150A (enExample)
NO (1) NO991358L (enExample)
NZ (1) NZ334580A (enExample)
PL (1) PL332305A1 (enExample)
RU (1) RU2245709C2 (enExample)
SK (1) SK31999A3 (enExample)
TR (1) TR199900618T2 (enExample)
TW (1) TW580385B (enExample)
UA (1) UA64726C2 (enExample)
WO (1) WO1998011884A1 (enExample)
ZA (1) ZA978450B (enExample)

Families Citing this family (42)

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GB9619757D0 (en) * 1996-09-21 1996-11-06 Knoll Ag Chemical process
EP1093370B1 (en) * 1998-06-30 2006-02-22 Takeda Pharmaceutical Company Limited Pharmaceutical composition for the treatment of diabetes
JP2000080047A (ja) * 1998-06-30 2000-03-21 Takeda Chem Ind Ltd 医 薬
US6974838B2 (en) * 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
US6476078B2 (en) * 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6331571B1 (en) 1998-08-24 2001-12-18 Sepracor, Inc. Methods of treating and preventing attention deficit disorders
US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
PL347634A1 (en) * 1998-11-12 2002-04-22 Smithkline Beecham Plc Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
AR023699A1 (es) * 1998-11-12 2002-09-04 Smithkline Beecham Corp Una composicion farmaceutica que comprende un estabilizador de insulina y un procedimiento para preparar una composicion farmaceutica
US20040102486A1 (en) * 1998-11-12 2004-05-27 Smithkline Beecham Corporation Novel method of treatment
US6696495B2 (en) 1998-12-02 2004-02-24 Snowden Pharmaceuticals, Llc Treatment of disorders secondary to organic impairments
US6323242B1 (en) 1998-12-02 2001-11-27 Peter Sterling Mueller Treatment of disorders secondary to organic impairments
US6552087B1 (en) 1999-03-19 2003-04-22 Abbott Gmbh & Co. Kg Therapeutic agent comprising (+)-sibutramine
US6680344B1 (en) 1999-06-01 2004-01-20 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylmethane derivatives
AU3712100A (en) 1999-06-01 2000-12-18 University Of Texas Southwestern Medical Center, The Method of treating hair loss using sulfonyl thyromimetic compounds
US6723717B1 (en) 1999-06-01 2004-04-20 The University Of Texas Southwestern Medical Center Sulfur-containing thyroxane derivatives and their use as hair growth promotors
GB9914744D0 (en) * 1999-06-24 1999-08-25 Knoll Ag Therapeutic agents
US6399826B1 (en) 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
WO2002083631A1 (en) * 2001-04-13 2002-10-24 Sepracor Inc. Methods of preparing didesmethylsibutramine and other sibutramine derivatives
KR100897890B1 (ko) 2002-06-17 2009-05-18 인벤티아 헬스케어 피브이티. 엘티디. 티아졸리딘디온 및 바이구아나이드를 함유하는 다층 정제및 그의 제조 방법
EP1545484A4 (en) * 2002-10-05 2010-01-13 Hanmi Pharm Ind Co Ltd PHARMACEUTICAL COMPOSITION WITH CRYSTALLINE SIBUTRAMINE METHANSULFONATE HEMIHYDRATE
US20050131074A1 (en) * 2003-08-04 2005-06-16 Beckman Kristen M. Methods for treating metabolic syndrome
PE20050335A1 (es) * 2003-08-07 2005-06-01 Sb Pharmco Inc Forma de dosificacion oral que comprende 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona y procedimiento para la preparacion
GB0318824D0 (en) * 2003-08-11 2003-09-10 Glaxo Group Ltd Novel composition
CN1874774B (zh) 2003-10-31 2011-04-13 武田药品工业株式会社 包含胰岛素致敏剂、胰岛素促分泌素和聚氧乙烯脱水山梨醇脂肪酸酯的固体制剂
KR100627687B1 (ko) * 2005-04-20 2006-09-25 주식회사 씨티씨바이오 시부트라민 유리염기 함유 조성물 및 이의 제조방법
CA2636324C (en) * 2006-01-06 2012-03-20 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
CN101626768B (zh) 2006-09-15 2013-08-21 雷维瓦药品公司 环烷基甲胺的合成、使用方法和组合物
KR100812538B1 (ko) * 2006-10-23 2008-03-11 한올제약주식회사 약물 제어방출형 메트포르민-글리메피리드 복합제제
EP2083867A1 (en) * 2006-11-22 2009-08-05 SK Chemicals, Co., Ltd. Inclusion complex of sibutramine and beta-cyclodextrin
PL2118123T3 (pl) 2007-01-31 2016-06-30 Dana Farber Cancer Inst Inc Stabilizowane peptydy p53 i ich zastosowania
KR101525754B1 (ko) 2007-03-28 2015-06-09 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
EP2448485B1 (en) 2009-07-02 2021-08-25 Dexcom, Inc. Analyte sensor
WO2012003501A2 (en) 2010-07-02 2012-01-05 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
CA2807685C (en) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. P53 derived peptidomimetic macrocycle
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
BR112014016122A8 (pt) 2011-12-30 2017-07-04 Reviva Pharmaceuticals Inc composto, e, composição farmacêutica
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
KR20150082307A (ko) 2012-11-01 2015-07-15 에일러론 테라퓨틱스 인코포레이티드 이치환 아미노산 및 이의 제조 및 사용 방법
MX2017003797A (es) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52768B1 (en) * 1981-04-06 1988-02-17 Boots Co Ltd 1-arylcyclobutylalkylamine compounds useful as therapeutic agents
GB8531071D0 (en) * 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound
GB8704777D0 (en) * 1987-02-28 1987-04-01 Boots Co Plc Medical treatment
JP2675573B2 (ja) * 1988-03-31 1997-11-12 科研製薬株式会社 脳機能改善剤
IE61928B1 (en) * 1988-11-29 1994-11-30 Boots Co Plc Treatment of obesity
WO1995010292A1 (en) 1993-10-14 1995-04-20 Biomedica California, Inc. Diabetes treatment and prophylaxis
US5459164A (en) * 1994-02-03 1995-10-17 Boots Pharmaceuticals, Inc. Medical treatment
GB9619757D0 (en) * 1996-09-21 1996-11-06 Knoll Ag Chemical process

Also Published As

Publication number Publication date
IL128850A0 (en) 2000-01-31
BG103277A (en) 2000-01-31
ID18320A (id) 1998-03-26
MY116150A (en) 2003-11-28
CA2266401C (en) 2007-01-30
UA64726C2 (uk) 2004-03-15
KR20000048501A (ko) 2000-07-25
AU4774097A (en) 1998-04-14
US6174925B1 (en) 2001-01-16
IL128850A (en) 2003-07-31
EP0927028A1 (en) 1999-07-07
NO991358D0 (no) 1999-03-19
US6617360B1 (en) 2003-09-09
AU724488B2 (en) 2000-09-21
HUP9904026A2 (hu) 2000-05-28
BR9711517A (pt) 1999-08-24
NO991358L (no) 1999-03-19
NZ334580A (en) 2000-09-29
RU2245709C2 (ru) 2005-02-10
GB9619757D0 (en) 1996-11-06
PL332305A1 (en) 1999-08-30
US20040077730A1 (en) 2004-04-22
BG64473B1 (bg) 2005-04-30
CA2266401A1 (en) 1998-03-26
TW580385B (en) 2004-03-21
WO1998011884A1 (en) 1998-03-26
ZA978450B (en) 1999-03-19
HUP9904026A3 (en) 2000-07-28
TR199900618T2 (xx) 1999-06-21
JP2001503737A (ja) 2001-03-21
HRP970505A2 (en) 1998-08-31
SK31999A3 (en) 1999-12-10
CZ93699A3 (cs) 1999-08-11

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