CN1235015A - 毫微分散体在化妆品最终制剂中的用途 - Google Patents
毫微分散体在化妆品最终制剂中的用途 Download PDFInfo
- Publication number
- CN1235015A CN1235015A CN99106369A CN99106369A CN1235015A CN 1235015 A CN1235015 A CN 1235015A CN 99106369 A CN99106369 A CN 99106369A CN 99106369 A CN99106369 A CN 99106369A CN 1235015 A CN1235015 A CN 1235015A
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- Prior art keywords
- nanodispersion
- component
- cosmetics
- final preparation
- fatty acid
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- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 238000004659 sterilization and disinfection Methods 0.000 description 1
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- 235000021286 stilbenes Nutrition 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
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- 239000010677 tea tree oil Substances 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
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- 230000002992 thymic effect Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
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- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
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Abstract
本发明公开了含有(a)膜-形成分子,(b)辅助乳化剂和(c)亲脂成分,的毫微分散体在化妆品最终制剂中的用途,该毫微分散体可通过(α)将组分(a),(b)和(c)混合直至得到均一澄清液体,并且(β)将步骤(α)得到的液体加到化妆品最终制剂的水相中而获得,步骤(α)和(β)在没有任何外加能量的情况下进行。根据本发明的毫微分散体易于制备并且适宜作非常宽范围的化妆品活性剂和脂溶性染料的载体系统。
Description
本发明涉及毫微分散体在化妆品最终制剂中的用途,含有所述毫微分散体的化妆品最终制剂和这些最终制剂的不同美容用途。
化妆品最终制剂除含有用于形成化妆品最终制剂的基质物质外,还含有其它功能活性剂。将其(活性剂)加入化妆品基质组合物中可以用于,例如,治疗,保护,调色,清洁,消毒,润湿皮肤和使皮肤或毛发再生和活化。
为了使这些物质在所需部位起作用。它们必须通过所谓载体或运输载体(载体系统)被运输到各自的部位,例如皮肤表面,粘膜,指甲,牙釉质或头发,以及表皮和皮肤的所有区域。为此,将美容活性剂例如水溶性维生素,氨基酸基团或水溶性黑色素包裹在脂质体中。由于脂质体的特性,亲脂物质只能很少量地被包裹在脂质体膜的亲脂区域。由于这个原因,所谓的毫微分散体,也称为毫微颗粒可用于这些物质,如脂溶性维生素。
由于膜和膜-形成分子的物理和化学特性,化妆品最终制剂中常用载体的使用受到了严格的限制。
常规结构的膜与两性物质有很高的相容性,两性物质例如是形成化妆品制剂基质或在化妆品最终制剂中作为活性剂或赋形剂的离子化或非离子化的乳化剂,脂肪胺,两性乳化剂,洗涤剂表面活性剂,增稠剂或防腐剂。这些物质的存在会引起膜结构的改变,从而导致制剂过程中所加载体系的破坏。
常用的膜还会受到酸或碱的侵袭。这就需要,例如载体系含有只能在所谓最佳pH范围,约为pH6.5使用的磷脂。降低或升高PH均将导致膜-形成分子的水解。
令人惊奇地,现已发现有适宜组成的毫微分散体能够在两性物质存在下,在很宽的PH范围内用简单的方法掺入化妆品最终制剂中,同时又保持其形态和理化特性。
因此,本发明涉及毫微分散体在化妆品最终制剂中的用途,该毫微分散体含有
(a)膜-形成分子
(b)辅助乳化剂及
(c)亲脂成分,
该毫微分散体可以通过下列方法获得:(α)将成分(a),(b)和(c)混合直至得到均一的澄清液体(所谓毫微分散体前相),和
(β)将步骤(α)得到的液体加到化妆品最终制剂的水相中,步骤(α)和(β)可以在不需要任何外加能量下进行。
步骤(α)常常在室温下进行,如果需要可以加热并在常压条件下进行。混合可以用标准的搅拌仪器进行,例如推进器,角式搅拌器或磁力搅拌器,并且不需要使用任何特殊的机械搅拌辅助设备。
将组分(a),(b)和(c)(=步骤(α))在无水介质中混合,即不需要加水。
步骤(β)是通过将步骤(α)得到的液体,毫微分散体前相,加到化妆品最终制剂的水相中而完成。组分(a),(b)和(c)颗粒的选择可以直接得到超细,单分散的毫微分散体。在此情况下可能先通过喷射器,转子-定子搅拌器或超声均化器将其均化,常常完成粗分散体的转化或至少将多分散系转化为细的单分散系。步骤(β)的特征是不需要高剪切力或空化力。
步骤(β)通常在室温下进行,该温度是各自的油/水相转化温度(PIT)范围。
毫微分散体的特征是步骤(α)和(β)中含有平均直径<50nm,典型地小于30nm的颗粒。分布是单分散并且符合高斯分布(方程)。
根据本发明,优选使用含有下列成分的毫微分散体,
(a)作为膜-形成分子的是适宜形成所谓双层(结构)的物质,
(b)作为辅助乳化剂的是易于形成油/水(O/W)结构的物质及,
(c)作为亲脂成分的是化妆品中常用的亲脂剂活性剂。
毫微分散体优选含有作为组分(a)的磷脂,水合的或部分水合的磷脂,溶血磷脂,神经酰胺,或这些化合物的混合物。
其中
R1是C10-C20酰基;
R2是氢原子或C10-C20酰基
R3是氢原子,2-三甲基氨基-1-乙基,2-氨基-1-乙基;未取代或被1个或多个羧基,羟基或氨基取代的C1-C5烷基;肌醇或甘油基。
C10-C20酰基优选含偶数个碳原子的直链C10-C20链烷酰基和含双键和偶数个碳原子的直链C10-C20链烯酰基。
含偶数个碳原子的直链C10-C20链烷酰基是,例如正十二烷酰基,正十四烷酰基,正十六烷酰基或正十八烷酰基。
含双键和偶数个碳原子的直链C10-C20链烯酰基是,例如,是6-顺-或6-反-,9-顺-或9-反-十二碳烯酰基,十四碳烯酰基,十六碳烯酰基,十八碳烯酰基或二十碳烯酰基,优选9-顺-十八碳烯酰基(油酰基),以及9,12-顺-十八碳二烯酰基或9,12,15-顺-十八碳三烯酰基。
其中R3是2-三甲基氨基-1-乙基的式(1)磷脂的俗名是卵磷脂,其中R3是2-氨基-1-乙基的式(1)磷脂的俗名是脑磷脂。适宜的实例是,例如天然存在的卵磷脂或脑磷脂,如从大豆或鸡蛋中得到具有不同或相同酰基的卵磷脂或脑磷脂,或其混合物。
式(1)的磷脂可以合成。“合成磷脂”用于定义对于R1和R2具有均一组成的磷脂。这种合成磷脂优选前面定义的卵磷脂和脑磷脂,其中酰基R1和R2具有所定义的结构并且是从所定义的纯度大于95%的脂肪酸衍生而来的。R1和R2可以相同或不同并且可以是不饱和的或饱和的。优选R1是饱和的,例如正十六烷酰基,和R2是不饱和的,如9-顺-十八碳烯酰基(油酰基)。
“天然存在的”磷脂的表达用于定义对于R1和R2没有均一组成的磷脂。这种天然磷脂类似于卵磷脂和脑磷脂,其中酰基R1和R2是从天然存在的脂肪酸混合物衍生而来的。
“基本纯的”式(1)磷脂的要求是指按重量计式(1)磷脂大于90%,优选大于95%的纯度,该纯度可以通过适宜的测定方法测定,例如通过纸层析,薄层层析,HPLC或酶染色试验测定。
在式(1)磷脂中,R3定义为C1-C4烷基,例如甲基或乙基。优选甲基。
R3定义为被一个或多个羧基,羟基或氨基取代的C1-C5烷基是,例如2-羟基乙基,2,3-二羟基-正丙基,羧基甲基,1-或2-羧基乙基,二羧基甲基,2-羧基-2-羟基乙基或3-羧基-2,3-二羟基-正丙基,3-氨基-3-羧基-正丙基或2-氨基-2-羧基-正丙基,优选2-氨基-2-羧基乙基。
含有这些基团的式(1)磷脂可以盐的形式存在,例如钠或钾盐。
其中R3是肌醇基或甘油基的式(1)磷脂是已知的,其名称分别为磷脂酰肌醇和磷脂酰甘油。
式(1)磷脂中的酰基通常是已知的且其名称在括号中给出:
9-顺-十二碳烯酰基(月桂烯酰基),9-顺-十四碳烯酰基(肉豆蔻脑酰基),9-顺-十六碳烯酰基(棕榈油酰基),6-顺-十八碳烯酰基(岩芹酰基),6-反-十八碳烯酰基(反岩芹酰基),9-顺-十八碳烯酰基(油酰基),9-反-十八碳烯酰基(反油酰基),9,12-顺-十八碳二烯酰基(亚油酰基),9,12,15-顺-十八碳三烯酰基(亚麻酰基),11-顺-十八碳烯酰基(十八碳烯酰基vaccenoyl),9-顺-二十碳烯酰基(顺式二十碳烯酰基),5,8,11,14-反-二十碳四烯酰基(花生四烯酰基),正十二烷酰基(月桂酰基),正十四烷酰基(肉豆蔻酰基),正十六烷酰基(棕榈酰基),正十八烷酰基(硬脂酰基),正二十烷酰基(花生酰基),正二十二烷酰基(山萮酰基),正二十四烷酰基(二十四烷酰基lignoceroyl)。
式(1)磷脂的盐优选可用于化妆品的盐。盐是指在取代基R3上存在盐-形成基团及在磷原子上有游离羟基。也可能形成内盐。优选碱金属盐,特别是钠盐。
在本发明的具体优选方案中,使用的纯卵磷脂是从优质LIPOID S100或S75大豆中得到的,或在美国药典单行本USP23/NF18上定义的卵磷脂。
组分(a)的浓度优选是基于组分(a),(b)和(c)总重量的约0.1至30%重量比。
组分(b)优选为可形成优选的油/水(O/W)结构的乳化剂或乳化剂混合物。
特别优选的乳化剂是
-脂肪酸的碱金属,铵和胺盐。其实例是锂,钠,钾,铵,三乙胺,乙醇胺,二乙醇胺或三乙醇胺盐。优选使用钠,钾或铵(NR1R2R3)盐,其中R1,R2和R3分别为氢原子,C1-C4烷基或C1-C4羟基烷基。
-饱和或不饱和的烷基硫酸盐,如十二烷基硫酸钠和链烷基磺酸盐如十二烷基磺酸钠;
-肠酸盐,如胆酸钠,甘胆酸钠和牛磺胆酸钠;
-转化皂液(四倍(quats)),如氯化zetyl吡啶翁;
-脱水山梨糖醇的部分脂肪酸酯,如脱水山梨糖醇单月桂酸酯;
-脂肪酸糖酯例如蔗糖单月桂酸酯;
-烷基葡萄糖甙,如正辛基葡萄糖甙或正十二烷基葡萄糖甙;
-烷基麦芽糖甙,如正十二烷基麦芽糖甙;
-脂肪酸部分甘油酯,如月桂酸单甘油酯;
-C8-C18甜菜碱,C8-C24烷基酰氨基-C1-C4亚烷基甜菜碱和C8-C18硫代甜菜碱;
-蛋白质,如酪蛋白;
-脂肪酸多甘油酯;
-脂肪酸丙二醇酯;
-脂肪酸乳酸盐,如硬脂酰乳酰基-2-乳酸钠;
-脂肪醇磷酸酯。
特别优选聚氧乙烯型的乳化剂。这类乳化剂的实例是:
-聚乙氧基脱水山梨糖醇脂肪酸酯,如多乙氧基醚;
-聚乙氧基脂肪醇,如oleth-20;
-聚乙氧基脂肪酸,如硬脂酸-20-聚烃氧基酯;
-聚乙氧基维生素E衍生物,如维生素E聚乙二醇1000琥珀酸酯;
-聚乙氧基羊毛脂和羊毛脂衍生物,如laneth-20;
-聚乙氧基脂肪酸部分甘油酯,如二乙二醇单硬脂酸酯;
-聚乙氧基烷基苯酚,如乙基酚聚(乙二醇醚)11;
-聚乙氧基脂肪醇半硫酸酯和其盐,如C12-C14脂肪醇醚硫酸-2EO-钠盐;
-聚乙氧基脂肪胺和脂肪酰胺;
-聚乙氧基碳水化合物
-环氧乙烷和环氧丙烷嵌段共聚物,如poloxamer 188。
毫微分散体优选含有作为组分(b)的至少一种聚氧乙烯型的乳化剂,特别优选聚氧乙烯型乳化剂或这些物质的混合物。
根据本发明使用的毫微分散体中组分(b)的浓度是基于组分(a),(b)和(c)总重量的约1-约50%重量比。
组分(c)优选天然或合成或半合成的二或三甘油酯,矿物油,硅油,蜡,脂肪醇,格尔伯特醇或其酯,亲脂美容活性剂如防晒剂或这些物质的混合物。
组分(c)优选防晒剂或脂溶性维生素。
已经发现特别适宜皮肤美容的活性剂组合物或活性剂是可以用于皮肤或局部使用的活性成分或活性成分的混合物。活性剂的实例如下:
-具有清洁皮肤表面和头发作用的活性剂。包括可用于清洁皮肤的物质,如油,肥皂,合成洗涤剂和固体物质;
-具有除臭和防汗作用的活性剂:包括以铝或锌盐为基础的防汗剂,含有抗菌或抑菌除臭作用的除臭剂,例如二氯苯氧氯酚,双三氯酚,醇和阳离子物质,例如季铵盐和吸味剂,如Grillocin(高油酸锌(rizinoleate)和不同的添加剂的结合)
或柠檬酸三乙酯,任选地与抗氧化剂如丁基羟基甲苯的结合),或离子交换树脂。
-具有抗阳光作用的活性剂(UV滤过剂):适宜的活性剂是能够从阳光中吸收UV辐射并将其转化为热能的滤过物质(防晒剂)。根据所需的作用,优选下列防晒剂:选择性地吸收波长范围为约280至315nm的高能灼伤UV辐射并传导范围为315至400nm(UV-A范围)长波的防晒剂(UV-B吸收剂),和仅吸收从315至400nm的UV-A范围的长波辐射的防晒剂(UV-A吸收剂)。
适宜的防晒剂是,例如下列的有机UV吸收剂:对-氨基苯甲酸衍生物,水杨酸衍生物,二苯甲酮衍生物,二苯甲酰基甲烷衍生物,二苯基丙烯酸酯衍生物,苯并呋喃衍生物,含有一个或多个有机硅基团的聚合UV吸收剂,肉桂酸衍生物,樟脑衍生物,三苯胺基-S-三唑衍生物,苯基苯并咪唑磺酸和其盐,氨茴香酸甲酯,苯并三唑衍生物,和/或选自下列的无机超细颜料:TiO2,氧化锌或用氧化铝或二氧化硅包裹的云母。
对-氨基苯甲酸衍生物化合物的实例是:
4-氨基苯甲酸(PABA);下式的乙基二羟基丙基-PABA下式的PEG-25-PABA其中m,n和x相同并且各自最多为25;下式的辛基二甲基PABA或下式的氨基苯甲酸甘油酯水杨酸衍生的化合物实例是:下式的水杨酸三甲环己酯下式的水杨酸三乙醇胺下式的对-二甲基氨基水杨酸戊酯下式的水杨酸辛酯或下式的水杨酸4-异丙基苄基酯
二苯甲酮衍生的化合物实例是:
二苯甲酮-3-(2-羟基-4-甲氧基二苯甲酮),二苯甲酮-4-(2-羟基-4-甲氧基二苯甲酮-5-磺酸)或二苯甲酮-8-(2,2’-二羟基-4-甲氧基-二苯甲酮)。
二苯甲酰基甲烷衍生的化合物是:
丁基甲氧基二苯甲酰基甲烷-[1-(4-叔丁基)-3-(4-甲氧基苯基)丙基-1,3-二酮]。
二苯基丙烯酸酯衍生的化合物实例是:
氰双苯丙烯酸辛酯(2-乙基己基-2-氰基-3,3’-二苯基丙烯酸酯)或氰双苯丙烯酸壬酯(乙基-2-氰基-3,3’-二苯基丙烯酸酯)。
苯并呋喃衍生的化合物实例是:
含有一个或多个有机硅基团的的聚合UV吸收剂化合物的实例是:
肉桂酸酯化合物的实例是:甲氧基肉桂酸辛酯(4-甲氧基肉桂酸-2-乙基己基酯),二乙醇胺甲氧基肉桂酸酯(4-甲氧内桂酸二乙醇胺盐),对甲氧肉桂酸异戊酯(4-乙氧基肉桂酸-2-异戊酯),2,5-二异丙基甲基肉桂酸酯或肉桂酸酰胺衍生物。
樟脑衍生的化合物实例是:
4-甲基亚苄基樟脑[3-(4’-甲基)亚苄基坎烷-2-酮],3-亚苄基樟脑(3-亚苄基坎烷-2-酮),聚丙烯基酰胺基甲基亚苄基樟脑{N-[2(和4)-2-氧坎烷-3-亚基甲基)苄基]丙烯酰胺聚合物},三monium亚苄基樟脑硫酸盐-[3-(4’-三甲基铵)亚苯基坎烷-2-酮甲基硫酸酯],对苯二亚甲基樟脑磺酸(3,3’-(1,4-亚苯基二次甲基)-双-(7,7-二甲基-2-氧双环-[2.2.1]庚烷-1-甲烷磺酸}或其盐,或亚苄基樟脑磺酸[3-(4’-硫代)亚苄基坎烷-2-酮]或其盐
三苯胺基-S-三嗪衍生的化合物实例是:
辛基三嗪-[2,4,6-三苯胺基-(对-羰-2’-乙基-1’-氧)-1,3,5-三嗪和在US-A-5,332,568,US-A-5,252,323,WO93/17002和WO97/03642和EP-A-0,517,104中公开的三苯胺基-S-三嗪衍生物;EP-A-0,775,698公开的间苯二酚基三嗪,特别是下式化合物或
苯并三唑化合物的实例是:
2-(2-羟基-5-甲基苯基)苯并三唑;
其中T2是氢原子;或C1-C8烷基;
-昆虫驱除剂:驱除剂是能够防止昆虫接触皮肤并在皮肤产生活性的组合物。它们可以驱除昆虫并缓缓蒸发。最常用的驱除剂是dethytoluamide(DEET)。其它常用的驱除剂可参见“W.Raab和U.Kindl,“Pflegekosmetik”,Gustsav-Fischer-VerlagStuttgart/New York,1991,P161;
-对化学和机械伤害具有保护作用的活性剂:包括可以在皮肤和外界的伤害源之间形成屏蔽的所有物质,例如石蜡油,硅油,植物油,PCL产品和羊毛脂作为抗水溶液,成影剂如藻酸钠,藻酸三乙醇胺,聚丙烯酸酯的保护剂,聚乙烯醇或纤维素醚作为抗有机溶剂作用的保护剂,或以矿物油,植物油或硅油为基础的“润滑剂”抗皮肤高机械强度的伤害;
-保湿物质:下列物质用于保湿:乳酸钠,尿素,醇,山梨糖醇,甘油,丙二醇,胶原蛋白,弹性蛋白或透明质酸;
-具有角膜形成的活性剂:苯甲酰剂过氧化物,视黄酸,胶态硫和间苯二酚;
-抗微生物剂,例如二氯苯氧氯酚或季铵化合物;
-用于皮肤的油状或脂溶性维生素或维生素衍生物:如维生素A(getinol游离酸或其衍生物),泛醇,泛酸,叶酸,和其混合物,维生素E(生育酚),F;必须脂肪酸;或烟酰胺(烟酸酰胺);
-基于维生素的胎盘提取物:主要含有维生素A,C,E,B21,B12的活性剂组合物,叶酸和生物素,氨基酸和酶,以及微量元素镁,硅,磷,钙,锰,铁或铜等的化合物。
-皮肤修复配合物:可通过将灭活和降解对裂细菌的培养物获得;
-植物和植物提取物:例如山金车属植物,芦荟,髯石竹地衣,长春藤,荨麻,人参,散沫花,春黄菊油,金盏花,薄荷,鼠尾草,木贼属植物或百里香;
-动物提取物:例如蜂乳,蜂胶,蛋白质或胸腺提取物;
-皮肤用化妆油:miglyol 812型的中性油,杏仁油,油梨油,巴巴苏仁油,棉籽油,琉璃苣油,蓟油,花生油,γ-青鳉油(gammaoryzanol),rosehip籽油,大麻油,榛子油,黑醋栗子油,希蒙德木油,樱核油,鲑鱼油,亚麻子油,玉米油,马卡达姆籽油,扁桃仁油,月见草油,水貂油,橄榄油,山核桃油,桃仁油,阿月浑籽油,油菜籽油,大米胚芽油,海狸油,红花油,芝麻油,大豆油,向日葵油,茶树油,葡萄籽油或小麦胚芽油。
根据本发明使用的毫微分散体中组分(c)的浓度优选基于组分(a),(b)和(c)总重量的0.1-80%重量比。
根据本发明使用的毫微分散体中的组分(a),(b)和(c)可以是单个的化合物或几个不同的单个组分的混合物。
毫微分散体组合物中组分(a),(b)或(c)中至少有一个是化妆品中常用的治疗或保护皮肤,粘膜和头发的功能活性剂。
根据本发明使用的毫微分散体可任意地含有可选择的组分(d)的加溶剂,优选C2-C8醇,如乙醇或丙二醇。
含有组分(a),(b),(c)和任选的(d)的毫微分散体具有优异的溶解化妆品活性剂的相特性。因此如果其是乳白色的并在入射光中是透明的,仅有轻微的混浊则说明该分散体还是实质上不同于真正的分子溶液的理想状态。电子显微镜成像显示出现在高斯分布中的98%以上为悬浮颗粒(毫微颗粒),其颗粒的大小为小于50nm,典型地小于约30nm。但是,这种与真正溶液的区别是允许的,因为可以证明分散体具有特别好的均一性,例如,具有令人惊异的高储藏稳定性,如在高于室温的温度下储藏数月未分离(推算的最佳保质期:超过两年)。
激光散射测定法和电子显微镜分析(Cryo-TEM)证实了毫微分散体中的毫微颗粒是非常小的并有优异的均一性。
根据本发明使用的毫微分散体的另一个优点是它们易于制备。
根据本发发明以权利要求1为特征的毫微分散体可用于化妆品最终制剂中。
本发明也涉及所谓毫微分散体前相,其特征在于它可通过步骤(α),在无水介质中将下列组分混合直至获得均一澄清的液体而获得:
(a)膜-形成分子,
(b)辅助乳化剂,
(c)亲脂组分及,任选地,
(d)C2-C8醇,优选丙二醇和更优选乙醇。
根据本发明,毫微分散体前相也可直接用于化妆品最终制剂中。
化妆品最终制剂包括非常宽范围的化妆品产品。适宜的产品具体举例如下:
-护肤产品,例如肥皂条或液体肥皂,合成洗涤剂或洗涤膏形式的洗涤和清洁皮肤的产品,
-沐浴产品,例如液体(泡沫沐浴液,奶液,淋浴产品)固体沐浴产品,如珠状肥皂和沫浴盐;
-护肤产品,如润肤乳液,多重乳液或润肤油;
-化妆产品,例如日霜或粉底,粉(干粉或粉饼)胭脂或膏状化妆品形式的脸部化妆品,眼部护肤产品,如眼影,mascara,眼线笔,眼霜或眼部定形霜;用于唇部化妆的产品例如口红,唇膏,唇线笔;用于指甲的化妆品,例如指甲彩油,指甲油清除剂,指甲固化剂或指甲膜清除剂;
-女性卫生产品,如女性卫生洗液或喷雾剂;
-护脚产品,例如脚部沐浴液,脚用粉,脚霜或脚用香脂,特别是除臭剂或防汗剂或刮除脚胝的产品;
-防晒剂,例如防晒乳,膏,霜,油,遮阳剂或薄型外衣织物,日晒前或日晒后产品;
-晒棕色产品,例如自身棕色霜;
-去斑产品,例如漂白或使皮肤亮泽的产品;
-昆虫驱除剂,例如驱虫油,洗液,喷雾剂或条;
-除臭剂,例如除臭喷雾剂,非气溶胶喷雾剂,除臭胶,条或辊棒;
-防汗剂,例如防汗条,霜或辊棒;
-清洁或治疗不纯皮肤的产品,例如合成洗涤剂(固体或液体),剥离或刮除产品或剥离膜;
-化学脱毛产品,例如脱毛粉,液体脱毛产品,霜状或膏状的脱毛产品,脱毛胶或气体泡沫;
-刮胡产品,例如刮胡皂,泡沫刮胡霜,非泡沫刮胡霜,刮胡泡沫和刮胡胶,用于干刮胡的刮胡前产品,刮胡后或刮胡后洗液;
-香料,例如香水(Eau de Cologne,Eau de Toilette,Eau deParfum,Parfum de toilette,香水),香油或香脂霜;
-口服或牙科卫生产品及假牙,例如牙膏,牙胶,牙粉,漱口浓缩液,抗蚀斑漱口剂,假牙清洁产品或假牙粘合产品;
-用于头发治疗的化妆品制剂,例如香波,头发调节剂形式的头发洗涤剂,护发产品,例如前治疗产品,头发滋补剂,头发定形霜和胶,润发油,洗发剂,深层调节剂和强化头发保护剂,烫发产品,例如电烫剂(热烫,温和烫,冷烫),直发产品,液体头发定形剂,头发泡沫,头发喷雾剂,漂白剂,例如过氧化氢溶液,漂白香波,漂白霜,漂白粉,漂白膏或油,暂时,稍长或永久染发剂,含有自身氧化染色剂或天然染发剂的产品,如散沫花或春黄菊油。
以上列出的最终制剂可以以很多形式使用,例如
-以油/水(O/W)乳液形式的液体制剂,
-胶体形式,
-油,霜,奶液或洗液形式,
-粉,涂抹剂,丸剂或化妆品形式,
-棒状形式
-喷雾形式(有推进器的喷雾或非气体喷雾)或气雾剂形式,
-泡沫形式,或
-糊剂形式。
液体或半固体形式的制剂中含有在水相中具有组分(a),(b)和(c)的毫微分散体并含有一个或多个上述功能性化妆品活性剂。固体制剂含有脱水形式的毫微分散体,脱水作用常常通过冷冻干燥或喷雾干燥常用辅料的方法进行。对于有些最终制剂易于用相应的毫微分散体前相替换毫微分散体。
乳液是含有两个不相或仅部分相互混溶的液体(相)非均一系。其中一个相是液滴(分散或内相)形式,而另一相连续是液相。在O/W乳液的情况下,其基本上是以水为特征的,非常细小的油滴分散在水中。
霜通常在皮肤的温度范围内是可分散的,同时,洗液或奶液倾向于是可流动的。
胶体是半固体的,多或少的透明系其中所谓胶体形成剂形成三-维网状结构其中液体是固定的。对于主要含有水的不透明水胶,水溶性物质和增稠剂或胶体形成剂是澄清的。如果另加入脂质体,可以得到有点象霜的水分散胶。相反,油胶不含水并以脂质体为液体成分。
以上述形式存在的含有一个或多个上述活性成分的化妆品最终制剂含有根据本发明的毫微分散体的浓度是0.01至100,优选0.01至20.0更优选0.05至5%重量比。
这些最终制剂是本发明的另一个主题。
在这些最终制剂的水相中含有毫微分散体的浓度是0.01-20.0优选0.05-10,更优选0.1-5%重量比。
根据本发明的化妆品组合物还可含有其它成分,例如,润滑剂,乳液稳定剂,皮肤湿润剂,晒棕促进剂,增稠剂,例如苍尔烷,保湿剂,如甘油,防腐剂,如对羟基苯甲酸酯类化合物,也可含有香料和调色剂。
根据实施例14至21的化妆品最终制剂的基质组合物是根据“Kosmeik;Entwicklung,Herstellung und Anwendungkosmetischer Mittel”(ED.:w.Umbach,Georg Thieme VerlagStuttgart,New York)和从“DGK Fortbildungskurs1998,Entwicklung moderner Hautpflegemittel”得到的文献中教导的方法制备的。
最终制剂是用常规的已知方法制备的,其中的一些方法公开于上述文献中。对于液体和半固体最终制剂,总是将毫微分散体掺入最终制剂的水相中。为此,可以将其溶解在很小一部分水相中然后再加入活性剂相,最后在20至30℃制备最终相。也可以用毫微分散前相来代替毫微分散体加到最终制剂的水相中。搅拌下并优选在各自的油/水相转化温度(PIT)的温度范围内将毫微分散体加到水相中。
对于固体制剂优选将脱水形式的毫微分散体与固体物质混合物混合。
化妆品最终制剂优选用于治疗和保护皮肤,粘膜,头发并且特别优选作为防晒剂或日晒后制剂。
根据本发明的亳微分散体也可作为脂溶性染料的运输载体。
另一方面,本发明也涉及权利要求1定义的毫微分散体用作脂溶性染料的载体系统的应用。
适宜的染料是合成的也可是天然的并且来源于所有已知色素,例如偶氯,偶氮,蒽醌,caratenoid,喹诺啉,苍耳烷,二芳基甲烷,三芳基甲烷,二苯乙烯,靛,酞菁,硝基染料,也可以是其它已知染料,如列于染料索引(Colour Index)C1 11000-C177999的染料。
在染料中,特别感兴趣的是至少部分易溶于有机介质如油中的染料。包括,例如被称为溶剂染料或分散染料的染料,分散染料也包括不承载的直接被头发吸收的染料基团,例如硝基苯或硝基二苯基胺衍生物。
根据本发明的溶剂染料的实例是:溶剂黑3(Cas-No.:4197-25-5);溶剂黑5(Cas-No.:11099-03-9);溶剂黑35(Cas-No.:12769-17-4);溶剂绿3;溶剂绿7(Cas-No.:6358-69-6);溶剂橙1(Cas-No:2051-85-6);溶剂红24(Cas-No.:85-83-6);溶剂红43(Cas-No.:15086-94-9);溶剂红48(Cas-No.:13473-26-2);溶剂红49:1(Cas-No.:6373-07-5);溶剂红72(Cas-No.:596-03-2);溶剂黄44(Cas-No.:2478-20-8);溶剂黄18(Cas-No.:6407-76-9)。
根据本发明的分散染料的实例是:
分散黑9(CAS No.:12222-60-4);分散兰1(CASNo.:2475-45-8);分散兰3(CAS No.:2475-46-9);分散棕1(CASNo.:23355-64-8);分散橙3(CAS No.:730-40-5);下式化合物
直接被头发吸收的染料(不承载)实例是:
HC兰No.7(CAS-No.:90817-34-8);HC兰No.8(CAS-No.:22366-99-0);HC兰No.9(CAS-No.:114087-42-2);HC兰No.10(CAS-No.:102767-27-1);HC兰No.11(CAS-No.:23920-15-2);HC兰No.12(CAS-No.:132885-85-9);下式化合物
HC兰No.14(CAS-No.:99788-75-7);HC橙No.1(CAS-No.:54381-08-7);HC橙No.2(CAS-No.:85765-48-6);HC橙No.3(CAS-No.:81612-54-6);下式化合物
HC红No.1(CAS-No.:2784-89-6);HC红No.3(CAS-No.:2781-01-4);HC红No.7(CAS-No.:24905-87-1);HC红No.8(CAS-No.:13556-29-1);HC红No.9(CAS-No.:56330-88-2);HC红No.10(CAS-No.:95576-89-9);HC红No.11(CAS-No.:95576-92-4);HC红No.13(CAS-No.:94158-13-1);下式化合物
HC黄No.2(CAS-No.:4926-55-0);HC黄No.4(CAS-No.:59820-43-8);HC黄No.5(CAS-No.:56932-44-6);HC黄No.6(CAS-No.:104335-00-6);下式化合物
HC黄No.8(CAS-No.:66612-11-1);HC黄No.9(CAS-No.:86419-69-4);HC黄No.10(CAS-No.:109023-83-8);HC黄No.11(CAS-No.:73388-54-2);HC黄No.12(CAS-No.:59320-13-7);HC黄No.13(CAS-No.:10442-83-8);下式化合物下式的HC化合物下式化合物
HC棕No.1(CAS-No.:83803-98-9);HC棕No.2(CAS-No.:83803-99-0);HC绿No.1(CAS-No.:52136-25-1)。
根据本发明的毫微分散体具有以下功能:
-作为载体使染料透过某些潜在的屏障而进入介质如皮肤,头发或指甲;
-保护染料与组合物中的其它活性成分的分离(换句话说,保护组合与其它染料的分离),例如为了消除组合物与固体间的不相容性。然后将毫微分散体核芯中的染料从组合物残留物中分离。这可能阻止染料与其它活性成分发生由光-引发的链反应;
-将只溶于油相中的染料导入水系统中并使其稳定。然后将染料溶于亳微分散体核芯(油相)中并将毫微分散体颗粒依次分散到水相中。
在下列实施例中,百分比为重量比。除非另有说明,化合物的量基于纯物质的用量。
毫微分散体前相的制备实施例
实施例1:Miglyol 812毫微分散体前相
大豆卵磷脂 17.30%
多乙氧基醚 34.00%
miglyol 812 34.50%
乙醇 14.20%
制备:将miglyol 812与多乙氧基醚混合。将大豆卵磷脂溶解在乙醇中并加到该混合物中,得到均一的澄清液体。
实施例2:Miglyol 812毫微分散体前相
大豆卵磷脂 17.30%
oleth-20 34.00%
miglyol 812 34.50%
乙醇 14.20%制备:在加热下,将miglyol 812与oleth-20混合。将大豆卵磷脂溶解在乙醇中并加到该混合物中,得到均一的澄清液体。实施例3:Miglyol 812毫微分散体前相
大豆卵磷脂 17.30%
laneth-20 34.00%
miglyol 812 34.50%
乙醇 14.20%制备:在加热下,将miglyol 812与laneth-20混合。将大豆卵磷脂溶解在乙醇中并加到该混合物中,得到均一的澄清液体。实施例4:Miglyol 812毫微分散体前相
大豆卵磷脂 17.30%
维生素E聚乙二醇琥珀酸酯 34.00%
(维生素ETPGS,Eastman)
miglyol 812 34.50%
乙醇 14.20%制备:在加热下,将miglyol 812与维生素E聚乙二醇琥珀酸酯混合。将大豆卵磷脂溶解在乙醇中并加到该混合物中,得到均一的澄清液体。实施例5:维生素E乙酸酯亳微分散体前相
大豆卵磷脂 9.00%
多乙氧基醚 34.00%
维生素E乙酸酯 36.60%
miglyol 812 13.00%
乙醇 7.40%制备:将miglyol 812,维生素E乙酸酯和多乙氧基醚混合。将大豆卵磷脂溶解在乙醇中并加到该混合物中,得到均一的澄清液体。实施例6:Parsol/MCX/Parsol 5000毫微分散体前相
大豆卵磷脂 5.00%
多乙氧基醚 34.00%
Parsol MCX 25.90%
(甲氧基肉桂酸辛酯)
parsol 5000 11.10%
(4-甲基苯亚甲基樟脑)
miglyol 812 13.00%
乙醇 11.00%制备:将Parsol 5000溶解在Parsol MXC中并将其与miglyol812和多乙氧基醚混合。将大豆卵磷脂溶解在乙醇中并加到该混合物中,得到均一的澄清液体。毫微分散体制备实施例实施例7:Miglyol 812毫微分散体
大豆卵磷脂 1.73%
多乙氧基醚 3.40%
miglyol 812 3.45%
乙醇 1.42%
纯水 加到100.00%制备:在50℃和搅拌下(如磁力搅拌器)将水相(如90kg)放置在容器中。在搅拌下(磁力搅拌器)将实施例1中制备的液体毫微分散体前相(如10kg)加到水相中。实施例8:Miglyol 812毫微分散体
大豆卵磷脂 1.73%
oleth-20 3.40%
miglyol 812 3.45%
乙醇 1.42%
纯水 加到100.00%用与实施例7相似的方法制备毫微分散体。实施例9:Miglyol 812微分散体
大豆卵磷脂 1.73%
laneth-20 3.40%
miglyol 812 3.45%
乙醇 1.42%
纯水 加到100.00%用与实施例7相似的方法制备毫微分散体。实施例10:Miglyol 812毫微分散体
大豆卵磷脂 1.73%
维生素E聚乙二醇琥珀酸酯 3.40%
(维生素ETPGS,Eastman)
miglyol 812 3.45%
乙醇 1.42%
纯水 加到100.00%
用与实施例7相似的方法制备毫微分散体。
实施例11:右泛醇毫微分散体
右泛醇 5.00%
大豆卵磷脂 1.73%
多乙氧基醚 3.40%
miglyol 812 3.45%
乙醇 1.42%
纯水 加到100.00%
制备:在50℃和搅拌下(如磁力搅拌器)将含有右泛醇的水相(如90kg)放置在容器中。在搅拌下(磁力搅拌器)将实施例1中制备的液体毫微分散体前相(如10kg)加到水相中。
实施例12:维生素E乙酸酯毫微分散体
维生素E乙酸酯 2.00%
大豆卵磷脂 0.49%
多乙氧基醚 1.86%
miglyol 812 0.71%
乙醇 0.63%
纯水 加到100.00%
制备:在50℃和搅拌下(如磁力搅拌器)将水相(如94.54kg)放置在容器中。在搅拌下(磁力搅拌器)将实施例5中制备的液体毫微分散体前相(如5.46kg)加到水相中。
实施例13:Parsol MCX/Parsol 5000毫微分散体
Parsol MCX 2.59%
(甲氧基肉桂酸辛酯)
Parsol 5000 1.11%
(4-甲基苯亚甲基樟脑)
miglyol 812 1.30%
大豆卵磷脂 0.50%
多乙氧基醚 3.40%
乙醇 1.10%
纯水 加到100.00%
用与实施例7相似的方法制备毫微分散体。毫微分散体中颗粒的大小和颗粒大小的分布列于表1中。
表1
毫微分散体 | 颗粒直径1[nm] | 标准偏差[nm] | 颗粒大小分布 |
miglyol 812毫微分散体 实施例7 | 13.8 | 4.1 | 高斯 |
右泛醇毫微分散体实施例11 | 19.7 | 5.4 | 高斯 |
维生素E乙酸酯毫微分散体 实施例12 | 12.2 | 5.5 | 高斯 |
Parsol MCX/Parsol5000毫微分散体实施例13 | 14.6 | 5.2 | 高斯 |
1颗粒直径和颗粒大小分布通过激光散射法确定(Nicomp370Submicron Particle Sizer,数量加权)
下表显示毫微分散体还具有优异的储藏稳定性:
右泛醇毫微分散体(实施例11)
表2
储存条件 | pH | 直径2[nm] | 标准偏差[nm] | 右泛醇3含量[%] | |
时间[月] | 温度[℃] | ||||
0 | 6.1 | 19.7 | 5.4 | 5.37 | |
3 | 72540 | 6.16.16.3 | 19.022.236.6 | 6.77.714.2 | 5.365.325.23 |
6 | 72540 | 6.16 26.4 | 20.824.135.4 | 7.39.217.7 | 5.305.265.20 |
2颗粒直径和颗粒大小分布通过激光散射法确定(Nicomp370Submicron Particle Sizer,体积加权)
3右泛醇含量通过HPLC确定
维生素E乙酸酯毫微分散体(实施例12)
表3
储存条件 | pH | 直径4[nm] | 标准偏差[nm] | 维生素E乙酸酯含量[%]5 | |
时间[月] | 温度[℃] | ||||
0 | 6.1 | 12.2 | 5.5 | 2.04 | |
3 | 72540 | 6.16.16.0 | 16.117.515.4 | 6.67.06.8 | 2.022.042.01 |
6 | 72540 | 6.16.06.0 | 17.017.620.8 | 6.97.27.9 | 2.042.032.02 |
4颗粒直径和颗粒大小分布通过激光散射法确定(Nicomp370Submicron Particle Sizer,体积加权)
5维生素E乙酸酯含量通过HPLC确定
含毫微分散体或化妆品最终制剂的制备实施例
实施例14:O/W治疗洗液
聚甘油甲基葡萄糖二硬脂酸酯 2.00%
癸酸/三甘油辛酯 6.50%
矿物油 6.50%
甘油 3.00%
实施例12的毫微分散体 5.00%
carbomer 0.20%
乙醇 10.00%
苯氧基乙醇+甲基-,乙基-, 0.30%
丙基-,丁基对羟基苯甲酸酯
香料 0.30%
氢氧化钠(45%) 0.09%
水 加到100.00%
实施例15:具有UV保护作用的日霜(O/W)
PEG-5甘油硬脂酸酯 5.0%
steareth-21 2.0%
矿物油 30.0%
鲸蜡醇 2.0%
微晶蜡 1.0%
丙二醇 6.0%
实施例13毫微分散体 10.0%
苯氧基乙醇+甲基-,乙基-, 0.3%
丙基-,丁基对羟基苯甲酸酯
水 加到100.0%
实施例16:具有脂肪还原特性的液体合成洗涤剂
脂肪醇醚硫酸酯 7.5%
脂肪复原剂 3.0%
珠光 2.0%
增稠剂 1.0%
实施例10的毫微分散体 5.0%
香料 0.3%
水 加到100.0%实施例17:具有治疗作用的泡沫浴液
月桂基醚硫酸钠 9.0%
可可脂肪酸二乙醇酰胺 2.0%
脂肪酸聚甘油酯(3EO) 3.0%
香料 1.0%
实施例7毫微分散体 4.0%
防腐剂,柠檬酸,氯化钠,水 加到100.0%实施例18:缓解O/W洗液
硬脂酸 1.50%
山梨糖醇单硬脂酸酯 1.00%
山梨糖醇单油酸酯 1.00%
矿物油 7.00%
棕榈酸鲸蜡醇酯 1.00%
聚甲基硅氧烷 1.50%
甘油 2.00%
1,2-丙二醇 2.00%
实施例11的毫微分散体 3.00%
聚丙烯酸 0.15%
氢氧化钠 0.30%
香料 0.50%
防腐剂,水 加到100.00%实施例19:皮肤保护W/O洗液
甘油山梨糖醇脂肪酸酯 2.0%
聚乙氧基脂肪酸酯 2.0%
异硬脂酸异丙酯 5.0%
矿物油 7.0%
棕榈酸异丙酯 4.0%
小麦胚芽油 3.0%
丙二醇 3.8%
实施例1 2的毫微分散体 5.0%
MgSO4x7H2O 0.7%
香料 0.5%
防腐剂,水 加到100.0%实施例20:化妆品
甘油单硬脂酸酯 4.0%
鲸蜡醇 1.0%
硬脂酸 2.0%
矿物油 4.5%
鲸蜡基硬脂酸辛酯 5.0%
棕榈酸辛酯 3.0%
滑石粉 4.0%
二氧化钛 1.5%
氧化铁 0.8%
丙二醇 5.0%
多乙氧基山梨糖醇单月桂酸酯 1.0%
苍耳烷 0.4%
镁-铝-硅 0.3%
甘油 5.0%
实施例13的毫微分散体 5.0%
防腐剂,水 加到100.0%
实施例21:右泛醇缓释型喷雾剂
苯氧基乙醇 0.5%
实施例11的毫微分散体 加到100.0%
Claims (31)
1.用毫微分散体制备化妆品最终制剂的方法,该毫微分散体含有
(a)膜-形成分子
(b)辅助乳化剂及
(c)亲脂成分,
该方法包括(α)将组分(a),(b)和(c)混合直至得到均一的澄清液体(所谓毫微分散体前相),和
(β)将步骤(α)得到的液体加到化妆品最终制剂的水相中,步骤(α)和(β)可以在不需要任何外加能量下进行。
2.根据权利要求1的方法,其特征在于步骤(α)在无水介质中进行。
3.根据权利要求1的方法,其特征在于步骤(β)不需要均化而进行。
4.根据权利要求1的方法,其特征在于毫微分散体中颗粒的平均直径<50nm。
5.根据权利要求1的方法,其特征在于毫微分散体含有,
(a)作为膜-形成分子的是适宜形成所谓双层结构的物质,
(b)作为辅助乳化剂的是易于形成油/水结构的物质及,
(c)作为亲脂成分的是化妆品中常用的亲脂活性剂。
6.根据权利要求1的方法,其特征在于毫微分散体含有作为组分
(a)的磷脂,水合的或部分水合的磷脂,溶血磷脂,神经酰胺,或它们的混合物。
7.根据权利要求6的方法,其特征在于毫微分散体中组分(a)的浓度是基于组分(a),(b)和(c)总重量的0.1至30%重量比。
8.根据权利要求1的方法,其特征在于毫微分散体含有作为组分
(b)的聚氧乙烯型的乳化剂,饱和和不饱和C8-C18烷基硫酸盐,C8-C20脂肪酸的碱金属,铵或胺盐,C8-C20链烷基磺酸盐,脂肪醇磷酸盐,肠酸盐,转化皂液(quats);山梨糖醇的部分脂肪酸酯,脂肪酸糖酯,脂肪酸部分甘油酯,烷基麦芽糖甙,烷基葡萄糖甙,C8-C18甜菜碱,C8-C18硫代甜菜碱,或C8-C24烷基酰氨基-C1-C4亚烷基甜菜碱,蛋白质,脂肪酸聚乙二醇酯,脂肪酸丙二醇酯,脂肪酸乳酸酯或这些物质的混合物。
9.根据权利要求8的方法,其特征在于毫微分散体含有作为组分
(b)的至少一种聚氧乙烯型乳化剂。
10.根据权利要求1的方法,其特征在于毫微分散体含有作为组分
(b)的聚氧乙烯型乳化剂或这些物质的混合物。
11.根据权利要求10的方法,其特征在于毫微分散体中组分(b)是
聚乙氧基山梨糖醇脂肪酸酯,聚乙氧基脂肪醇,聚乙氧基脂肪酸,聚乙氧基维生素E衍生物,聚乙氧基羊毛脂和其衍生物,聚乙氧基脂肪酸部分甘油酯,聚乙氧基烷基苯酚,硫酸半酯,聚乙氧基脂肪醇和其衍生物,聚乙氧基脂肪胺和脂肪酸酰胺,聚乙氧基碳水化合物,环氧乙烷和环氧丙烷的嵌段共聚物。
12.根据权利要求1的方法,其特征在于根据本发明的毫微分散体中组分(b)的浓度是基于组分(a),(b)和(c)总重量的1至50%重量比。
13.根据权利要求1的方法,其特征在于毫微分散体中含有作为组分
(c)的天然或合成或部分合成的二-或三甘油酯,矿物油,硅油,蜡,脂肪醇,格尔伯特醇或其酯,包括防晒剂的亲脂功能化妆品活性剂或这些物质的混合物。
14.根据权利要求13的方法,其特征在于毫微分散体中含有作为组分(c)的防晒剂或脂溶性维生素。
15.根据权利要求1的方法,其特征在于根据本发明的毫微分散体中组分(c)的浓度是0.1至80%重量比。
16.根据权利要求1的方法,其特征在于毫微分散体含有作为组分。
(d)的C2-C8醇
17.根据权利要求1的方法,其特征在于最终制剂中的毫微分散体的浓度是0.01至99%重量比。
18.根据权利要求1的方法,其特征在于组分(a),(b)或(c)中至少有一种组分是用在化妆品中用作治疗或保护皮肤,粘膜和头发作用的活性剂。
19.含有权利要求1定义的毫微分散体的化妆品最终制剂是胶体。
20.含有权利要求1定义的毫微分散体化妆品最终制剂是霜,洗液或奶液。
21.含有权利要求1定义的毫微分散体的化妆品最终制剂是棒状的。
22.含有权利要求1定义的毫微分散体的化妆品最终制剂是喷雾剂或气雾剂。
23.含有权利要求1定义的毫微分散体的化妆品最终制剂是泡沫。
24.含有权利要求1定义的毫微分散体的化妆品最终制剂是糊剂。
25.根据权利要求19的化妆品最终制剂,其中毫微分散体在水相中。
26.根据权利要求19的化妆品最终制剂,其中亳微分散体在水相中的浓度是0.01至20%重量比。
27.含有权利要求1定义的毫微分散体的化妆品最终制剂是粉,涂抹剂,丸剂或化妆品形式。
28.毫微分散体前相,该毫微分散体前相是通过将下列组分
(a)膜-形成分子,
(b)辅助乳化剂和
(c)亲脂成分和,任选地
(d)C2-C8醇
混合直至得到均一澄清的液体而获得,混合在无水介质中进行。
29.根据权利要求28的毫微分散体前相,其特征在于混合是在没有任何外加能量的条件下进行的。
30.含有权利要求28定义的毫微分散体前相的油或涂抹剂形式的化妆品最终制剂。
31.毫微分散体,其中包括
(a)膜-形成分子,
(b)辅助乳化剂和
(c)亲脂成分,
该毫微分散体可通过下列方法获得
(α)将成分(a),(b)和(c)混合直至得到均一的澄清液体,和
(β)将步骤(α)得到的液体加到水相中,步骤(α)和(β)可以在不需要任何外加能量下进行。
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GB0301279D0 (en) * | 2003-01-20 | 2003-02-19 | Syngenta Ltd | Method of dermal protection |
FR2856302B1 (fr) * | 2003-06-20 | 2005-12-02 | Anben Pharma | Composition pharmaceutique utilisee en tant qu'agent anti-infectueux des voies respiratoires superieures |
CH715855B1 (de) * | 2003-08-28 | 2020-08-14 | Mibelle Ag | Zubereitung bestehend aus mindestens zwei Nanoemulsionen. |
AU2004271979A1 (en) * | 2003-09-10 | 2005-03-24 | The Procter & Gamble Company | Skin care composition |
DE102004003435A1 (de) * | 2004-01-21 | 2005-08-11 | Beiersdorf Ag | Dünnflüssige O/W-Emulsion |
KR20050097587A (ko) * | 2004-04-01 | 2005-10-10 | 주식회사 태평양 | 폴리글리세릴-3 메틸글루코스디스테아레이트를 사용하여제조된 수중유형의 화장료 조성물 |
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BR9903600A (pt) | 2000-09-26 |
ZA993201B (en) | 1999-11-11 |
BRPI9903600B1 (pt) | 2015-12-08 |
AR018601A1 (es) | 2001-11-28 |
HUP9901572A2 (hu) | 2000-01-28 |
ID22566A (id) | 1999-11-11 |
CZ167099A3 (cs) | 1999-11-17 |
US7008638B2 (en) | 2006-03-07 |
AU764038B2 (en) | 2003-08-07 |
DE59913204D1 (de) | 2006-05-04 |
CN1133414C (zh) | 2004-01-07 |
EP0956851A1 (de) | 1999-11-17 |
ES2259231T3 (es) | 2006-09-16 |
RU2209618C2 (ru) | 2003-08-10 |
HUP9901572A3 (en) | 2001-11-28 |
US20020106390A1 (en) | 2002-08-08 |
KR19990088175A (ko) | 1999-12-27 |
EP0956851B1 (de) | 2006-03-08 |
HU9901572D0 (en) | 1999-07-28 |
TW592713B (en) | 2004-06-21 |
JP4294160B2 (ja) | 2009-07-08 |
JPH11335261A (ja) | 1999-12-07 |
AU2805299A (en) | 1999-11-18 |
PL332935A1 (en) | 1999-11-22 |
KR100630246B1 (ko) | 2006-10-02 |
MY133152A (en) | 2007-10-31 |
ATE319504T1 (de) | 2006-03-15 |
SG72949A1 (en) | 2000-05-23 |
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